{"id":"https://openalex.org/W4312218458","doi":"https://doi.org/10.1186/s12880-022-00959-3","title":"Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study","display_name":"Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study","publication_year":2022,"publication_date":"2022-12-26","ids":{"openalex":"https://openalex.org/W4312218458","doi":"https://doi.org/10.1186/s12880-022-00959-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/36572873"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-022-00959-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-022-00959-3","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-022-00959-3","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-022-00959-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028579678","display_name":"Hirofumi Koike","orcid":"https://orcid.org/0000-0001-9460-0928"},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hirofumi Koike","raw_affiliation_strings":["Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. kei16231623@gmail.com","Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. kei16231623@gmail.com","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103696947","display_name":"Minoru Morikawa","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Morikawa","raw_affiliation_strings":["Department of Radiology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079175124","display_name":"Hideki Ishimaru","orcid":"https://orcid.org/0000-0002-7817-0507"},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Ishimaru","raw_affiliation_strings":["Department of Radiology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050305489","display_name":"Reiko Ideguchi","orcid":"https://orcid.org/0000-0003-4283-2473"},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Ideguchi","raw_affiliation_strings":["Department of Radioisotope Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radioisotope Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037317578","display_name":"Masataka Uetani","orcid":"https://orcid.org/0000-0001-5922-0508"},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Uetani","raw_affiliation_strings":["Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081014953","display_name":"Takeshi Hiu","orcid":"https://orcid.org/0000-0001-7090-1662"},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Hiu","raw_affiliation_strings":["Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003543378","display_name":"Takayuki Matsuo","orcid":"https://orcid.org/0000-0002-1430-7316"},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Matsuo","raw_affiliation_strings":["Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052799408","display_name":"Mitsuharu Miyoshi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuharu Miyoshi","raw_affiliation_strings":["MR Application and Workflow, GE Healthcare Japan, 4-7-127 Asahigaoka, Hino, Tokyo, 191-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MR Application and Workflow, GE Healthcare Japan, 4-7-127 Asahigaoka, Hino, Tokyo, 191-8503, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028579678"],"corresponding_institution_ids":["https://openalex.org/I43777268"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.5573,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67180301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"227","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"Progressive multifocal leukoencephalopathy","score":0.6632364392280579},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6446641087532043},{"id":"https://openalex.org/keywords/primary-central-nervous-system-lymphoma","display_name":"Primary central nervous system lymphoma","score":0.5275813341140747},{"id":"https://openalex.org/keywords/predictive-value","display_name":"Predictive value","score":0.5038623213768005},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"Cerebrospinal fluid","score":0.473755419254303},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4663616418838501},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4624697268009186},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4411679208278656},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3755861520767212},{"id":"https://openalex.org/keywords/lymphoma","display_name":"Lymphoma","score":0.3358212113380432},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23335713148117065},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.17010775208473206},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.07766991853713989}],"concepts":[{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.6632364392280579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6446641087532043},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.5275813341140747},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.5038623213768005},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.473755419254303},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4663616418838501},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4624697268009186},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4411679208278656},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3755861520767212},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3358212113380432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23335713148117065},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.17010775208473206},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07766991853713989}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-022-00959-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-022-00959-3","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-022-00959-3","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:36572873","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36572873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9793649","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9793649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:38e11f03751a47838cbc4fdcbb233770","is_oa":false,"landing_page_url":"https://doaj.org/article/38e11f03751a47838cbc4fdcbb233770","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 22, Iss 1, Pp 1-10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12880-022-00959-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-022-00959-3","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-022-00959-3","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.41999998688697815,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G8315538217","display_name":"Brain Plasticity in Functional Recovery Following Stem Cell Transplantation for Stroke","funder_award_id":"20K09328","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312218458.pdf","grobid_xml":"https://content.openalex.org/works/W4312218458.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1244697533","https://openalex.org/W1778954217","https://openalex.org/W1964371781","https://openalex.org/W1970499209","https://openalex.org/W1970547229","https://openalex.org/W1970855001","https://openalex.org/W1989488484","https://openalex.org/W1994190129","https://openalex.org/W1995673555","https://openalex.org/W1995721991","https://openalex.org/W2000379621","https://openalex.org/W2003126239","https://openalex.org/W2019724964","https://openalex.org/W2021452802","https://openalex.org/W2030841669","https://openalex.org/W2048919807","https://openalex.org/W2051834273","https://openalex.org/W2053683902","https://openalex.org/W2064173386","https://openalex.org/W2066520774","https://openalex.org/W2068023438","https://openalex.org/W2068248363","https://openalex.org/W2068559318","https://openalex.org/W2070231190","https://openalex.org/W2072418533","https://openalex.org/W2076894467","https://openalex.org/W2092155837","https://openalex.org/W2093861785","https://openalex.org/W2096842388","https://openalex.org/W2100485814","https://openalex.org/W2102500913","https://openalex.org/W2103914213","https://openalex.org/W2106643634","https://openalex.org/W2107475064","https://openalex.org/W2116016714","https://openalex.org/W2130901509","https://openalex.org/W2139085887","https://openalex.org/W2149080643","https://openalex.org/W2150435592","https://openalex.org/W2154242572","https://openalex.org/W2160826774","https://openalex.org/W2169726349","https://openalex.org/W2327294402","https://openalex.org/W2363367799","https://openalex.org/W2410376563","https://openalex.org/W2415962744","https://openalex.org/W2460393693","https://openalex.org/W2806582318","https://openalex.org/W3101882702","https://openalex.org/W4213068981","https://openalex.org/W4224231482","https://openalex.org/W4229956748","https://openalex.org/W4300718545","https://openalex.org/W6682371025"],"related_works":["https://openalex.org/W3032556640","https://openalex.org/W2110792834","https://openalex.org/W2954223102","https://openalex.org/W2047755629","https://openalex.org/W2381735876","https://openalex.org/W2805966349","https://openalex.org/W2039102742","https://openalex.org/W1996894961","https://openalex.org/W3008151329","https://openalex.org/W4296078333"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Progressive":[2],"multifocal":[3],"leukoencephalopathy":[4],"(PML)":[5],"is":[6],"a":[7,130],"demyelinating":[8],"disease":[9],"of":[10,41,50,132,214,227,239,252],"the":[11,17,48,135,163,170,178],"central":[12,30],"nerve":[13],"system":[14,32],"caused":[15],"by":[16],"John":[18],"Cunningham":[19],"virus.":[20],"On":[21],"MRI,":[22],"PML":[23,58,66,164,189,198,207,232,270],"may":[24],"sometimes":[25],"appear":[26],"similar":[27],"to":[28,46,144,271],"primary":[29],"nervous":[31],"lymphoma":[33],"(PCNSL)":[34],"and":[35,61,110,173,190,196,199,223,248,256],"glioblastoma":[36],"multiforme":[37],"(GBM).":[38],"The":[39,153],"purpose":[40],"this":[42],"pilot":[43],"study":[44],"was":[45,142],"evaluate":[47],"potential":[49],"amide":[51],"proton":[52],"transfer":[53,117],"(APT)":[54],"imaging":[55,128,266],"for":[56,148],"differentiating":[57,206,231],"from":[59,208,233,264,275],"PCNSL":[60,78,171,191,278],"GBM.":[62,280],"Methods":[63],"Patients":[64],"with":[65,269,277],"(n":[67,79,92],"=":[68,80,93,194,203],"4;":[69],"two":[70],"men;":[71,96],"mean":[72,84,97,154],"age":[73,85,98],"52.3":[74],"\u00b1":[75,87,100,160,167,175],"6.1":[76],"years),":[77,89],"7;":[81],"four":[82],"women;":[83],"74.4":[86],"5.8":[88],"or":[90,279],"GBM":[91,179,200],"11;":[94],"6":[95],"65.0":[99],"15.2":[101],"years)":[102],"who":[103],"underwent":[104],"APT-CEST":[105],"MRI":[106],"between":[107,188,197],"January":[108],"2021":[109],"September":[111],"2022":[112],"were":[113,124,158,182],"retrospectively":[114],"evaluated.":[115],"Magnetization":[116],"ratio":[118],"asymmetry":[119],"(MTR":[120],"asym":[121,150,156,187,212,237,261],")":[122],"values":[123,157,262],"measured":[125],"on":[126],"APT":[127,265],"using":[129],"region":[131],"interest":[133],"within":[134],"lesion.":[136],"Receiver":[137],"operating":[138],"characteristics":[139],"curve":[140],"analysis":[141],"used":[143],"determine":[145],"diagnostic":[146,217,242],"cutoffs":[147],"MTR":[149,155,186,211,236,260],".":[151],"Results":[152],"0.005":[159,161,168],"in":[162,169,177,185],"group,":[165,172],"0.025":[166,174],"0.009":[176],"group.":[180],"There":[181],"significant":[183],"differences":[184],"(":[192,201],"P":[193,202],"0.023),":[195],"0.015).":[204],"For":[205,230],"PCNSL,":[209],"an":[210,235],"threshold":[213,238],"0.0165":[215],"gave":[216,241],"sensitivity,":[218,243],"specificity,":[219,244],"positive":[220,245],"predictive":[221,225,246,250],"value,":[222,247],"negative":[224,249],"value":[226,251],"100%":[228],"(all).":[229],"GBM,":[234],"0.015":[240],"100%,":[253,257],"90.9%,":[254],"80.0%,":[255],"respectively.":[258],"Conclusion":[259],"obtained":[263],"allowed":[267],"patients":[268,276],"be":[272],"clearly":[273],"discriminated":[274]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}