{"id":"https://openalex.org/W4414547297","doi":"https://doi.org/10.1186/s12880-025-01914-8","title":"Efficacy of PSMA PET/CT radiomics analysis for risk stratification in newly diagnosed prostate cancer: a multicenter study","display_name":"Efficacy of PSMA PET/CT radiomics analysis for risk stratification in newly diagnosed prostate cancer: a multicenter study","publication_year":2025,"publication_date":"2025-09-26","ids":{"openalex":"https://openalex.org/W4414547297","doi":"https://doi.org/10.1186/s12880-025-01914-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/41013451"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-025-01914-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01914-8","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01914-8","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01914-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064777652","display_name":"Esmail Jafari","orcid":"https://orcid.org/0000-0001-9249-9248"},"institutions":[{"id":"https://openalex.org/I52623189","display_name":"Bushehr University of Medical Sciences","ror":"https://ror.org/02y18ts25","country_code":"IR","type":"education","lineage":["https://openalex.org/I52623189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Esmail Jafari","raw_affiliation_strings":["The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran"],"affiliations":[{"raw_affiliation_string":"The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran","institution_ids":["https://openalex.org/I52623189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112919678","display_name":"Amin Zarei","orcid":null},"institutions":[{"id":"https://openalex.org/I52623189","display_name":"Bushehr University of Medical Sciences","ror":"https://ror.org/02y18ts25","country_code":"IR","type":"education","lineage":["https://openalex.org/I52623189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amin Zarei","raw_affiliation_strings":["The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran"],"affiliations":[{"raw_affiliation_string":"The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran","institution_ids":["https://openalex.org/I52623189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079511375","display_name":"Habibollah Dadgar","orcid":"https://orcid.org/0000-0001-6073-7547"},"institutions":[{"id":"https://openalex.org/I4210088705","display_name":"Imam Reza International University","ror":"https://ror.org/007jfm765","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210088705"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Habibollah Dadgar","raw_affiliation_strings":["Cancer Research Center, RAZAVI Hospital, Imam Reza International University, Mashhad, Iran"],"affiliations":[{"raw_affiliation_string":"Cancer Research Center, RAZAVI Hospital, Imam Reza International University, Mashhad, Iran","institution_ids":["https://openalex.org/I4210088705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026041687","display_name":"Ahmad Keshavarz","orcid":"https://orcid.org/0000-0002-5103-8311"},"institutions":[{"id":"https://openalex.org/I90767664","display_name":"Persian Gulf University","ror":"https://ror.org/03n2mgj60","country_code":"IR","type":"education","lineage":["https://openalex.org/I90767664"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ahmad Keshavarz","raw_affiliation_strings":["IoT and Signal Processing Research Group, ICT Research Institute, Faculty of Intelligent Systems Engineering and Data Science, Persian Gulf University, Bushehr, Iran"],"affiliations":[{"raw_affiliation_string":"IoT and Signal Processing Research Group, ICT Research Institute, Faculty of Intelligent Systems Engineering and Data Science, Persian Gulf University, Bushehr, Iran","institution_ids":["https://openalex.org/I90767664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075700698","display_name":"Hamid Abdollahi","orcid":"https://orcid.org/0000-0002-5994-6365"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hamid Abdollahi","raw_affiliation_strings":["Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada","Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048541207","display_name":"Rezvan Samimi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109871","display_name":"Khatam University","ror":"https://ror.org/016tr2g85","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210109871"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Rezvan Samimi","raw_affiliation_strings":["Khatam PET/CT Center, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Khatam PET/CT Center, Tehran, Iran","institution_ids":["https://openalex.org/I4210109871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032276703","display_name":"Reyhaneh Manafi\u2010Farid","orcid":"https://orcid.org/0000-0003-2833-8276"},"institutions":[{"id":"https://openalex.org/I4210108448","display_name":"Shariati Hospital","ror":"https://ror.org/01rb4vv49","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210108448"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Reyhaneh Manafi-Farid","raw_affiliation_strings":["Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210108448","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038394289","display_name":"Ghasemali Divband","orcid":"https://orcid.org/0000-0001-6011-8236"},"institutions":[{"id":"https://openalex.org/I4210109871","display_name":"Khatam University","ror":"https://ror.org/016tr2g85","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210109871"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"GhasemAli Divband","raw_affiliation_strings":["Khatam PET/CT Center, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Khatam PET/CT Center, Tehran, Iran","institution_ids":["https://openalex.org/I4210109871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038865244","display_name":"Babak Nikkholgh","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109871","display_name":"Khatam University","ror":"https://ror.org/016tr2g85","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210109871"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Babak Nikkholgh","raw_affiliation_strings":["Khatam PET/CT Center, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Khatam PET/CT Center, Tehran, Iran","institution_ids":["https://openalex.org/I4210109871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012381486","display_name":"Babak Fallahi","orcid":"https://orcid.org/0000-0002-0576-1672"},"institutions":[{"id":"https://openalex.org/I4210108448","display_name":"Shariati Hospital","ror":"https://ror.org/01rb4vv49","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210108448"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Babak Fallahi","raw_affiliation_strings":["Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210108448","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059503754","display_name":"Hamidreza Amini","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109871","display_name":"Khatam University","ror":"https://ror.org/016tr2g85","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210109871"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"HamidReza Amini","raw_affiliation_strings":["Khatam PET/CT Center, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Khatam PET/CT Center, Tehran, Iran","institution_ids":["https://openalex.org/I4210109871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001442023","display_name":"Hojjat Ahmadzadehfar","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088357","display_name":"Klinikum Westfalen (Germany)","ror":"https://ror.org/004sfne89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088357"]},{"id":"https://openalex.org/I4210112654","display_name":"Universit\u00e4tsklinikum Knappschaftskrankenhaus Bochum","ror":"https://ror.org/024j3hn90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210112654"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hojjat Ahmadzadehfar","raw_affiliation_strings":["Department of Nuclear Medicine, Institute of Radiology, Neuroradiology and Nuclear Medicine, University Hospital Knappschaftskrankenhaus, Bochum, Germany","Department of Nuclear Medicine, Klinikum Westfalen, Dortmund, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Institute of Radiology, Neuroradiology and Nuclear Medicine, University Hospital Knappschaftskrankenhaus, Bochum, Germany","institution_ids":["https://openalex.org/I4210112654"]},{"raw_affiliation_string":"Department of Nuclear Medicine, Klinikum Westfalen, Dortmund, Germany","institution_ids":["https://openalex.org/I4210088357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021438906","display_name":"Arman Rahmim","orcid":"https://orcid.org/0000-0002-9980-2403"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arman Rahmim","raw_affiliation_strings":["Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada","Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071063591","display_name":"Farshad Zohrabi","orcid":"https://orcid.org/0000-0002-8330-6202"},"institutions":[{"id":"https://openalex.org/I52623189","display_name":"Bushehr University of Medical Sciences","ror":"https://ror.org/02y18ts25","country_code":"IR","type":"education","lineage":["https://openalex.org/I52623189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farshad Zohrabi","raw_affiliation_strings":["Department of Urology, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Urology, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran","institution_ids":["https://openalex.org/I52623189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103157316","display_name":"Majid Assadi","orcid":"https://orcid.org/0000-0002-2166-3765"},"institutions":[{"id":"https://openalex.org/I52623189","display_name":"Bushehr University of Medical Sciences","ror":"https://ror.org/02y18ts25","country_code":"IR","type":"education","lineage":["https://openalex.org/I52623189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Majid Assadi","raw_affiliation_strings":["The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. assadipoya@yahoo.com","The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran"],"affiliations":[{"raw_affiliation_string":"The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. assadipoya@yahoo.com","institution_ids":["https://openalex.org/I52623189"]},{"raw_affiliation_string":"The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran","institution_ids":["https://openalex.org/I52623189"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5064777652"],"corresponding_institution_ids":["https://openalex.org/I52623189"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.5932,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86600754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"375","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.7903000116348267},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.7671999931335449},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.5218999981880188},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.515999972820282},{"id":"https://openalex.org/keywords/multicenter-study","display_name":"Multicenter study","score":0.4745999872684479},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.4438000023365021},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.4309000074863434},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"Prostate-specific antigen","score":0.4219000041484833}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8119999766349792},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.7903000116348267},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7671999931335449},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5218999981880188},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.515999972820282},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.4745999872684479},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.4438000023365021},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4309000074863434},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.4219000041484833},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4178999960422516},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.3605000078678131},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3547999858856201},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3538999855518341},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3147999942302704},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.31130000948905945},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.2653999924659729},{"id":"https://openalex.org/C2910607126","wikidata":"https://www.wikidata.org/wiki/Q48790829","display_name":"Multiparametric MRI","level":4,"score":0.26190000772476196},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.2572999894618988},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2572000026702881}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s12880-025-01914-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01914-8","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01914-8","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41013451","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41013451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:3eb2214da62447a5b733f4c45734027c","is_oa":true,"landing_page_url":"https://doaj.org/article/3eb2214da62447a5b733f4c45734027c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 25, Iss 1, Pp 1-11 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11273700","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12465446","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12465446","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12465446/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-025-01914-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01914-8","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01914-8","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414547297.pdf","grobid_xml":"https://content.openalex.org/works/W4414547297.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W2326657743","https://openalex.org/W2346685985","https://openalex.org/W2591849683","https://openalex.org/W2740524391","https://openalex.org/W2890919948","https://openalex.org/W2913023403","https://openalex.org/W2984343731","https://openalex.org/W2990778187","https://openalex.org/W3007051767","https://openalex.org/W3007254442","https://openalex.org/W3014013305","https://openalex.org/W3046865842","https://openalex.org/W3084519881","https://openalex.org/W3097158220","https://openalex.org/W3113311516","https://openalex.org/W3123621850","https://openalex.org/W3132649949","https://openalex.org/W3159496914","https://openalex.org/W3165536575","https://openalex.org/W3180972814","https://openalex.org/W3199011255","https://openalex.org/W4293168699","https://openalex.org/W4296186975","https://openalex.org/W4309213070","https://openalex.org/W4311872728","https://openalex.org/W4321435953","https://openalex.org/W4327677460","https://openalex.org/W4327811821","https://openalex.org/W4386531233","https://openalex.org/W4390630688","https://openalex.org/W4402175126","https://openalex.org/W4403851952","https://openalex.org/W4410899554"],"related_works":[],"abstract_inverted_index":{"Prostate-specific":[0],"membrane":[1],"antigen":[2],"(PSMA)":[3],"PET/CT":[4,17,35,82,342,349],"plays":[5],"an":[6],"increasing":[7],"role":[8],"in":[9,38,60,116,122,223,238,242,291,297,367],"prostate":[10,65,75,115,121,290,370],"cancer":[11,76],"management.":[12],"Radiomics":[13],"analysis":[14,37,139],"of":[15,33,96,195,318],"PSMA":[16,34],"images":[18],"may":[19,359],"provide":[20,360],"additional":[21],"information":[22,362],"for":[23,83,363],"risk":[24,365],"stratification.":[25],"This":[26],"study":[27],"aimed":[28],"to":[29,142],"evaluate":[30],"the":[31,93,113,119,208,220,224,229,243,281,288,294,298,303,307,316,331,340],"performance":[32,156,222,296,309,333],"radiomics":[36],"differentiating":[39],"between":[40],"Gleason":[41],"Grade":[42],"Groups":[43],"(GGG":[44],"1\u20133":[45,204],"vs.":[46,54,278],"GGG":[47,203,206],"4\u20135)":[48],"and":[49,92,118,182,252,320,327],"predicting":[50],"PSA":[51,272],"levels":[52],"(below":[53],"at":[55],"or":[56],"above":[57],"20":[58,276],"ng/ml)":[59],"patients":[61,71,190],"with":[62,72,152,159,191,337],"newly":[63,368],"diagnosed":[64,369],"cancer.":[66,371],"In":[67,185,302],"this":[68,186],"multicenter":[69],"study,":[70,188],"confirmed":[73],"primary":[74],"were":[77,105,127,199],"enrolled":[78],"who":[79],"underwent":[80],"[68Ga]Ga-PSMA":[81,348],"staging.":[84],"Inclusion":[85],"criteria":[86],"required":[87],"intraprostatic":[88,108,356],"lesions":[89,110,237],"on":[90,111,145],"PET":[91,218,239,264,292,319],"International":[94],"Society":[95],"Urological":[97],"Pathology":[98],"(ISUP)":[99],"grade":[100],"information.":[101],"Three":[102],"different":[103],"segments":[104],"delineated":[106],"including":[107,170],"PSMA-avid":[109,236,263,357],"PET,":[112,117],"whole":[114,120,289],"CT.":[123,321],"Radiomic":[124],"features":[125,214,353],"(RFs)":[126,215],"extracted":[128],"from":[129,147,205,216,235,262,287,315,339,355],"all":[130],"segments.":[131],"Dimensionality":[132],"reduction":[133],"was":[134,157,310,334],"achieved":[135,219,293,336],"through":[136],"principal":[137],"component":[138],"(PCA)":[140],"prior":[141],"model":[143],"training":[144],"data":[146,161,265],"two":[148],"centers":[149],"(186":[150],"cases)":[151,164],"10-fold":[153],"cross-validation.":[154],"Model":[155],"validated":[158],"external":[160,244,253,304,328],"set":[162],"(57":[163],"using":[165,212,233,260,285,312],"various":[166],"machine":[167,177],"learning":[168],"models":[169],"random":[171,230],"forest,":[172],"nearest":[173,209,282],"centroid,":[174],"support":[175],"vector":[176],"(SVM),":[178],"calibrated":[179,257],"classifier":[180,211,232,258,284],"CV":[181,259],"logistic":[183],"regression.":[184],"retrospective":[187],"243":[189],"a":[192,256],"median":[193],"age":[194],"69":[196],"(range:":[197],"46\u201389)":[198],"enrolled.":[200],"For":[201],"distinguishing":[202],"4\u20135,":[207],"centroid":[210,283],"radiomic":[213,350],"whole-prostate":[217],"best":[221,241,295,332],"internal":[225,251,299,326],"test":[226,245,254,300,305,329],"set,":[227,306],"while":[228],"forest":[231],"RFs":[234,261,286,313,338],"performed":[240],"set.":[246,301],"However,":[247],"when":[248,323],"considering":[249],"both":[250,325],"sets,":[255,330],"showed":[266],"slightly":[267],"improved":[268],"overall":[269],"performance.":[270],"Regarding":[271],"level":[273],"classification":[274],"(<":[275],"ng/ml":[277],"\u226520":[279],"ng/ml),":[280],"highest":[308],"observed":[311],"derived":[314,354],"concatenation":[317],"Notably,":[322],"combining":[324],"again":[335],"concatenated":[341],"data.":[343],"Our":[344],"research":[345],"suggests":[346],"that":[347],"features,":[351],"particularly":[352],"lesions,":[358],"valuable":[361],"pre-biopsy":[364],"stratification":[366]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}