{"id":"https://openalex.org/W3196335355","doi":"https://doi.org/10.1186/s12880-021-00662-9","title":"Automatic identification of suspicious bone metastatic lesions in bone scintigraphy using convolutional neural network","display_name":"Automatic identification of suspicious bone metastatic lesions in bone scintigraphy using convolutional neural network","publication_year":2021,"publication_date":"2021-09-04","ids":{"openalex":"https://openalex.org/W3196335355","doi":"https://doi.org/10.1186/s12880-021-00662-9","mag":"3196335355","pmid":"https://pubmed.ncbi.nlm.nih.gov/34481459"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-021-00662-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-021-00662-9","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-021-00662-9","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-021-00662-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081691388","display_name":"Yemei Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yemei Liu","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019594660","display_name":"Pei Yang","orcid":"https://orcid.org/0000-0001-8926-9695"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei Yang","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043276076","display_name":"Yong Pi","orcid":"https://orcid.org/0000-0003-0794-5499"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Pi","raw_affiliation_strings":["Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056992453","display_name":"Lisha Jiang","orcid":"https://orcid.org/0000-0002-5602-3792"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lisha Jiang","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113638199","display_name":"Xiao Zhong","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zhong","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103100709","display_name":"Junjun Cheng","orcid":"https://orcid.org/0000-0002-3926-1481"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjun Cheng","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037964528","display_name":"Yongzhao Xiang","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzhao Xiang","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001159193","display_name":"Jianan Wei","orcid":"https://orcid.org/0000-0001-7238-294X"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianan Wei","raw_affiliation_strings":["Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412926","display_name":"Lin Li","orcid":"https://orcid.org/0000-0003-0426-6546"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Li","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388053","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0001-7201-2092"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Yi","raw_affiliation_strings":["Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051190727","display_name":"Huawei Cai","orcid":"https://orcid.org/0000-0003-1341-8417"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huawei Cai","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China. hw.cai@yahoo.com","Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China. hw.cai@yahoo.com","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100665356","display_name":"Zhao Zhen","orcid":"https://orcid.org/0000-0001-5406-6441"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen Zhao","raw_affiliation_strings":["Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China. zhaozhen1982@126.com","Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China. zhaozhen1982@126.com","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051190727","https://openalex.org/A5100665356"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":2.1558,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87761801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"131","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.35670000314712524,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.35670000314712524,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies","score":0.08429999649524689,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7541999816894531},{"id":"https://openalex.org/keywords/bone-scintigraphy","display_name":"Bone scintigraphy","score":0.7219756841659546},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.7218983173370361},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6644014120101929},{"id":"https://openalex.org/keywords/malignancy","display_name":"Malignancy","score":0.6417999863624573},{"id":"https://openalex.org/keywords/lesion","display_name":"Lesion","score":0.5880874991416931},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.5164332985877991},{"id":"https://openalex.org/keywords/bone-metastasis","display_name":"Bone metastasis","score":0.44718044996261597},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3999292850494385},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36944037675857544},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.3678243160247803},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3317534923553467},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2623506188392639},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.21773818135261536},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12684091925621033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7541999816894531},{"id":"https://openalex.org/C2776049877","wikidata":"https://www.wikidata.org/wiki/Q1928938","display_name":"Bone scintigraphy","level":2,"score":0.7219756841659546},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.7218983173370361},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6644014120101929},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6417999863624573},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5880874991416931},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5164332985877991},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.44718044996261597},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3999292850494385},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36944037675857544},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.3678243160247803},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3317534923553467},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2623506188392639},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21773818135261536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12684091925621033}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-021-00662-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-021-00662-9","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-021-00662-9","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:34481459","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34481459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:f8ebccf7c2a2409faeeb59aacd28d8dd","is_oa":true,"landing_page_url":"https://doaj.org/article/f8ebccf7c2a2409faeeb59aacd28d8dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 21, Iss 1, Pp 1-9 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8417997","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8417997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-021-00662-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-021-00662-9","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-021-00662-9","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1359259511","display_name":null,"funder_award_id":"ZYGD18016","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G2352941459","display_name":null,"funder_award_id":"2018AAA0100201","funder_id":"https://openalex.org/F4320335960","funder_display_name":"National Major Science and Technology Projects of China"},{"id":"https://openalex.org/G5327689620","display_name":null,"funder_award_id":"1.3.5 project","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G7899741169","display_name":null,"funder_award_id":"1.3.5","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"}],"funders":[{"id":"https://openalex.org/F4320322297","display_name":"Jiangsu Development and Reform Commission","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320335960","display_name":"National Major Science and Technology Projects of China","ror":null},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196335355.pdf","grobid_xml":"https://content.openalex.org/works/W3196335355.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1971535810","https://openalex.org/W2004276737","https://openalex.org/W2005153291","https://openalex.org/W2033876623","https://openalex.org/W2034317130","https://openalex.org/W2039694164","https://openalex.org/W2045541128","https://openalex.org/W2050035270","https://openalex.org/W2079449116","https://openalex.org/W2081596675","https://openalex.org/W2113701976","https://openalex.org/W2132857889","https://openalex.org/W2159635409","https://openalex.org/W2164275775","https://openalex.org/W2183341477","https://openalex.org/W2280853162","https://openalex.org/W2302341444","https://openalex.org/W2338790358","https://openalex.org/W2415720263","https://openalex.org/W2898090397","https://openalex.org/W2899771611","https://openalex.org/W2921674884","https://openalex.org/W2937051639","https://openalex.org/W2963446712","https://openalex.org/W3004643414","https://openalex.org/W3043289003","https://openalex.org/W3045786341","https://openalex.org/W3092312060","https://openalex.org/W3100786207","https://openalex.org/W3108891141","https://openalex.org/W3138784776","https://openalex.org/W3146230509","https://openalex.org/W6698183232","https://openalex.org/W6756040250"],"related_works":["https://openalex.org/W2378340649","https://openalex.org/W2377586003","https://openalex.org/W2409836843","https://openalex.org/W2418967832","https://openalex.org/W4221076339","https://openalex.org/W2617715906","https://openalex.org/W2412197126","https://openalex.org/W2957285621","https://openalex.org/W1974670859","https://openalex.org/W2591479215"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"aimed":[2],"to":[3],"construct":[4],"an":[5],"artificial":[6],"intelligence":[7],"(AI)":[8],"guided":[9],"identification":[10],"of":[11,59,101,119,171],"suspicious":[12,139,246],"bone":[13,19,34,42,140,250,254],"metastatic":[14],"lesions":[15,35,43,141,251],"from":[16,36,252],"the":[17,60,72,87,99,116,120,124,132,152,167,174,177,186,196,205,212,218],"whole-body":[18,253],"scintigraphy":[20],"(WBS)":[21],"images":[22,31],"by":[23,47,65],"convolutional":[24],"neural":[25],"networks":[26],"(CNNs).":[27],"METHODS:":[28],"Tc-MDP":[29],"WBS":[30],"with":[32,39,71,143],"confirmed":[33],"3352":[37],"patients":[38],"malignancy.":[40],"14,972":[41],"were":[44,95,160],"delineated":[45],"manually":[46],"physicians":[48],"and":[49,53,69,86,112,148,158,162,202,233,248],"annotated":[50],"as":[51],"benign":[52,247],"malignant.":[54],"The":[55,81,239],"lesion-based":[56,155],"differentiating":[57],"performance":[58],"proposed":[61,129],"network":[62,130],"was":[63,183,224],"evaluated":[64],"fivefold":[66,125],"cross":[67,126],"validation,":[68,127],"compared":[70,142],"other":[73],"three":[74,213],"popular":[75],"CNN":[76,153,240],"architectures":[77],"for":[78,115,226,230,235],"medical":[79],"imaging.":[80],"average":[82,134,156],"sensitivity,":[83],"specificity,":[84],"accuracy":[85,135],"area":[88,175],"under":[89,176],"receiver":[90,178],"operating":[91,179],"characteristic":[92,180],"curve":[93,181],"(AUC)":[94,182],"calculated.":[96],"To":[97],"delve":[98],"outcomes":[100],"this":[102],"study,":[103],"we":[104],"conducted":[105],"subgroup":[106],"analyses,":[107],"including":[108],"lesion":[109,168,220],"burden":[110,169],"number":[111,190],"tumor":[113,216],"type":[114],"classifying":[117],"ability":[118],"CNN.":[121],"RESULTS:":[122],"In":[123],"our":[128],"reached":[131],"best":[133],"(81.23%)":[136],"in":[137,185,195,204,244],"identifying":[138,221,245],"InceptionV3":[144],"(80.61%),":[145],"VGG16":[146],"(81.13%)":[147],"DenseNet169":[149],"(76.71%).":[150],"Additionally,":[151],"model's":[154],"sensitivity":[157],"specificity":[159],"81.30%":[161],"81.14%,":[163],"respectively.":[164],"Based":[165],"on":[166],"numbers":[170],"each":[172],"image,":[173],"0.847":[184],"few":[187],"group":[188,198,207],"(lesion":[189],"n":[191],"\u2264":[192],"3),":[193],"0.838":[194],"medium":[197],"(n":[199,208],"=":[200],"4-6),":[201],"0.862":[203],"extensive":[206],">":[209],"6).":[210],"For":[211],"major":[214],"primary":[215],"types,":[217],"CNN-based":[219],"AUC":[222],"value":[223],"0.870":[225],"lung":[227],"cancer,":[228,232],"0.900":[229],"prostate":[231],"0.899":[234],"breast":[236],"cancer.":[237],"CONCLUSION:":[238],"model":[241],"suggests":[242],"potential":[243],"malignant":[249],"scintigraphic":[255],"images.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}