{"id":"https://openalex.org/W4376225469","doi":"https://doi.org/10.1186/s12859-023-05323-y","title":"Pan-cancer analysis of SYNGR2 with a focus on clinical implications and immune landscape in liver hepatocellular carcinoma","display_name":"Pan-cancer analysis of SYNGR2 with a focus on clinical implications and immune landscape in liver hepatocellular carcinoma","publication_year":2023,"publication_date":"2023-05-11","ids":{"openalex":"https://openalex.org/W4376225469","doi":"https://doi.org/10.1186/s12859-023-05323-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/37170221"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05323-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05323-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05323-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05323-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019293912","display_name":"Chunxun Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunxun Liu","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100969682","display_name":"Zhao-Wei Qu","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaowei Qu","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007635199","display_name":"Haoran Zhao","orcid":"https://orcid.org/0000-0002-0859-4136"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoran Zhao","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396036","display_name":"Peng Wang","orcid":"https://orcid.org/0000-0002-4983-9953"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100710702","display_name":"Chao Zhan","orcid":"https://orcid.org/0000-0001-5732-8857"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Zhan","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100626052","display_name":"Yubao Zhang","orcid":"https://orcid.org/0000-0001-8991-4906"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubao Zhang","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China. zhangyubao@hrbmu.edu.cn","Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China. zhangyubao@hrbmu.edu.cn","institution_ids":["https://openalex.org/I4210103956","https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.4252,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.82618669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"192","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.3325999975204468,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.3325999975204468,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.7654827833175659},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"Microsatellite instability","score":0.7581229209899902},{"id":"https://openalex.org/keywords/nomogram","display_name":"Nomogram","score":0.7433099746704102},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6329816579818726},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.6316297650337219},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5310388207435608},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5285557508468628},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.517997145652771},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5083617568016052},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.5073391795158386},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4821445643901825},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.46282416582107544},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"Immune checkpoint","score":0.43792724609375},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.4263416528701782},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3753533363342285},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3578970730304718},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.35717877745628357},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3135160207748413},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26843249797821045},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2652627229690552},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2446260154247284},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.2397100031375885},{"id":"https://openalex.org/keywords/microsatellite","display_name":"Microsatellite","score":0.1523188054561615},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1112554669380188}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7654827833175659},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.7581229209899902},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.7433099746704102},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6329816579818726},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.6316297650337219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5310388207435608},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5285557508468628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.517997145652771},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5083617568016052},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5073391795158386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4821445643901825},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.46282416582107544},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.43792724609375},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.4263416528701782},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3753533363342285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3578970730304718},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.35717877745628357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3135160207748413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26843249797821045},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2652627229690552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2446260154247284},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.2397100031375885},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.1523188054561615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1112554669380188}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D062805","descriptor_name":"Synaptogyrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062805","descriptor_name":"Synaptogyrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062805","descriptor_name":"Synaptogyrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05323-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05323-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05323-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37170221","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37170221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10173524","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10173524","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10173524/pdf/12859_2023_Article_5323.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:540b94fe4a38476ca946f265dcb749f0","is_oa":true,"landing_page_url":"https://doaj.org/article/540b94fe4a38476ca946f265dcb749f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05323-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05323-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05323-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7099999785423279,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312270","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376225469.pdf"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1955793736","https://openalex.org/W1984252723","https://openalex.org/W1985987855","https://openalex.org/W1999575402","https://openalex.org/W2017399951","https://openalex.org/W2051886117","https://openalex.org/W2130410032","https://openalex.org/W2130430382","https://openalex.org/W2144261049","https://openalex.org/W2164542609","https://openalex.org/W2166593999","https://openalex.org/W2254576822","https://openalex.org/W2317962661","https://openalex.org/W2607129810","https://openalex.org/W2617691667","https://openalex.org/W2736730167","https://openalex.org/W2766209631","https://openalex.org/W2782248232","https://openalex.org/W2788142646","https://openalex.org/W2796494201","https://openalex.org/W2885738414","https://openalex.org/W2906815954","https://openalex.org/W2930324748","https://openalex.org/W2949273159","https://openalex.org/W2949498852","https://openalex.org/W2966710588","https://openalex.org/W2983258509","https://openalex.org/W2995684511","https://openalex.org/W3002686604","https://openalex.org/W3005245715","https://openalex.org/W3007391700","https://openalex.org/W3018298886","https://openalex.org/W3049389667","https://openalex.org/W3125923658","https://openalex.org/W4206123003","https://openalex.org/W4206975770","https://openalex.org/W4285594364","https://openalex.org/W4285604883","https://openalex.org/W4293276539","https://openalex.org/W7073956966"],"related_works":["https://openalex.org/W2981371073","https://openalex.org/W2092777970","https://openalex.org/W1987706726","https://openalex.org/W2010497734","https://openalex.org/W2078763660","https://openalex.org/W4312174640","https://openalex.org/W3126879016","https://openalex.org/W2099952417","https://openalex.org/W2035185296","https://openalex.org/W2914989599"],"abstract_inverted_index":{"BACKGROUND:":[0],"Synaptogyrin-2":[1],"(SYNGR2),":[2],"as":[3,246],"a":[4,93,187,217,247],"member":[5],"of":[6,15,20,51,59,95,117,138,179,210],"synaptogyrin":[7],"gene":[8,78],"family,":[9],"is":[10,24,216],"overexpressed":[11],"in":[12,22,53,111,135,153,184,220,225,236,252],"several":[13],"types":[14,137],"cancer.":[16,139],"However,":[17],"the":[18,29,43,57,121,177,205,226,233],"role":[19],"SYNGR2":[21,52,60,107,118,149,161,180,190,215,223,243],"pan-cancer":[23],"largely":[25],"unexplored.":[26],"METHODS:":[27],"From":[28],"TCGA":[30],"and":[31,38,48,55,72,101,131,170,191,199,208,229],"GEO":[32],"databases,":[33],"we":[34,91],"obtained":[35],"bulk":[36],"transcriptomes,":[37],"clinical":[39],"information.":[40],"We":[41,174],"examined":[42],"expression":[44,61,116,162],"patterns,":[45],"prognostic":[46],"values,":[47],"diagnostic":[49],"value":[50],"pan-cancer,":[54,253],"investigated":[56],"relationship":[58],"with":[62,165,181],"tumor":[63,237],"mutation":[64],"burden":[65],"(TMB),":[66],"microsatellite":[67],"instability":[68],"(MSI),":[69],"immune":[70,73,168,171,234],"infiltration,":[71],"checkpoint":[74],"(ICP)":[75],"genes.":[76],"The":[77,114],"set":[79],"enrichment":[80],"analysis":[81,146],"(GSEA)":[82],"software":[83],"was":[84,108,163,197],"used":[85],"to":[86,232,250],"perform":[87],"pathway":[88],"analysis.":[89],"Besides,":[90],"built":[92,198],"nomogram":[94,188],"liver":[96],"hepatocellular":[97],"carcinoma":[98],"patients":[99],"(LIHC)":[100],"validated":[102],"its":[103],"prediction":[104],"accuracy.":[105],"RESULTS:":[106],"highly":[109],"expressed":[110],"most":[112],"cancers.":[113],"high":[115,151],"significantly":[119],"reduced":[120],"overall":[122],"survival":[123,126],"(OS),":[124],"disease-specific":[125],"(DSS),":[127],"disease-free":[128],"interval":[129,133],"(DFI),":[130],"progression-free":[132],"(PFI)":[134],"multiple":[136],"Also,":[140],"receiver":[141],"operating":[142],"characteristic":[143],"(ROC)":[144],"curve":[145],"demonstrated":[147],"that":[148,242],"showed":[150],"accuracy":[152],"distinguishing":[154],"cancerous":[155],"tissues":[156],"from":[157],"normal":[158],"ones.":[159],"Moreover,":[160],"correlated":[164],"TMB,":[166],"MSI,":[167],"scores,":[169],"cell":[172],"infiltrations.":[173],"also":[175],"analyzed":[176],"association":[178],"immunotherapy":[182],"response":[183],"LIHC.":[185,255],"Finally,":[186],"including":[189],"pathologic":[192],"T,":[193],"N,":[194],"M":[195],"stage":[196],"exhibited":[200],"good":[201],"predictive":[202],"power":[203],"for":[204],"OS,":[206],"DSS,":[207],"PFI":[209],"LIHC":[211],"patients.":[212],"CONCLUSION:":[213],"Overall,":[214],"critical":[218],"oncogene":[219],"various":[221],"tumors.":[222],"participates":[224],"carcinogenic":[227],"progression,":[228],"may":[230],"contribute":[231],"infiltration":[235],"microenvironment.":[238],"Our":[239],"study":[240],"suggests":[241],"can":[244],"serve":[245],"predictor":[248],"related":[249],"prognosis":[251],"especially":[254]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
