{"id":"https://openalex.org/W2601377193","doi":"https://doi.org/10.1186/s12864-017-3495-y","title":"Active module identification in intracellular networks using a memetic algorithm with a new binary decoding scheme","display_name":"Active module identification in intracellular networks using a memetic algorithm with a new binary decoding scheme","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2601377193","doi":"https://doi.org/10.1186/s12864-017-3495-y","mag":"2601377193","pmid":"https://pubmed.ncbi.nlm.nih.gov/28361692"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-017-3495-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-017-3495-y","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-017-3495-y","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-017-3495-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038578857","display_name":"Dong Li","orcid":"https://orcid.org/0000-0001-9284-7150"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dong Li","raw_affiliation_strings":["School of Computer Science, University of Birmingham, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037669752","display_name":"Zhisong Pan","orcid":"https://orcid.org/0000-0001-8615-7313"},"institutions":[{"id":"https://openalex.org/I4210163363","display_name":"PLA Army Engineering University","ror":"https://ror.org/05mgp8x93","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163363"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhisong Pan","raw_affiliation_strings":["PLA University of Science and Technology, Nanjing, 210007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PLA University of Science and Technology, Nanjing, 210007, China","institution_ids":["https://openalex.org/I4210163363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078945147","display_name":"Guyu Hu","orcid":"https://orcid.org/0000-0003-3486-6614"},"institutions":[{"id":"https://openalex.org/I4210163363","display_name":"PLA Army Engineering University","ror":"https://ror.org/05mgp8x93","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163363"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guyu Hu","raw_affiliation_strings":["PLA University of Science and Technology, Nanjing, 210007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PLA University of Science and Technology, Nanjing, 210007, China","institution_ids":["https://openalex.org/I4210163363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052762681","display_name":"Zexuan Zhu","orcid":"https://orcid.org/0000-0001-8479-6904"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zexuan Zhu","raw_affiliation_strings":["College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, 518060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, 518060, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011186506","display_name":"Shan He","orcid":"https://orcid.org/0000-0003-1694-1465"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Shan He","raw_affiliation_strings":["School of Computer Science, University of Birmingham, Birmingham, B15 2TT, UK. s.he@cs.bham.ac.uk","School of Computer Science, University of Birmingham, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Birmingham, B15 2TT, UK. s.he@cs.bham.ac.uk","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011186506"],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.6081,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64994776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"S2","first_page":"209","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7186999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7186999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memetic-algorithm","display_name":"Memetic algorithm","score":0.8219871520996094},{"id":"https://openalex.org/keywords/decoding-methods","display_name":"Decoding methods","score":0.710430383682251},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6866873502731323},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5932176113128662},{"id":"https://openalex.org/keywords/scheme","display_name":"Scheme (mathematics)","score":0.5791023969650269},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4968850910663605},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.48606589436531067},{"id":"https://openalex.org/keywords/encoding","display_name":"Encoding (memory)","score":0.4415307343006134},{"id":"https://openalex.org/keywords/local-search","display_name":"Local search (optimization)","score":0.3937380611896515},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2967830300331116},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2388337254524231},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20470279455184937}],"concepts":[{"id":"https://openalex.org/C35129592","wikidata":"https://www.wikidata.org/wiki/Q324793","display_name":"Memetic algorithm","level":3,"score":0.8219871520996094},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.710430383682251},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6866873502731323},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5932176113128662},{"id":"https://openalex.org/C77618280","wikidata":"https://www.wikidata.org/wiki/Q1155772","display_name":"Scheme (mathematics)","level":2,"score":0.5791023969650269},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4968850910663605},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.48606589436531067},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.4415307343006134},{"id":"https://openalex.org/C135320971","wikidata":"https://www.wikidata.org/wiki/Q1868524","display_name":"Local search (optimization)","level":2,"score":0.3937380611896515},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2967830300331116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2388337254524231},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20470279455184937},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12864-017-3495-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-017-3495-y","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-017-3495-y","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:28361692","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28361692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":null},{"id":"pmh:oai:pure.atira.dk:publications/fc4df7c0-fbd7-4d72-a904-0b03a10c0877","is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85015190749&partnerID=8YFLogxK","pdf_url":"http://pure-oai.bham.ac.uk/ws/files/146059336/s12864_017_3495_y.pdf","source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:5374686","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5374686","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/fc4df7c0-fbd7-4d72-a904-0b03a10c0877","is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/fc4df7c0-fbd7-4d72-a904-0b03a10c0877","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Li, D, Pan, Z, Hu, G, Zhu, Z & He, S 2017, 'Active module identification in intracellular networks using a memetic algorithm with a new binary decoding scheme', BMC Genomics, vol. 18, no. S2, 209. https://doi.org/10.1186/s12864-017-3495-y","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12864-017-3495-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-017-3495-y","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-017-3495-y","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3647123273","display_name":"Engineered nanomaterial mechanisms of interactions with living systems and the environment: a universal framework for safe nanotechnology","funder_award_id":"310451","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G439245370","display_name":null,"funder_award_id":"BIR002","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G4840719577","display_name":null,"funder_award_id":"NMP4-LA-2013-310451","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2601377193.pdf","grobid_xml":"https://content.openalex.org/works/W2601377193.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W18216792","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1649408115","https://openalex.org/W1687801715","https://openalex.org/W1781719596","https://openalex.org/W1876024155","https://openalex.org/W1971421925","https://openalex.org/W1974259787","https://openalex.org/W1985213868","https://openalex.org/W2008434012","https://openalex.org/W2008584608","https://openalex.org/W2032188826","https://openalex.org/W2040847667","https://openalex.org/W2046892904","https://openalex.org/W2062533676","https://openalex.org/W2066356146","https://openalex.org/W2096173332","https://openalex.org/W2112811019","https://openalex.org/W2122510010","https://openalex.org/W2126022585","https://openalex.org/W2130410032","https://openalex.org/W2140937045","https://openalex.org/W2145290999","https://openalex.org/W2149491227","https://openalex.org/W2153624566","https://openalex.org/W2155262811","https://openalex.org/W2159675211","https://openalex.org/W2162243457","https://openalex.org/W2165885026","https://openalex.org/W2168846334","https://openalex.org/W2170974939","https://openalex.org/W2191255018","https://openalex.org/W2318518019","https://openalex.org/W2343267230","https://openalex.org/W2401610261","https://openalex.org/W2413892857","https://openalex.org/W2504891296","https://openalex.org/W2915975108","https://openalex.org/W3009559552","https://openalex.org/W3023540311","https://openalex.org/W4210767115"],"related_works":["https://openalex.org/W2163647484","https://openalex.org/W2368824897","https://openalex.org/W47248985","https://openalex.org/W2000270779","https://openalex.org/W2129486222","https://openalex.org/W3144175025","https://openalex.org/W1778024729","https://openalex.org/W2042716007","https://openalex.org/W2043816158","https://openalex.org/W1587473980"],"abstract_inverted_index":{"BACKGROUND:":[0],"Active":[1],"modules":[2,22],"are":[3],"connected":[4],"regions":[5],"in":[6,13],"biological":[7],"network":[8],"which":[9],"show":[10],"significant":[11],"changes":[12],"expression":[14],"over":[15],"particular":[16],"conditions.":[17],"The":[18,95],"identification":[19,51],"of":[20,68,97],"such":[21],"is":[23,100],"important":[24],"since":[25],"it":[26],"may":[27],"reveal":[28],"the":[29,66,69,75,87],"regulatory":[30],"and":[31,80,105],"signaling":[32],"mechanisms":[33],"that":[34],"associate":[35],"with":[36],"a":[37,47,55,60,82],"given":[38],"cellular":[39],"response.":[40],"RESULTS:":[41],"In":[42],"this":[43],"paper,":[44],"we":[45,77],"propose":[46,59],"novel":[48,61],"active":[49,71],"module":[50],"algorithm":[52,89,99],"based":[53],"on":[54,74,102],"memetic":[56,88],"algorithm.":[57],"We":[58],"encoding/decoding":[62],"scheme":[63],"to":[64,90],"ensure":[65],"connectedness":[67],"identified":[70],"modules.":[72],"Based":[73],"scheme,":[76],"also":[78],"design":[79],"incorporate":[81],"local":[83],"search":[84],"operator":[85],"into":[86],"improve":[91],"its":[92],"performance.":[93],"CONCLUSION:":[94],"effectiveness":[96],"proposed":[98],"validated":[101],"both":[103],"small":[104],"large":[106],"protein":[107],"interaction":[108],"networks.":[109]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}