{"id":"https://openalex.org/W4391613554","doi":"https://doi.org/10.1186/s12859-024-05674-0","title":"Enabling personalised disease diagnosis by combining a patient\u2019s time-specific gene expression profile with a biomedical knowledge base","display_name":"Enabling personalised disease diagnosis by combining a patient\u2019s time-specific gene expression profile with a biomedical knowledge base","publication_year":2024,"publication_date":"2024-02-07","ids":{"openalex":"https://openalex.org/W4391613554","doi":"https://doi.org/10.1186/s12859-024-05674-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38326757"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05674-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05674-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05674-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05674-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063962595","display_name":"Ghanshyam Verma","orcid":"https://orcid.org/0000-0002-1394-6386"},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Ghanshyam Verma","raw_affiliation_strings":["Insight Centre for Data Analytics, School of Computer Science, University of Galway, Galway, Ireland. ghanshyam.verma@insight-centre.org","School of Computer Science, University of Galway, Galway, Ireland. ghanshyam.verma@insight-centre.org","Insight Centre for Data Analytics, School of Computer Science, University of Galway, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insight Centre for Data Analytics, School of Computer Science, University of Galway, Galway, Ireland. ghanshyam.verma@insight-centre.org","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Computer Science, University of Galway, Galway, Ireland. ghanshyam.verma@insight-centre.org","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Insight Centre for Data Analytics, School of Computer Science, University of Galway, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006224704","display_name":"Dietrich Rebholz\u2010Schuhmann","orcid":"https://orcid.org/0000-0002-1018-0370"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210112663","display_name":"ZB MED - Information Centre for Life Sciences","ror":"https://ror.org/0259fwx54","country_code":"DE","type":"archive","lineage":["https://openalex.org/I4210112663"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietrich Rebholz-Schuhmann","raw_affiliation_strings":["ZB MED - Information Centre for Life Sciences, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZB MED - Information Centre for Life Sciences, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210112663","https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006608063","display_name":"Michael G. Madden","orcid":"https://orcid.org/0000-0002-4443-7285"},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael G. Madden","raw_affiliation_strings":["Insight Centre for Data Analytics, School of Computer Science, University of Galway, Galway, Ireland","School of Computer Science, University of Galway, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insight Centre for Data Analytics, School of Computer Science, University of Galway, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Computer Science, University of Galway, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063962595"],"corresponding_institution_ids":["https://openalex.org/I188760350"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.7465,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68003626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"25","issue":"1","first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6842190623283386},{"id":"https://openalex.org/keywords/knowledge-base","display_name":"Knowledge base","score":0.5530680418014526},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5528784990310669},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5401893854141235},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48733410239219666},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.47752514481544495},{"id":"https://openalex.org/keywords/base","display_name":"Base (topology)","score":0.47593262791633606},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.42435795068740845},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.41741061210632324},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3459742069244385},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34467393159866333},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33732378482818604},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.320953905582428},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2887181043624878},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2509561777114868},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.159864604473114},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07645285129547119}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6842190623283386},{"id":"https://openalex.org/C4554734","wikidata":"https://www.wikidata.org/wiki/Q593744","display_name":"Knowledge base","level":2,"score":0.5530680418014526},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5528784990310669},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5401893854141235},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48733410239219666},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.47752514481544495},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.47593262791633606},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42435795068740845},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41741061210632324},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3459742069244385},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34467393159866333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33732378482818604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.320953905582428},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2887181043624878},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2509561777114868},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.159864604473114},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07645285129547119},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-024-05674-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05674-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05674-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38326757","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38326757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10848462","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10848462","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10848462/pdf/12859_2024_Article_5674.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:14cc0a9450754bdd8ca94d2ea9a87ae9","is_oa":true,"landing_page_url":"https://doaj.org/article/14cc0a9450754bdd8ca94d2ea9a87ae9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-26 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05674-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05674-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05674-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions","score":0.46000000834465027}],"awards":[{"id":"https://openalex.org/G3259019331","display_name":null,"funder_award_id":"12/RC/2289_P2","funder_id":"https://openalex.org/F4320331354","funder_display_name":"Insight SFI Research Centre for Data Analytics"},{"id":"https://openalex.org/G3695527833","display_name":"INSIGHT_Phase 2","funder_award_id":"12/RC/2289_P2","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G5098725405","display_name":null,"funder_award_id":"12/RC/","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320861","display_name":"University of Galway","ror":"https://ror.org/03bea9k73"},{"id":"https://openalex.org/F4320330055","display_name":"Irish Centre for High-End Computing","ror":"https://ror.org/04te6a418"},{"id":"https://openalex.org/F4320331354","display_name":"Insight SFI Research Centre for Data Analytics","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4391613554.pdf"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W103049419","https://openalex.org/W582147111","https://openalex.org/W1520812622","https://openalex.org/W1570448133","https://openalex.org/W1651215666","https://openalex.org/W1723619723","https://openalex.org/W1971524600","https://openalex.org/W1986145335","https://openalex.org/W2000264668","https://openalex.org/W2016753842","https://openalex.org/W2030966511","https://openalex.org/W2040475982","https://openalex.org/W2048987737","https://openalex.org/W2085764144","https://openalex.org/W2103017472","https://openalex.org/W2107658650","https://openalex.org/W2130410032","https://openalex.org/W2136640051","https://openalex.org/W2139212933","https://openalex.org/W2143426320","https://openalex.org/W2145686583","https://openalex.org/W2147625347","https://openalex.org/W2159092541","https://openalex.org/W2165428180","https://openalex.org/W2168264491","https://openalex.org/W2226877337","https://openalex.org/W2238160795","https://openalex.org/W2279836332","https://openalex.org/W2295598076","https://openalex.org/W2300469216","https://openalex.org/W2509893387","https://openalex.org/W2622424115","https://openalex.org/W2622701666","https://openalex.org/W2728059831","https://openalex.org/W2739458618","https://openalex.org/W2739999456","https://openalex.org/W2746296828","https://openalex.org/W2759136286","https://openalex.org/W2773309042","https://openalex.org/W2887634117","https://openalex.org/W2906797014","https://openalex.org/W2908674601","https://openalex.org/W2911964244","https://openalex.org/W2938937533","https://openalex.org/W2947858052","https://openalex.org/W2949311246","https://openalex.org/W2969710364","https://openalex.org/W2974225674","https://openalex.org/W2980664920","https://openalex.org/W2988630324","https://openalex.org/W3004035003","https://openalex.org/W3015461837","https://openalex.org/W3016218187","https://openalex.org/W3036397942","https://openalex.org/W3091928167","https://openalex.org/W3093194543","https://openalex.org/W3093988619","https://openalex.org/W3098012550","https://openalex.org/W3132689447","https://openalex.org/W3162538759","https://openalex.org/W3163233738","https://openalex.org/W3204438512","https://openalex.org/W3214608846","https://openalex.org/W4206025858","https://openalex.org/W4302446287","https://openalex.org/W4309506674"],"related_works":["https://openalex.org/W2392243736","https://openalex.org/W86652014","https://openalex.org/W2328518092","https://openalex.org/W3101249758","https://openalex.org/W2382079200","https://openalex.org/W3129895999","https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W2385713529","https://openalex.org/W2599749361"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"developments":[2],"in":[3,22,32,58,105,208,280,340,349],"the":[4,23,33,52,71,106,121,147,188,209,248,255,273,289,311,321,341],"domain":[5],"of":[6,25,35,54,108,120,133,141,149,154,211,229,271,288,308,320],"biomedical":[7,17,36,56],"knowledge":[8,18],"bases":[9],"(KBs)":[10],"open":[11],"up":[12,204],"new":[13,85],"ways":[14],"to":[15,73,90,111,200,205,222,297],"exploit":[16],"that":[19,153,291],"is":[20,198,294],"available":[21,104],"form":[24,107],"KBs.":[26],"Significant":[27],"work":[28],"has":[29,70],"been":[30],"done":[31],"direction":[34],"KB":[37,40,284,305],"creation":[38],"and":[39,47,88,100,126,167,177,185,214,218,233,275,334],"completion,":[41],"specifically,":[42],"those":[43],"having":[44],"gene-disease":[45,98],"associations":[46],"other":[48,101,335],"related":[49,102],"entities.":[50],"However,":[51],"use":[53],"such":[55],"KBs":[57,125],"combination":[59,281],"with":[60,97,152,169,193,203,231,257,282,306,329,338],"patients'":[61],"temporal":[62],"clinical":[63],"data":[64,96],"still":[65],"largely":[66],"remains":[67],"unexplored,":[68],"but":[69],"potential":[72],"immensely":[74],"benefit":[75],"medical":[76],"diagnostic":[77],"decision":[78],"support":[79,345],"systems.":[80],"RESULTS:":[81],"We":[82,116,144,265],"propose":[83],"two":[84,124,173],"algorithms,":[86,252],"LOADDx":[87,186,219],"SCADDx,":[89],"combine":[91],"a":[92,109,178,283,292,300,304,316],"patient's":[93],"gene":[94,130],"expression":[95,131],"association":[99],"information":[103],"KB,":[110,342],"assist":[112],"personalized":[113],"disease":[114],"diagnosis.":[115],"have":[117,298],"tested":[118],"both":[119,194],"algorithms":[122,151,160,190,313],"on":[123,127,261],"four":[128,240],"real-world":[129],"datasets":[132],"respiratory":[134],"viral":[135],"infection":[136,225,230,256],"caused":[137],"by":[138],"Influenza-like":[139],"viruses":[140],"19":[142],"subtypes.":[143],"also":[145],"compare":[146],"performance":[148],"proposed":[150,312],"five":[155],"existing":[156,189,249],"state-of-the-art":[157],"machine":[158,250],"learning":[159,251],"(k-NN,":[161],"Random":[162],"Forest,":[163],"XGBoost,":[164,243],"Linear":[165],"SVM,":[166],"SVM":[168],"RBF":[170],"Kernel)":[171],"using":[172,272],"validation":[174,181,195],"approaches:":[175],"LOOCV":[176],"single":[179],"internal":[180],"set.":[182],"Both":[183],"SCADDx":[184,197,217],"outperform":[187],"when":[191],"evaluated":[192],"approaches.":[196],"able":[199,221],"detect":[201,223,254],"infections":[202],"100%":[206],"accuracy":[207,236,260],"cases":[210],"Datasets":[212],"2":[213],"3.":[215],"Overall,":[216],"are":[220],"an":[224,262],"within":[226],"72":[227],"h":[228],"91.38%":[232],"92.66%":[234],"average":[235],"respectively":[237],"considering":[238],"all":[239],"datasets,":[241],"whereas":[242],"which":[244,343],"performed":[245],"best":[246],"among":[247],"can":[253,285,314,344],"only":[258],"86.43%":[259],"average.":[263],"CONCLUSIONS:":[264],"demonstrate":[266],"how":[267],"our":[268],"novel":[269],"idea":[270],"most":[274,295,322,331],"least":[276],"differentially":[277],"expressed":[278],"genes":[279],"enable":[286],"identification":[287],"diseases":[290,324],"patient":[293,327],"likely":[296,323],"at":[299],"particular":[301],"time,":[302],"from":[303],"thousands":[307],"diseases.":[309],"Moreover,":[310],"provide":[315],"short":[317],"ranked":[318],"list":[319],"for":[325],"each":[326],"along":[328],"their":[330,350],"affected":[332],"genes,":[333],"entities":[336],"linked":[337],"them":[339],"health":[346],"care":[347],"professionals":[348],"decision-making.":[351]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}