{"id":"https://openalex.org/W7161575188","doi":"https://doi.org/10.1186/s12859-026-06469-1","title":"Selecting synthetic data for successful simulation-based transfer learning in dynamical biological systems","display_name":"Selecting synthetic data for successful simulation-based transfer learning in dynamical biological systems","publication_year":2026,"publication_date":"2026-05-18","ids":{"openalex":"https://openalex.org/W7161575188","doi":"https://doi.org/10.1186/s12859-026-06469-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42151772"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-026-06469-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-026-06469-1","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12859-026-06469-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027402526","display_name":"Simon Witzke","orcid":"https://orcid.org/0009-0002-7596-1730"},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]},{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simon Witzke","raw_affiliation_strings":["Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038033729","display_name":"Julian Zabbarov","orcid":"https://orcid.org/0009-0002-5060-7399"},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]},{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julian Zabbarov","raw_affiliation_strings":["Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006710049","display_name":"Maximilian Kleissl","orcid":null},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]},{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Kleissl","raw_affiliation_strings":["Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048889230","display_name":"Pascal Iversen","orcid":"https://orcid.org/0000-0001-9877-4300"},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]},{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pascal Iversen","raw_affiliation_strings":["Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany","Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005996110","display_name":"Bernhard Y. Renard","orcid":"https://orcid.org/0000-0003-4589-9809"},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]},{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard Y. Renard","raw_affiliation_strings":["Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067843065","display_name":"Katharina Baum","orcid":"https://orcid.org/0000-0001-7256-0566"},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Katharina Baum","raw_affiliation_strings":["Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany. katharina.baum@fu-berlin.de","Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany. katharina.baum@fu-berlin.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany. katharina.baum@fu-berlin.de","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany. katharina.baum@fu-berlin.de","institution_ids":["https://openalex.org/I143288331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067843065"],"corresponding_institution_ids":["https://openalex.org/I143288331","https://openalex.org/I75951250"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49010286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11206","display_name":"Model Reduction and Neural Networks","score":0.7366999983787537,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11206","display_name":"Model Reduction and Neural Networks","score":0.7366999983787537,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.053199999034404755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transfer-of-learning","display_name":"Transfer of learning","score":0.7591999769210815},{"id":"https://openalex.org/keywords/synthetic-data","display_name":"Synthetic data","score":0.6886000037193298},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.5206000208854675},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.4740000069141388},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.4074000120162964},{"id":"https://openalex.org/keywords/coherence","display_name":"Coherence (philosophical gambling strategy)","score":0.4016999900341034},{"id":"https://openalex.org/keywords/applicability-domain","display_name":"Applicability domain","score":0.39739999175071716},{"id":"https://openalex.org/keywords/interdependence","display_name":"Interdependence","score":0.375900000333786},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C150899416","wikidata":"https://www.wikidata.org/wiki/Q1820378","display_name":"Transfer of learning","level":2,"score":0.7591999769210815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7174999713897705},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.6886000037193298},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.670799970626831},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5820000171661377},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.5206000208854675},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4740000069141388},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4074000120162964},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C107908354","wikidata":"https://www.wikidata.org/wiki/Q4781456","display_name":"Applicability domain","level":3,"score":0.39739999175071716},{"id":"https://openalex.org/C185874996","wikidata":"https://www.wikidata.org/wiki/Q269699","display_name":"Interdependence","level":2,"score":0.375900000333786},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.3334999978542328},{"id":"https://openalex.org/C2776960227","wikidata":"https://www.wikidata.org/wiki/Q2586354","display_name":"Knowledge transfer","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.29420000314712524},{"id":"https://openalex.org/C175801342","wikidata":"https://www.wikidata.org/wiki/Q1988917","display_name":"Data analysis","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C207685749","wikidata":"https://www.wikidata.org/wiki/Q2088941","display_name":"Domain knowledge","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C151406439","wikidata":"https://www.wikidata.org/wiki/Q186588","display_name":"Time series","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C77967617","wikidata":"https://www.wikidata.org/wiki/Q4677561","display_name":"Active learning (machine learning)","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.2547000050544739}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098410","descriptor_name":"Transfer Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-026-06469-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-026-06469-1","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:42151772","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42151772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e7b4920770174c6194a647d6835f9273","is_oa":true,"landing_page_url":"https://doaj.org/article/e7b4920770174c6194a647d6835f9273","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 27, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13188243","is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42151772/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-026-06469-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-026-06469-1","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324521","display_name":"Freie Universit\u00e4t Berlin","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W257638949","https://openalex.org/W1534304300","https://openalex.org/W1851422093","https://openalex.org/W1977738976","https://openalex.org/W1991288592","https://openalex.org/W2010453474","https://openalex.org/W2022189875","https://openalex.org/W2039240409","https://openalex.org/W2047694274","https://openalex.org/W2096990683","https://openalex.org/W2106362845","https://openalex.org/W2107062718","https://openalex.org/W2111406701","https://openalex.org/W2126643167","https://openalex.org/W2139997707","https://openalex.org/W2165698076","https://openalex.org/W2293578667","https://openalex.org/W2486999229","https://openalex.org/W2592329794","https://openalex.org/W2615117870","https://openalex.org/W2626108736","https://openalex.org/W2751687090","https://openalex.org/W2786235792","https://openalex.org/W2801312853","https://openalex.org/W2806157403","https://openalex.org/W2809933567","https://openalex.org/W2898843852","https://openalex.org/W2902000707","https://openalex.org/W2909877301","https://openalex.org/W2940375021","https://openalex.org/W2950340994","https://openalex.org/W2950665010","https://openalex.org/W2954996726","https://openalex.org/W2994774314","https://openalex.org/W3022574011","https://openalex.org/W3023190093","https://openalex.org/W3029447859","https://openalex.org/W3031514878","https://openalex.org/W3036953288","https://openalex.org/W3042645205","https://openalex.org/W3080930191","https://openalex.org/W3088063380","https://openalex.org/W3099892132","https://openalex.org/W3118792136","https://openalex.org/W3125676075","https://openalex.org/W3163993681","https://openalex.org/W3166254754","https://openalex.org/W3175110359","https://openalex.org/W4206564475","https://openalex.org/W4210916416","https://openalex.org/W4220685469","https://openalex.org/W4236990395","https://openalex.org/W4283379274","https://openalex.org/W4283588627","https://openalex.org/W4292554450","https://openalex.org/W4318773819","https://openalex.org/W4381051623","https://openalex.org/W4382318725","https://openalex.org/W4383199543","https://openalex.org/W4386107400","https://openalex.org/W4387745481","https://openalex.org/W4388297464","https://openalex.org/W4393791625","https://openalex.org/W4396685672","https://openalex.org/W4396887701","https://openalex.org/W4402253475","https://openalex.org/W4403369610","https://openalex.org/W4403626794","https://openalex.org/W4406234152"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Accurate":[1],"prediction":[2],"of":[3,7,43,57,90,99,115,132,187,199,222,226],"the":[4,39,54,88,96,100,130,181,185,188,191,220,231],"temporal":[5],"dynamics":[6,42,186],"biological":[8],"systems":[9,151],"is":[10,50,247],"crucial":[11],"for":[12,25,207,229,241],"informing":[13,65],"timely":[14],"and":[15,113,152,165],"effective":[16],"interventions,":[17],"e.g.,":[18],"in":[19,28,37,203,236],"ecological":[20],"or":[21,24],"epidemiological":[22],"contexts,":[23],"treatment":[26],"adjustments":[27],"therapy.":[29],"While":[30],"machine":[31,66],"learning":[32,67,70,138,170,210],"has":[33,81],"proven":[34],"its":[35,47],"capabilities":[36],"generalizing":[38],"underlying":[40,190],"non-linear":[41],"such":[44,109,133],"systems,":[45],"unlocking":[46],"predictive":[48],"power":[49],"often":[51],"restrained":[52],"by":[53,68],"limited":[55],"availability":[56],"large,":[58],"curated":[59],"datasets.":[60,122,155],"To":[61],"supplement":[62],"real-world":[63,154,175],"data,":[64],"transfer":[69,137,169,209],"with":[71,184],"synthetic":[72,101,119,162,192,227],"data":[73,176,228],"derived":[74],"from":[75],"simulations":[76],"using":[77],"ordinary":[78,116,237],"differential":[79,117,238],"equations":[80],"emerged":[82],"as":[83,110,178,180],"a":[84,142,158,196],"promising":[85],"solution.":[86],"However,":[87],"success":[89],"this":[91],"approach":[92],"highly":[93],"depends":[94],"on":[95,136,145,174],"designed":[97],"characteristics":[98,177],"data.":[102,193],"RESULTS:":[103],"We":[104,140,156,194],"suggest":[105],"scrutinizing":[106],"these":[107],"characteristics,":[108],"size,":[111],"diversity,":[112],"noise,":[114],"equation-based":[118],"time":[120],"series":[121],"Here,":[123],"we":[124],"demonstrate":[125],"how":[126],"to":[127,201,212],"systematically":[128],"evaluate":[129],"influence":[131],"design":[134],"choices":[135],"performance.":[139],"conduct":[141],"proof-of-concept":[143],"study":[144],"three":[146],"simple,":[147],"but":[148],"widely":[149],"used":[150],"four":[153],"find":[157],"strong":[159],"interdependency":[160],"between":[161],"dataset":[163],"size":[164],"diversity":[166],"effects.":[167],"Good":[168],"settings":[171],"heavily":[172],"rely":[173],"well":[179],"data's":[182],"coherence":[183],"model":[189],"achieve":[195],"performance":[197],"improvement":[198],"up":[200],"95%":[202],"mean":[204],"absolute":[205],"error":[206],"simulation-based":[208],"compared":[211],"non-informed":[213],"deep":[214],"learning.":[215],"CONCLUSIONS:":[216],"Our":[217],"work":[218],"emphasizes":[219],"relevance":[221],"carefully":[223],"selecting":[224],"properties":[225],"leveraging":[230],"valuable":[232],"domain":[233],"knowledge":[234],"contained":[235],"equation":[239],"models":[240],"machine-learning":[242],"based":[243],"predictions.":[244],"The":[245],"code":[246],"available":[248],"at":[249],"https://github.com/DILiS-lab/opt-synthdata-4tl":[250],".":[251]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2026-05-19T00:00:00"}
