{"id":"https://openalex.org/W4379534861","doi":"https://doi.org/10.1186/s12859-023-05302-3","title":"Comprehensive analyses of a CD8+ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma","display_name":"Comprehensive analyses of a CD8+ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma","publication_year":2023,"publication_date":"2023-06-06","ids":{"openalex":"https://openalex.org/W4379534861","doi":"https://doi.org/10.1186/s12859-023-05302-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/37280525"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05302-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05302-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05302-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05302-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059738737","display_name":"Chen Liang","orcid":"https://orcid.org/0000-0003-0578-7589"},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Chen","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111632176","display_name":"Yiming Weng","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Weng","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101793953","display_name":"Xue Cui","orcid":"https://orcid.org/0009-0003-6370-6561"},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Cui","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037145422","display_name":"Qian Li","orcid":"https://orcid.org/0000-0002-3675-7131"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Li","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102001654","display_name":"Min Peng","orcid":"https://orcid.org/0000-0001-6648-945X"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Peng","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China. mpeng320@whu.edu.cn","Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China. mpeng320@whu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102201896","display_name":"Qibin Song","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qibin Song","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China. qibinsong@whu.edu.cn","Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China. qibinsong@whu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5059738737"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.3909,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.92977112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"238","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.790912389755249},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.6817805767059326},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.6806004047393799},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5975778102874756},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.48724427819252014},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.45959481596946716},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4523329734802246},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma-of-the-lung","display_name":"Squamous-cell carcinoma of the lung","score":0.4467832148075104},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.43597328662872314},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.4156375527381897},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.403575599193573},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.39820873737335205},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.34948158264160156},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3395320177078247},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2701647877693176}],"concepts":[{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.790912389755249},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6817805767059326},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6806004047393799},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5975778102874756},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48724427819252014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45959481596946716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4523329734802246},{"id":"https://openalex.org/C2779327097","wikidata":"https://www.wikidata.org/wiki/Q5749020","display_name":"Squamous-cell carcinoma of the lung","level":3,"score":0.4467832148075104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43597328662872314},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4156375527381897},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.403575599193573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39820873737335205},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34948158264160156},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3395320177078247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2701647877693176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05302-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05302-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05302-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37280525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37280525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10246359","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10246359","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10246359/pdf/12859_2023_Article_5302.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2ee8a1a2937c4395b4f28fde1bf28125","is_oa":true,"landing_page_url":"https://doaj.org/article/2ee8a1a2937c4395b4f28fde1bf28125","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-21 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05302-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05302-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05302-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"awards":[{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3425285751","display_name":null,"funder_award_id":"2022-02","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G37568934","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5783365073","display_name":null,"funder_award_id":"320.6750","funder_id":"https://openalex.org/F4320332531","funder_display_name":"Wu Jieping Medical Foundation"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6984591891","display_name":null,"funder_award_id":"No. 81770169","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8612929915","display_name":null,"funder_award_id":"81770169","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332531","display_name":"Wu Jieping Medical Foundation","ror":"https://ror.org/05dgwj702"},{"id":"https://openalex.org/F4320336485","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4379534861.pdf"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1498900438","https://openalex.org/W1827639246","https://openalex.org/W1850463836","https://openalex.org/W1922412259","https://openalex.org/W1942897646","https://openalex.org/W1966327575","https://openalex.org/W1971762239","https://openalex.org/W1982488143","https://openalex.org/W2022996006","https://openalex.org/W2032831781","https://openalex.org/W2039123767","https://openalex.org/W2042484209","https://openalex.org/W2042699075","https://openalex.org/W2044511084","https://openalex.org/W2049491375","https://openalex.org/W2066671159","https://openalex.org/W2071793654","https://openalex.org/W2075294566","https://openalex.org/W2089220120","https://openalex.org/W2092772483","https://openalex.org/W2099328098","https://openalex.org/W2112601576","https://openalex.org/W2130410032","https://openalex.org/W2130430382","https://openalex.org/W2136989592","https://openalex.org/W2156359701","https://openalex.org/W2159482845","https://openalex.org/W2159707944","https://openalex.org/W2165365045","https://openalex.org/W2214074259","https://openalex.org/W2251227974","https://openalex.org/W2340636398","https://openalex.org/W2508069933","https://openalex.org/W2560367415","https://openalex.org/W2560704457","https://openalex.org/W2572174216","https://openalex.org/W2578528809","https://openalex.org/W2587048937","https://openalex.org/W2753490666","https://openalex.org/W2770609569","https://openalex.org/W2782998220","https://openalex.org/W2784371446","https://openalex.org/W2788142646","https://openalex.org/W2887577080","https://openalex.org/W2896872272","https://openalex.org/W2905644126","https://openalex.org/W2907564726","https://openalex.org/W2910873889","https://openalex.org/W2938006760","https://openalex.org/W2949273159","https://openalex.org/W2963686803","https://openalex.org/W2966710588","https://openalex.org/W2969718750","https://openalex.org/W2976744492","https://openalex.org/W2996238888","https://openalex.org/W3003807413","https://openalex.org/W3046492887","https://openalex.org/W3047106569","https://openalex.org/W3102922803","https://openalex.org/W3128646645","https://openalex.org/W3151814790","https://openalex.org/W3179304282","https://openalex.org/W3194967298","https://openalex.org/W3203575974","https://openalex.org/W3204698434","https://openalex.org/W4224211731","https://openalex.org/W4282935115","https://openalex.org/W4293109981","https://openalex.org/W4294216483","https://openalex.org/W4307425304"],"related_works":["https://openalex.org/W3029386772","https://openalex.org/W3159716479","https://openalex.org/W3093899576","https://openalex.org/W4206523383","https://openalex.org/W2340237593","https://openalex.org/W2020684972","https://openalex.org/W2041921061","https://openalex.org/W3030597314","https://openalex.org/W1572148375","https://openalex.org/W2379544873"],"abstract_inverted_index":{"Lung":[0],"squamous":[1],"cell":[2,17,37,105,116,176,246,262],"carcinoma":[3],"(LUSC)":[4],"is":[5,44,269],"associated":[6],"with":[7,81,300],"a":[8,168,287,309,322],"worse":[9],"prognosis":[10,330],"than":[11,108,225,292],"other":[12],"histological":[13],"subtypes":[14],"of":[15,25,34,46,54,60,72,89,102,113,134,215,227,313],"non-small":[16],"lung":[18],"cancer.":[19],"Due":[20],"to":[21,68,94,154,161,285,290,328],"the":[22,32,70,79,87,99,110,156,181,199,219,228,232,249,265,276,280,295,314],"vital":[23],"role":[24],"CD8<sup>+</sup>":[26,35,74,103,114,162,174,255],"T":[27,36,75,104,115,163,175,256,261],"cells":[28,76,137,257],"in":[29,42,98,109,138,209,218,231,238,248,264,279,294,318],"anti-tumor":[30],"immunity,":[31],"characterization":[33],"infiltration-related":[38],"(CTLIR)":[39],"gene":[40,158,170,200,316],"signature":[41,171,201,317],"LUSC":[43,55,90,139,187,210,216,277,319,326],"worthy":[45],"in-depth":[47],"exploration.":[48],"In":[49,305],"our":[50],"study,":[51],"tumor":[52,250],"tissues":[53],"patients":[56,91,140,188,217,278,327],"from":[57,125],"Renmin":[58],"Hospital":[59],"Wuhan":[61],"University":[62],"were":[63,283],"stained":[64],"by":[65,143],"multiplex":[66],"immunohistochemistry":[67],"evaluate":[69],"density":[71,101,112],"infiltrated":[73],"and":[77,147,179,191,196,252,258,302,320,331],"explore":[78],"correlation":[80,149],"immunotherapy":[82,95,291,332],"response.":[83,333],"We":[84,165,243],"found":[85,253],"that":[86,226],"proportion":[88],"who":[92],"responded":[93],"was":[96,141,152,202,222,236],"higher":[97],"high":[100],"infiltration":[106,117,247,263],"group":[107,221,230,282,297],"low":[111],"group.":[118],"Subsequently,":[119],"we":[120,307],"collected":[121],"bulk":[122],"RNA-sequencing":[123],"data":[124],"The":[126,132,212],"Cancer":[127],"Genome":[128],"Atlas":[129],"(TCGA)":[130],"database.":[131],"abundance":[133],"infiltrating":[135],"immune":[136,245],"analyzed":[142,244],"using":[144],"CIBERSORT":[145],"algorithm,":[146],"weighted":[148],"network":[150],"analysis":[151,312],"performed":[153,308],"identify":[155],"co-expressed":[157,177],"modules":[159],"related":[160],"cells.":[164],"then":[166],"developed":[167],"prognostic":[169,207],"based":[172],"on":[173],"genes":[178],"calculated":[180],"CTLIR":[182,315],"risk":[183,323],"score,":[184],"which":[185,235,268],"stratified":[186],"into":[189],"high-risk":[190,220,266,281],"low-risk":[192,229,296],"groups.":[193],"With":[194],"univariate":[195],"multivariate":[197],"analyses,":[198],"identified":[203],"as":[204,271],"an":[205,272],"independent":[206],"factor":[208],"patients.":[211],"overall":[213],"survival":[214],"significantly":[223],"shorter":[224],"TCGA":[233],"cohort,":[234],"validated":[237],"Gene":[239],"Expression":[240],"Omnibus":[241],"datasets.":[242],"microenviroment":[251],"fewer":[254],"more":[259],"regulatory":[260],"group,":[267],"characterized":[270],"immunosuppressive":[273],"phenotype.":[274],"Furthermore,":[275],"predicted":[284],"have":[286],"better":[288],"response":[289],"those":[293],"when":[298],"treated":[299],"PD-1":[301],"CTLA4":[303],"inhibitors.":[304],"conclusion,":[306],"comprehensive":[310],"molecular":[311],"constructed":[321],"model":[324],"for":[325],"predict":[329]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2023-06-07T00:00:00"}