{"id":"https://openalex.org/W4386985985","doi":"https://doi.org/10.1186/s12859-023-05489-5","title":"Fast and sensitive validation of fusion transcripts in whole-genome sequencing data","display_name":"Fast and sensitive validation of fusion transcripts in whole-genome sequencing data","publication_year":2023,"publication_date":"2023-09-23","ids":{"openalex":"https://openalex.org/W4386985985","doi":"https://doi.org/10.1186/s12859-023-05489-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/37741966"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05489-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05489-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05489-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05489-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021383252","display_name":"V\u00f6lundur Hafsta\u00f0","orcid":null},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"V\u00f6lundur Hafsta\u00f0","raw_affiliation_strings":["Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048408312","display_name":"Jari H\u00e4kkinen","orcid":"https://orcid.org/0000-0002-8466-9179"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jari H\u00e4kkinen","raw_affiliation_strings":["Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071741051","display_name":"Helena Persson","orcid":"https://orcid.org/0000-0002-5187-6446"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Helena Persson","raw_affiliation_strings":["Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden. helena.persson@med.lu.se","Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden. helena.persson@med.lu.se","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund University Cancer Centre, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071741051"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.7759,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.92452054,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"359","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.14720000326633453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.14720000326633453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06419999897480011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusion-gene","display_name":"Fusion gene","score":0.7049202919006348},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6253272891044617},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6226634979248047},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6085072755813599},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5820398330688477},{"id":"https://openalex.org/keywords/gene-prediction","display_name":"Gene prediction","score":0.49866414070129395},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4939427971839905},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.48209288716316223},{"id":"https://openalex.org/keywords/fusion-transcript","display_name":"Fusion transcript","score":0.43395310640335083},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.21461650729179382}],"concepts":[{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.7049202919006348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6253272891044617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6226634979248047},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6085072755813599},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5820398330688477},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.49866414070129395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4939427971839905},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.48209288716316223},{"id":"https://openalex.org/C2778274637","wikidata":"https://www.wikidata.org/wiki/Q5510282","display_name":"Fusion transcript","level":4,"score":0.43395310640335083},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21461650729179382}],"mesh":[{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-023-05489-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05489-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05489-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37741966","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37741966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10518092","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10518092","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10518092/pdf/12859_2023_Article_5489.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5cdbaa78e4fc4c5bb2e5ba32e33d7122","is_oa":true,"landing_page_url":"https://doaj.org/article/5cdbaa78e4fc4c5bb2e5ba32e33d7122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:5d8b8688-2561-498b-a431-f453012916b6","is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/5d8b8688-2561-498b-a431-f453012916b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1471-2105","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05489-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05489-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05489-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1364868472","display_name":null,"funder_award_id":"2018-05973","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G3321450376","display_name":null,"funder_award_id":"05973","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G712881263","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8978830693","display_name":null,"funder_award_id":"2018-05973","funder_id":"https://openalex.org/F4320321806","funder_display_name":"Lunds Universitet"}],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320321806","display_name":"Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320322128","display_name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","ror":"https://ror.org/0433fd238"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320336376","display_name":"Uppsala Multidisciplinary Center for Advanced Computational Science","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4386985985.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W46978697","https://openalex.org/W1729105152","https://openalex.org/W1970261657","https://openalex.org/W1982640053","https://openalex.org/W1995156882","https://openalex.org/W2019643724","https://openalex.org/W2057271193","https://openalex.org/W2064505617","https://openalex.org/W2079110747","https://openalex.org/W2088990880","https://openalex.org/W2089122153","https://openalex.org/W2103569192","https://openalex.org/W2136983648","https://openalex.org/W2169810552","https://openalex.org/W2174938954","https://openalex.org/W2175981288","https://openalex.org/W2557863110","https://openalex.org/W2760505083","https://openalex.org/W2790254562","https://openalex.org/W2915524647","https://openalex.org/W2944727022","https://openalex.org/W2965739592","https://openalex.org/W3003946104","https://openalex.org/W3008042230","https://openalex.org/W3032673000","https://openalex.org/W3036917249","https://openalex.org/W3095652692","https://openalex.org/W3118238647","https://openalex.org/W3131055609","https://openalex.org/W3167706804","https://openalex.org/W3198204027","https://openalex.org/W3214706220","https://openalex.org/W4213203967","https://openalex.org/W4225792098","https://openalex.org/W4226225785","https://openalex.org/W4297694265","https://openalex.org/W4362610983","https://openalex.org/W4382937456","https://openalex.org/W6637743270","https://openalex.org/W6766325090","https://openalex.org/W6788212595","https://openalex.org/W7075602604"],"related_works":["https://openalex.org/W1501720035","https://openalex.org/W2010507532","https://openalex.org/W2911167977","https://openalex.org/W2350670584","https://openalex.org/W59832779","https://openalex.org/W2161099760","https://openalex.org/W2321864840","https://openalex.org/W2489687894","https://openalex.org/W1986850084","https://openalex.org/W72388909"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,243],"cancer,":[2],"genomic":[3,126,233],"rearrangements":[4],"can":[5,35,57,149,216],"create":[6],"fusion":[7,33,66,77,97,117,162],"genes":[8,18,34],"that":[9,147,177,240],"either":[10],"combine":[11],"protein-coding":[12],"sequences":[13],"from":[14],"two":[15],"different":[16,184],"partner":[17],"or":[19],"place":[20],"one":[21],"gene":[22,157,206,222,252],"under":[23],"the":[24,27,238],"control":[25],"of":[26,29,74,96,186,205,232,237],"promoter":[28],"another":[30],"gene.":[31],"These":[32],"act":[36],"as":[37,52],"oncogenic":[38],"drivers":[39],"in":[40,60,102,211],"tumor":[41],"development":[42],"and":[43,86,119,135,141,145,159,168,174,199,227,235],"several":[44],"fusions":[45,56,158,207,223,253],"involving":[46],"kinases":[47],"have":[48,129,195],"been":[49],"successfully":[50],"exploited":[51],"drug":[53],"targets.":[54],"Expressed":[55],"be":[58,150,217],"identified":[59],"RNA":[61],"sequencing":[62,105],"(RNA-Seq)":[63],"data,":[64],"but":[65],"prediction":[67],"software":[68,176],"often":[69],"has":[70],"a":[71,92,190,197,244],"high":[72],"fraction":[73],"false":[75],"positive":[76],"transcript":[78],"predictions.":[79],"This":[80],"is":[81,178],"problematic":[82],"for":[83,94,138,203,224,254],"both":[84,139,154],"research":[85],"clinical":[87,245],"applications.":[88],"RESULTS:":[89],"We":[90,128,194],"describe":[91],"method":[93],"validation":[95,204,231],"transcripts":[98],"detected":[99,208],"by":[100,209],"RNA-Seq":[101,134,210],"matched":[103,133,212],"whole-genome":[104],"(WGS)":[106],"data.":[107,214],"Our":[108],"pipeline":[109,202],"uses":[110],"discordant":[111],"read":[112,122],"pairs":[113],"to":[114,124,152,181,219],"identify":[115,220],"supported":[116],"events":[118],"analyzes":[120],"soft-clipped":[121],"alignments":[123],"determine":[125],"breakpoints.":[127],"tested":[130],"it":[131,148,247],"on":[132,189],"WGS":[136,213],"data":[137],"tumors":[140],"cancer":[142],"cell":[143],"lines":[144],"show":[146],"used":[151,218],"validate":[153],"new":[155],"predicted":[156],"experimentally":[160],"validated":[161],"events.":[163],"It":[164,215],"was":[165],"considerably":[166],"faster":[167],"more":[169],"sensitive":[170,201],"than":[171],"using":[172],"BreakDancer":[173],"Manta,":[175],"instead":[179],"designed":[180],"detect":[182],"many":[183],"types":[185],"structural":[187],"variants":[188],"genome-wide":[191],"scale.":[192],"CONCLUSIONS:":[193],"developed":[196],"fast":[198],"very":[200],"high-quality":[221],"further":[225],"bioinformatic":[226],"experimental":[228],"studies,":[229],"including":[230],"breakpoints":[234],"studies":[236],"mechanisms":[239],"generate":[241],"fusions.":[242],"setting,":[246],"could":[248],"help":[249],"find":[250],"expressed":[251],"personalized":[255],"therapy.":[256]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":2}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}