{"id":"https://openalex.org/W4376131137","doi":"https://doi.org/10.1186/s12859-023-05312-1","title":"Integrated bioinformatics analysis for conducting a prognostic model and identifying immunotherapeutic targets in gastric cancer","display_name":"Integrated bioinformatics analysis for conducting a prognostic model and identifying immunotherapeutic targets in gastric cancer","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W4376131137","doi":"https://doi.org/10.1186/s12859-023-05312-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37161430"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05312-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05312-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05312-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05312-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110973912","display_name":"YaLing Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YaLing Liu","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380794","display_name":"Dan Li","orcid":"https://orcid.org/0000-0003-1975-3785"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, 350001, China","Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, 350001, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]},{"raw_affiliation_string":"Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047358063","display_name":"Yong Chen","orcid":"https://orcid.org/0000-0003-1528-3456"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Chen","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025984290","display_name":"Yijuan Liu","orcid":"https://orcid.org/0000-0002-2486-8037"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YiJuan Liu","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068574869","display_name":"YiJuan Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YiJuan Lin","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101332221","display_name":"XunRu Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XunRu Huang","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044384270","display_name":"Ting Wu","orcid":"https://orcid.org/0000-0002-5350-1277"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wu","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020004662","display_name":"Chengdang Wang","orcid":"https://orcid.org/0000-0003-0855-9055"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ChengDang Wang","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066699447","display_name":"Jian Ding","orcid":"https://orcid.org/0000-0002-3132-0045"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Ding","raw_affiliation_strings":["Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China. dingjian@fjmu.edu.cn","Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. dingjian@fjmu.edu.cn","Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China. dingjian@fjmu.edu.cn","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. dingjian@fjmu.edu.cn","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.837,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86146504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"191","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.4187999963760376,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.4187999963760376,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.7209718227386475},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.7128088474273682},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6404386758804321},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6026653051376343},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5830656290054321},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.5730067491531372},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.4921199679374695},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4270833134651184},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3554326891899109},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.33403146266937256},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32098156213760376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24594390392303467}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7209718227386475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7128088474273682},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6404386758804321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6026653051376343},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5830656290054321},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5730067491531372},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4921199679374695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4270833134651184},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3554326891899109},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33403146266937256},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32098156213760376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24594390392303467}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05312-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05312-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05312-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37161430","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37161430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10170748","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10170748","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10170748/pdf/12859_2023_Article_5312.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:96db03411c774aeb9b6f82a3987245c5","is_oa":true,"landing_page_url":"https://doaj.org/article/96db03411c774aeb9b6f82a3987245c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-21 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05312-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05312-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05312-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.550000011920929,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4376131137.pdf"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1999439172","https://openalex.org/W2035618305","https://openalex.org/W2049553585","https://openalex.org/W2050457398","https://openalex.org/W2060462114","https://openalex.org/W2081484203","https://openalex.org/W2087751238","https://openalex.org/W2104885590","https://openalex.org/W2149441684","https://openalex.org/W2159482845","https://openalex.org/W2230320310","https://openalex.org/W2281046076","https://openalex.org/W2327519840","https://openalex.org/W2336083362","https://openalex.org/W2560367415","https://openalex.org/W2576334800","https://openalex.org/W2587048937","https://openalex.org/W2617691667","https://openalex.org/W2747774814","https://openalex.org/W2753413024","https://openalex.org/W2764159587","https://openalex.org/W2765224588","https://openalex.org/W2792959776","https://openalex.org/W2797069917","https://openalex.org/W2797605742","https://openalex.org/W2801279436","https://openalex.org/W2802657011","https://openalex.org/W2884640344","https://openalex.org/W2885139325","https://openalex.org/W2885229054","https://openalex.org/W2885715971","https://openalex.org/W2896864420","https://openalex.org/W2896872272","https://openalex.org/W2911909558","https://openalex.org/W2913930991","https://openalex.org/W2940561057","https://openalex.org/W2942610007","https://openalex.org/W2946860111","https://openalex.org/W2949273159","https://openalex.org/W2956286257","https://openalex.org/W2965067427","https://openalex.org/W2967492826","https://openalex.org/W2970027515","https://openalex.org/W2971316059","https://openalex.org/W2992210240","https://openalex.org/W2995684511","https://openalex.org/W2997645486","https://openalex.org/W3003649900","https://openalex.org/W3005148546","https://openalex.org/W3011996328","https://openalex.org/W3013125967","https://openalex.org/W3014160477","https://openalex.org/W3017925477","https://openalex.org/W3035999666","https://openalex.org/W3046552417","https://openalex.org/W3092460423","https://openalex.org/W3102888556","https://openalex.org/W3108993377","https://openalex.org/W3116384399","https://openalex.org/W3128646645","https://openalex.org/W3129551551","https://openalex.org/W3134862436","https://openalex.org/W3151554208","https://openalex.org/W3157208801","https://openalex.org/W3197441882","https://openalex.org/W3200528953","https://openalex.org/W3209967106","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4360983034","https://openalex.org/W4286629873","https://openalex.org/W4281389645","https://openalex.org/W4304979265","https://openalex.org/W2938706471","https://openalex.org/W3217412908","https://openalex.org/W4385847677","https://openalex.org/W3151427897","https://openalex.org/W2074869009","https://openalex.org/W2898701288"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gastric":[1],"cancer":[2,11,26,38,53,87,164,197,217],"is":[3],"the":[4,46,59,65,95,121,148,171,221],"third":[5],"leading":[6],"cause":[7],"of":[8,61],"death":[9],"from":[10,41],"worldwide":[12],"and":[13,21,45,55,64,81,94,111,153,157,174,181,192,201,211,219],"has":[14,31],"a":[15,77,208],"poor":[16],"prognosis.":[17],"Practical":[18],"risk":[19,101,117,138,209],"scores":[20],"prognostic":[22,78],"models":[23],"for":[24,52,85,116,195,215],"gastric":[25,37,86,163,196,216,226],"are":[27,50],"lacking.":[28],"While":[29],"immunotherapy":[30,56,69,224],"succeeded":[32],"in":[33,68,120,162,184,225],"some":[34],"cancers,":[35],"few":[36],"patients":[39,89,198,218],"benefit":[40],"immunotherapy.":[42],"Immune":[43],"genes":[44,63,93],"tumor":[47,66,96,129],"microenvironment":[48,67],"(TME)":[49],"essential":[51],"progression":[54],"response.":[57],"However,":[58],"roles":[60],"immune":[62,92,145,149],"remain":[70],"unclear.":[71],"The":[72,137,176],"study":[73],"aimed":[74],"to":[75],"construct":[76],"prediction":[79,213],"model":[80],"identify":[82],"immunotherapeutic":[83],"targets":[84],"(GC)":[88],"by":[90,127],"exploring":[91],"microenvironment.":[97],"RESULTS:":[98],"An":[99],"immune-related":[100],"score":[102],"(IRRS)":[103],"model,":[104],"including":[105],"APOH,":[106],"RNASE2,":[107],"F2R,":[108],"DEFB126,":[109],"CXCL6,":[110],"CXCL3":[112,156],"genes,":[113],"was":[114,125,140],"constructed":[115],"stratification.":[118],"Patients":[119],"low-risk":[122],"group,":[123],"which":[124],"characterized":[126],"elevated":[128],"mutation":[130],"burden":[131],"(TMB)":[132],"have":[133],"higher":[134],"survival":[135,187],"rate.":[136],"level":[139],"remarkably":[141],"correlated":[142],"with":[143,167],"tumor-infiltrating":[144],"cells":[146],"(TIICs),":[147],"checkpoint":[150],"molecule":[151],"expression,":[152],"immunophenoscore":[154],"(IPS).":[155],"CXCL6":[158],"were":[159],"significantly":[160],"upregulated":[161],"tissues":[165,169],"compared":[166],"normal":[168],"using":[170,199],"UALCAN":[172],"database":[173],"RT-qPCR.":[175],"nomogram":[177],"showed":[178],"good":[179],"calibration":[180],"moderate":[182],"discrimination":[183],"predicting":[185],"overall":[186],"(OS)":[188],"at":[189],"1-,":[190],"3-,":[191],"5-":[193],"year":[194],"risk-level":[200],"clinical":[202],"characteristics.":[203],"CONCLUSION:":[204],"Our":[205],"findings":[206],"provided":[207],"stratification":[210],"prognosis":[212],"tool":[214],"further":[220],"research":[222],"into":[223],"cancer.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}