{"id":"https://openalex.org/W4400797309","doi":"https://doi.org/10.1186/s12859-024-05863-x","title":"Identifying vital nodes for yeast network by dynamic network entropy","display_name":"Identifying vital nodes for yeast network by dynamic network entropy","publication_year":2024,"publication_date":"2024-07-18","ids":{"openalex":"https://openalex.org/W4400797309","doi":"https://doi.org/10.1186/s12859-024-05863-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/39026169"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05863-x","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05863-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05863-x.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05863-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101049088","display_name":"Jingchen Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingchen Liu","raw_affiliation_strings":["Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Hainan University, Haikou, 570228, Hainan, People's Republic of China","School of Mathematics and Statistics, Hainan University, Haikou, 570228, Hainan, People's Republic of China","School of Mathematics, Shandong University, Jinan, 250100, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Hainan University, Haikou, 570228, Hainan, People's Republic of China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Mathematics and Statistics, Hainan University, Haikou, 570228, Hainan, People's Republic of China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, 250100, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695550","display_name":"Yan Wang","orcid":"https://orcid.org/0009-0002-2584-9337"},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, People's Republic of China","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114193812","display_name":"Jiali Men","orcid":null},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Men","raw_affiliation_strings":["School of Life Sciences, Hainan University, Haikou, 570228, Hainan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Hainan University, Haikou, 570228, Hainan, People's Republic of China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034422116","display_name":"Haohua Wang","orcid":"https://orcid.org/0000-0003-4451-8883"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haohua Wang","raw_affiliation_strings":["Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Hainan University, Haikou, 570228, Hainan, People's Republic of China. huazi8112@hainanu.edu.cn","School of Mathematics and Statistics, Hainan University, Haikou, 570228, Hainan, People's Republic of China. huazi8112@hainanu.edu.cn","Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Hainan University, Haikou, 570228, Hainan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Hainan University, Haikou, 570228, Hainan, People's Republic of China. huazi8112@hainanu.edu.cn","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Mathematics and Statistics, Hainan University, Haikou, 570228, Hainan, People's Republic of China. huazi8112@hainanu.edu.cn","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Hainan University, Haikou, 570228, Hainan, People's Republic of China","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034422116"],"corresponding_institution_ids":["https://openalex.org/I20942203"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06706031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"242","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7018198370933533},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.563801109790802},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.5135653018951416},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5065122842788696},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4756317138671875},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.46575814485549927},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43800872564315796},{"id":"https://openalex.org/keywords/decipher","display_name":"DECIPHER","score":0.43071314692497253},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41175633668899536},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4039335250854492},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29335784912109375},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22343942523002625},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.22019386291503906}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7018198370933533},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.563801109790802},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.5135653018951416},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5065122842788696},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4756317138671875},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.46575814485549927},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43800872564315796},{"id":"https://openalex.org/C164614171","wikidata":"https://www.wikidata.org/wiki/Q5204775","display_name":"DECIPHER","level":2,"score":0.43071314692497253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41175633668899536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4039335250854492},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29335784912109375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22343942523002625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22019386291503906},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-024-05863-x","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05863-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05863-x.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39026169","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39026169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11555816","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11555816","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11555816/pdf/12859_2024_Article_5863.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1fda129c5eff413daa3bafb8b8eb7319","is_oa":true,"landing_page_url":"https://doaj.org/article/1fda129c5eff413daa3bafb8b8eb7319","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05863-x","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05863-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-024-05863-x.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.550000011920929}],"awards":[{"id":"https://openalex.org/G5052309491","display_name":null,"funder_award_id":"12261028, 11961018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G786225975","display_name":null,"funder_award_id":"12261028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7963907384","display_name":"\u57fa\u4e8e\u795e\u7ecf\u52a8\u529b\u7cfb\u7edf\u7684\u975e\u5149\u6ed1\u4f18\u5316\u65b9\u6cd5\u7814\u7a76","funder_award_id":"11961018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8647179300","display_name":null,"funder_award_id":"120RC451 \uff0c2019RC168","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400797309.pdf","grobid_xml":"https://content.openalex.org/works/W4400797309.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W55455380","https://openalex.org/W1481919380","https://openalex.org/W1970783685","https://openalex.org/W1971798955","https://openalex.org/W1972312016","https://openalex.org/W1993418188","https://openalex.org/W1994501020","https://openalex.org/W2007853809","https://openalex.org/W2011617253","https://openalex.org/W2016517861","https://openalex.org/W2030405489","https://openalex.org/W2031198628","https://openalex.org/W2031584019","https://openalex.org/W2031966872","https://openalex.org/W2049438326","https://openalex.org/W2051835055","https://openalex.org/W2053961182","https://openalex.org/W2060489532","https://openalex.org/W2061064014","https://openalex.org/W2062319807","https://openalex.org/W2062533676","https://openalex.org/W2063759666","https://openalex.org/W2064249717","https://openalex.org/W2068681052","https://openalex.org/W2073307618","https://openalex.org/W2090592322","https://openalex.org/W2094923559","https://openalex.org/W2095622082","https://openalex.org/W2103453943","https://openalex.org/W2107325325","https://openalex.org/W2111123076","https://openalex.org/W2121609415","https://openalex.org/W2125631472","https://openalex.org/W2139361807","https://openalex.org/W2153011302","https://openalex.org/W2158128075","https://openalex.org/W2161511352","https://openalex.org/W2162141656","https://openalex.org/W2167190345","https://openalex.org/W2168662100","https://openalex.org/W2204797108","https://openalex.org/W2792970174","https://openalex.org/W3005814150","https://openalex.org/W3012124203","https://openalex.org/W3111258566","https://openalex.org/W3118450989","https://openalex.org/W4236354166","https://openalex.org/W4285076853","https://openalex.org/W4286009485","https://openalex.org/W4307502334","https://openalex.org/W4312084649","https://openalex.org/W4319339280","https://openalex.org/W4380357101"],"related_works":["https://openalex.org/W2115350162","https://openalex.org/W2330145053","https://openalex.org/W4249875204","https://openalex.org/W4242620632","https://openalex.org/W3205440178","https://openalex.org/W4256069380","https://openalex.org/W2416520078","https://openalex.org/W2113606293","https://openalex.org/W2117976558","https://openalex.org/W2367975519"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,280],"progress":[2],"of":[3,7,26,55,92,98,169,181,237,289,297,318],"the":[4,10,16,38,42,47,53,65,84,90,96,105,110,114,120,124,131,137,143,153,158,167,170,182,186,191,196,204,208,212,224,228,263,268,273,277,287,293,298,310,315],"cell":[5,67,99,300],"cycle":[6,68,100],"yeast":[8,66,299],"involves":[9],"regulatory":[11,43,62,231,246],"relationships":[12],"between":[13],"genes":[14,88],"and":[15,34,74,87,141,152,243,271],"interactions":[17],"proteins.":[18],"However,":[19],"it":[20,307],"is":[21,177,227,235,305,308],"still":[22],"obscure":[23],"which":[24],"type":[25],"protein":[27],"plays":[28],"a":[29,71,76,148,216],"decisive":[30],"role":[31],"in":[32,41,52,89,211,276,313],"regulation":[33],"how":[35],"to":[36,69,81,109,118,134,241,249,261],"identify":[37,82],"vital":[39,274],"nodes":[40,86,275],"network.":[44,126],"To":[45],"elucidate":[46],"sensitive":[48,85,230],"node":[49,205],"or":[50,285,295],"gene":[51,144,225,245,250,319],"progression":[54],"yeast,":[56],"here,":[57],"we":[58,102,129,200,256],"select":[59],"8":[60],"crucial":[61],"factors":[63],"from":[64],"decipher":[70],"specific":[72,125,139,155,171,183,193,213,278],"network":[73,132,156,172,175,184,194,214,221,264,269],"propose":[75],"simple":[77],"mixed":[78],"K2":[79,106],"algorithm":[80,107,260,304],"effectively":[83,135],"evolution":[91],"yeast.":[93],"RESULTS:":[94],"Considering":[95],"multivariate":[97],"data,":[101],"first":[103,311],"utilize":[104],"limited":[108],"stationary":[111],"interval":[112],"for":[113,122,252],"time":[115],"series":[116],"segmentation":[117],"measure":[119],"scores":[121],"refining":[123],"After":[127],"that,":[128],"employ":[130],"entropy":[133,176,222,270],"screen":[136],"obtained":[138,192],"network,":[140],"simulate":[142],"expression":[145,288],"data":[146],"by":[147,157,174,189,220,266],"normal":[149],"distribution":[150],"approximation":[151],"screened":[154,173],"partial":[159],"least":[160],"squares":[161],"method.":[162],"We":[163],"can":[164,201,291],"conclude":[165],"that":[166,180,203,283],"robustness":[168],"better":[178],"than":[179],"with":[185,195],"determined":[187,197],"relationship":[188],"comparing":[190],"relationship.":[198],"Finally,":[199],"determine":[202],"CDH1":[206,226,290],"has":[207],"highest":[209],"score":[210,218],"through":[215],"sensitivity":[217],"calculated":[219],"implying":[223],"most":[229],"factor.":[232],"CONCLUSIONS:":[233],"It":[234],"clearly":[236],"great":[238],"potential":[239],"value":[240],"reconstruct":[242],"visualize":[244],"networks":[247],"according":[248],"databases":[251],"life":[253],"activities.":[254],"Here,":[255],"present":[257],"an":[258],"available":[259],"achieve":[262],"reconstruction":[265],"measuring":[267],"identifying":[272],"nodes.":[279],"results":[281],"indicate":[282],"inhibiting":[284],"enhancing":[286],"maximize":[292],"inhibition":[294],"enhancement":[296],"cycle.":[301],"Although":[302],"our":[303],"simple,":[306],"also":[309],"step":[312],"deciphering":[314],"profound":[316],"mystery":[317],"regulation.":[320]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}