{"id":"https://openalex.org/W4367368463","doi":"https://doi.org/10.1186/s12859-023-05299-9","title":"Screening prognostic markers for hepatocellular carcinoma based on pyroptosis-related lncRNA pairs","display_name":"Screening prognostic markers for hepatocellular carcinoma based on pyroptosis-related lncRNA pairs","publication_year":2023,"publication_date":"2023-04-29","ids":{"openalex":"https://openalex.org/W4367368463","doi":"https://doi.org/10.1186/s12859-023-05299-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/37120506"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05299-9","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05299-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05299-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05299-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101813382","display_name":"Tong Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Wu","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368210","display_name":"Na Li","orcid":"https://orcid.org/0000-0003-3619-7899"},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022729788","display_name":"Fengyuan Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyuan Luo","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430128","display_name":"Zhihong Chen","orcid":"https://orcid.org/0000-0002-7359-9056"},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihong Chen","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084562639","display_name":"Liyuan Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Ma","raw_affiliation_strings":["School of Public Health and Health Management, Gannan Medical University, Ganzhou, 341000, China","School of Public Health and Health Management, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Health Management, Gannan Medical University, Ganzhou, 341000, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Public Health and Health Management, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053415156","display_name":"Tao Hu","orcid":"https://orcid.org/0000-0002-0418-1246"},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Hu","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103052282","display_name":"Guini Hong","orcid":"https://orcid.org/0000-0002-0277-6123"},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guini Hong","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China. hongguini08@gmail.com","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China. hongguini08@gmail.com","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101819060","display_name":"Hong\u2010Dong Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongdong Li","raw_affiliation_strings":["School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China. biomantis_lhd@163.com","School of Medical Information Engineering, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, 341000, China. biomantis_lhd@163.com","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"School of Medical Information Engineering, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101819060","https://openalex.org/A5103052282"],"corresponding_institution_ids":["https://openalex.org/I4210113195"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.4036,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64387356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"24","issue":"1","first_page":"176","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.6507265567779541},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.6069196462631226},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5312445163726807},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.5230116248130798},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.4690808653831482},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.46624675393104553},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43873706459999084},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"Competing endogenous RNA","score":0.4260638952255249},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4142017066478729},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.4093344807624817},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40413305163383484},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35302406549453735},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3205132484436035},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29496073722839355},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"Long non-coding RNA","score":0.22276535630226135},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.19436660408973694},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14313507080078125},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10423609614372253},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08241528272628784}],"concepts":[{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6507265567779541},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6069196462631226},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5312445163726807},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.5230116248130798},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4690808653831482},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.46624675393104553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43873706459999084},{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.4260638952255249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4142017066478729},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4093344807624817},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40413305163383484},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35302406549453735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3205132484436035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29496073722839355},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.22276535630226135},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.19436660408973694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14313507080078125},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10423609614372253},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08241528272628784}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05299-9","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05299-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05299-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37120506","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37120506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10148420","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10148420","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10148420/pdf/12859_2023_Article_5299.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9bce5047b06d4c6c8f03fd74d1e07409","is_oa":true,"landing_page_url":"https://doaj.org/article/9bce5047b06d4c6c8f03fd74d1e07409","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05299-9","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-023-05299-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05299-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2725284638","display_name":null,"funder_award_id":"Grant No. 61961002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2963555711","display_name":null,"funder_award_id":"61961002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326701","display_name":"Recruitment Program of Global Experts","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367368463.pdf","grobid_xml":"https://content.openalex.org/works/W4367368463.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W861551241","https://openalex.org/W1893007615","https://openalex.org/W1985987855","https://openalex.org/W2025345760","https://openalex.org/W2238063610","https://openalex.org/W2321992114","https://openalex.org/W2431332237","https://openalex.org/W2560658543","https://openalex.org/W2655262992","https://openalex.org/W2793308884","https://openalex.org/W2914396734","https://openalex.org/W2915006341","https://openalex.org/W2926096131","https://openalex.org/W2950245505","https://openalex.org/W2977165675","https://openalex.org/W2983020673","https://openalex.org/W2989955733","https://openalex.org/W3005889306","https://openalex.org/W3011500848","https://openalex.org/W3023170814","https://openalex.org/W3029717128","https://openalex.org/W3033560784","https://openalex.org/W3036762817","https://openalex.org/W3039436229","https://openalex.org/W3040967714","https://openalex.org/W3122331031","https://openalex.org/W3135850479","https://openalex.org/W3167306794","https://openalex.org/W3180882235","https://openalex.org/W3181214796","https://openalex.org/W3183286210","https://openalex.org/W3188985011","https://openalex.org/W3192091695","https://openalex.org/W3195139750","https://openalex.org/W3196304799","https://openalex.org/W3200197106","https://openalex.org/W3201486703","https://openalex.org/W3206956285","https://openalex.org/W3212529016","https://openalex.org/W3214132926","https://openalex.org/W4206380558","https://openalex.org/W4207026808","https://openalex.org/W4214833093","https://openalex.org/W4221051195","https://openalex.org/W4224990981","https://openalex.org/W4281483833","https://openalex.org/W4283380478"],"related_works":["https://openalex.org/W2049578243","https://openalex.org/W1828158523","https://openalex.org/W2122079181","https://openalex.org/W2000145235","https://openalex.org/W1985848810","https://openalex.org/W2889939530","https://openalex.org/W2399195672","https://openalex.org/W3121881699","https://openalex.org/W2748838164","https://openalex.org/W2066015000"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pyroptosis":[1],"is":[2,298],"closely":[3],"related":[4],"to":[5,13,75,275,322],"cancer":[6],"prognosis.":[7,310],"In":[8],"this":[9],"study,":[10],"we":[11],"tried":[12],"construct":[14],"an":[15],"individualized":[16],"prognostic":[17,161,283],"risk":[18,90,162,183,271],"model":[19,91,163,184,272,297],"for":[20,92,166,185,301],"hepatocellular":[21],"carcinoma":[22],"(HCC)":[23],"based":[24,55,82,115],"on":[25,56,83,116],"within-sample":[26],"relative":[27],"expression":[28],"orderings":[29],"(REOs)":[30],"of":[31,38,85,174,181,229,241,279,288],"pyroptosis-related":[32,67],"lncRNAs":[33,59],"(PRlncRNAs).":[34],"METHODS:":[35],"RNA-seq":[36],"data":[37],"343":[39],"HCC":[40,93,147,289,309],"samples":[41,148],"derived":[42,121],"from":[43,122],"The":[44,168,296],"Cancer":[45],"Genome":[46],"Atlas":[47],"(TCGA)":[48],"database":[49],"were":[50,53,191,211,267],"analyzed.":[51],"PRlncRNAs":[52],"detected":[54],"differentially":[57],"expressed":[58],"between":[60,143,306],"sample":[61],"groups":[62],"clustered":[63],"by":[64,96],"40":[65],"reported":[66],"genes":[68],"(PRGs).":[69],"Univariate":[70],"Cox":[71,102,153],"regression":[72,103],"was":[73,94,113,164],"used":[74],"screen":[76],"out":[77],"prognosis-related":[78,86,107],"PRlncRNA":[79,87,138,282],"pairs.":[80],"Then,":[81],"REOs":[84,145],"pairs,":[88],"a":[89,106,226,238],"constructed":[95,165],"combining":[97],"LASSO":[98],"and":[99,125,131,149,188,194,234,237,293,308,317],"stepwise":[100],"multivariate":[101],"analysis.":[104],"Finally,":[105,259],"competing":[108],"endogenous":[109],"RNA":[110],"(ceRNA)":[111],"network":[112],"built":[114],"information":[117],"about":[118],"lncRNA-miRNA-mRNA":[119,261],"interactions":[120],"the":[123,171,182,197,214,247,277,280,286,303],"miRNet":[124],"TargetScan":[126],"databases.":[127],"RESULTS:":[128],"(FC)|>":[129],"1":[130],"FDR":[132],"<":[133,156,219],"5%).":[134],"Among":[135],"them,":[136],"83":[137],"pairs":[139],"showed":[140,205],"significant":[141],"associations":[142],"their":[144],"within":[146],"overall":[150],"survival":[151,190],"(Univariate":[152],"regression,":[154],"p":[155],"0.005).":[157],"An":[158],"optimal":[159],"11-PRlncRNA-pair":[160],"HCC.":[167],"areas":[169],"under":[170],"curves":[172,180],"(AUCs)":[173],"time-dependent":[175],"receiver":[176],"operating":[177],"characteristic":[178],"(ROC)":[179],"1-,":[186],"3-,":[187],"5-year":[189],"0.737,":[192],"0.705,":[193],"0.797":[195],"in":[196,213,246,256,285],"validation":[198],"set,":[199],"respectively.":[200],"Gene":[201],"Set":[202],"Enrichment":[203],"Analysis":[204],"that":[206,251],"inflammation-related":[207],"interleukin":[208],"signaling":[209],"pathways":[210],"upregulated":[212],"predicted":[215],"high-risk":[216,248,257],"group":[217],"(p":[218],"0.05).":[220],"Tumor":[221],"immune":[222,323],"infiltration":[223],"analysis":[224],"revealed":[225],"higher":[227],"abundance":[228,240],"regulatory":[230,262],"T":[231,244],"cells":[232,245],"(Tregs)":[233],"M2":[235],"macrophages":[236],"lower":[239],"CD8":[242],"+":[243],"group,":[249],"indicating":[250],"excessive":[252,315],"pyroptosis":[253,266,307,316],"might":[254],"occur":[255],"patients.":[258],"eleven":[260],"axes":[263],"associated":[264],"with":[265],"established.":[268],"CONCLUSION:":[269],"Our":[270],"allowed":[273],"us":[274],"determine":[276],"robustness":[278],"REO-based":[281],"biomarkers":[284],"stratification":[287],"patients":[290,312],"at":[291],"high":[292],"low":[294],"risk.":[295],"also":[299],"helpful":[300],"understanding":[302],"molecular":[304],"mechanisms":[305],"High-risk":[311],"may":[313],"have":[314],"thus":[318],"be":[319],"less":[320],"sensitive":[321],"therapy.":[324]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-10-10T00:00:00"}