{"id":"https://openalex.org/W4409686339","doi":"https://doi.org/10.1186/s12859-025-06122-3","title":"HPOseq: a deep ensemble model for predicting the protein-phenotype relationships based on protein sequences","display_name":"HPOseq: a deep ensemble model for predicting the protein-phenotype relationships based on protein sequences","publication_year":2025,"publication_date":"2025-04-22","ids":{"openalex":"https://openalex.org/W4409686339","doi":"https://doi.org/10.1186/s12859-025-06122-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40263997"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-025-06122-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-025-06122-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06122-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06122-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066909470","display_name":"Kai Zhao","orcid":"https://orcid.org/0000-0002-5448-9919"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Zhao","raw_affiliation_strings":["School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067978579","display_name":"Zhongzhong Ji","orcid":"https://orcid.org/0000-0003-0562-2477"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuocheng Ji","raw_affiliation_strings":["School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437378","display_name":"Linlin Zhang","orcid":"https://orcid.org/0000-0002-0823-7825"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Zhang","raw_affiliation_strings":["School of Software, Xinjiang University, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi, 830011, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022558170","display_name":"Quan Na","orcid":"https://orcid.org/0000-0002-7315-0283"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Quan","raw_affiliation_strings":["School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652791","display_name":"Yuheng Li","orcid":"https://orcid.org/0000-0002-1865-1122"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuheng Li","raw_affiliation_strings":["School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xinjiang University, Urumqi, 830011, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072554320","display_name":"Guanglei Yu","orcid":"https://orcid.org/0000-0003-0954-3397"},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanglei Yu","raw_affiliation_strings":["College of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China","School Of Computer Science and Engineering, Central South University, Changsha, 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"School Of Computer Science and Engineering, Central South University, Changsha, 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036241949","display_name":"Xuehua Bi","orcid":"https://orcid.org/0009-0004-4861-1588"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuehua Bi","raw_affiliation_strings":["College of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China. bxh0327@foxmail.com","School Of Computer Science and Engineering, Central South University, Changsha, 410083, China. bxh0327@foxmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China. bxh0327@foxmail.com","institution_ids":[]},{"raw_affiliation_string":"School Of Computer Science and Engineering, Central South University, Changsha, 410083, China. bxh0327@foxmail.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5066909470"],"corresponding_institution_ids":["https://openalex.org/I96908189"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.070955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"110","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8069999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8069999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1396999955177307,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6550199389457703},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5943907499313354},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5417348742485046},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40393465757369995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3808237314224243},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3690609931945801},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3571200966835022},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34878009557724},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2181335985660553},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08813345432281494}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6550199389457703},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5943907499313354},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5417348742485046},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40393465757369995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3808237314224243},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3690609931945801},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3571200966835022},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34878009557724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2181335985660553},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08813345432281494}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-025-06122-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-025-06122-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06122-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40263997","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40263997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12013097","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12013097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c576aff5241d4fa0b88361542a81d0ad","is_oa":true,"landing_page_url":"https://doaj.org/article/c576aff5241d4fa0b88361542a81d0ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 26, Iss 1, Pp 1-15 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-025-06122-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-025-06122-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06122-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G8370080615","display_name":null,"funder_award_id":"62366052","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328898","display_name":"Natural Science Foundation of Xinjiang","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409686339.pdf","grobid_xml":"https://content.openalex.org/works/W4409686339.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1982267716","https://openalex.org/W1987370810","https://openalex.org/W2037085464","https://openalex.org/W2066852475","https://openalex.org/W2143664838","https://openalex.org/W2154139219","https://openalex.org/W2155201844","https://openalex.org/W2157585454","https://openalex.org/W2158714788","https://openalex.org/W2161409682","https://openalex.org/W2171400002","https://openalex.org/W2558825838","https://openalex.org/W2577977610","https://openalex.org/W2582372140","https://openalex.org/W2755012395","https://openalex.org/W2809000676","https://openalex.org/W2887905891","https://openalex.org/W2905102681","https://openalex.org/W2966590054","https://openalex.org/W2967967714","https://openalex.org/W2992810674","https://openalex.org/W3014663601","https://openalex.org/W3022179362","https://openalex.org/W3023746197","https://openalex.org/W3046280678","https://openalex.org/W3080498684","https://openalex.org/W3081499927","https://openalex.org/W3089088681","https://openalex.org/W3106811464","https://openalex.org/W3133259203","https://openalex.org/W3153713962","https://openalex.org/W3164046276","https://openalex.org/W3193569972","https://openalex.org/W3206782361","https://openalex.org/W4206242528","https://openalex.org/W4236358448","https://openalex.org/W4281742441","https://openalex.org/W4308834893","https://openalex.org/W4309425098","https://openalex.org/W4322724394","https://openalex.org/W4366684923","https://openalex.org/W4387425086","https://openalex.org/W4388515776","https://openalex.org/W4391111375","https://openalex.org/W4391609537","https://openalex.org/W4391785146"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W1840542775","https://openalex.org/W2416830231","https://openalex.org/W4405776396","https://openalex.org/W3003578468","https://openalex.org/W2336657400","https://openalex.org/W2088351705","https://openalex.org/W179926425","https://openalex.org/W2551532359","https://openalex.org/W2415545834"],"abstract_inverted_index":{"BACKGROUND:":[0],"Understanding":[1],"the":[2,12,19,43,60,118,146,154,180,190],"relationships":[3,90],"between":[4,133],"proteins":[5,134],"and":[6,17,41,45,64,185],"specific":[7],"disease":[8],"phenotypes":[9],"contributes":[10],"to":[11,101,116,144,188],"early":[13],"detection":[14],"of":[15,21,26,30,62,160,182,193],"diseases":[16],"advances":[18],"development":[20],"personalized":[22],"medicine.":[23],"The":[24,121,158],"acquisition":[25],"a":[27,124],"large":[28],"amount":[29],"proteomics":[31],"data":[32],"has":[33],"facilitated":[34],"this":[35,72,76],"process.":[36,73],"To":[37],"improve":[38],"discovery":[39],"efficiency":[40],"reduce":[42],"time":[44],"financial":[46],"costs":[47],"associated":[48,119],"with":[49],"biological":[50],"experiments,":[51],"various":[52],"computational":[53],"methods":[54,169],"have":[55],"yielded":[56],"promising":[57],"results.":[58],"However,":[59],"lack":[61],"rich":[63],"reliable":[65],"protein-related":[66],"information":[67,108,132],"still":[68],"presents":[69],"challenges":[70],"in":[71,153],"RESULTS:":[74],"In":[75],"paper,":[77],"we":[78,175],"propose":[79],"an":[80,139],"ensemble":[81,140],"prediction":[82],"model,":[83],"named":[84],"HPOseq,":[85],"which":[86],"predicts":[87],"human":[88],"protein-phenotype":[89,172],"based":[91,127],"only":[92],"on":[93,128],"sequence":[94,129],"information.":[95],"HPOseq":[96,165],"establishes":[97],"two":[98],"base":[99,150],"models":[100],"achieve":[102],"objectives.":[103],"One":[104],"directly":[105],"extracts":[106],"internal":[107],"from":[109,148,179],"amino":[110],"acid":[111],"sequences":[112],"as":[113],"protein":[114,186],"features":[115],"predict":[117],"phenotypes.":[120],"other":[122],"builds":[123],"protein-protein":[125],"network":[126],"similarity,":[130],"extracting":[131],"for":[135,170],"phenotype":[136,183],"prediction.":[137,156],"Ultimately,":[138],"module":[141],"is":[142],"employed":[143],"integrate":[145],"predictions":[147],"both":[149],"models,":[151],"resulting":[152],"final":[155],"CONCLUSION:":[157],"results":[159],"5-fold":[161],"cross-validation":[162],"reveal":[163],"that":[164],"outperforms":[166],"seven":[167],"baseline":[168],"predicting":[171],"relationships.":[173],"Moreover,":[174],"conduct":[176],"case":[177],"studies":[178],"points":[181],"annotation":[184],"analysis":[187],"verify":[189],"practical":[191],"significance":[192],"HPOseq.":[194]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
