{"id":"https://openalex.org/W4399114879","doi":"https://doi.org/10.1186/s12859-024-05971-8","title":"Conformal novelty detection for multiple metabolic networks","display_name":"Conformal novelty detection for multiple metabolic networks","publication_year":2024,"publication_date":"2024-11-16","ids":{"openalex":"https://openalex.org/W4399114879","doi":"https://doi.org/10.1186/s12859-024-05971-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/39550534"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05971-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05971-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05971-8.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05971-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080683838","display_name":"Ariane Marandon","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariane Marandon","raw_affiliation_strings":["LPSM, Sorbonne university, 4 place Jussieu, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LPSM, Sorbonne university, 4 place Jussieu, 75005, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011379612","display_name":"Tabea Rebafka","orcid":"https://orcid.org/0000-0002-8998-7109"},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210159481","display_name":"Math\u00e9matiques et Informatique Appliqu\u00e9es du G\u00e9nome \u00e0 l'Environnement","ror":"https://ror.org/05qdnns64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210099460","https://openalex.org/I4210159481"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tabea Rebafka","raw_affiliation_strings":["LPSM, Sorbonne university, 4 place Jussieu, 75005, Paris, France","MaIAGE, INRAE, Domaine de Vilvert, 78350, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LPSM, Sorbonne university, 4 place Jussieu, 75005, Paris, France","institution_ids":[]},{"raw_affiliation_string":"MaIAGE, INRAE, Domaine de Vilvert, 78350, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210159481","https://openalex.org/I4210088668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038700830","display_name":"Nataliya Sokolovska","orcid":"https://orcid.org/0000-0001-8841-1725"},"institutions":[{"id":"https://openalex.org/I4210097156","display_name":"Biologie Computationnelle, Quantitative et Synth\u00e9tique","ror":"https://ror.org/00pcqj134","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210097156"]},{"id":"https://openalex.org/I51101395","display_name":"Universit\u00e9 Paris 1 Panth\u00e9on-Sorbonne","ror":"https://ror.org/002t25c44","country_code":"FR","type":"education","lineage":["https://openalex.org/I51101395"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nataliya Sokolovska","raw_affiliation_strings":["LCQB, Sorbonne university, 4 place Jussieu, 75005, Paris, France. nataliya.sokolovska@sorbonne-universite.fr","LCQB, Sorbonne university, 4 place Jussieu, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LCQB, Sorbonne university, 4 place Jussieu, 75005, Paris, France. nataliya.sokolovska@sorbonne-universite.fr","institution_ids":["https://openalex.org/I51101395"]},{"raw_affiliation_string":"LCQB, Sorbonne university, 4 place Jussieu, 75005, Paris, France","institution_ids":["https://openalex.org/I4210097156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021381890","display_name":"H\u00e9di Soula","orcid":"https://orcid.org/0000-0001-5306-9712"},"institutions":[{"id":"https://openalex.org/I4210096450","display_name":"Nutrition et ob\u00e9sit\u00e9 : approches syst\u00e9miques","ror":"https://ror.org/00qdphm77","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096450"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9di Soula","raw_affiliation_strings":["NutriOmics, Sorbonne university, 91 boulevard de l'H\u00f4pital, 75013, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NutriOmics, Sorbonne university, 91 boulevard de l'H\u00f4pital, 75013, Paris, France","institution_ids":["https://openalex.org/I4210096450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038700830"],"corresponding_institution_ids":["https://openalex.org/I4210097156","https://openalex.org/I51101395"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07601811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"358","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.36640000343322754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.36640000343322754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.1177000030875206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.11020000278949738,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/novelty","display_name":"Novelty","score":0.6577707529067993},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5568556785583496},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4783722460269928},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4692399799823761},{"id":"https://openalex.org/keywords/conformal-map","display_name":"Conformal map","score":0.4556787610054016},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3286954164505005},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1898168921470642},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1547985076904297},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13336744904518127},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12373155355453491},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.07938680052757263}],"concepts":[{"id":"https://openalex.org/C2778738651","wikidata":"https://www.wikidata.org/wiki/Q16546687","display_name":"Novelty","level":2,"score":0.6577707529067993},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5568556785583496},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4783722460269928},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4692399799823761},{"id":"https://openalex.org/C98214594","wikidata":"https://www.wikidata.org/wiki/Q850275","display_name":"Conformal map","level":2,"score":0.4556787610054016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3286954164505005},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1898168921470642},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1547985076904297},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13336744904518127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12373155355453491},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07938680052757263},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-024-05971-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05971-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05971-8.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39550534","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39550534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-04588564v1","is_oa":true,"landing_page_url":"https://hal.science/hal-04588564/document","pdf_url":"https://hal.science/hal-04588564v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2024, 25 (1), pp.358. ⟨10.1186/s12859-024-05971-8⟩","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:11569617","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11569617","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11569617/pdf/12859_2024_Article_5971.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:36b5f1d4faee491c9b4c96463c1595b6","is_oa":true,"landing_page_url":"https://doaj.org/article/36b5f1d4faee491c9b4c96463c1595b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05971-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05971-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05971-8.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399114879.pdf","grobid_xml":"https://content.openalex.org/works/W4399114879.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1981276685","https://openalex.org/W1987588766","https://openalex.org/W2010707723","https://openalex.org/W2071128523","https://openalex.org/W2121501997","https://openalex.org/W2142678031","https://openalex.org/W2144885342","https://openalex.org/W2159482845","https://openalex.org/W2294798173","https://openalex.org/W2788919350","https://openalex.org/W2907492528","https://openalex.org/W2925177113","https://openalex.org/W2962810718","https://openalex.org/W2980664250","https://openalex.org/W3103523530","https://openalex.org/W3103786587","https://openalex.org/W3135437578","https://openalex.org/W3156397721","https://openalex.org/W3168570233","https://openalex.org/W3176437359","https://openalex.org/W4210257598","https://openalex.org/W4213235856","https://openalex.org/W4281724904","https://openalex.org/W4283692713","https://openalex.org/W4283837400","https://openalex.org/W4294216483","https://openalex.org/W4296780664","https://openalex.org/W4303423597","https://openalex.org/W4310917248","https://openalex.org/W4312294904","https://openalex.org/W4382632329","https://openalex.org/W4385164057","https://openalex.org/W4385764404","https://openalex.org/W4390690828","https://openalex.org/W6600076646","https://openalex.org/W6681029592","https://openalex.org/W6762839895","https://openalex.org/W6779121023","https://openalex.org/W6838425549"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2381242807","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W3126131230"],"abstract_inverted_index":{"BACKGROUND:":[0],"Graphical":[1],"representations":[2],"are":[3,65],"useful":[4],"to":[5,98,126,203,225,254,276],"model":[6],"complex":[7,241,269,278],"data":[8,162,231,242],"in":[9,14,25,59,68,104,110,118,138,239],"general":[10],"and":[11,37,72,163,201,224,281],"biological":[12],"interactions":[13],"particular.":[15],"Our":[16,114,234],"main":[17],"motivation":[18],"is":[19,41,124,133,143,148,191,198,214,263],"the":[20,26,60,80,100,139,146,161,188,204,244,250,256],"comparison":[21,36],"of":[22,29,39,48,79,182,187,207,217,221,268],"metabolic":[23,209,219],"networks":[24,56],"wider":[27],"context":[28],"developing":[30],"noninvasive":[31],"accurate":[32],"diagnostic":[33],"tools.":[34],"However,":[35],"classification":[38,75,106,267],"graphs":[40,109],"still":[42,66],"extremely":[43],"challenging,":[44],"although":[45],"a":[46,94,105,111,119,122,128,149,169,215,222,229],"number":[47],"highly":[49,240],"efficient":[50],"methods":[51],"such":[52],"as":[53,168],"graph":[54,69,123,213],"neural":[55],"were":[57],"developed":[58],"recent":[61],"decade.":[62],"Important":[63],"aspects":[64],"lacking":[67],"classification:":[70],"interpretability":[71],"guarantees":[73],"on":[74,160,193,265],"quality,":[76],"i.e.,":[77],"control":[78,99],"risk":[81],"level":[82],"or":[83],"false":[84,101,245],"discovery":[85,102,246,252],"rate":[86,103,253],"control.":[87],"RESULTS:":[88],"In":[89],"our":[90],"contribution,":[91],"we":[92],"introduce":[93],"statistically":[95],"sound":[96],"approach":[97,235],"task":[107,206,227],"for":[108],"semi-supervised":[112],"setting.":[113],"procedure":[115,147],"identifies":[116],"novelties":[117],"dataset,":[120],"where":[121,211],"considered":[125],"be":[127,166,273],"novelty":[129],"when":[130],"its":[131],"topology":[132],"significantly":[134],"different":[135],"from":[136,228],"those":[137],"reference":[140],"class.":[141],"It":[142,197],"noteworthy":[144],"that":[145,164,177],"conformal":[150],"prediction":[151],"approach,":[152],"which":[153],"does":[154],"not":[155],"make":[156],"any":[157],"distributional":[158],"assumptions":[159],"can":[165,272],"seen":[167],"wrapper":[170],"around":[171],"traditional":[172],"machine":[173],"learning":[174],"models,":[175],"so":[176],"it":[178],"takes":[179],"full":[180],"advantage":[181],"existing":[183],"methods.":[184],"The":[185],"performance":[186],"proposed":[189],"method":[190],"assessed":[192],"several":[194],"standard":[195],"benchmarks.":[196],"also":[199],"adapted":[200],"applied":[202],"difficult":[205],"classifying":[208],"networks,":[210],"each":[212],"representation":[216],"all":[218],"reactions":[220],"bacterium":[223],"real":[226],"cancer":[230],"repository.":[232],"CONCLUSIONS:":[233],"efficiently":[236],"controls":[237],"-":[238,243],"rate,":[247],"while":[248],"maximizing":[249],"true":[251],"get":[255],"most":[257],"reasonable":[258],"predictive":[259],"performance.":[260],"This":[261],"contribution":[262],"focused":[264],"confident":[266],"data,":[270],"what":[271],"further":[274],"used":[275],"explore":[277],"human":[279],"pathologies":[280],"their":[282],"mechanisms.":[283]},"counts_by_year":[],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}