{"id":"https://openalex.org/W4392369486","doi":"https://doi.org/10.1186/s12880-024-01232-5","title":"Transfer learning\u2013based PET/CT three-dimensional convolutional neural network fusion of image and clinical information for prediction of EGFR mutation in lung adenocarcinoma","display_name":"Transfer learning\u2013based PET/CT three-dimensional convolutional neural network fusion of image and clinical information for prediction of EGFR mutation in lung adenocarcinoma","publication_year":2024,"publication_date":"2024-03-04","ids":{"openalex":"https://openalex.org/W4392369486","doi":"https://doi.org/10.1186/s12880-024-01232-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/38438844"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-024-01232-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-024-01232-5","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01232-5","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01232-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047749030","display_name":"Xiaonan Shao","orcid":"https://orcid.org/0000-0002-5697-9225"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaonan Shao","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. scorey@sina.com","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China. scorey@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. scorey@sina.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China. scorey@sina.com","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039829069","display_name":"Xinyu Ge","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Ge","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087420172","display_name":"Jianxiong Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxiong Gao","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112663072","display_name":"Rong Niu","orcid":"https://orcid.org/0000-0001-9482-207X"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Niu","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006373079","display_name":"Yunmei Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunmei Shi","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102811720","display_name":"Xiaoliang Shao","orcid":"https://orcid.org/0000-0003-0007-4336"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoliang Shao","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. scorey@sina.com","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China. scorey@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. scorey@sina.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China. scorey@sina.com","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048845528","display_name":"Zhenxing Jiang","orcid":"https://orcid.org/0000-0002-1677-2895"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxing Jiang","raw_affiliation_strings":["Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069062595","display_name":"Renyuan Li","orcid":"https://orcid.org/0000-0003-1943-9403"},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renyuan Li","raw_affiliation_strings":["Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, 310009, China","Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, 310009, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004539673","display_name":"Yuetao Wang","orcid":"https://orcid.org/0000-0003-2859-8625"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuetao Wang","raw_affiliation_strings":["Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. yuetao-w@163.com","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China. yuetao-w@163.com","Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. yuetao-w@163.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China. yuetao-w@163.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, 213003, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5047749030"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":6.4189,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.96955184,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"24","issue":"1","first_page":"54","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.7857000231742859,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.7857000231742859,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6735593676567078},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6443918943405151},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5486649870872498},{"id":"https://openalex.org/keywords/test-set","display_name":"Test set","score":0.5275794267654419},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5090822577476501},{"id":"https://openalex.org/keywords/transfer-of-learning","display_name":"Transfer of learning","score":0.49878501892089844},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.4907613694667816},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.47081026434898376},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4471288025379181},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.42987436056137085},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3872247636318207},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3829934000968933},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.26680201292037964},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.17001944780349731},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15698611736297607}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6735593676567078},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6443918943405151},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5486649870872498},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.5275794267654419},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5090822577476501},{"id":"https://openalex.org/C150899416","wikidata":"https://www.wikidata.org/wiki/Q1820378","display_name":"Transfer of learning","level":2,"score":0.49878501892089844},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4907613694667816},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.47081026434898376},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4471288025379181},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.42987436056137085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3872247636318207},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3829934000968933},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.26680201292037964},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17001944780349731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15698611736297607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-024-01232-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-024-01232-5","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01232-5","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:38438844","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38438844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10913633","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10913633","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10913633/pdf/12880_2024_Article_1232.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:eacda03bf80b4cd899c9b73435d7bcea","is_oa":true,"landing_page_url":"https://doaj.org/article/eacda03bf80b4cd899c9b73435d7bcea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 24, Iss 1, Pp 1-13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12880-024-01232-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-024-01232-5","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-024-01232-5","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392369486.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1988827171","https://openalex.org/W2017214085","https://openalex.org/W2069540737","https://openalex.org/W2088783247","https://openalex.org/W2113876238","https://openalex.org/W2121641332","https://openalex.org/W2162746494","https://openalex.org/W2290433232","https://openalex.org/W2328176404","https://openalex.org/W2397899173","https://openalex.org/W2515760025","https://openalex.org/W2527086993","https://openalex.org/W2533964882","https://openalex.org/W2594318146","https://openalex.org/W2910380368","https://openalex.org/W2910922831","https://openalex.org/W2920070632","https://openalex.org/W2962858109","https://openalex.org/W2979892984","https://openalex.org/W2988049398","https://openalex.org/W2998789541","https://openalex.org/W3004966381","https://openalex.org/W3007829463","https://openalex.org/W3016836174","https://openalex.org/W3016888440","https://openalex.org/W3021843318","https://openalex.org/W3093156106","https://openalex.org/W3133666709","https://openalex.org/W3155088231","https://openalex.org/W3161263649","https://openalex.org/W3164829384","https://openalex.org/W3171512834","https://openalex.org/W3185262280","https://openalex.org/W3205594709","https://openalex.org/W4206764591","https://openalex.org/W4211260867","https://openalex.org/W4223899585","https://openalex.org/W4224274506","https://openalex.org/W4280533169","https://openalex.org/W4282979895","https://openalex.org/W4368342591","https://openalex.org/W4376630924","https://openalex.org/W4389149401"],"related_works":["https://openalex.org/W4385649027","https://openalex.org/W2970784617","https://openalex.org/W2791025012","https://openalex.org/W4387327236","https://openalex.org/W2183488467","https://openalex.org/W1990237101","https://openalex.org/W4309907966","https://openalex.org/W4387896287","https://openalex.org/W2187490799","https://openalex.org/W3170838353"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"introduce":[2],"a":[3,81,231],"three-dimensional":[4],"convolutional":[5],"neural":[6],"network":[7],"(3D":[8],"CNN)":[9],"leveraging":[10],"transfer":[11,66,83],"learning":[12,61,84,226],"for":[13,233,244],"fusing":[14,76],"PET/CT":[15,38,224],"images":[16],"and":[17,42,53,70,78,80,99,118,145,173,196,251],"clinical":[18,40,88],"data":[19,31,89],"to":[20,216],"predict":[21],"EGFR":[22,43,130,235],"mutation":[23,44,131,221,236],"status":[24],"in":[25,127,141,150,156,169,178,188,219,237],"lung":[26],"adenocarcinoma":[27],"(LADC).":[28],"METHODS:":[29],"Retrospective":[30],"from":[32],"516":[33],"LADC":[34],"patients,":[35],"encompassing":[36],"preoperative":[37],"images,":[39],"information,":[41],"status,":[45,132],"were":[46,63,90,206],"divided":[47],"into":[48],"training":[49,143,171],"(n":[50,56],"=":[51,57,139,148,167,176],"404)":[52],"test":[54,153,180],"sets":[55],"112).":[58],"Several":[59],"deep":[60,225],"models":[62],"developed":[64],"utilizing":[65],"learning,":[67],"involving":[68],"CT-only":[69],"PET-only":[71],"models.":[72],"A":[73],"dual-stream":[74],"model":[75,85,112,123,160,183,205,227],"PET":[77],"CT":[79],"three-stream":[82],"(TS_TL)":[86],"integrating":[87],"also":[91],"developed.":[92],"Image":[93],"preprocessing":[94],"includes":[95],"semi-automatic":[96],"segmentation,":[97],"resampling,":[98],"image":[100],"cropping.":[101],"Considering":[102],"the":[103,108,111,129,142,151,159,170,179,200,204],"impact":[104],"of":[105,110,136,164],"class":[106],"imbalance,":[107],"performance":[109,126],"was":[113],"evaluated":[114],"using":[115],"ROC":[116],"curves":[117],"AUC":[119,135,163],"values.":[120],"RESULTS:":[121],"TS_TL":[122],"demonstrated":[124],"promising":[125],"predicting":[128,234],"with":[133,194],"an":[134,162],"0.883":[137],"(95%CI":[138,147,166,175],"0.849-0.917)":[140],"set":[144,172],"0.730":[146],"0.629-0.830)":[149],"independent":[152],"set.":[154,181],"Particularly":[155],"advanced":[157],"LADC,":[158],"achieved":[161],"0.871":[165],"0.823-0.919)":[168],"0.760":[174],"0.638-0.881)":[177],"The":[182],"identified":[184],"distinct":[185],"activation":[186],"areas":[187],"solid":[189],"or":[190],"subsolid":[191],"lesions":[192],"associated":[193],"wild":[195],"mutant":[197],"types.":[198],"Additionally,":[199,239],"patterns":[201],"captured":[202],"by":[203,209],"significantly":[207],"altered":[208],"effective":[210],"tyrosine":[211],"kinase":[212],"inhibitors":[213],"treatment,":[214],"leading":[215],"notable":[217],"changes":[218],"predicted":[220],"probabilities.":[222],"CONCLUSION:":[223],"can":[228],"act":[229],"as":[230],"tool":[232],"LADC.":[238],"it":[240],"offers":[241],"clinicians":[242],"insights":[243],"treatment":[245],"decisions":[246],"through":[247],"evaluations":[248],"both":[249],"before":[250],"after":[252],"treatment.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}