{"id":"https://openalex.org/W4400589272","doi":"https://doi.org/10.1186/s12859-024-05854-y","title":"expHRD: an individualized, transcriptome-based prediction model for homologous recombination deficiency assessment in cancer","display_name":"expHRD: an individualized, transcriptome-based prediction model for homologous recombination deficiency assessment in cancer","publication_year":2024,"publication_date":"2024-07-12","ids":{"openalex":"https://openalex.org/W4400589272","doi":"https://doi.org/10.1186/s12859-024-05854-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/38997639"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05854-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05854-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05854-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05854-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100719142","display_name":"Jae-Jun Lee","orcid":"https://orcid.org/0000-0003-4453-4373"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]},{"id":"https://openalex.org/I4210123907","display_name":"National University College","ror":"https://ror.org/02hs8e066","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210123907"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES","PR"],"is_corresponding":false,"raw_author_name":"Jae Jun Lee","raw_affiliation_strings":["Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594","https://openalex.org/I4210138819"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041174459","display_name":"Hyun Ju Kang","orcid":"https://orcid.org/0000-0003-4885-9503"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]},{"id":"https://openalex.org/I4210123907","display_name":"National University College","ror":"https://ror.org/02hs8e066","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210123907"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES","KR","PR"],"is_corresponding":true,"raw_author_name":"Jae Jun Lee","raw_affiliation_strings":["Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594","https://openalex.org/I4210138819"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015105642","display_name":"Donghyo Kim","orcid":"https://orcid.org/0000-0002-8097-3675"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Ju Kang","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073767338","display_name":"Si On Lim","orcid":"https://orcid.org/0000-0003-1524-174X"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Donghyo Kim","raw_affiliation_strings":["Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea","Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089735037","display_name":"Stephanie Kim","orcid":"https://orcid.org/0000-0002-5116-0798"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Si On Lim","raw_affiliation_strings":["Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102027708","display_name":"Gahyun Kim","orcid":"https://orcid.org/0000-0002-6864-0907"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Stephanie S. Kim","raw_affiliation_strings":["Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077132257","display_name":"Sang\u2010Uk Kim","orcid":"https://orcid.org/0009-0007-3765-2212"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Stephanie S. Kim","raw_affiliation_strings":["Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076987475","display_name":"Jin\u2010Ku Lee","orcid":"https://orcid.org/0000-0003-0263-3234"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gahyun Kim","raw_affiliation_strings":["Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366811","display_name":"Jinho Kim","orcid":"https://orcid.org/0000-0001-8732-1779"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sanguk Kim","raw_affiliation_strings":["Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077132257","display_name":"Sang\u2010Uk Kim","orcid":"https://orcid.org/0009-0007-3765-2212"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sanguk Kim","raw_affiliation_strings":["Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea. sukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076987475","display_name":"Jin\u2010Ku Lee","orcid":"https://orcid.org/0000-0003-0263-3234"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]},{"id":"https://openalex.org/I4210123907","display_name":"National University College","ror":"https://ror.org/02hs8e066","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210123907"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES","PR"],"is_corresponding":false,"raw_author_name":"Jin-Ku Lee","raw_affiliation_strings":["Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594","https://openalex.org/I4210138819"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076987475","display_name":"Jin\u2010Ku Lee","orcid":"https://orcid.org/0000-0003-0263-3234"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]},{"id":"https://openalex.org/I4210123907","display_name":"National University College","ror":"https://ror.org/02hs8e066","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210123907"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES","PR"],"is_corresponding":true,"raw_author_name":"Jin-Ku Lee","raw_affiliation_strings":["Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Cancer Genomics Groups, Spanish Cancer Research Center (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594","https://openalex.org/I4210138819"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]},{"raw_affiliation_string":"Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine (SNUCM), Seoul, 03080, Republic of Korea. jinkulee@snu.ac.kr","institution_ids":["https://openalex.org/I4210123907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100366811","display_name":"Jinho Kim","orcid":"https://orcid.org/0000-0001-8732-1779"},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinho Kim","raw_affiliation_strings":["Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea. jinho.kim@snubh.org","Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, 13620, Republic of Korea. jinho.kim@snubh.org","Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea. jinho.kim@snubh.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea. jinho.kim@snubh.org","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, 13620, Republic of Korea. jinho.kim@snubh.org","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea. jinho.kim@snubh.org","institution_ids":["https://openalex.org/I2803058125"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041174459","https://openalex.org/A5076987475","https://openalex.org/A5077132257","https://openalex.org/A5100366811","https://openalex.org/A5102027708"],"corresponding_institution_ids":["https://openalex.org/I123900574","https://openalex.org/I139264467","https://openalex.org/I2803058125","https://openalex.org/I4210089594","https://openalex.org/I4210123907","https://openalex.org/I4210138819"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.3848,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83847693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"25","issue":"1","first_page":"236","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6361101269721985},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5428304076194763},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5087757706642151},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.4516562223434448},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36088424921035767},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33287307620048523},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24482271075248718},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20651373267173767},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2024630308151245},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1318967044353485}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6361101269721985},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5428304076194763},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5087757706642151},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4516562223434448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36088424921035767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33287307620048523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24482271075248718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20651373267173767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2024630308151245},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1318967044353485}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-024-05854-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05854-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05854-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38997639","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38997639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11241885","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11241885","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11241885/pdf/12859_2024_Article_5854.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e274f62f8c0b4cfd914d0c83244325dd","is_oa":false,"landing_page_url":"https://doaj.org/article/e274f62f8c0b4cfd914d0c83244325dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)","raw_type":"article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/209013","is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/209013","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05854-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05854-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05854-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3200450660","display_name":null,"funder_award_id":"RS-2023-00222910","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G7685134749","display_name":null,"funder_award_id":"100010434","funder_id":"https://openalex.org/F4320330256","funder_display_name":"Fundaci\u00f3n Bancaria Caixa d'Estalvis i Pensions de Barcelona"}],"funders":[{"id":"https://openalex.org/F4320316485","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320330256","display_name":"Fundaci\u00f3n Bancaria Caixa d'Estalvis i Pensions de Barcelona","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400589272.pdf"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1515564094","https://openalex.org/W1781764024","https://openalex.org/W1984919526","https://openalex.org/W1998058908","https://openalex.org/W2003581594","https://openalex.org/W2010711320","https://openalex.org/W2028069515","https://openalex.org/W2074952360","https://openalex.org/W2094929011","https://openalex.org/W2100419317","https://openalex.org/W2123696077","https://openalex.org/W2146512944","https://openalex.org/W2147629880","https://openalex.org/W2158485828","https://openalex.org/W2159707944","https://openalex.org/W2168409298","https://openalex.org/W2295085830","https://openalex.org/W2612428976","https://openalex.org/W2621271973","https://openalex.org/W2623410148","https://openalex.org/W2811060920","https://openalex.org/W2897430921","https://openalex.org/W2963372022","https://openalex.org/W2975141952","https://openalex.org/W3005714839","https://openalex.org/W3084114043","https://openalex.org/W3095003868","https://openalex.org/W3121412620","https://openalex.org/W3134914296","https://openalex.org/W3163378364","https://openalex.org/W3177914501","https://openalex.org/W3209436856","https://openalex.org/W4226370990","https://openalex.org/W4281783847","https://openalex.org/W4283014430","https://openalex.org/W4296240023","https://openalex.org/W4310493943","https://openalex.org/W4379053129","https://openalex.org/W4384120316"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"BACKGROUND:":[0],"Homologous":[1],"recombination":[2],"deficiency":[3],"(HRD)":[4],"stands":[5],"as":[6,49,107,214],"a":[7,108,154],"clinical":[8,174,254],"indicator":[9],"for":[10,146,173,194,249],"discerning":[11],"responsive":[12],"outcomes":[13],"to":[14,28,97,113,200,252],"platinum-based":[15],"chemotherapy":[16],"and":[17,159,170,179],"poly":[18],"ADP-ribose":[19],"polymerase":[20],"(PARP)":[21],"inhibitors.":[22],"One":[23],"of":[24,68,196,204,229],"the":[25,39,45,58,102,125,131,143,148,177,180,202,223,227,239],"conventional":[26],"approaches":[27],"HRD":[29,75,88,115,144,205,230],"prognostication":[30],"has":[31,61,121],"generally":[32],"centered":[33],"on":[34],"identifying":[35],"deleterious":[36],"mutations":[37],"within":[38],"BRCA1/2":[40],"genes,":[41],"along":[42],"with":[43,55,157,210,232,242],"quantifying":[44],"genomic":[46],"scars,":[47],"such":[48],"Genomic":[50,181],"Instability":[51],"Score":[52],"(GIS)":[53],"estimation":[54],"scarHRD.":[56,98],"However,":[57],"scarHRD":[59,158],"method":[60,129,237],"limitations":[62],"in":[63,130,162,176],"scenarios":[64],"involving":[65],"tumors":[66],"bereft":[67],"corresponding":[69],"germline":[70],"data.":[71],"Although":[72],"several":[73],"RNA-seq-based":[74],"prediction":[76,119,206,228],"algorithms":[77],"have":[78],"been":[79,122],"developed,":[80],"they":[81],"mainly":[82],"support":[83],"cohort-wise":[84],"classification,":[85],"thereby":[86],"yielding":[87],"status":[89,231],"without":[90],"furnishing":[91],"an":[92,215],"analogous":[93],"quantitative":[94],"metric":[95],"akin":[96],"This":[99,235],"study":[100],"introduces":[101],"expHRD":[103,149,152],"method,":[104],"which":[105],"operates":[106],"novel":[109,220],"transcriptome-based":[110],"framework":[111],"tailored":[112],"n-of-1-style":[114],"scoring.":[116],"RESULTS:":[117],"The":[118,139,151,189],"model":[120],"established":[123],"using":[124],"elastic":[126],"net":[127],"regression":[128],"Cancer":[132],"Genome":[133],"Atlas":[134],"(TCGA)":[135],"pan-cancer":[136],"training":[137],"set.":[138],"bootstrap":[140],"technique":[141],"derived":[142],"geneset":[145],"applying":[147],"calculation.":[150],"demonstrated":[153],"notable":[155],"correlation":[156],"superior":[160],"performance":[161],"predicting":[163],"HRD-high":[164],"samples.":[165],"We":[166],"also":[167],"performed":[168],"intra-":[169],"extra-cohort":[171],"evaluations":[172],"feasibility":[175],"TCGA-OV":[178],"Data":[182],"Commons":[183],"(GDC)":[184],"ovarian":[185,211],"cancer":[186,212],"cohort,":[187],"respectively.":[188],"innovative":[190,236],"web":[191],"service":[192],"designed":[193],"ease":[195],"use":[197],"is":[198],"poised":[199],"extend":[201],"realms":[203],"across":[207],"diverse":[208],"malignancies,":[209],"standing":[213],"emblematic":[216],"example.":[217],"CONCLUSIONS:":[218],"Our":[219],"approach":[221],"leverages":[222],"transcriptome":[224],"data,":[225,245],"enabling":[226],"remarkable":[233],"precision.":[234],"addresses":[238],"challenges":[240],"associated":[241],"limited":[243],"available":[244],"opening":[246],"new":[247],"avenues":[248],"utilizing":[250],"transcriptomics":[251],"inform":[253],"decisions.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-05T07:55:05.734416","created_date":"2025-10-10T00:00:00"}