{"id":"https://openalex.org/W4389088378","doi":"https://doi.org/10.1186/s12859-023-05561-0","title":"Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia","display_name":"Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia","publication_year":2023,"publication_date":"2023-11-28","ids":{"openalex":"https://openalex.org/W4389088378","doi":"https://doi.org/10.1186/s12859-023-05561-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38017410"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05561-0","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05561-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05561-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05561-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031980913","display_name":"Nan Shao","orcid":"https://orcid.org/0000-0003-4483-1693"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Shao","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China","University of Chinese Academy of Sciences, Beijing, 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I4210112540","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057978385","display_name":"Chenshuo Ren","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenshuo Ren","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China","University of Chinese Academy of Sciences, Beijing, 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I4210112540","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081788625","display_name":"Tianyuan Hu","orcid":"https://orcid.org/0000-0002-8145-5802"},"institutions":[{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyuan Hu","raw_affiliation_strings":["State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I4210147887","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057640178","display_name":"Dianbing Wang","orcid":"https://orcid.org/0000-0001-6225-7010"},"institutions":[{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dianbing Wang","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I4210112540","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020924929","display_name":"Xiaofan Zhu","orcid":"https://orcid.org/0000-0002-2572-6495"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofan Zhu","raw_affiliation_strings":["State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I4210147887","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400730","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-3230-7678"},"institutions":[{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I4210112540","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060867127","display_name":"Tao Cheng","orcid":"https://orcid.org/0000-0002-5925-2769"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Cheng","raw_affiliation_strings":["State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I4210147887","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011164870","display_name":"Yingchi Zhang","orcid":"https://orcid.org/0000-0003-1429-0152"},"institutions":[{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingchi Zhang","raw_affiliation_strings":["State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. zhangyingchi@ihcams.ac.cn","State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. zhangyingchi@ihcams.ac.cn","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Experimental Haematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I4210147887","https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065279811","display_name":"Xian\u2010En Zhang","orcid":"https://orcid.org/0000-0003-1347-3168"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xian-En Zhang","raw_affiliation_strings":["Faculty of Synthetic Biology, University of Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. zhangxe@ibp.ac.cn","National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. zhangxe@ibp.ac.cn","University of Chinese Academy of Sciences, Beijing, 100049, China. zhangxe@ibp.ac.cn","Faculty of Synthetic Biology, University of Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Synthetic Biology, University of Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. zhangxe@ibp.ac.cn","institution_ids":[]},{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. zhangxe@ibp.ac.cn","institution_ids":[]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China. zhangxe@ibp.ac.cn","institution_ids":[]},{"raw_affiliation_string":"Faculty of Synthetic Biology, University of Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5065279811"],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31609232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":"450","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5217999815940857,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5217999815940857,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.36239999532699585,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-cytometry","display_name":"Mass cytometry","score":0.6298528909683228},{"id":"https://openalex.org/keywords/myeloid","display_name":"Myeloid","score":0.5955401062965393},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5085610151290894},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.4733712077140808},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.44971004128456116},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4375010132789612},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"Bone marrow","score":0.43208563327789307},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"Immunophenotyping","score":0.42848584055900574},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.4171949625015259},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.41672199964523315},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41187068819999695},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4003724455833435},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.28003591299057007},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2658892273902893},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19746607542037964}],"concepts":[{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.6298528909683228},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5955401062965393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5085610151290894},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4733712077140808},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44971004128456116},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4375010132789612},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.43208563327789307},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.42848584055900574},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4171949625015259},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.41672199964523315},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41187068819999695},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4003724455833435},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28003591299057007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2658892273902893},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19746607542037964}],"mesh":[{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05561-0","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05561-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05561-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38017410","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38017410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10683216","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10683216","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10683216/pdf/12859_2023_Article_5561.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d0b7353eb9f34c9db8be013bdc62389d","is_oa":true,"landing_page_url":"https://doaj.org/article/d0b7353eb9f34c9db8be013bdc62389d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05561-0","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05561-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05561-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6499999761581421,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G454020510","display_name":null,"funder_award_id":"XDB29050100","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5175465814","display_name":null,"funder_award_id":"2017YFA0205503","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7150367633","display_name":null,"funder_award_id":"21890743","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320330117","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30"},{"id":"https://openalex.org/F4320335305","display_name":"School of Medicine, Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389088378.pdf","grobid_xml":"https://content.openalex.org/works/W4389088378.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1588109483","https://openalex.org/W1631320694","https://openalex.org/W1798290921","https://openalex.org/W1988397531","https://openalex.org/W1995764941","https://openalex.org/W2047738133","https://openalex.org/W2054449135","https://openalex.org/W2409070137","https://openalex.org/W2522866345","https://openalex.org/W2526724898","https://openalex.org/W2560012305","https://openalex.org/W2620676965","https://openalex.org/W2730666287","https://openalex.org/W2789661952","https://openalex.org/W2791459799","https://openalex.org/W2795095043","https://openalex.org/W2795739855","https://openalex.org/W2811405063","https://openalex.org/W2897014915","https://openalex.org/W2916458303","https://openalex.org/W2951508326","https://openalex.org/W2951876422","https://openalex.org/W2971793138","https://openalex.org/W2991222749","https://openalex.org/W3047511714","https://openalex.org/W3096699846","https://openalex.org/W3097248527","https://openalex.org/W3103188645","https://openalex.org/W3130903278"],"related_works":["https://openalex.org/W2159717395","https://openalex.org/W2393383561","https://openalex.org/W2972831924","https://openalex.org/W4303684949","https://openalex.org/W2070503238","https://openalex.org/W4387115112","https://openalex.org/W2012639655","https://openalex.org/W3165424022","https://openalex.org/W4313373161","https://openalex.org/W4285176314"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"myeloid":[2,12,27],"leukaemia":[3],"(AML)":[4],"is":[5],"characterised":[6],"by":[7,68,90],"the":[8,61,101,109,113,121,148,166,181,193,196,208,240,249],"malignant":[9],"accumulation":[10],"of":[11,34,63,124,152,165,195,262,273],"progenitors":[13],"with":[14,97,173,216,242,269,276],"a":[15,25,31,86,130,226,253,258,270,287,302,306],"high":[16],"recurrence":[17],"rate":[18],"after":[19,201],"chemotherapy.":[20],"Blasts":[21],"(leukaemia":[22],"cells)":[23],"exhibit":[24],"complete":[26,277],"differentiation":[28,98,231],"hierarchy":[29],"hiding":[30],"wide":[32],"range":[33],"temporal":[35,294],"information":[36],"from":[37,103,189],"initial":[38,260],"to":[39,53,82,141,212,236,266],"mature":[40,104],"clones,":[41],"including":[42],"genesis,":[43],"phenotypic":[44],"transformation,":[45],"and":[46,76,119,143,150,192,200,233,313],"cell":[47],"fate":[48],"decisions,":[49],"which":[50,146],"might":[51],"contribute":[52],"relapse":[54,274,312],"in":[55,133,248,293],"AML":[56,64,117,158,190,311],"patients.":[57,238],"METHODS:":[58],"Based":[59],"on":[60,85,180,207,301],"landscape":[62],"surface":[65],"antigens":[66,132,224],"generated":[67,285],"mass":[69],"cytometry":[70],"(CyTOF),":[71],"we":[72,111,221],"combined":[73],"manifold":[74],"analysis":[75,169],"principal":[77],"curve-based":[78],"trajectory":[79,102,168],"inference":[80],"algorithm":[81],"align":[83],"myelocytes":[84],"single-linear":[87],"evolution":[88,122],"axis":[89],"considering":[91],"their":[92],"phenotype":[93],"continuum":[94],"that":[95],"correlated":[96],"order.":[99],"Backtracking":[100],"clusters":[105,135],"located":[106],"automatically":[107],"at":[108],"terminal,":[110],"recurred":[112],"molecular":[114,244],"dynamics":[115],"during":[116],"progression":[118],"confirmed":[120],"stage":[123,251],"single":[125,178],"cells.":[126],"We":[127],"also":[128],"designed":[129],"'dispersive":[131],"neighbouring":[134],"exhibition":[136],"(DANCE)'":[137],"feature":[138],"selection":[139],"method":[140,170],"simplify":[142],"unify":[144],"trajectories,":[145],"enabled":[147],"exploration":[149],"comparison":[151],"relapse-related":[153],"traits":[154,295],"among":[155,296],"43":[156,213],"paediatric":[157],"bone":[159],"marrow":[160],"specimens.":[161],"RESULTS:":[162],"The":[163],"feasibility":[164],"proposed":[167],"was":[171,204,284],"verified":[172],"public":[174],"datasets.":[175],"After":[176],"aligning":[177],"cells":[179],"pseudotime":[182,283],"axis,":[183],"primitive":[184,250],"clones":[185],"were":[186],"recognized":[187],"precisely":[188],"blasts,":[191],"expression":[194],"inner":[197],"molecules":[198],"before":[199],"drug":[202,315],"stimulation":[203],"accurately":[205],"plotted":[206],"trajectory.":[209],"Applying":[210],"DANCE":[211],"clinical":[214],"samples":[215,297],"different":[217],"responses":[218,316],"for":[219,229,309],"chemotherapy,":[220],"selected":[222],"12":[223],"as":[225,286],"general":[227],"panel":[228],"myeloblast":[230],"performance,":[232],"obtain":[234],"trajectories":[235,241],"those":[237],"For":[239],"unified":[243],"dynamics,":[245],"CD11c":[246],"overexpression":[247],"indicated":[252],"good":[254],"chemotherapy":[255],"outcome.":[256],"Moreover,":[257],"later":[259],"peak":[261],"stemness":[263],"heterogeneity":[264],"tended":[265],"be":[267,299],"associated":[268],"higher":[271],"risk":[272],"compared":[275],"remission.":[278],"CONCLUSIONS:":[279],"In":[280],"this":[281],"study,":[282],"new":[288,307],"single-cell":[289],"feature.":[290],"Minute":[291],"differences":[292],"could":[298],"exhibited":[300],"trajectory,":[303],"thus":[304],"providing":[305],"strategy":[308],"predicting":[310],"monitoring":[314],"over":[317],"time":[318],"scale.":[319]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
