{"id":"https://openalex.org/W4387311115","doi":"https://doi.org/10.1186/s12859-023-05479-7","title":"DrugRep-HeSiaGraph: when heterogenous siamese neural network meets knowledge graphs for drug repurposing","display_name":"DrugRep-HeSiaGraph: when heterogenous siamese neural network meets knowledge graphs for drug repurposing","publication_year":2023,"publication_date":"2023-10-03","ids":{"openalex":"https://openalex.org/W4387311115","doi":"https://doi.org/10.1186/s12859-023-05479-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/37789314"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05479-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05479-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05479-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05479-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012715487","display_name":"Zahra Ghorbanali","orcid":"https://orcid.org/0000-0003-4809-1311"},"institutions":[{"id":"https://openalex.org/I158248296","display_name":"Amirkabir University of Technology","ror":"https://ror.org/04gzbav43","country_code":"IR","type":"education","lineage":["https://openalex.org/I158248296"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Ghorbanali","raw_affiliation_strings":["Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I158248296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067478126","display_name":"Fatemeh Zare\u2010Mirakabad","orcid":"https://orcid.org/0000-0003-2849-3778"},"institutions":[{"id":"https://openalex.org/I158248296","display_name":"Amirkabir University of Technology","ror":"https://ror.org/04gzbav43","country_code":"IR","type":"education","lineage":["https://openalex.org/I158248296"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Fatemeh Zare-Mirakabad","raw_affiliation_strings":["Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran. f.zare@aut.ac.ir","Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran. f.zare@aut.ac.ir","institution_ids":["https://openalex.org/I158248296"]},{"raw_affiliation_string":"Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I158248296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028437755","display_name":"Najmeh Salehi","orcid":"https://orcid.org/0000-0002-7337-4404"},"institutions":[{"id":"https://openalex.org/I4210146419","display_name":"Institute for Research in Fundamental Sciences","ror":"https://ror.org/04xreqs31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210146419"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Najmeh Salehi","raw_affiliation_strings":["School of Biological Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran","institution_ids":["https://openalex.org/I4210146419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101478081","display_name":"Mohammad Esmaeil Akbari","orcid":"https://orcid.org/0000-0002-2467-5542"},"institutions":[{"id":"https://openalex.org/I158248296","display_name":"Amirkabir University of Technology","ror":"https://ror.org/04gzbav43","country_code":"IR","type":"education","lineage":["https://openalex.org/I158248296"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Akbari","raw_affiliation_strings":["Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center (CBRC), Department of Mathematics and Computer Science, Amirkabir University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I158248296"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030421501","display_name":"Ali Masoudi\u2010Nejad","orcid":"https://orcid.org/0000-0003-0659-5183"},"institutions":[{"id":"https://openalex.org/I23946033","display_name":"University of Tehran","ror":"https://ror.org/05vf56z40","country_code":"IR","type":"education","lineage":["https://openalex.org/I23946033"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ali Masoudi-Nejad","raw_affiliation_strings":["Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran","institution_ids":["https://openalex.org/I23946033"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067478126"],"corresponding_institution_ids":["https://openalex.org/I158248296"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.804,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87413876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"374","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5665000081062317,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5665000081062317,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8654071092605591},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.8133453130722046},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6800332069396973},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5575947761535645},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.5306248664855957},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5250275731086731},{"id":"https://openalex.org/keywords/knowledge-graph","display_name":"Knowledge graph","score":0.5222790241241455},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5141423344612122},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.49238407611846924},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.44029369950294495},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3289627730846405},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22604352235794067},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.19572392106056213},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.17818763852119446},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10591790080070496}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8654071092605591},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.8133453130722046},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6800332069396973},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5575947761535645},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.5306248664855957},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5250275731086731},{"id":"https://openalex.org/C2987255567","wikidata":"https://www.wikidata.org/wiki/Q33002955","display_name":"Knowledge graph","level":2,"score":0.5222790241241455},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5141423344612122},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.49238407611846924},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.44029369950294495},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3289627730846405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22604352235794067},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.19572392106056213},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17818763852119446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10591790080070496},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05479-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05479-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05479-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37789314","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37789314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10548718","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10548718","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10548718/pdf/12859_2023_Article_5479.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d390806d949b4d16b8afe62b0252c36d","is_oa":true,"landing_page_url":"https://doaj.org/article/d390806d949b4d16b8afe62b0252c36d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-31 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05479-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05479-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05479-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387311115.pdf","grobid_xml":"https://content.openalex.org/works/W4387311115.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W901067443","https://openalex.org/W1647961127","https://openalex.org/W1991716975","https://openalex.org/W1998186208","https://openalex.org/W2029667189","https://openalex.org/W2082893943","https://openalex.org/W2115339329","https://openalex.org/W2119111857","https://openalex.org/W2131701266","https://openalex.org/W2145578524","https://openalex.org/W2148143831","https://openalex.org/W2154019529","https://openalex.org/W2521200999","https://openalex.org/W2567353202","https://openalex.org/W2581659613","https://openalex.org/W2612436700","https://openalex.org/W2767891136","https://openalex.org/W2799845593","https://openalex.org/W2837999301","https://openalex.org/W2899070097","https://openalex.org/W2900569176","https://openalex.org/W2903942159","https://openalex.org/W2905315292","https://openalex.org/W2922405516","https://openalex.org/W2936926121","https://openalex.org/W2944507545","https://openalex.org/W2946099214","https://openalex.org/W2955244377","https://openalex.org/W2962756421","https://openalex.org/W2964393652","https://openalex.org/W2966692841","https://openalex.org/W2966864197","https://openalex.org/W2981162242","https://openalex.org/W2982905073","https://openalex.org/W2983166786","https://openalex.org/W2998922495","https://openalex.org/W3012088820","https://openalex.org/W3018746053","https://openalex.org/W3042702491","https://openalex.org/W3043400518","https://openalex.org/W3043498388","https://openalex.org/W3043927884","https://openalex.org/W3049572366","https://openalex.org/W3080427797","https://openalex.org/W3081081984","https://openalex.org/W3084084616","https://openalex.org/W3087194367","https://openalex.org/W3089113296","https://openalex.org/W3093667855","https://openalex.org/W3111251354","https://openalex.org/W3112376646","https://openalex.org/W3118274859","https://openalex.org/W3120712761","https://openalex.org/W3123867528","https://openalex.org/W3126641732","https://openalex.org/W3135802851","https://openalex.org/W3137080614","https://openalex.org/W3144041472","https://openalex.org/W3175151568","https://openalex.org/W3182446092","https://openalex.org/W3184045280","https://openalex.org/W3185197558","https://openalex.org/W3185914370","https://openalex.org/W3199283437","https://openalex.org/W3201778843","https://openalex.org/W3202913869","https://openalex.org/W4206547282","https://openalex.org/W4214699963","https://openalex.org/W4221154868","https://openalex.org/W4281253250","https://openalex.org/W4283026843","https://openalex.org/W4292547247","https://openalex.org/W4296777868","https://openalex.org/W4303475380","https://openalex.org/W4318624508","https://openalex.org/W4319455836","https://openalex.org/W4323052085","https://openalex.org/W4323363795","https://openalex.org/W4362678463","https://openalex.org/W4364382314","https://openalex.org/W4384485979","https://openalex.org/W4385064547","https://openalex.org/W4394157528","https://openalex.org/W6624196680","https://openalex.org/W6648359365","https://openalex.org/W6737188399","https://openalex.org/W6745511995","https://openalex.org/W6755922719","https://openalex.org/W6780521988","https://openalex.org/W6787264416","https://openalex.org/W6907704324","https://openalex.org/W7075604449"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"repurposing":[2],"is":[3,83,116],"an":[4,150,154,158,167],"approach":[5],"that":[6],"holds":[7],"promise":[8],"for":[9,14,25,95,142,184,206,239],"identifying":[10,181],"new":[11,87,132],"therapeutic":[12],"uses":[13],"existing":[15],"drugs.":[16],"Recently,":[17],"knowledge":[18,42,62,79],"graphs":[19],"have":[20],"emerged":[21],"as":[22,186,202],"significant":[23],"tools":[24],"addressing":[26,226],"the":[27,60,65,74,96,101,106,120,174,177,195,209,219,223,230],"challenges":[28,228],"of":[29,67,122,152,156,160,164,169,176,197,211,222,232],"drug":[30,140,233],"repurposing.":[31,234],"However,":[32],"there":[33],"are":[34,98,241],"still":[35],"major":[36],"issues":[37],"with":[38,64],"constructing":[39],"and":[40,90,124,166,208,237],"embedding":[41,121],"graphs.":[43],"RESULTS:":[44],"This":[45,217],"study":[46,193],"proposes":[47],"a":[48,68,77,109,131,162,187,203],"two-step":[49],"method":[50,58,179],"called":[51,114],"DrugRep-HeSiaGraph":[52,144,240],"to":[53,118],"address":[54],"these":[55],"challenges.":[56],"The":[57,235],"integrates":[59],"drug-disease":[61,78],"graph":[63,80],"application":[66,221],"heterogeneous":[69,110],"siamese":[70,111],"neural":[71,112],"network.":[72],"In":[73,105,190],"first":[75],"step,":[76,108],"named":[81],"DDKG-V1":[82],"constructed":[84],"by":[85,126],"defining":[86],"relationship":[88],"types,":[89],"then":[91],"numerical":[92],"vector":[93],"representations":[94],"nodes":[97],"created":[99],"using":[100],"distributional":[102],"learning":[103],"method.":[104],"second":[107],"network":[113],"HeSiaNet":[115],"applied":[117],"enrich":[119],"drugs":[123,183],"diseases":[125],"bringing":[127],"them":[128],"closer":[129],"in":[130,180,214,225,229],"unified":[133],"latent":[134],"space.":[135],"Then,":[136],"it":[137],"predicts":[138],"potential":[139,182,204],"candidates":[141],"diseases.":[143],"achieves":[145],"impressive":[146],"performance":[147],"metrics,":[148],"including":[149],"AUC-ROC":[151],"91.16%,":[153],"AUC-PR":[155],"90.32%,":[157],"accuracy":[159],"84.63%,":[161],"BS":[163],"0.119,":[165],"MCC":[168],"69.31%.":[170],"CONCLUSION:":[171],"We":[172],"demonstrate":[173],"effectiveness":[175,210],"proposed":[178],"COVID-19":[185],"case":[188],"study.":[189],"addition,":[191],"this":[192],"shows":[194],"role":[196],"dipeptidyl":[198],"peptidase":[199],"4":[200],"(DPP-4)":[201],"receptor":[205],"SARS-CoV-2":[207],"DPP-4":[212],"inhibitors":[213],"facing":[215],"COVID-19.":[216],"highlights":[218],"practical":[220],"model":[224],"real-world":[227],"field":[231],"code":[236],"data":[238],"publicly":[242],"available":[243],"at":[244],"https://github.com/CBRC-lab/DrugRep-HeSiaGraph":[245],".":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}