{"id":"https://openalex.org/W4407870217","doi":"https://doi.org/10.1186/s12880-024-01534-8","title":"A prior information-based multi-population multi-objective optimization for estimating 18F-FDG PET/CT pharmacokinetics of hepatocellular carcinoma","display_name":"A prior information-based multi-population multi-objective optimization for estimating 18F-FDG PET/CT pharmacokinetics of hepatocellular carcinoma","publication_year":2025,"publication_date":"2025-02-24","ids":{"openalex":"https://openalex.org/W4407870217","doi":"https://doi.org/10.1186/s12880-024-01534-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/39994556"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-024-01534-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-024-01534-8","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01534-8","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01534-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100311092","display_name":"Yiwei Xiong","orcid":null},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Xiong","raw_affiliation_strings":["Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670861","display_name":"Siming Li","orcid":"https://orcid.org/0000-0002-4566-9483"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siming Li","raw_affiliation_strings":["Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062082438","display_name":"Jianfeng He","orcid":"https://orcid.org/0000-0001-6995-2980"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng He","raw_affiliation_strings":["Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China. jfenghe@foxmail.com","School of Physics and Electronic Engineering, Yuxi Normal University, Yuxi, 653100, China. jfenghe@foxmail.com","Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China. jfenghe@foxmail.com","institution_ids":[]},{"raw_affiliation_string":"School of Physics and Electronic Engineering, Yuxi Normal University, Yuxi, 653100, China. jfenghe@foxmail.com","institution_ids":[]},{"raw_affiliation_string":"Faculty of Information Engineering and Automation, Yunnan Key Laboratory of Artificial Intelligence, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100693332","display_name":"Shaobo Wang","orcid":"https://orcid.org/0000-0002-2745-522X"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaobo Wang","raw_affiliation_strings":["PET/CT Center, Affiliated Hospital of Kunming University of Science and Technology, First People's Hospital of Yunnan, Kunming, 650031, China. wshbo_98@126.com","PET/CT Center, Affiliated Hospital of Kunming University of Science and Technology, First People's Hospital of Yunnan, Kunming, 650031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PET/CT Center, Affiliated Hospital of Kunming University of Science and Technology, First People's Hospital of Yunnan, Kunming, 650031, China. wshbo_98@126.com","institution_ids":[]},{"raw_affiliation_string":"PET/CT Center, Affiliated Hospital of Kunming University of Science and Technology, First People's Hospital of Yunnan, Kunming, 650031, China","institution_ids":["https://openalex.org/I10660446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100693332"],"corresponding_institution_ids":["https://openalex.org/I10660446"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03625184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"59","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.31209999322891235,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.31209999322891235,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.23510000109672546,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.77051842212677},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.49321335554122925},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48923635482788086},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"Population pharmacokinetics","score":0.4733833372592926},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.40774258971214294},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3753994107246399},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3734479546546936},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19168496131896973}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.77051842212677},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49321335554122925},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48923635482788086},{"id":"https://openalex.org/C3020755252","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Population pharmacokinetics","level":3,"score":0.4733833372592926},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.40774258971214294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3753994107246399},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3734479546546936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19168496131896973},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-024-01534-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-024-01534-8","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01534-8","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:39994556","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39994556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:41327c4bd03e4c669968d06f175dd572","is_oa":false,"landing_page_url":"https://doaj.org/article/41327c4bd03e4c669968d06f175dd572","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 25, Iss 1, Pp 1-12 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11854238","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11854238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-024-01534-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-024-01534-8","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01534-8","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5261570663","display_name":null,"funder_award_id":"82160347","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407870217.pdf"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1509585976","https://openalex.org/W1583045879","https://openalex.org/W1595159159","https://openalex.org/W1951442280","https://openalex.org/W1972632273","https://openalex.org/W1972926425","https://openalex.org/W1986624978","https://openalex.org/W2018715138","https://openalex.org/W2027235021","https://openalex.org/W2035143394","https://openalex.org/W2076560915","https://openalex.org/W2087070363","https://openalex.org/W2090306035","https://openalex.org/W2094847554","https://openalex.org/W2097274481","https://openalex.org/W2101301278","https://openalex.org/W2132408815","https://openalex.org/W2152195021","https://openalex.org/W2161642153","https://openalex.org/W2170842763","https://openalex.org/W2252429551","https://openalex.org/W2276581426","https://openalex.org/W2286499419","https://openalex.org/W2321904707","https://openalex.org/W2328176404","https://openalex.org/W2502548072","https://openalex.org/W2765375430","https://openalex.org/W2953202586","https://openalex.org/W3012520181","https://openalex.org/W3100970271","https://openalex.org/W3163973768","https://openalex.org/W3164069191","https://openalex.org/W4206281902","https://openalex.org/W4210419184","https://openalex.org/W4250503569","https://openalex.org/W4309998794","https://openalex.org/W4378070711"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2352350815","https://openalex.org/W2106727887","https://openalex.org/W3143178787","https://openalex.org/W2391487123","https://openalex.org/W2146085427","https://openalex.org/W2082998857","https://openalex.org/W2001429049"],"abstract_inverted_index":{"18F":[0],"fluoro-D-glucose":[1],"(18F-FDG)":[2],"positron":[3],"emission":[4],"tomography/computed":[5],"tomography":[6],"(PET/CT)":[7],"pharmacokinetics":[8,66],"is":[9,242],"an":[10],"approach":[11,47,261],"for":[12,61,268],"efficiently":[13],"quantifying":[14],"perfusion":[15],"and":[16,28,100,108,132,136,142,169,178,185,190,199,220,238,249],"metabolic":[17,116],"processes":[18],"in":[19,167,174,183,197,230,263],"the":[20,23,63,115,148,153,157,175,179,208,213,231],"liver,":[21],"but":[22],"conventional":[24],"single-individual":[25,119],"optimization":[26,30,45,138,182],"algorithms":[27,31,124,139],"single-population":[29,123,206],"have":[32],"difficulty":[33],"obtaining":[34],"reasonable":[35],"physiological":[36],"characteristics":[37],"from":[38,74,194,272],"estimated":[39],"parameters.":[40,149,258],"A":[41,95],"prior-based":[42],"multi-population":[43],"multi-objective":[44],"(p-MPMOO)":[46],"using":[48],"two":[49,53],"sub-populations":[50],"based":[51],"on":[52,244,255],"categories":[54],"of":[55,67,80,156,234],"prior":[56],"information":[57],"was":[58],"preliminarily":[59],"proposed":[60,262],"estimating":[62],"18F-FDG":[64],"PET/CT":[65,83],"patients":[68],"with":[69,85,205],"hepatocellular":[70,76],"carcinoma.":[71],"PET":[72,88],"data":[73],"24":[75],"carcinoma":[77],"(HCC)":[78],"tumors":[79,271],"5-min":[81],"dynamic":[82],"supplemented":[84],"1-min":[86],"static":[87],"at":[89],"60":[90],"min":[91],"were":[92,111,144,161],"prospectively":[93],"collected.":[94],"reversible":[96],"double-input":[97],"three-compartment":[98],"model":[99],"kinetic":[101],"parameters":[102],"(K1,":[103],"k2,":[104,218,235,246],"k3,":[105,219,236,247],"k4,":[106,237,248],"fa,":[107],"$$\\:{v}_{b}$$":[109],")":[110],"used":[112,145],"to":[113,146],"quantify":[114],"information.":[117],"The":[118,150,222,240,251,259],"Levenberg\u2013Marquardt":[120],"(LM)":[121],"algorithm,":[122],"(Particle":[125],"Swarm":[126],"Optimization":[127],"(PSO),":[128],"Differential":[129],"Evolution":[130],"(DE),":[131],"Genetic":[133],"Algorithm":[134],"(GA))":[135],"p-MPMO":[137,159,210],"(p-MPMOPSO,":[140],"p-MPMODE,":[141],"p-MPMOGA)":[143],"estimate":[147],"areas":[151],"under":[152],"curve":[154],"(AUCs)":[155],"three":[158,209],"methods":[160,166,196,211],"significantly":[162],"higher":[163],"than":[164],"other":[165,195],"K1":[168],"k4":[170],"(P":[171,187,201,227],"<":[172,188,228],"0.05":[173],"DeLong":[176],"test)":[177],"single":[180],"population":[181],"k2":[184],"k3":[186],"0.05),":[189],"did":[191],"not":[192],"differ":[193],"fa":[198],"vb":[200],">":[202],"0.05).":[203],"Compared":[204],"optimization,":[207],"improved":[212],"significant":[214,225],"differences":[215,226],"between":[216],"K1,":[217,245],"k4.":[221],"p-MPMOPSO":[223],"showed":[224],"0.05)":[229],"parameter":[232],"estimation":[233],"fa.":[239],"p-MPMODE":[241],"implemented":[243],"fa;":[250],"p-MPMOGA":[252],"does":[253],"it":[254],"all":[256],"six":[257],"p-MPMOO":[260],"this":[264],"paper":[265],"performs":[266],"well":[267],"distinguishing":[269],"HCC":[270],"normal":[273],"liver":[274],"tissue.":[275]},"counts_by_year":[],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-02-24T00:00:00"}