{"id":"https://openalex.org/W4401429293","doi":"https://doi.org/10.1186/s12859-024-05870-y","title":"Occlusion enhanced pan-cancer classification via deep learning","display_name":"Occlusion enhanced pan-cancer classification via deep learning","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401429293","doi":"https://doi.org/10.1186/s12859-024-05870-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/39118043"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05870-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05870-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05870-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05870-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091404327","display_name":"Zhao Xing","orcid":"https://orcid.org/0000-0001-7800-4085"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Xing Zhao","raw_affiliation_strings":["Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China","Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-7800-4085","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065617411","display_name":"Zigui Chen","orcid":"https://orcid.org/0000-0002-8577-1298"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zigui Chen","raw_affiliation_strings":["Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-8577-1298","affiliations":[{"raw_affiliation_string":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056069573","display_name":"Huating Wang","orcid":"https://orcid.org/0000-0001-5474-2905"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Huating Wang","raw_affiliation_strings":["Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-5474-2905","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001836351","display_name":"Hao Sun","orcid":"https://orcid.org/0000-0002-5547-9501"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. sunhao100@cuhk.edu.cn","Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, People's Republic of China. sunhao100@cuhk.edu.cn","Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-5547-9501","affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. sunhao100@cuhk.edu.cn","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, People's Republic of China. sunhao100@cuhk.edu.cn","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210116924"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091404327"],"corresponding_institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210116924"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.0499,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77546206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"260","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5204054117202759},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5189875960350037},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49292826652526855},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4819500148296356},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.46375444531440735},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.43790215253829956},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4284428656101227},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.424225389957428},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4071906805038452},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33771124482154846},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3178651034832001},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18613162636756897}],"concepts":[{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5204054117202759},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5189875960350037},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49292826652526855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4819500148296356},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.46375444531440735},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43790215253829956},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4284428656101227},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.424225389957428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4071906805038452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33771124482154846},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3178651034832001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18613162636756897}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-024-05870-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05870-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05870-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39118043","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39118043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11308240","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11308240","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11308240/pdf/12859_2024_Article_5870.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:966e5d0fd27c4fe8898a223a6fb66358","is_oa":false,"landing_page_url":"https://doaj.org/article/966e5d0fd27c4fe8898a223a6fb66358","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-24 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05870-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05870-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05870-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401429293.pdf"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1128957151","https://openalex.org/W1488903292","https://openalex.org/W1551434007","https://openalex.org/W1849277567","https://openalex.org/W1884519301","https://openalex.org/W1981963681","https://openalex.org/W1986553481","https://openalex.org/W2018838463","https://openalex.org/W2050540135","https://openalex.org/W2071071105","https://openalex.org/W2106876831","https://openalex.org/W2110015307","https://openalex.org/W2121040919","https://openalex.org/W2136342095","https://openalex.org/W2138207763","https://openalex.org/W2141221830","https://openalex.org/W2143612262","https://openalex.org/W2146849272","https://openalex.org/W2146994504","https://openalex.org/W2165909549","https://openalex.org/W2167898988","https://openalex.org/W2170551349","https://openalex.org/W2233603983","https://openalex.org/W2236822143","https://openalex.org/W2250478016","https://openalex.org/W2273169659","https://openalex.org/W2286000425","https://openalex.org/W2556098785","https://openalex.org/W2749613778","https://openalex.org/W2770646498","https://openalex.org/W2792287712","https://openalex.org/W2798590501","https://openalex.org/W2801062973","https://openalex.org/W2801082204","https://openalex.org/W2803591850","https://openalex.org/W2806876056","https://openalex.org/W2809879579","https://openalex.org/W2886121770","https://openalex.org/W2887743107","https://openalex.org/W2913080875","https://openalex.org/W2913088660","https://openalex.org/W2936702565","https://openalex.org/W2954220835","https://openalex.org/W2954796233","https://openalex.org/W2991151930","https://openalex.org/W2995004719","https://openalex.org/W2999679570","https://openalex.org/W3003663164","https://openalex.org/W3012942685","https://openalex.org/W3014321973","https://openalex.org/W3016136518","https://openalex.org/W3034624838","https://openalex.org/W3036414263","https://openalex.org/W3042150802","https://openalex.org/W3091783136","https://openalex.org/W3093438112","https://openalex.org/W3117898086","https://openalex.org/W3127937250","https://openalex.org/W3128941837","https://openalex.org/W3168859728","https://openalex.org/W3173362574","https://openalex.org/W3207513046","https://openalex.org/W4200416840","https://openalex.org/W4206666657","https://openalex.org/W4211038303","https://openalex.org/W4211247697","https://openalex.org/W4220751358","https://openalex.org/W4224295629","https://openalex.org/W4225845169","https://openalex.org/W4285739735","https://openalex.org/W4319950426","https://openalex.org/W4387782708","https://openalex.org/W7073762635"],"related_works":["https://openalex.org/W4375867731","https://openalex.org/W2611989081","https://openalex.org/W4230611425","https://openalex.org/W106077234","https://openalex.org/W2041374557","https://openalex.org/W2081929287","https://openalex.org/W2132561013","https://openalex.org/W2144348650","https://openalex.org/W1994852842","https://openalex.org/W4246178523"],"abstract_inverted_index":{"Quantitative":[0],"measurement":[1],"of":[2,32,34,105,111,139,143,145,159,182,195,203,207,236],"RNA":[3],"expression":[4,62],"levels":[5],"through":[6],"RNA-Seq":[7,21,114,241],"is":[8],"an":[9,191],"ideal":[10],"replacement":[11],"for":[12,79],"conventional":[13],"cancer":[14,52],"diagnosis":[15],"via":[16],"microscope":[17],"examination.":[18],"Currently,":[19],"cancer-related":[20],"studies":[22,42],"focus":[23],"on":[24],"two":[25],"aspects:":[26],"classifying":[27],"the":[28,87,107,132,137,157,201,205,208,234],"status":[29],"and":[30,37,51,65,82,109,141],"tissue":[31],"origin":[33],"a":[35,76,98,119,179,248],"sample":[36],"discovering":[38],"marker":[39,45,58,83,121,224,245],"genes.":[40,185,217],"Existing":[41],"typically":[43],"identify":[44],"genes":[46,59,146,158,225,246],"by":[47,69],"statistically":[48],"comparing":[49],"healthy":[50],"samples.":[53],"However,":[54],"this":[55],"approach":[56],"overlooks":[57],"with":[60,92,131],"low":[61],"level":[63],"differences":[64],"may":[66],"be":[67],"influenced":[68],"experimental":[70],"results.":[71],"This":[72],"paper":[73],"introduces":[74],"\"GENESO,\"":[75],"novel":[77,120],"framework":[78],"pan-cancer":[80,152,198],"classification":[81,153],"gene":[84,122],"discovery":[85,123],"using":[86,214,239],"occlusion":[88],"method":[89,124,220,238],"in":[90,151,172,197,222],"conjunction":[91],"deep":[93,100],"learning.":[94],"we":[95,117,162,232],"first":[96],"trained":[97],"baseline":[99,133,187],"LSTM":[101,134,174],"neural":[102,169,188],"network":[103,189,210],"capable":[104],"distinguishing":[106],"origins":[108],"statuses":[110],"samples":[112],"utilizing":[113],"data.":[115],"Then,":[116],"propose":[118],"called":[125],"\"Symmetrical":[126],"Occlusion":[127],"(SO)\".":[128],"It":[129],"collaborates":[130],"network,":[135],"mimicking":[136],"\"gain":[138],"function\"":[140,144],"\"loss":[142],"to":[147,166],"evaluate":[148],"their":[149],"importance":[150],"quantitatively.":[154],"By":[155],"identifying":[156,223],"utmost":[160],"importance,":[161],"then":[163],"isolate":[164],"them":[165],"train":[167],"new":[168],"networks,":[170],"resulting":[171],"higher-performance":[173],"models":[175],"that":[176,226],"utilize":[177],"only":[178],"reduced":[180],"set":[181],"highly":[183],"relevant":[184],"The":[186],"achieves":[190],"impressive":[192],"validation":[193,249],"accuracy":[194,206],"96.59%":[196],"classification.":[199],"With":[200],"help":[202],"SO,":[204],"second":[209],"reaches":[211],"98.30%,":[212],"while":[213],"67%":[215],"fewer":[216],"Notably,":[218],"our":[219,237],"excels":[221],"are":[227],"not":[228],"differentially":[229],"expressed.":[230],"Moreover,":[231],"assessed":[233],"feasibility":[235],"single-cell":[240],"data,":[242],"employing":[243],"known":[244],"as":[247],"test.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}