{"id":"https://openalex.org/W4412450116","doi":"https://doi.org/10.1186/s12880-025-01823-w","title":"Non-invasive liver fibrosis screening on CT images using radiomics","display_name":"Non-invasive liver fibrosis screening on CT images using radiomics","publication_year":2025,"publication_date":"2025-07-15","ids":{"openalex":"https://openalex.org/W4412450116","doi":"https://doi.org/10.1186/s12880-025-01823-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/40665242"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-025-01823-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01823-w","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01823-w","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01823-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089734706","display_name":"Jay J. Yoo","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4210127509","display_name":"Vector Institute","ror":"https://ror.org/03kqdja62","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210127509"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jay J. Yoo","raw_affiliation_strings":["Department of Computer Science, University of Toronto, 40 St. George Street, Toronto, ON, M5S 2E4, Canada","Department of Diagnostic Imaging & Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada","Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada","Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, 40 St. George Street, Toronto, ON, M5S 2E4, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Diagnostic Imaging & Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada","institution_ids":["https://openalex.org/I4210127509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085138985","display_name":"Khashayar Namdar","orcid":"https://orcid.org/0000-0003-0497-6206"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4210127509","display_name":"Vector Institute","ror":"https://ror.org/03kqdja62","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210127509"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Khashayar Namdar","raw_affiliation_strings":["Department of Diagnostic Imaging & Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada","Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada","Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Imaging & Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada","institution_ids":["https://openalex.org/I4210127509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082304822","display_name":"S. Carey","orcid":"https://orcid.org/0000-0002-0221-6871"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sean Carey","raw_affiliation_strings":["Joint Department of Medical Imaging, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Department of Medical Imaging, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","institution_ids":["https://openalex.org/I2801845744","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081545818","display_name":"Sandra E. Fischer","orcid":"https://orcid.org/0000-0001-8859-4525"},"institutions":[{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sandra E. Fischer","raw_affiliation_strings":["Laboratory Medicine & Pathobiology - Anatomic Pathology, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine & Pathobiology - Anatomic Pathology, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","institution_ids":["https://openalex.org/I2801845744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044425152","display_name":"Chris McIntosh","orcid":"https://orcid.org/0000-0003-1371-1250"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4210127509","display_name":"Vector Institute","ror":"https://ror.org/03kqdja62","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210127509"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chris McIntosh","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada","Joint Department of Medical Imaging, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","Peter Munk Cardiac Center, University Health Network, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2C4, Canada","Techna Institute, University Health Network, 190 Elizabeth Street, Toronto, ON, M5G 2C4, Canada","Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Joint Department of Medical Imaging, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","institution_ids":["https://openalex.org/I2801845744","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Peter Munk Cardiac Center, University Health Network, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2C4, Canada","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Techna Institute, University Health Network, 190 Elizabeth Street, Toronto, ON, M5G 2C4, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada","institution_ids":["https://openalex.org/I4210127509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034208717","display_name":"Farzad Khalvati","orcid":"https://orcid.org/0000-0001-5616-8660"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4210127509","display_name":"Vector Institute","ror":"https://ror.org/03kqdja62","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210127509"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Farzad Khalvati","raw_affiliation_strings":["Department of Computer Science, University of Toronto, 40 St. George Street, Toronto, ON, M5S 2E4, Canada. farzad.khalvati@utoronto.ca","Department of Diagnostic Imaging & Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. farzad.khalvati@utoronto.ca","Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON, M5S 3G8, Canada. farzad.khalvati@utoronto.ca","Department of Medical Imaging, University of Toronto, 263 McCaul Street, Toronto, ON, M5T 1W7, Canada. farzad.khalvati@utoronto.ca","Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. farzad.khalvati@utoronto.ca","Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada. farzad.khalvati@utoronto.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, 40 St. George Street, Toronto, ON, M5S 2E4, Canada. farzad.khalvati@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Diagnostic Imaging & Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. farzad.khalvati@utoronto.ca","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON, M5S 3G8, Canada. farzad.khalvati@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medical Imaging, University of Toronto, 263 McCaul Street, Toronto, ON, M5T 1W7, Canada. farzad.khalvati@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. farzad.khalvati@utoronto.ca","institution_ids":["https://openalex.org/I2801862477"]},{"raw_affiliation_string":"Vector Institute, 661 University Avenue, Toronto, ON, M5G 1M1, Canada. farzad.khalvati@utoronto.ca","institution_ids":["https://openalex.org/I4210127509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069757332","display_name":"Patrik Rogalla","orcid":"https://orcid.org/0000-0002-7281-4850"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrik Rogalla","raw_affiliation_strings":["Joint Department of Medical Imaging, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Department of Medical Imaging, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada","institution_ids":["https://openalex.org/I2801845744","https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":5.3189,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.95978778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"25","issue":"1","first_page":"285","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.7175999879837036,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.7175999879837036,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.8292384147644043},{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.7483826279640198},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.6565569639205933},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.5664324164390564},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5546395778656006},{"id":"https://openalex.org/keywords/asymptomatic","display_name":"Asymptomatic","score":0.5400320887565613},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.491389662027359},{"id":"https://openalex.org/keywords/neuroradiology","display_name":"Neuroradiology","score":0.4701552391052246},{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.44853267073631287},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.4352370500564575},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3593277335166931},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3555023968219757},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16139286756515503},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.15776106715202332}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8292384147644043},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.7483826279640198},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6565569639205933},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5664324164390564},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5546395778656006},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5400320887565613},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.491389662027359},{"id":"https://openalex.org/C2779889316","wikidata":"https://www.wikidata.org/wiki/Q642836","display_name":"Neuroradiology","level":3,"score":0.4701552391052246},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.44853267073631287},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.4352370500564575},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3593277335166931},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3555023968219757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16139286756515503},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15776106715202332},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000097188","descriptor_name":"Radiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097188","descriptor_name":"Radiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097188","descriptor_name":"Radiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011857","descriptor_name":"Radiographic Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011857","descriptor_name":"Radiographic Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011857","descriptor_name":"Radiographic Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061705","descriptor_name":"Image-Guided Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061705","descriptor_name":"Image-Guided Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061705","descriptor_name":"Image-Guided Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-025-01823-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01823-w","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01823-w","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:40665242","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40665242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:efd8af34a5a443eda6b71d2f2a9a2d50","is_oa":true,"landing_page_url":"https://doaj.org/article/efd8af34a5a443eda6b71d2f2a9a2d50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 25, Iss 1, Pp 1-14 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12265201","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12265201","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-025-01823-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01823-w","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01823-w","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.44999998807907104}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412450116.pdf","grobid_xml":"https://content.openalex.org/works/W4412450116.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1574141134","https://openalex.org/W1645341736","https://openalex.org/W1991181258","https://openalex.org/W1993123466","https://openalex.org/W2013716066","https://openalex.org/W2069274229","https://openalex.org/W2086719465","https://openalex.org/W2114376411","https://openalex.org/W2117128468","https://openalex.org/W2147583694","https://openalex.org/W2170338356","https://openalex.org/W2415195051","https://openalex.org/W2580009538","https://openalex.org/W2596381034","https://openalex.org/W2761134105","https://openalex.org/W2765626268","https://openalex.org/W2767128594","https://openalex.org/W2800737063","https://openalex.org/W2891968130","https://openalex.org/W2899847761","https://openalex.org/W2980135163","https://openalex.org/W3005375511","https://openalex.org/W3047003037","https://openalex.org/W3087554715","https://openalex.org/W3137377211","https://openalex.org/W3162617702","https://openalex.org/W3174905293","https://openalex.org/W4210681529","https://openalex.org/W4211191129","https://openalex.org/W4213023844","https://openalex.org/W4226338824","https://openalex.org/W4289884494","https://openalex.org/W4302195001","https://openalex.org/W4392735353","https://openalex.org/W4394610575"],"related_works":["https://openalex.org/W3000891326","https://openalex.org/W4205100762","https://openalex.org/W2559998622","https://openalex.org/W2605851261","https://openalex.org/W2734724112","https://openalex.org/W2582997534","https://openalex.org/W3009210156","https://openalex.org/W4388577230","https://openalex.org/W2097753790","https://openalex.org/W2049776456"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"develop":[2,136],"a":[3,146,184,233],"radiomics":[4],"machine":[5,104],"learning":[6,105],"model":[7,141,179,187,229,243,270],"for":[8,110,237],"detecting":[9],"liver":[10,39,111,139,240,249,263,267],"fibrosis":[11,112,140,250,268],"on":[12,62,115,125,145],"CT":[13,43,64,160,169,208,260],"images":[14],"of":[15,59,101,191],"the":[16,63,69,76,98,119,126,152,256],"liver.":[17],"METHODS:":[18],"With":[19],"Ethics":[20],"Board":[21],"approval,":[22],"169":[23],"patients":[24],"(68":[25],"women,":[26],"101":[27],"men;":[28],"mean":[29],"age,":[30],"51.2":[31],"years":[32],"\u00b1":[33],"14.7":[34],"[SD])":[35],"underwent":[36],"an":[37,247],"ultrasound-guided":[38],"biopsy":[40,70,77],"with":[41,188,213],"simultaneous":[42],"acquisitions":[44],"without":[45],"and":[46,72,88,107,196],"following":[47],"intravenous":[48],"contrast":[49],"material":[50],"administration.":[51],"Radiomic":[52],"features":[53,109,190],"were":[54,132],"extracted":[55,203],"from":[56,75,204],"two":[57],"regions":[58],"interest":[60],"(ROIs)":[61],"images,":[65],"one":[66,137],"placed":[67],"at":[68],"site":[71],"another":[73],"distant":[74],"site.":[78],"A":[79],"development":[80],"cohort,":[81],"which":[82,142],"was":[83,94,143,180],"split":[84],"further":[85],"into":[86],"training":[87],"validation":[89,127],"cohorts":[90],"across":[91,154],"100":[92],"trials,":[93],"used":[95,134],"to":[96,135,182],"determine":[97],"optimal":[99,130],"combinations":[100,131],"contrast,":[102],"normalization,":[103],"model,":[106],"radiomic":[108],"detection":[113,235,269],"based":[114],"their":[116],"Area":[117],"Under":[118],"Receiver":[120],"Operating":[121],"Characteristic":[122],"curve":[123],"(AUC)":[124],"cohort.":[128,148],"The":[129,176,224,242,265],"then":[133],"final":[138,266],"evaluated":[144],"test":[147],"RESULTS:":[149],"When":[150],"averaging":[151],"AUC":[153],"all":[155],"combinations,":[156],"non-contrast":[157,205],"enhanced":[158,206],"(NC)":[159],"(AUC,":[161,170,217],"0.6100;":[162],"95%":[163,172,219],"CI:":[164,173,220],"0.5897,":[165],"0.6303)":[166],"outperformed":[167],"contrast-enhanced":[168],"0.5680;":[171],"0.5471,":[174],"0.5890).":[175],"most":[177],"effective":[178],"found":[181],"be":[183],"logistic":[185,227],"regression":[186,228],"input":[189],"maximum,":[192],"energy,":[193],"kurtosis,":[194],"skewness,":[195],"small":[197],"area":[198],"high":[199],"gray":[200],"level":[201],"emphasis":[202],"NC":[207],"normalized":[209],"using":[210],"Gamma":[211],"correction":[212],"\u03b3":[214],"=":[215],"1.5":[216],"0.7833;":[218],"0.7821,":[221],"0.7845).":[222],"CONCLUSIONS:":[223],"presented":[225],"radiomics-based":[226],"holds":[230],"promise":[231],"as":[232,246],"non-invasive":[234],"tool":[236,252],"subclinical,":[238],"asymptomatic":[239],"fibrosis.":[241],"may":[244],"serve":[245],"opportunistic":[248],"screening":[251],"when":[253],"operated":[254],"in":[255],"background":[257],"during":[258],"routine":[259],"examinations":[261],"covering":[262],"parenchyma.":[264],"is":[271],"made":[272],"publicly":[273],"available":[274],"at:":[275],"https://github.com/IMICSLab/RadiomicsLiverFibrosisDetection":[276],".":[277]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-07-07T14:30:12.667765","created_date":"2025-10-10T00:00:00"}