{"id":"https://openalex.org/W7128686881","doi":"https://doi.org/10.1186/s12859-026-06395-2","title":"hStouffer: the enhanced meta-analysis method for the comprehensive analysis of large-scale RNA-seq data","display_name":"hStouffer: the enhanced meta-analysis method for the comprehensive analysis of large-scale RNA-seq data","publication_year":2026,"publication_date":"2026-02-12","ids":{"openalex":"https://openalex.org/W7128686881","doi":"https://doi.org/10.1186/s12859-026-06395-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/41680606"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-026-06395-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-026-06395-2","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12859-026-06395-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100383808","display_name":"Daehee Kim","orcid":"https://orcid.org/0000-0002-0816-8137"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Daehee Kim","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024574646","display_name":"Seongjun Byun","orcid":"https://orcid.org/0000-0002-0186-5976"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seongjun Byun","raw_affiliation_strings":["KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618956","display_name":"Jaehyun Park","orcid":"https://orcid.org/0000-0002-5264-6941"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaehyun Park","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125771192","display_name":"Soo-Jin Jang","orcid":null},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Jin Jang","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121949699","display_name":"Yongku Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yongku Kim","raw_affiliation_strings":["Department of Statistics, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052475847","display_name":"Seung Yeop Yang","orcid":"https://orcid.org/0009-0009-8420-5196"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Yeop Yang","raw_affiliation_strings":["Department of Mathematics, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122368827","display_name":"Myungjin Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myungjin Kim","raw_affiliation_strings":["Department of Statistics, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125728323","display_name":"Semin Oh","orcid":null},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Semin Oh","raw_affiliation_strings":["KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103146896","display_name":"J. H. Lee","orcid":"https://orcid.org/0000-0001-9921-7629"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jieun Lee","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143822425","display_name":"Jieun Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jieun Lee","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000762926","display_name":"Kee\u2010Beom Kim","orcid":"https://orcid.org/0000-0003-0132-8924"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kee-Beom Kim","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125694345","display_name":"Dong Kyu Choi","orcid":null},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Kyu Choi","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141261847","display_name":"Samuel Beck","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Beck","raw_affiliation_strings":["Department of Dermatology, Center for Aging Research, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Center for Aging Research, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026197268","display_name":"Jun-Yeong Lee","orcid":"https://orcid.org/0000-0002-4342-1863"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jun-Yeong Lee","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026197268","display_name":"Jun-Yeong Lee","orcid":"https://orcid.org/0000-0002-4342-1863"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun-Yeong Lee","raw_affiliation_strings":["BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, 41566, South Korea. junyeong@knu.ac.kr","institution_ids":["https://openalex.org/I31419693"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026197268","https://openalex.org/A5103146896"],"corresponding_institution_ids":["https://openalex.org/I31419693"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12824694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.3971000015735626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.3971000015735626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.30709999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.7623000144958496},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.5602999925613403},{"id":"https://openalex.org/keywords/exponential-growth","display_name":"Exponential growth","score":0.5011000037193298},{"id":"https://openalex.org/keywords/false-positives-and-false-negatives","display_name":"False positives and false negatives","score":0.4357999861240387},{"id":"https://openalex.org/keywords/false-positive-rate","display_name":"False positive rate","score":0.41110000014305115},{"id":"https://openalex.org/keywords/cutoff","display_name":"Cutoff","score":0.40049999952316284},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.3894999921321869},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.3849000036716461}],"concepts":[{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.7623000144958496},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6718000173568726},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5817000269889832},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.5602999925613403},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.5011000037193298},{"id":"https://openalex.org/C112789634","wikidata":"https://www.wikidata.org/wiki/Q18207010","display_name":"False positives and false negatives","level":3,"score":0.4357999861240387},{"id":"https://openalex.org/C95922358","wikidata":"https://www.wikidata.org/wiki/Q5432725","display_name":"False positive rate","level":2,"score":0.41110000014305115},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.3849000036716461},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.3833000063896179},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3813999891281128},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.350600004196167},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C151376022","wikidata":"https://www.wikidata.org/wiki/Q168698","display_name":"Exponential function","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C40969351","wikidata":"https://www.wikidata.org/wiki/Q3516228","display_name":"Word error rate","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C2989486834","wikidata":"https://www.wikidata.org/wiki/Q3808900","display_name":"True positive rate","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.2531000077724457}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-026-06395-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-026-06395-2","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41680606","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41680606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:14af6118edc64288b09452b56c5db2b9","is_oa":true,"landing_page_url":"https://doaj.org/article/14af6118edc64288b09452b56c5db2b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 27, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13005553","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13005553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-026-06395-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-026-06395-2","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1119736456","display_name":null,"funder_award_id":"R01AG068179","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5249511491","display_name":null,"funder_award_id":"RS-2023-00301914","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6695731458","display_name":null,"funder_award_id":"RS-2024-00408736","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1824047490","https://openalex.org/W1978172027","https://openalex.org/W1983993360","https://openalex.org/W1998712640","https://openalex.org/W2047100183","https://openalex.org/W2048529464","https://openalex.org/W2050691209","https://openalex.org/W2073116379","https://openalex.org/W2103365735","https://openalex.org/W2107060225","https://openalex.org/W2107328434","https://openalex.org/W2131581981","https://openalex.org/W2151975241","https://openalex.org/W2152274187","https://openalex.org/W2179438025","https://openalex.org/W2236822143","https://openalex.org/W2520263151","https://openalex.org/W2807407168","https://openalex.org/W2906546755","https://openalex.org/W2912934387","https://openalex.org/W2945883683","https://openalex.org/W2953067954","https://openalex.org/W3003257820","https://openalex.org/W3131305282","https://openalex.org/W3137679227","https://openalex.org/W3139265997","https://openalex.org/W4223464414","https://openalex.org/W4280565676","https://openalex.org/W4287120304","https://openalex.org/W4295901295","https://openalex.org/W4310038901","https://openalex.org/W4366695774"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"the":[2,49,60,85,88,119,138,142,149,160],"exponential":[3],"growth":[4],"of":[5,51,63,80,87,163],"public":[6],"RNA-seq":[7,186],"datasets,":[8],"meta-analysis":[9,96],"has":[10],"become":[11],"a":[12,41,70,77,94,128,177],"crucial":[13],"tool":[14,157],"for":[15,36,158,184,191],"integrating":[16],"studies":[17],"to":[18,107,167,200],"increase":[19],"statistical":[20],"power":[21],"and":[22,39,83,105,180,194,204],"identify":[23],"consistent":[24],"biological":[25,151,170],"patterns.":[26],"However,":[27],"conventional":[28],"p":[29,66,100],"value":[30,101],"combination":[31],"methods":[32],"were":[33],"not":[34],"designed":[35],"large-scale":[37,185],"integration":[38],"exhibit":[40],"critical":[42],"flaw:":[43],"as":[44],"more":[45,202],"datasets":[46],"are":[47],"added,":[48],"rate":[50,132],"false":[52,130,195],"positives":[53],"increases":[54],"dramatically.":[55],"This":[56],"issue":[57],"stems":[58],"from":[59,68,207],"disproportionate":[61],"influence":[62],"extremely":[64],"low":[65],"values":[67],"just":[69],"few":[71],"individual":[72],"studies,":[73],"which":[74],"can":[75],"create":[76],"misleading":[78],"signal":[79],"overall":[81],"significance":[82],"undermine":[84],"reliability":[86],"findings.":[89],"RESULTS:":[90],"Here,":[91],"we":[92],"introduce":[93],"robust":[95,179],"framework":[97,114],"that":[98,141],"incorporates":[99],"capping,":[102],"cutoff":[103],"thresholding,":[104],"bagging":[106],"alleviate":[108],"this":[109,113],"issue.":[110],"We":[111],"implemented":[112],"using":[115],"Stouffer\u2019s":[116],"method,":[117],"termed":[118],"hybrid":[120],"Stouffer":[121],"(hStouffer)":[122],"method.":[123],"The":[124,173],"proposed":[125],"method":[126,175],"demonstrates":[127],"reduced":[129],"positive":[131],"while":[133],"preserving":[134],"high":[135],"sensitivity.":[136],"Furthermore,":[137],"validation":[139],"showed":[140],"DEGs":[143],"identified":[144],"by":[145],"hStouffer":[146,174],"accurately":[147],"reflect":[148],"underlying":[150],"phenomena,":[152],"making":[153],"it":[154,197],"an":[155],"essential":[156],"leveraging":[159],"full":[161],"potential":[162],"expanding":[164],"genomic":[165],"databases":[166],"understand":[168],"complex":[169],"processes.":[171],"CONCLUSIONS:":[172],"provides":[176],"statistically":[178],"biologically":[181],"coherent":[182],"solution":[183],"meta-analysis.":[187],"By":[188],"effectively":[189],"controlling":[190],"technical":[192],"artifacts":[193],"discoveries,":[196],"enables":[198],"researchers":[199],"extract":[201],"reliable":[203],"meaningful":[205],"insights":[206],"complex,":[208],"aggregated":[209],"transcriptomic":[210],"data.":[211]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2026-02-13T00:00:00"}
