{"id":"https://openalex.org/W4407874335","doi":"https://doi.org/10.1186/s12859-025-06070-y","title":"goloco: a web application to create genome scale information from surprisingly small experiments","display_name":"goloco: a web application to create genome scale information from surprisingly small experiments","publication_year":2025,"publication_date":"2025-02-25","ids":{"openalex":"https://openalex.org/W4407874335","doi":"https://doi.org/10.1186/s12859-025-06070-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/39994507"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-025-06070-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-025-06070-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06070-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06070-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113133852","display_name":"Sajid Hossain","orcid":null},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sajid M. Hossain","raw_affiliation_strings":["Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA","Department of Therapeutic Radiology, Yale School of Medicine, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Therapeutic Radiology, Yale School of Medicine, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057981573","display_name":"Yiyun Rao","orcid":"https://orcid.org/0000-0003-0296-3073"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiyun Rao","raw_affiliation_strings":["The Huck Institute for the Life Sciences, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Huck Institute for the Life Sciences, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036495416","display_name":"J. Hossain","orcid":"https://orcid.org/0000-0001-5144-7919"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahid O. Hossain","raw_affiliation_strings":["Department of Bioengineering, Lehigh University, Bethlehem, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Lehigh University, Bethlehem, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014147401","display_name":"Justin R. Pritchard","orcid":"https://orcid.org/0000-0001-7749-4473"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin R. Pritchard","raw_affiliation_strings":["Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA. jrp94@psu.edu","The Huck Institute for the Life Sciences, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA. jrp94@psu.edu","The Huck Institute for the Life Sciences, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA. jrp94@psu.edu","institution_ids":[]},{"raw_affiliation_string":"The Huck Institute for the Life Sciences, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA. jrp94@psu.edu","institution_ids":[]},{"raw_affiliation_string":"The Huck Institute for the Life Sciences, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026905446","display_name":"Boyang Zhao","orcid":"https://orcid.org/0000-0002-9386-2659"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boyang Zhao","raw_affiliation_strings":["Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA. bozhao@alum.mit.edu","Quantalarity Research Group, Houston, TX, USA. bozhao@alum.mit.edu","Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA. bozhao@alum.mit.edu","institution_ids":[]},{"raw_affiliation_string":"Quantalarity Research Group, Houston, TX, USA. bozhao@alum.mit.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering, The Pennsylvania State University, 211 Wartik Lab, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113133852"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I32971472"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0286567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"61","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.21170000731945038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.19050000607967377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5285436511039734},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5219175815582275},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.5135045647621155},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4835679233074188},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4780500531196594},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46016666293144226},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4561445415019989},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2464352250099182},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.13260701298713684},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10176578164100647}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5285436511039734},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5219175815582275},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.5135045647621155},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4835679233074188},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4780500531196594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46016666293144226},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4561445415019989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2464352250099182},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.13260701298713684},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10176578164100647},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-025-06070-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-025-06070-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06070-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39994507","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39994507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f5281234686b48f29ff40c84bfc7875a","is_oa":true,"landing_page_url":"https://doaj.org/article/f5281234686b48f29ff40c84bfc7875a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 26, Iss 1, Pp 1-8 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11854281","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11854281","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-025-06070-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-025-06070-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-025-06070-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407874335.pdf"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2741508285","https://openalex.org/W2950595506","https://openalex.org/W2993894543","https://openalex.org/W3042896257","https://openalex.org/W4200497629","https://openalex.org/W4210349800"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2086525401","https://openalex.org/W2006735166","https://openalex.org/W2079327011","https://openalex.org/W2053325634","https://openalex.org/W3178279768","https://openalex.org/W2888097224","https://openalex.org/W2773861473","https://openalex.org/W193851735","https://openalex.org/W1971903861"],"abstract_inverted_index":{"BACKGROUND:":[0],"Functional":[1],"genomics":[2,159],"aims":[3],"to":[4,55,78,93,108,144],"decipher":[5],"gene":[6],"function":[7],"by":[8,25,62,124],"observing":[9],"cellular":[10],"changes":[11],"when":[12],"specific":[13],"genes":[14],"are":[15,23],"disrupted":[16],"using":[17],"CRISPR":[18,29,60],"technology.":[19],"However,":[20],"these":[21],"experiments":[22],"limited":[24],"scalability,":[26],"as":[27,114,116],"comprehensive":[28],"screens":[30,61,85],"require":[31],"extensive":[32],"resources,":[33],"involving":[34],"millions":[35],"of":[36,40,59,128,156],"cells":[37],"and":[38,135],"thousands":[39],"sgRNAs,":[41],"making":[42],"large-scale":[43,157],"studies":[44,148],"challenging.":[45],"We":[46],"propose":[47],"a":[48,125],"novel":[49],"approach":[50,91],"with":[51,149],"\"CRISPR":[52],"lossy":[53],"compression\"":[54],"reduce":[56],"the":[57,94,154],"complexity":[58],"focusing":[63],"on":[64],"key":[65],"genetic":[66],"nodes":[67],"that":[68,105],"can":[69],"infer":[70],"genome-wide":[71,84],"phenotypes.":[72],"These":[73],"condensed":[74],"sets,":[75],"comprising":[76],"100":[77,117],"1,000":[79],"genes,":[80],"enable":[81],"previously":[82],"impractical":[83],"tractable.":[86],"RESULTS:":[87],"To":[88],"make":[89],"this":[90],"accessible":[92],"wider":[95],"scientific":[96],"community,":[97],"we":[98],"developed":[99],"goloco,":[100],"an":[101],"interactive":[102],"web":[103],"application":[104],"allows":[106],"users":[107],"explore":[109],"genome-scale":[110,146],"loss-of-function":[111],"phenotypes":[112],"from":[113],"few":[115],"pooled":[118],"measurements.":[119],"The":[120],"tool":[121,140],"is":[122],"complemented":[123],"wide":[126],"array":[127],"analyses,":[129],"including":[130],"volcano":[131],"plot":[132],"visualizations,":[133],"regression":[134],"network":[136],"analyses.":[137],"CONCLUSIONS:":[138],"This":[139],"goloco":[141],"empowers":[142],"researchers":[143],"conduct":[145],"functional":[147,158],"minimal":[150],"experimental":[151],"overhead,":[152],"broadening":[153],"accessibility":[155],"research.":[160]},"counts_by_year":[],"updated_date":"2026-05-15T08:27:34.491423","created_date":"2025-10-10T00:00:00"}
