{"id":"https://openalex.org/W4366684923","doi":"https://doi.org/10.1186/s12859-023-05285-1","title":"Predicting disease genes based on multi-head attention fusion","display_name":"Predicting disease genes based on multi-head attention fusion","publication_year":2023,"publication_date":"2023-04-21","ids":{"openalex":"https://openalex.org/W4366684923","doi":"https://doi.org/10.1186/s12859-023-05285-1"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05285-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05285-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05285-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05285-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100437378","display_name":"Linlin Zhang","orcid":"https://orcid.org/0000-0002-0823-7825"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linlin Zhang","raw_affiliation_strings":["College of Software Engineering, Xinjiang University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Software Engineering, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001199873","display_name":"Dianrong Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dianrong Lu","raw_affiliation_strings":["College of information Science and Engineering, Xinjiang University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of information Science and Engineering, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036241949","display_name":"Xuehua Bi","orcid":"https://orcid.org/0009-0004-4861-1588"},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuehua Bi","raw_affiliation_strings":["Medical Engineering and Technology College, Xinjiang Medical University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Engineering and Technology College, Xinjiang Medical University, Urumqi, China","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066909470","display_name":"Kai Zhao","orcid":"https://orcid.org/0000-0002-5448-9919"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Zhao","raw_affiliation_strings":["College of information Science and Engineering, Xinjiang University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of information Science and Engineering, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072554320","display_name":"Guanglei Yu","orcid":"https://orcid.org/0000-0003-0954-3397"},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanglei Yu","raw_affiliation_strings":["Medical Engineering and Technology College, Xinjiang Medical University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Engineering and Technology College, Xinjiang Medical University, Urumqi, China","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022558170","display_name":"Quan Na","orcid":"https://orcid.org/0000-0002-7315-0283"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Quan","raw_affiliation_strings":["College of information Science and Engineering, Xinjiang University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of information Science and Engineering, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100437378"],"corresponding_institution_ids":["https://openalex.org/I96908189"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.0352,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86550699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6144886612892151},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5608693361282349},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.5533964037895203},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4933542311191559},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4393376410007477},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4325310289859772},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.42163556814193726},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.417710542678833},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40270864963531494},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.38639503717422485},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38117751479148865},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3655663728713989},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.284426748752594},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1875944435596466},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15577954053878784},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09601941704750061}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6144886612892151},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5608693361282349},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.5533964037895203},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4933542311191559},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4393376410007477},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4325310289859772},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.42163556814193726},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.417710542678833},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40270864963531494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38639503717422485},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38117751479148865},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3655663728713989},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.284426748752594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1875944435596466},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15577954053878784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09601941704750061},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-023-05285-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05285-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05285-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10122338","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10122338","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10122338/pdf/12859_2023_Article_5285.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c66c264b015441c28c315f25e6775223","is_oa":true,"landing_page_url":"https://doaj.org/article/c66c264b015441c28c315f25e6775223","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05285-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05285-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05285-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2398480082","display_name":null,"funder_award_id":"12061071","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325419","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4366684923.pdf"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W134776625","https://openalex.org/W1554187497","https://openalex.org/W1888005072","https://openalex.org/W1889698115","https://openalex.org/W2008081023","https://openalex.org/W2020755434","https://openalex.org/W2053039860","https://openalex.org/W2103478816","https://openalex.org/W2146653758","https://openalex.org/W2146858327","https://openalex.org/W2174734928","https://openalex.org/W2298399661","https://openalex.org/W2343509590","https://openalex.org/W2567080747","https://openalex.org/W2582585762","https://openalex.org/W2588025094","https://openalex.org/W2601349417","https://openalex.org/W2735687500","https://openalex.org/W2767734009","https://openalex.org/W2775321412","https://openalex.org/W2780779540","https://openalex.org/W2785628313","https://openalex.org/W2790106378","https://openalex.org/W2799259690","https://openalex.org/W2808373515","https://openalex.org/W2895679848","https://openalex.org/W2899288360","https://openalex.org/W2911286998","https://openalex.org/W2912263218","https://openalex.org/W2912672202","https://openalex.org/W2918710707","https://openalex.org/W2950777612","https://openalex.org/W2962756421","https://openalex.org/W2983166786","https://openalex.org/W3004052817","https://openalex.org/W3004554602","https://openalex.org/W3012114135","https://openalex.org/W3036981277","https://openalex.org/W3037835453","https://openalex.org/W3080501980","https://openalex.org/W3093030756","https://openalex.org/W3099929518","https://openalex.org/W3102751229","https://openalex.org/W3107677589","https://openalex.org/W3124828689","https://openalex.org/W3152635550","https://openalex.org/W3182125560","https://openalex.org/W4205450773","https://openalex.org/W4205567020","https://openalex.org/W4255156463","https://openalex.org/W4283718164","https://openalex.org/W4296919006","https://openalex.org/W6702248584","https://openalex.org/W6726335300"],"related_works":["https://openalex.org/W2155492529","https://openalex.org/W4252504573","https://openalex.org/W4385510321","https://openalex.org/W2101315668","https://openalex.org/W15348386","https://openalex.org/W2314128295","https://openalex.org/W4287026692","https://openalex.org/W1509942269","https://openalex.org/W2770735656","https://openalex.org/W2131550814"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,133],"identification":[3],"of":[4,8,16,40,82,106,138],"disease-related":[5],"genes":[6,84,154],"is":[7,44,125,150],"great":[9],"significance":[10],"for":[11,201],"the":[12,36,67,77,103,110,113,129,160,181],"diagnosis":[13],"and":[14,26,38,112,173,187,208],"treatment":[15],"human":[17],"disease.":[18],"Most":[19],"studies":[20,145],"have":[21],"focused":[22],"on":[23,71],"developing":[24],"efficient":[25],"accurate":[27,190],"computational":[28],"methods":[29,140],"to":[30,35,48,55,65,101,127,152,179],"predict":[31,66,128,153],"disease-causing":[32],"genes.":[33,58],"Due":[34],"sparsity":[37],"complexity":[39],"biomedical":[41,90],"data,":[42,166],"it":[43],"still":[45],"a":[46],"challenge":[47],"develop":[49],"an":[50,63],"effective":[51],"multi-feature":[52],"fusion":[53,74],"model":[54,124,135],"identify":[56],"disease":[57,83,170],"Results":[59],"This":[60],"paper":[61],"proposes":[62],"approach":[64],"pathogenic":[68],"gene":[69],"based":[70],"multi-head":[72,119],"attention":[73],"(MHAGP).":[75],"Firstly,":[76],"heterogeneous":[78,184],"biological":[79,163,185],"information":[80,182],"networks":[81,186],"are":[85,99,115],"constructed":[86],"by":[87,117],"integrating":[88],"multiple":[89],"knowledge":[91],"databases.":[92],"Secondly,":[93],"two":[94],"graph":[95],"representation":[96],"learning":[97],"algorithms":[98],"used":[100,126,200],"capture":[102],"feature":[104],"vectors":[105],"gene-disease":[107,130],"pairs":[108],"from":[109],"network,":[111],"features":[114],"fused":[116],"introducing":[118],"attention.":[120],"Finally,":[121],"multi-layer":[122],"perceptron":[123],"association.":[131],"Conclusions":[132],"MHAGP":[134,149,194],"outperforms":[136],"all":[137],"other":[139],"in":[141,183],"comparative":[142],"experiments.":[143],"Case":[144],"also":[146],"show":[147],"that":[148],"able":[151],"potentially":[155],"associated":[156],"with":[157,195],"diseases.":[158],"In":[159,192],"future,":[161],"more":[162,189],"entity":[164],"association":[165,207,210],"such":[167,204],"as":[168,205],"gene-drug,":[169],"phenotype-gene":[171],"ontology":[172],"so":[174],"on,":[175],"can":[176,198],"be":[177,199],"added":[178],"expand":[180],"achieve":[188],"predictions.":[191],"addition,":[193],"strong":[196],"expansibility":[197],"potential":[202],"tasks":[203],"gene-drug":[206],"drug-disease":[209],"prediction.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}