{"id":"https://openalex.org/W4396762869","doi":"https://doi.org/10.1186/s12859-024-05669-x","title":"Prediction of anticancer drug sensitivity using an interpretable model guided by deep learning","display_name":"Prediction of anticancer drug sensitivity using an interpretable model guided by deep learning","publication_year":2024,"publication_date":"2024-05-09","ids":{"openalex":"https://openalex.org/W4396762869","doi":"https://doi.org/10.1186/s12859-024-05669-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/38724920"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05669-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05669-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05669-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05669-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114081550","display_name":"Weixiong Pang","orcid":null},"institutions":[{"id":"https://openalex.org/I44675526","display_name":"Shanghai Ocean University","ror":"https://ror.org/04n40zv07","country_code":"CN","type":"education","lineage":["https://openalex.org/I44675526"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixiong Pang","raw_affiliation_strings":["College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China","Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China","institution_ids":["https://openalex.org/I44675526"]},{"raw_affiliation_string":"Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423295","display_name":"Ming Chen","orcid":"https://orcid.org/0000-0003-0506-5308"},"institutions":[{"id":"https://openalex.org/I44675526","display_name":"Shanghai Ocean University","ror":"https://ror.org/04n40zv07","country_code":"CN","type":"education","lineage":["https://openalex.org/I44675526"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Chen","raw_affiliation_strings":["College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China","Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China","institution_ids":["https://openalex.org/I44675526"]},{"raw_affiliation_string":"Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061679044","display_name":"Yufang Qin","orcid":"https://orcid.org/0000-0002-8906-8727"},"institutions":[{"id":"https://openalex.org/I4210134538","display_name":"Ministry of Agriculture","ror":"https://ror.org/044d6nj38","country_code":"FJ","type":"government","lineage":["https://openalex.org/I4210134538"]},{"id":"https://openalex.org/I44675526","display_name":"Shanghai Ocean University","ror":"https://ror.org/04n40zv07","country_code":"CN","type":"education","lineage":["https://openalex.org/I44675526"]}],"countries":["CN","FJ"],"is_corresponding":true,"raw_author_name":"Yufang Qin","raw_affiliation_strings":["College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China. yfqin@shou.edu.cn","Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, China. yfqin@shou.edu.cn","College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China. yfqin@shou.edu.cn","institution_ids":["https://openalex.org/I44675526"]},{"raw_affiliation_string":"Key Laboratory of Fisheries Information Ministry of Agriculture, Shanghai, China. yfqin@shou.edu.cn","institution_ids":["https://openalex.org/I4210134538"]},{"raw_affiliation_string":"College of Information Technology, Shanghai Ocean University, Hucheng Ring Road, Shanghai, China","institution_ids":["https://openalex.org/I44675526"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061679044"],"corresponding_institution_ids":["https://openalex.org/I4210134538","https://openalex.org/I44675526"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.7469,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.93905485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"182","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7576000094413757,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7576000094413757,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.624035120010376},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5926440358161926},{"id":"https://openalex.org/keywords/anticancer-drug","display_name":"Anticancer drug","score":0.5421245694160461},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.530700147151947},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49821019172668457},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4884563982486725},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.47180357575416565},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4668372869491577},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4527287483215332},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.332452654838562},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28314489126205444},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2219240367412567},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.21771833300590515},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09554022550582886},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.07762956619262695},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07755658030509949},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07248473167419434}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.624035120010376},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5926440358161926},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.5421245694160461},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.530700147151947},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49821019172668457},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4884563982486725},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.47180357575416565},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4668372869491577},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4527287483215332},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.332452654838562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28314489126205444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2219240367412567},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21771833300590515},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09554022550582886},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07762956619262695},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07755658030509949},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07248473167419434},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-024-05669-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05669-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05669-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38724920","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38724920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11080240","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11080240","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11080240/pdf/12859_2024_Article_5669.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5592c01828ce40768b4d98cbd29fc9f5","is_oa":true,"landing_page_url":"https://doaj.org/article/5592c01828ce40768b4d98cbd29fc9f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05669-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-024-05669-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05669-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5799999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2644716166","display_name":null,"funder_award_id":"61702325","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3484123739","display_name":null,"funder_award_id":"62372286","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396762869.pdf"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1841468505","https://openalex.org/W1996894903","https://openalex.org/W2043398720","https://openalex.org/W2046324375","https://openalex.org/W2103017472","https://openalex.org/W2104709519","https://openalex.org/W2108068107","https://openalex.org/W2130410032","https://openalex.org/W2283795047","https://openalex.org/W2461427403","https://openalex.org/W2558475804","https://openalex.org/W2790179710","https://openalex.org/W2808686685","https://openalex.org/W2892221324","https://openalex.org/W2895931986","https://openalex.org/W2903945923","https://openalex.org/W2910705748","https://openalex.org/W2921591500","https://openalex.org/W2944664266","https://openalex.org/W2948480420","https://openalex.org/W2950195240","https://openalex.org/W2951934944","https://openalex.org/W2963046727","https://openalex.org/W2963805156","https://openalex.org/W2969085937","https://openalex.org/W2971911873","https://openalex.org/W2986112724","https://openalex.org/W2994958138","https://openalex.org/W2996308816","https://openalex.org/W3023672269","https://openalex.org/W3049578031","https://openalex.org/W3081692890","https://openalex.org/W3091944805","https://openalex.org/W3094459686","https://openalex.org/W3094540299","https://openalex.org/W3097757778","https://openalex.org/W3123207167","https://openalex.org/W3188452318","https://openalex.org/W3216642120","https://openalex.org/W4282945959","https://openalex.org/W4286268312","https://openalex.org/W4367833893","https://openalex.org/W4383216745","https://openalex.org/W4385330534"],"related_works":["https://openalex.org/W4375867731","https://openalex.org/W2611989081","https://openalex.org/W2378757965","https://openalex.org/W4230611425","https://openalex.org/W2731899572","https://openalex.org/W4294635752","https://openalex.org/W4304166257","https://openalex.org/W4224903346","https://openalex.org/W1593262897","https://openalex.org/W2372869593"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,207],"prediction":[2,238,291,299],"of":[3,15,21,30,36,98,104,117,127,135,185,285],"drug":[4,31,61,66,190,211],"sensitivity":[5,212],"plays":[6],"a":[7,80,124,140,173,203],"crucial":[8],"role":[9],"in":[10,38,166,282,293,307],"improving":[11],"the":[12,19,27,34,121,132,160,167,181,216,223,231,247,261,283,290,294],"therapeutic":[13],"effect":[14],"drugs.":[16,186],"However,":[17],"testing":[18],"effectiveness":[20],"drugs":[22,106,252],"is":[23,48,234],"challenging":[24],"due":[25],"to":[26,50,64,107,138,179,271,279],"complex":[28],"mechanism":[29],"reactions":[32],"and":[33,42,60,69,82,101,145,163,196,198,222,253,259,296],"lack":[35],"interpretability":[37],"most":[39],"machine":[40],"learning":[41,44,85],"deep":[43,84,148],"methods.":[45,239],"Therefore,":[46,240],"it":[47],"imperative":[49],"establish":[51],"an":[52,146],"interpretable":[53,83,147],"model":[54,112,233,242,295],"that":[55,130,230],"receives":[56,156],"various":[57,257],"cell":[58,161,254],"line":[59,162],"feature":[62],"data":[63,213],"learn":[65],"response":[67,191],"mechanisms":[68,249],"achieve":[70],"stable":[71],"predictions":[72,192],"between":[73,250],"available":[74,311],"datasets.":[75],"RESULTS:":[76],"This":[77,111,301],"study":[78],"proposes":[79],"new":[81,305],"model,":[86],"DrugGene,":[87],"which":[88,275],"integrates":[89],"gene":[90,92,94],"expression,":[91],"mutation,":[93],"copy":[95],"number":[96],"variation":[97],"cancer":[99,153,308],"cells,":[100],"chemical":[102,182],"characteristics":[103],"anticancer":[105,251],"predict":[108],"their":[109,200],"sensitivity.":[110],"comprises":[113],"two":[114],"different":[115],"branches":[116],"neural":[118,142,149,176,273],"networks,":[119,274],"where":[120],"first":[122],"involves":[123],"hierarchical":[125],"structure":[126],"biological":[128,133,269],"subsystems":[129],"uses":[131],"processes":[134],"human":[136,152],"cells":[137],"form":[139],"visual":[141],"network":[143,150,177,286],"(VNN)":[144],"for":[151,317],"cells.":[154],"DrugGene":[155,187],"genotype":[157],"input":[158],"from":[159,215,256,319],"detects":[164],"changes":[165,281],"subsystem":[168],"states.":[169],"We":[170],"also":[171],"employ":[172],"traditional":[174],"artificial":[175],"(ANN)":[178],"capture":[180],"structural":[183],"features":[184],"generates":[188],"final":[189],"by":[193],"combining":[194],"VNN":[195],"ANN":[197],"integrating":[199],"outputs":[201],"into":[202],"fully":[204],"connected":[205],"layer.":[206],"experimental":[208],"results":[209,292],"using":[210],"extracted":[214],"Cancer":[217,224],"Drug":[218],"Sensitivity":[219],"Genome":[220],"Database":[221],"Treatment":[225],"Response":[226],"Portal":[227],"v2":[228],"reveal":[229],"proposed":[232],"better":[235],"than":[236],"existing":[237],"our":[241],"achieves":[243],"higher":[244],"accuracy,":[245],"learns":[246],"reaction":[248],"lines":[255],"features,":[258],"interprets":[260],"model's":[262],"predicted":[263],"results.":[264],"CONCLUSIONS:":[265],"Our":[266],"method":[267],"utilizes":[268],"pathways":[270],"construct":[272],"can":[276,314],"use":[277],"genotypes":[278],"monitor":[280],"state":[284],"subsystems,":[287],"thereby":[288],"interpreting":[289],"achieving":[297],"satisfactory":[298],"accuracy.":[300],"will":[302],"help":[303],"explore":[304],"directions":[306],"treatment.":[309],"More":[310],"code":[312],"resources":[313],"be":[315],"downloaded":[316],"free":[318],"GitHub":[320],"(":[321],"https://github.com/pangweixiong/DrugGene":[322],").":[323]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}
