{"id":"https://openalex.org/W2238824573","doi":"https://doi.org/10.1186/s12864-015-2302-x","title":"Medoidshift clustering applied to genomic bulk tumor data","display_name":"Medoidshift clustering applied to genomic bulk tumor data","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2238824573","doi":"https://doi.org/10.1186/s12864-015-2302-x","mag":"2238824573","pmid":"https://pubmed.ncbi.nlm.nih.gov/26817708"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-015-2302-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-015-2302-x","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-015-2302-x","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-015-2302-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065296454","display_name":"Theodore Roman","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Roman","raw_affiliation_strings":["Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. troman@andrew.cmu.edu","Joint Carnegie Mellon/University of Pittsburgh Ph.D. Program in Computational Biology, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. troman@andrew.cmu.edu","Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. troman@andrew.cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Joint Carnegie Mellon/University of Pittsburgh Ph.D. Program in Computational Biology, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. troman@andrew.cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033203853","display_name":"Lu Xie","orcid":"https://orcid.org/0000-0001-7541-2243"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Xie","raw_affiliation_strings":["Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. lxie1@andrew.cmu.edu","Joint Carnegie Mellon/University of Pittsburgh Ph.D. Program in Computational Biology, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. lxie1@andrew.cmu.edu","Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. lxie1@andrew.cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Joint Carnegie Mellon/University of Pittsburgh Ph.D. Program in Computational Biology, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. lxie1@andrew.cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051953313","display_name":"Russell Schwartz","orcid":"https://orcid.org/0000-0002-4970-2252"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell Schwartz","raw_affiliation_strings":["Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. russells@andrew.cmu.edu","Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, 15213, PA, USA. russells@andrew.cmu.edu","Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. russells@andrew.cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, 15213, PA, USA. russells@andrew.cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Computational Biology Department, School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.3985,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64764302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"17","issue":"S1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.693566620349884},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6577565670013428},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6352980136871338},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5702925324440002},{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.5571046471595764},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5464573502540588},{"id":"https://openalex.org/keywords/somatic-evolution-in-cancer","display_name":"Somatic evolution in cancer","score":0.4791514277458191},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4218669533729553},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.31657642126083374},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2948135733604431},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16969847679138184},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.16555440425872803},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14043205976486206}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.693566620349884},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6577565670013428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6352980136871338},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5702925324440002},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.5571046471595764},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5464573502540588},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.4791514277458191},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4218669533729553},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31657642126083374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2948135733604431},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16969847679138184},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.16555440425872803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14043205976486206}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12864-015-2302-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-015-2302-x","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-015-2302-x","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:26817708","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26817708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":null},{"id":"pmh:oai:d-scholarship.pitt.edu:28917","is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/28917/7/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402375","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:4895288","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4895288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12864-015-2302-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-015-2302-x","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-015-2302-x","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3988408848","display_name":null,"funder_award_id":"T32EB009403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5018101021","display_name":null,"funder_award_id":"1R01AI076318","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6273398171","display_name":null,"funder_award_id":"1R01CA140214","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310207","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2238824573.pdf","grobid_xml":"https://content.openalex.org/works/W2238824573.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1600006923","https://openalex.org/W1848675878","https://openalex.org/W1967940883","https://openalex.org/W1979107980","https://openalex.org/W2000111986","https://openalex.org/W2001141328","https://openalex.org/W2009569945","https://openalex.org/W2015182193","https://openalex.org/W2019863483","https://openalex.org/W2031674672","https://openalex.org/W2032518018","https://openalex.org/W2033403400","https://openalex.org/W2033825058","https://openalex.org/W2034629821","https://openalex.org/W2040458067","https://openalex.org/W2044823121","https://openalex.org/W2053186076","https://openalex.org/W2064397275","https://openalex.org/W2067191022","https://openalex.org/W2070761004","https://openalex.org/W2075780259","https://openalex.org/W2080365963","https://openalex.org/W2091870725","https://openalex.org/W2093402979","https://openalex.org/W2093573907","https://openalex.org/W2096148096","https://openalex.org/W2099377894","https://openalex.org/W2107580398","https://openalex.org/W2109488005","https://openalex.org/W2109991075","https://openalex.org/W2111187843","https://openalex.org/W2112641584","https://openalex.org/W2113054345","https://openalex.org/W2115162083","https://openalex.org/W2117649404","https://openalex.org/W2117656191","https://openalex.org/W2121232556","https://openalex.org/W2122683221","https://openalex.org/W2123696077","https://openalex.org/W2124531484","https://openalex.org/W2124810156","https://openalex.org/W2126903025","https://openalex.org/W2128985829","https://openalex.org/W2133811295","https://openalex.org/W2135029798","https://openalex.org/W2135461398","https://openalex.org/W2143093088","https://openalex.org/W2144847592","https://openalex.org/W2151571079","https://openalex.org/W2154068087","https://openalex.org/W2154330708","https://openalex.org/W2158485828","https://openalex.org/W2160450758","https://openalex.org/W2161724277","https://openalex.org/W2162098863","https://openalex.org/W2275877493","https://openalex.org/W2294798173","https://openalex.org/W2999905431","https://openalex.org/W3105265400","https://openalex.org/W3143596294","https://openalex.org/W4213060373","https://openalex.org/W4235169531","https://openalex.org/W6680012447"],"related_works":["https://openalex.org/W4251527294","https://openalex.org/W3090782779","https://openalex.org/W4296701479","https://openalex.org/W2037261263","https://openalex.org/W3149087629","https://openalex.org/W4231036715","https://openalex.org/W2032074591","https://openalex.org/W1986156575","https://openalex.org/W4242983818","https://openalex.org/W2970288912"],"abstract_inverted_index":{"Despite":[0],"the":[1,33,52,57,68,79,93,99,106,127,154,242],"enormous":[2,30],"medical":[3],"impact":[4],"of":[5,10,15,29,36,67,85,95,101,108,129,133,152,156,159,186,189,205,213,244],"cancers":[6],"and":[7,18,41,78,220,250],"intensive":[8],"study":[9],"their":[11],"biology,":[12],"detailed":[13],"characterization":[14],"tumor":[16,160,222,236,247],"growth":[17],"development":[19],"remains":[20],"elusive.":[21],"This":[22],"difficulty":[23,128],"occurs":[24],"in":[25,32,43,47,162,241],"large":[26],"part":[27],"because":[28],"heterogeneity":[31,116,253],"molecular":[34],"mechanisms":[35],"cancer":[37],"progression,":[38],"both":[39],"tumor-to-tumor":[40],"cell-to-cell":[42],"single":[44],"tumors.":[45],"Advances":[46],"genomic":[48,72,119,131,248],"technologies,":[49],"especially":[50],"at":[51],"single-cell":[53,102],"level,":[54],"are":[55,62,124],"improving":[56],"situation,":[58],"but":[59],"these":[60],"approaches":[61],"held":[63],"back":[64],"by":[65,126,176],"limitations":[66],"biotechnologies":[69],"for":[70,82,202],"gathering":[71],"data":[73,224,249],"from":[74,117,140,184,254],"heterogeneous":[75],"cell":[76],"populations":[77],"computational":[80,109],"methods":[81,97,112],"making":[83],"sense":[84],"those":[86],"data.":[87,120,256],"One":[88],"popular":[89],"way":[90],"to":[91,113,150,172,181,208,210,233],"gain":[92],"advantages":[94],"whole-genome":[96],"without":[98],"cost":[100],"genomics":[103],"has":[104],"been":[105],"use":[107],"deconvolution":[110],"(unmixing)":[111],"reconstruct":[114],"clonal":[115,138,190,252],"bulk":[118,141,255],"These":[121],"methods,":[122],"too,":[123],"limited":[125],"inferring":[130,251],"profiles":[132],"rare":[134],"or":[135],"subtly":[136],"varying":[137],"subpopulations":[139],"data,":[142],"a":[143,163,169,194,238],"problem":[144],"that":[145,151,174,225],"can":[146],"be":[147],"computationally":[148],"reduced":[149],"reconstructing":[153],"geometry":[155],"point":[157],"clouds":[158],"samples":[161],"genome":[164],"space.":[165],"Here,":[166],"we":[167],"present":[168],"new":[170,227],"method":[171,197,228],"improve":[173],"reconstruction":[175],"better":[177],"identifying":[178,203],"subspaces":[179],"corresponding":[180],"tumors":[182,206],"produced":[183],"mixtures":[185],"distinct":[187,211],"combinations":[188],"subpopulations.":[191],"We":[192,216],"develop":[193],"nonparametric":[195],"clustering":[196,201],"based":[198],"on":[199,218],"medoidshift":[200],"subgroups":[204],"expected":[207],"correspond":[209],"trajectories":[212],"evolutionary":[214],"progression.":[215],"show":[217],"synthetic":[219],"real":[221],"copy-number":[223],"this":[226],"substantially":[229],"improves":[230],"our":[231],"ability":[232],"resolve":[234],"discrete":[235],"subgroups,":[237],"key":[239],"step":[240],"process":[243],"accurately":[245],"deconvolving":[246]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
