{"id":"https://openalex.org/W4404523012","doi":"https://doi.org/10.1186/s12859-024-05976-3","title":"Drug\u2013target interaction prediction by integrating heterogeneous information with mutual attention network","display_name":"Drug\u2013target interaction prediction by integrating heterogeneous information with mutual attention network","publication_year":2024,"publication_date":"2024-11-19","ids":{"openalex":"https://openalex.org/W4404523012","doi":"https://doi.org/10.1186/s12859-024-05976-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/39563226"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05976-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05976-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05976-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05976-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100746477","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0000-0003-3935-3201"},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072945506","display_name":"Yingdong Wang","orcid":"https://orcid.org/0000-0001-5510-3160"},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingdong Wang","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chaoyong Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoyong Wu","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China"],"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031818710","display_name":"Lingmin Zhan","orcid":null},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingmin Zhan","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023468207","display_name":"Aoyi Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aoyi Wang","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111163386","display_name":"Caiping Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiping Cheng","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101985490","display_name":"Jinzhong Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinzhong Zhao","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035190973","display_name":"Wuxia Zhang","orcid":"https://orcid.org/0000-0002-0759-2489"},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wuxia Zhang","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China. wuxia200758@163.com","Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China. wuxia200758@163.com","institution_ids":["https://openalex.org/I119868032"]},{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379152","display_name":"Jianxin Chen","orcid":"https://orcid.org/0000-0003-4067-5638"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Chen","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. cjx@bucm.edu.cn","School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China"],"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. cjx@bucm.edu.cn","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100432626","display_name":"Peng Li","orcid":"https://orcid.org/0000-0001-7226-4214"},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China. lip@sxau.edu.cn","Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China"],"affiliations":[{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China. lip@sxau.edu.cn","institution_ids":["https://openalex.org/I119868032"]},{"raw_affiliation_string":"Shanxi Key Lab for Modernization of TCVM, College of Basic Sciences, Shanxi Agricultural University, Taigu, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100746477"],"corresponding_institution_ids":["https://openalex.org/I119868032"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":7.5717,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.97851575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"1","first_page":"361","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9767000079154968,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interaction-information","display_name":"Interaction information","score":0.6924312114715576},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6557933688163757},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.6386579275131226},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.6230521202087402},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6046583652496338},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.593321681022644},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5621633529663086},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.5592305660247803},{"id":"https://openalex.org/keywords/heterogeneous-network","display_name":"Heterogeneous network","score":0.5325310230255127},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5195634365081787},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5069118142127991},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.4500220715999603},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43756672739982605},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4217360019683838},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.39954736828804016},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3566521108150482},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.19128519296646118},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09443792700767517},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.08437150716781616}],"concepts":[{"id":"https://openalex.org/C38764148","wikidata":"https://www.wikidata.org/wiki/Q17098245","display_name":"Interaction information","level":2,"score":0.6924312114715576},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6557933688163757},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6386579275131226},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.6230521202087402},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6046583652496338},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.593321681022644},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5621633529663086},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.5592305660247803},{"id":"https://openalex.org/C158207573","wikidata":"https://www.wikidata.org/wiki/Q5747224","display_name":"Heterogeneous network","level":4,"score":0.5325310230255127},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5195634365081787},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5069118142127991},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.4500220715999603},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43756672739982605},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4217360019683838},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.39954736828804016},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3566521108150482},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19128519296646118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09443792700767517},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.08437150716781616},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C108037233","wikidata":"https://www.wikidata.org/wiki/Q11375","display_name":"Wireless network","level":3,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-024-05976-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05976-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05976-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39563226","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39563226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11577831","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11577831","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11577831/pdf/12859_2024_Article_5976.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:94a5f7836a444e61afbe7e44e93a3a9b","is_oa":true,"landing_page_url":"https://doaj.org/article/94a5f7836a444e61afbe7e44e93a3a9b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-16 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05976-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05976-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05976-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328120","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4404523012.pdf"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1500036797","https://openalex.org/W2009313526","https://openalex.org/W2018838463","https://openalex.org/W2038252445","https://openalex.org/W2087064593","https://openalex.org/W2096541451","https://openalex.org/W2145578524","https://openalex.org/W2152630148","https://openalex.org/W2204695023","https://openalex.org/W2259538443","https://openalex.org/W2271736303","https://openalex.org/W2558217333","https://openalex.org/W2612467560","https://openalex.org/W2753953057","https://openalex.org/W2790808809","https://openalex.org/W2890911816","https://openalex.org/W2950461129","https://openalex.org/W2951422523","https://openalex.org/W2952522777","https://openalex.org/W2970971581","https://openalex.org/W2997418660","https://openalex.org/W3035965352","https://openalex.org/W3093194543","https://openalex.org/W3099878876","https://openalex.org/W3107527779","https://openalex.org/W3109916301","https://openalex.org/W3112376646","https://openalex.org/W3211402536","https://openalex.org/W4281871249","https://openalex.org/W4282926473","https://openalex.org/W4296483470","https://openalex.org/W4300861664","https://openalex.org/W4308834638","https://openalex.org/W4309218736","https://openalex.org/W4318981550","https://openalex.org/W4362720950","https://openalex.org/W4366824201","https://openalex.org/W4391365310","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W4387572939","https://openalex.org/W4319455836","https://openalex.org/W2558461040","https://openalex.org/W4393906247","https://openalex.org/W4402504391","https://openalex.org/W2509838516","https://openalex.org/W2020286660","https://openalex.org/W2184981123","https://openalex.org/W4399733839","https://openalex.org/W2805086457"],"abstract_inverted_index":{"DrugMAN":[0,36,64,72],"achieved":[1],"the":[2,38],"best":[3],"performance":[4],"compared":[5],"with":[6,29],"cheminformation-based":[7],"methods":[8,16],"SVM,":[9,30],"RF,":[10,31],"DeepPurpose":[11],"and":[12,18,34,44,61,80,89],"network-based":[13],"deep":[14],"learing":[15],"DTINet":[17],"NeoDT":[19],"in":[20,25,41],"four":[21],"different":[22],"scenarios,":[23],"especially":[24],"real-world":[26],"scenarios.":[27,50],"Compared":[28],"deepurpose,":[32],"DTINet,":[33],"NeoDT,":[35],"showed":[37],"smallest":[39],"decrease":[40],"AUROC,":[42],"AUPRC,":[43],"F1-Score":[45],"from":[46,58],"warm-start":[47],"to":[48,55,76],"Both-cold":[49],"This":[51],"result":[52],"is":[53],"attributed":[54],"DrugMAN's":[56],"learning":[57],"heterogeneous":[59,74],"data":[60],"indicates":[62],"that":[63],"has":[65],"a":[66,83],"good":[67],"generalization":[68],"ability.":[69],"Taking":[70],"together,":[71],"spotlights":[73],"information":[75],"mine":[77],"drug-target":[78],"interactions":[79],"can":[81],"be":[82],"powerful":[84],"tool":[85],"for":[86],"drug":[87,90],"discovery":[88],"repurposing.":[91]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11}],"updated_date":"2026-03-31T07:56:22.981413","created_date":"2025-10-10T00:00:00"}