{"id":"https://openalex.org/W4385782706","doi":"https://doi.org/10.1186/s12859-023-05424-8","title":"An information-theoretic approach to single cell sequencing analysis","display_name":"An information-theoretic approach to single cell sequencing analysis","publication_year":2023,"publication_date":"2023-08-12","ids":{"openalex":"https://openalex.org/W4385782706","doi":"https://doi.org/10.1186/s12859-023-05424-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37573291"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05424-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05424-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05424-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05424-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061138871","display_name":"Michael J. Casey","orcid":"https://orcid.org/0000-0003-1099-1189"},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael J. Casey","raw_affiliation_strings":["Institute for Life Sciences, University of Southampton, Southampton, UK","Mathematical Sciences, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Life Sciences, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Mathematical Sciences, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019337941","display_name":"J\u00f6rg Fliege","orcid":"https://orcid.org/0000-0002-4459-5419"},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Fliege","raw_affiliation_strings":["Mathematical Sciences, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Sciences, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053298314","display_name":"Rub\u00e9n J. S\u00e1nchez-Garc\u00eda","orcid":"https://orcid.org/0000-0001-6479-3028"},"institutions":[{"id":"https://openalex.org/I125680101","display_name":"Turing Institute","ror":"https://ror.org/02x2mw849","country_code":"GB","type":"facility","lineage":["https://openalex.org/I125680101"]},{"id":"https://openalex.org/I4210128584","display_name":"The Alan Turing Institute","ror":"https://ror.org/035dkdb55","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210128584"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rub\u00e9n J. S\u00e1nchez-Garc\u00eda","raw_affiliation_strings":["Institute for Life Sciences, University of Southampton, Southampton, UK. R.Sanchez-Garcia@soton.ac.uk","Mathematical Sciences, University of Southampton, Southampton, UK. R.Sanchez-Garcia@soton.ac.uk","The Alan Turing Institute, London, UK. R.Sanchez-Garcia@soton.ac.uk","Mathematical Sciences, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Life Sciences, University of Southampton, Southampton, UK. R.Sanchez-Garcia@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Mathematical Sciences, University of Southampton, Southampton, UK. R.Sanchez-Garcia@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"The Alan Turing Institute, London, UK. R.Sanchez-Garcia@soton.ac.uk","institution_ids":["https://openalex.org/I4210128584","https://openalex.org/I125680101"]},{"raw_affiliation_string":"Mathematical Sciences, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034757003","display_name":"Ben D. MacArthur","orcid":"https://orcid.org/0000-0002-5396-9750"},"institutions":[{"id":"https://openalex.org/I125680101","display_name":"Turing Institute","ror":"https://ror.org/02x2mw849","country_code":"GB","type":"facility","lineage":["https://openalex.org/I125680101"]},{"id":"https://openalex.org/I4210128584","display_name":"The Alan Turing Institute","ror":"https://ror.org/035dkdb55","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210128584"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ben D. MacArthur","raw_affiliation_strings":["Centre for Human Development, Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton, UK. bdm@soton.ac.uk","Institute for Life Sciences, University of Southampton, Southampton, UK. bdm@soton.ac.uk","Mathematical Sciences, University of Southampton, Southampton, UK. bdm@soton.ac.uk","The Alan Turing Institute, London, UK. bdm@soton.ac.uk","Institute for Life Sciences, University of Southampton, Southampton, UK"],"raw_orcid":"https://orcid.org/0000-0002-5396-9750","affiliations":[{"raw_affiliation_string":"Centre for Human Development, Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton, UK. bdm@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Institute for Life Sciences, University of Southampton, Southampton, UK. bdm@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Mathematical Sciences, University of Southampton, Southampton, UK. bdm@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"The Alan Turing Institute, London, UK. bdm@soton.ac.uk","institution_ids":["https://openalex.org/I4210128584","https://openalex.org/I125680101"]},{"raw_affiliation_string":"Institute for Life Sciences, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034757003","https://openalex.org/A5053298314"],"corresponding_institution_ids":["https://openalex.org/I125680101","https://openalex.org/I4210128584","https://openalex.org/I43439940"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.7092,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72008474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"24","issue":"1","first_page":"311","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7007076144218445},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5486727952957153},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.5193151831626892},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4724208116531372},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.460094153881073},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.458657443523407},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4539009928703308},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41659173369407654},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3827507197856903},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3283197283744812},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.30501097440719604},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2398836612701416},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21340760588645935},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2107861340045929},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.15788578987121582}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7007076144218445},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5486727952957153},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5193151831626892},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4724208116531372},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.460094153881073},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.458657443523407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4539009928703308},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41659173369407654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3827507197856903},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3283197283744812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30501097440719604},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2398836612701416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21340760588645935},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2107861340045929},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15788578987121582},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-023-05424-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05424-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05424-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37573291","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37573291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:eprints.soton.ac.uk:482485","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.soton.ac.uk/482485/1/s12859_023_05424_8.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10422744","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10422744","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10422744/pdf/12859_2023_Article_5424.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:03c12c4bb60c47eba56ce3c798a3e635","is_oa":true,"landing_page_url":"https://doaj.org/article/03c12c4bb60c47eba56ce3c798a3e635","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-24 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05424-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05424-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05424-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4500485203","display_name":"The Alan Turing Institute","funder_award_id":"EP/N510129/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8597009950","display_name":null,"funder_award_id":"EP/N510129/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385782706.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1556911442","https://openalex.org/W1813068103","https://openalex.org/W1965555277","https://openalex.org/W1967327758","https://openalex.org/W1981641790","https://openalex.org/W1993616033","https://openalex.org/W1995875735","https://openalex.org/W2000359198","https://openalex.org/W2005126631","https://openalex.org/W2025828346","https://openalex.org/W2033403400","https://openalex.org/W2102212449","https://openalex.org/W2103017472","https://openalex.org/W2110065044","https://openalex.org/W2114104545","https://openalex.org/W2131681506","https://openalex.org/W2178888844","https://openalex.org/W2179438025","https://openalex.org/W2242464395","https://openalex.org/W2292721147","https://openalex.org/W2294418165","https://openalex.org/W2342688693","https://openalex.org/W2514159238","https://openalex.org/W2516455020","https://openalex.org/W2519132385","https://openalex.org/W2540833380","https://openalex.org/W2591733518","https://openalex.org/W2598326928","https://openalex.org/W2600453489","https://openalex.org/W2735360749","https://openalex.org/W2753908609","https://openalex.org/W2757234574","https://openalex.org/W2794891507","https://openalex.org/W2805619986","https://openalex.org/W2885781875","https://openalex.org/W2889326414","https://openalex.org/W2894687190","https://openalex.org/W2907783748","https://openalex.org/W2921230232","https://openalex.org/W2947877009","https://openalex.org/W2949177718","https://openalex.org/W2949237386","https://openalex.org/W2951337536","https://openalex.org/W2951506174","https://openalex.org/W2997280954","https://openalex.org/W2998065416","https://openalex.org/W2998840182","https://openalex.org/W3003257820","https://openalex.org/W3036334595","https://openalex.org/W3099768174","https://openalex.org/W3108829278","https://openalex.org/W3112600195","https://openalex.org/W3142000089","https://openalex.org/W4251287806","https://openalex.org/W4301730562","https://openalex.org/W6641869264","https://openalex.org/W6674851815","https://openalex.org/W6675471023","https://openalex.org/W6779732140"],"related_works":["https://openalex.org/W4298130764","https://openalex.org/W2804364458","https://openalex.org/W2132641928","https://openalex.org/W106077234","https://openalex.org/W2041374557","https://openalex.org/W2081929287","https://openalex.org/W2132561013","https://openalex.org/W2144348650","https://openalex.org/W1994852842","https://openalex.org/W4246178523"],"abstract_inverted_index":{"BACKGROUND:":[0],"Single-cell":[1],"sequencing":[2],"(sc-Seq)":[3],"experiments":[4],"are":[5,134],"producing":[6],"increasingly":[7],"large":[8,12,19],"data":[9,13],"sets.":[10],"However,":[11],"sets":[14],"do":[15],"not":[16],"necessarily":[17],"contain":[18],"amounts":[20],"of":[21,44,56,60,86,92,117,126,131,142,147,182],"information.":[22],"RESULTS:":[23],"Here,":[24],"we":[25,172],"formally":[26],"quantify":[27],"the":[28,89,178],"information":[29],"obtained":[30],"from":[31,184],"a":[32,50,93,101,122],"sc-Seq":[33,185],"experiment":[34],"and":[35,58,77,96,149,154,160,187],"show":[36,97],"that":[37,59,66,78,98,133],"it":[38,99],"corresponds":[39],"to":[40,69,121,139],"an":[41,174,189],"intuitive":[42],"notion":[43,55,125],"gene":[45,105,118,143],"expression":[46,71,106,166],"heterogeneity.":[47],"We":[48,82],"demonstrate":[49],"natural":[51],"relation":[52],"between":[53,72],"our":[54,84,115],"heterogeneity":[57,64,87,119],"cell":[61,73,111,127],"type,":[62,128],"decomposing":[63],"into":[65,152],"component":[67],"attributable":[68],"differential":[70],"types":[74],"(inter-cluster":[75],"heterogeneity)":[76],"remaining":[79],"(intra-cluster":[80],"heterogeneity).":[81],"test":[83],"definition":[85,116],"as":[88,129],"objective":[90],"function":[91],"clustering":[94,181],"algorithm,":[95],"is":[100,156],"useful":[102],"descriptor":[103],"for":[104,177],"patterns":[107,141],"associated":[108],"with":[109,137],"different":[110],"types.":[112],"CONCLUSIONS:":[113],"Thus,":[114],"leads":[120],"biologically":[123],"meaningful":[124],"groups":[130],"cells":[132,183],"statistically":[135],"equivalent":[136],"respect":[138],"their":[140],"expression.":[144],"Our":[145],"measure":[146],"heterogeneity,":[148],"its":[150],"decomposition":[151],"inter-":[153],"intra-cluster,":[155],"non-parametric,":[157],"intrinsic,":[158],"unbiased,":[159],"requires":[161],"no":[162],"additional":[163],"assumptions":[164],"about":[165],"patterns.":[167],"Based":[168],"on":[169],"this":[170],"theory,":[171],"develop":[173],"efficient":[175],"method":[176],"automatic":[179],"unsupervised":[180],"data,":[186],"provide":[188],"R":[190],"package":[191],"implementation.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":5}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}