{"id":"https://openalex.org/W4387216467","doi":"https://doi.org/10.1186/s12859-023-05478-8","title":"Predicting tumour content of liquid biopsies from cell-free DNA","display_name":"Predicting tumour content of liquid biopsies from cell-free DNA","publication_year":2023,"publication_date":"2023-09-30","ids":{"openalex":"https://openalex.org/W4387216467","doi":"https://doi.org/10.1186/s12859-023-05478-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37777714"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05478-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05478-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-023-05478-8.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12859-023-05478-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021848179","display_name":"Mathias Cardner","orcid":"https://orcid.org/0000-0001-5873-2632"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Mathias Cardner","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5873-2632","affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081092395","display_name":"Francesco Marass","orcid":"https://orcid.org/0000-0002-8993-7320"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210103595","display_name":"La Jolla Alcohol Research","ror":"https://ror.org/00vvpe721","country_code":"US","type":"other","lineage":["https://openalex.org/I4210103595"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Francesco Marass","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","PetDx, Inc, La Jolla, USA","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"PetDx, Inc, La Jolla, USA","institution_ids":["https://openalex.org/I4210103595"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038757682","display_name":"Erika Gedvilaite","orcid":"https://orcid.org/0000-0003-1749-0045"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Gedvilaite","raw_affiliation_strings":["Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017577465","display_name":"Julie L. Yang","orcid":"https://orcid.org/0000-0003-4747-6391"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie L. Yang","raw_affiliation_strings":["Epigenetics Research Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics Research Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015206910","display_name":"Dana W.Y. Tsui","orcid":"https://orcid.org/0000-0002-0595-6664"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4210093285","display_name":"DxDiscovery (United States)","ror":"https://ror.org/00mfy6m96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210093285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana W. Y. Tsui","raw_affiliation_strings":["Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. dtsui@petdx.com","PetDx, Inc, La Jolla, USA. dtsui@petdx.com","Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. dtsui@petdx.com","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"PetDx, Inc, La Jolla, USA. dtsui@petdx.com","institution_ids":["https://openalex.org/I4210093285"]},{"raw_affiliation_string":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035497488","display_name":"Niko Beerenwinkel","orcid":"https://orcid.org/0000-0002-0573-6119"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Niko Beerenwinkel","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5021848179"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I35440088"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1863,"currency":"EUR","value_usd":2009},"fwci":0.4566,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.74074503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"368","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"Liquid biopsy","score":0.8422315120697021},{"id":"https://openalex.org/keywords/cell-free-fetal-dna","display_name":"Cell-free fetal DNA","score":0.6764702200889587},{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.6134278774261475},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4881070554256439},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.4833669066429138},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4525716006755829},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.42585283517837524},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.36848360300064087},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.278763085603714},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24603378772735596},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.15966743230819702},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07561230659484863}],"concepts":[{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.8422315120697021},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.6764702200889587},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6134278774261475},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4881070554256439},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.4833669066429138},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4525716006755829},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42585283517837524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36848360300064087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.278763085603714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24603378772735596},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15966743230819702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07561230659484863},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-023-05478-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05478-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-023-05478-8.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37777714","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37777714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10543881","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10543881","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10543881/pdf/12859_2023_Article_5478.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bbde033bd9784290b10587b1b299e0ba","is_oa":true,"landing_page_url":"https://doaj.org/article/bbde033bd9784290b10587b1b299e0ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-9 (2023)","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/637187","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/637187","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 24 (1)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000637187","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000637187","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05478-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05478-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-023-05478-8.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2997357306","display_name":null,"funder_award_id":"MRD 2014/267","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"},{"id":"https://openalex.org/G7089058470","display_name":null,"funder_award_id":"2014/267","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"},{"id":"https://openalex.org/G7516160132","display_name":null,"funder_award_id":"Synergy Grant 609883","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320327577","display_name":"SystemsX.ch","ror":"https://ror.org/02s09gf16"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387216467.pdf","grobid_xml":"https://content.openalex.org/works/W4387216467.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1933386641","https://openalex.org/W1983466841","https://openalex.org/W1998643818","https://openalex.org/W2079345276","https://openalex.org/W2116815574","https://openalex.org/W2120869188","https://openalex.org/W2184877799","https://openalex.org/W2338663666","https://openalex.org/W2479773785","https://openalex.org/W2562162676","https://openalex.org/W2582743722","https://openalex.org/W2765435739","https://openalex.org/W2898815507","https://openalex.org/W2899063215","https://openalex.org/W2900295924","https://openalex.org/W2947989913","https://openalex.org/W3009023731","https://openalex.org/W3010889616","https://openalex.org/W3028644610","https://openalex.org/W3036545520","https://openalex.org/W3103162178","https://openalex.org/W3119672763","https://openalex.org/W3124986623","https://openalex.org/W3127011263","https://openalex.org/W3164452044","https://openalex.org/W3168693194","https://openalex.org/W3184558555","https://openalex.org/W3194069390","https://openalex.org/W3200489380","https://openalex.org/W4200479098","https://openalex.org/W6721652404"],"related_works":["https://openalex.org/W4304091561","https://openalex.org/W4384923668","https://openalex.org/W4281722455","https://openalex.org/W4381715349","https://openalex.org/W3023827600","https://openalex.org/W2544183085","https://openalex.org/W2601308395","https://openalex.org/W2561550857","https://openalex.org/W2919889630","https://openalex.org/W4386317609"],"abstract_inverted_index":{"BACKGROUND:":[0],"Liquid":[1],"biopsy":[2],"is":[3],"a":[4,63],"minimally-invasive":[5],"method":[6],"of":[7,12,15,19,59,80,99,105],"sampling":[8],"bodily":[9],"fluids,":[10],"capable":[11],"revealing":[13],"evidence":[14],"cancer.":[16],"The":[17,90],"distribution":[18],"cell-free":[20],"DNA":[21],"(cfDNA)":[22],"fragment":[23],"lengths":[24],"has":[25],"been":[26,52],"shown":[27],"to":[28,54,71],"differ":[29],"between":[30],"healthy":[31],"subjects":[32],"and":[33,77],"cancer":[34,88],"patients,":[35],"whereby":[36],"the":[37,42,57],"distributional":[38],"shift":[39],"correlates":[40],"with":[41],"sample's":[43],"tumour":[44,73,117],"content.":[45],"These":[46],"fragmentomic":[47,110],"data":[48],"have":[49],"not":[50],"yet":[51],"utilised":[53],"directly":[55],"quantify":[56],"proportion":[58],"tumour-derived":[60],"cfDNA":[61,81],"in":[62,84,119],"liquid":[64,120],"biopsy.":[65],"RESULTS:":[66],"We":[67],"used":[68],"statistical":[69],"learning":[70],"predict":[72],"content":[74,118],"from":[75,86],"Fourier":[76],"wavelet":[78],"transforms":[79],"length":[82],"distributions":[83],"samples":[85],"118":[87],"patients.":[89],"model":[91],"was":[92],"validated":[93],"on":[94],"an":[95],"independent":[96],"dilution":[97],"series":[98],"patient":[100],"plasma.":[101],"CONCLUSIONS:":[102],"This":[103],"proof":[104],"concept":[106],"suggests":[107],"that":[108],"our":[109],"methodology":[111],"could":[112],"be":[113],"useful":[114],"for":[115],"predicting":[116],"biopsies.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}
