{"id":"https://openalex.org/W4327676970","doi":"https://doi.org/10.1186/s12859-023-05162-x","title":"Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine","display_name":"Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine","publication_year":2023,"publication_date":"2023-03-16","ids":{"openalex":"https://openalex.org/W4327676970","doi":"https://doi.org/10.1186/s12859-023-05162-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/36927444"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05162-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05162-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05162-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05162-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046736174","display_name":"Shaima Belhechmi","orcid":"https://orcid.org/0000-0003-3505-7042"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Shaima Belhechmi","raw_affiliation_strings":["Bureau de Biostatistique et d'Epid\u00e9miologie, Gustave Roussy, Villejuif, France","Universit\u00e9 Paris-Saclay, CESP, INSERM U1018 Oncostat, labeled Ligue Contre le Cancer, Villejuif, France","IGR - Institut Gustave Roussy (114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bureau de Biostatistique et d'Epid\u00e9miologie, Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CESP, INSERM U1018 Oncostat, labeled Ligue Contre le Cancer, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210103698","https://openalex.org/I4210095243","https://openalex.org/I277688954"]},{"raw_affiliation_string":"IGR - Institut Gustave Roussy (114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)","institution_ids":["https://openalex.org/I4210103698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062301676","display_name":"Gw\u00e9na\u00ebl Le Teuff","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gw\u00e9na\u00ebl Le Teuff","raw_affiliation_strings":["Bureau de Biostatistique et d'Epid\u00e9miologie, Gustave Roussy, Villejuif, France","Universit\u00e9 Paris-Saclay, CESP, INSERM U1018 Oncostat, labeled Ligue Contre le Cancer, Villejuif, France","CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)","IGR - Institut Gustave Roussy (114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bureau de Biostatistique et d'Epid\u00e9miologie, Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CESP, INSERM U1018 Oncostat, labeled Ligue Contre le Cancer, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210103698","https://openalex.org/I4210095243","https://openalex.org/I277688954"]},{"raw_affiliation_string":"CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)","institution_ids":["https://openalex.org/I4210103698"]},{"raw_affiliation_string":"IGR - Institut Gustave Roussy (114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015048649","display_name":"Riccardo De Bin","orcid":"https://orcid.org/0000-0002-7441-6880"},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Riccardo De Bin","raw_affiliation_strings":["Department of Mathematics, University of Oslo, Oslo, Norway","UiO - University of Oslo (P.O 1072 Blindern 0316 Oslo - Norway)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"UiO - University of Oslo (P.O 1072 Blindern 0316 Oslo - Norway)","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038610822","display_name":"Federico Rotolo","orcid":"https://orcid.org/0000-0003-4837-6501"},"institutions":[{"id":"https://openalex.org/I4210143497","display_name":"Innate Pharma (France)","ror":"https://ror.org/055wa9133","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210143497"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Federico Rotolo","raw_affiliation_strings":["Biostatistics and Data Management Unit, Innate Pharma, Marseille, France","Innate Pharma (117, Avenue de Luminy - BP 30191 13276 Marseille Cedex 09 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Data Management Unit, Innate Pharma, Marseille, France","institution_ids":["https://openalex.org/I4210143497"]},{"raw_affiliation_string":"Innate Pharma (117, Avenue de Luminy - BP 30191 13276 Marseille Cedex 09 - France)","institution_ids":["https://openalex.org/I4210143497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814767","display_name":"Stefan Michiels","orcid":"https://orcid.org/0000-0002-6963-2968"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stefan Michiels","raw_affiliation_strings":["Bureau de Biostatistique et d'Epid\u00e9miologie, Gustave Roussy, Villejuif, France. Stefan.MICHIELS@gustaveroussy.fr","Universit\u00e9 Paris-Saclay, CESP, INSERM U1018 Oncostat, labeled Ligue Contre le Cancer, Villejuif, France. Stefan.MICHIELS@gustaveroussy.fr","IGR - Institut Gustave Roussy (114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bureau de Biostatistique et d'Epid\u00e9miologie, Gustave Roussy, Villejuif, France. Stefan.MICHIELS@gustaveroussy.fr","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CESP, INSERM U1018 Oncostat, labeled Ligue Contre le Cancer, Villejuif, France. Stefan.MICHIELS@gustaveroussy.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210103698","https://openalex.org/I2801843802","https://openalex.org/I277688954"]},{"raw_affiliation_string":"IGR - Institut Gustave Roussy (114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)","institution_ids":["https://openalex.org/I4210103698"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.2845,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55874317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"24","issue":"1","first_page":"96","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.6610000133514404,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.6610000133514404,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.10480000078678131,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.7420562505722046},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.5209166407585144},{"id":"https://openalex.org/keywords/wald-test","display_name":"Wald test","score":0.48240911960601807},{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.4635429084300995},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4602592885494232},{"id":"https://openalex.org/keywords/model-selection","display_name":"Model selection","score":0.4437258839607239},{"id":"https://openalex.org/keywords/elastic-net-regularization","display_name":"Elastic net regularization","score":0.43208327889442444},{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.4230855405330658},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.3621905446052551},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.35684558749198914},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3343436121940613},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3314884603023529},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3313637375831604},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.297779381275177},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.259644478559494},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10390344262123108}],"concepts":[{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.7420562505722046},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5209166407585144},{"id":"https://openalex.org/C203274628","wikidata":"https://www.wikidata.org/wiki/Q748664","display_name":"Wald test","level":3,"score":0.48240911960601807},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4635429084300995},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4602592885494232},{"id":"https://openalex.org/C93959086","wikidata":"https://www.wikidata.org/wiki/Q6888345","display_name":"Model selection","level":2,"score":0.4437258839607239},{"id":"https://openalex.org/C203868755","wikidata":"https://www.wikidata.org/wiki/Q5353562","display_name":"Elastic net regularization","level":3,"score":0.43208327889442444},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.4230855405330658},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.3621905446052551},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.35684558749198914},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3343436121940613},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3314884603023529},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3313637375831604},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.297779381275177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.259644478559494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10390344262123108},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-023-05162-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05162-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05162-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36927444","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36927444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-04068577v1","is_oa":true,"landing_page_url":"https://hal.science/hal-04068577","pdf_url":"https://hal.science/hal-04068577/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2023, 24 (1), ⟨10.1186/s12859-023-05162-x⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10022294","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10022294","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10022294/pdf/12859_2023_Article_5162.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6d55fabc0d1942cc8579637748337697","is_oa":true,"landing_page_url":"https://doaj.org/article/6d55fabc0d1942cc8579637748337697","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-23 (2023)","raw_type":"article"},{"id":"pmh:oai:www.duo.uio.no:10852/101666","is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/101666","pdf_url":null,"source":{"id":"https://openalex.org/S4306401717","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05162-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05162-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05162-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1233420221","display_name":null,"funder_award_id":"U10-CA-69651","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2018742695","display_name":null,"funder_award_id":"U10-CA-69651","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2984511635","display_name":null,"funder_award_id":"U10-CA-37377","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4917586417","display_name":null,"funder_award_id":"U10-CA-12027","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5050820015","display_name":null,"funder_award_id":"U10-CA-37377","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5259609748","display_name":null,"funder_award_id":"U10-CA-12027","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8133433219","display_name":null,"funder_award_id":"U10-CA-69974","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G979864291","display_name":null,"funder_award_id":"U10-CA-69974","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4327676970.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1523985187","https://openalex.org/W1547008859","https://openalex.org/W1589848011","https://openalex.org/W1606003127","https://openalex.org/W1965125844","https://openalex.org/W1971545665","https://openalex.org/W1983724690","https://openalex.org/W1987371344","https://openalex.org/W2000515943","https://openalex.org/W2001414552","https://openalex.org/W2003942385","https://openalex.org/W2005732955","https://openalex.org/W2020925091","https://openalex.org/W2023247746","https://openalex.org/W2031258330","https://openalex.org/W2037559873","https://openalex.org/W2053277483","https://openalex.org/W2065428188","https://openalex.org/W2106298710","https://openalex.org/W2120160881","https://openalex.org/W2120579447","https://openalex.org/W2122825543","https://openalex.org/W2128909276","https://openalex.org/W2134696273","https://openalex.org/W2135046866","https://openalex.org/W2138019504","https://openalex.org/W2140435154","https://openalex.org/W2148487094","https://openalex.org/W2148773517","https://openalex.org/W2152759249","https://openalex.org/W2154779071","https://openalex.org/W2157076315","https://openalex.org/W2163128364","https://openalex.org/W2165139474","https://openalex.org/W2339398872","https://openalex.org/W2554645567","https://openalex.org/W2754214645","https://openalex.org/W2893791232","https://openalex.org/W3018618214","https://openalex.org/W3038489539","https://openalex.org/W3098306969","https://openalex.org/W3099014882","https://openalex.org/W3102650760","https://openalex.org/W3124934600","https://openalex.org/W3147894994","https://openalex.org/W3182571381","https://openalex.org/W3197097833","https://openalex.org/W4232605254","https://openalex.org/W4234698323","https://openalex.org/W4237210482","https://openalex.org/W4288625073"],"related_works":["https://openalex.org/W2468272465","https://openalex.org/W2429564919","https://openalex.org/W757986597","https://openalex.org/W4212910148","https://openalex.org/W4210804200","https://openalex.org/W4213314600","https://openalex.org/W4285814086","https://openalex.org/W3123944750","https://openalex.org/W2787225985","https://openalex.org/W2999956516"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,18,129,201],"research":[2],"of":[3,81,92,132,180,232,243,277,285,287,321,328,337],"biomarker-treatment":[4,323],"interactions":[5,252,280],"is":[6,44,136],"commonly":[7],"investigated":[8],"in":[9,29,38,47,194,223,316,334],"randomized":[10],"clinical":[11],"trials":[12],"(RCT)":[13],"for":[14,59,65,72,124,199,239],"improving":[15],"medicine":[16],"precision.":[17],"hierarchical":[19,74,83,219,319],"interaction":[20,25,84,99,220,291],"constraint":[21,43,320],"states":[22],"that":[23,205],"an":[24],"should":[26],"only":[27],"be":[28],"a":[30,57,159,274,282],"model":[31,67],"if":[32],"its":[33,98,293],"main":[34,95,241,294],"effects":[35,242],"are":[36],"also":[37],"the":[39,48,63,70,73,79,82,93,105,125,178,195,206,213,218,224,229,240,244,259,264,270,289,308,318,322,326,329,335],"model.":[40],"However,":[41,325],"this":[42],"not":[45],"guaranteed":[46],"standard":[49],"penalized":[50],"statistical":[51],"approaches.":[52],"We":[53,111],"aimed":[54],"to":[55,88,103,138,176,332],"find":[56],"compromise":[58],"high-dimensional":[60],"data":[61,189],"between":[62,273],"need":[64,71],"sparse":[66],"selection":[68,107,130,286],"and":[69,97,102,119,154,210,212,235,281,292,302,307],"constraint.":[75,221],"RESULTS:":[76],"To":[77],"favor":[78],"property":[80],"constraint,":[85],"we":[86],"proposed":[87,112],"create":[89],"groups":[90],"composed":[91],"biomarker":[94],"effect":[96,179],"with":[100,144,171,187,299],"treatment":[101],"perform":[104],"bi-level":[106],"on":[108,183],"these":[109,133],"groups.":[110],"two":[113,134],"weighting":[114,306],"approaches":[115,135,312],"(Single":[116],"Wald":[117,301],"(SW)":[118,267],"likelihood":[120,303],"ratio":[121,304],"test":[122,305],"(LRT))":[123],"adaptive":[126,207,265],"lasso":[127,140,143,153,208,216,266,298,311],"method.":[128],"performance":[131,327],"compared":[137],"alternative":[139,225],"extensions":[141],"(adaptive":[142],"ridge-based":[145],"weights,":[146],"composite":[147],"Minimax":[148],"Concave":[149],"Penalty,":[150],"group":[151,214,309],"exponential":[152,215,310],"Sparse":[155],"Group":[156],"Lasso)":[157],"through":[158],"simulation":[160,202],"study.":[161],"A":[162],"RCT":[163],"(NSABP":[164],"B-31)":[165],"randomizing":[166],"1574":[167],"patients":[168],"(431":[169],"events)":[170],"early":[172],"breast":[173],"cancer":[174],"aiming":[175],"evaluate":[177],"adjuvant":[181],"trastuzumab":[182],"distant-recurrence":[184],"free":[185],"survival":[186],"expression":[188],"from":[190],"462":[191],"genes":[192],"measured":[193],"tumour":[196],"will":[197],"serve":[198],"illustration.":[200],"study":[203],"illustrates":[204],"LRT":[209],"SW,":[211],"favored":[217],"Overall,":[222],"scenarios,":[226],"they":[227],"had":[228],"best":[230,271],"balance":[231],"false":[233,236],"discovery":[234],"negative":[237],"rates":[238],"selected":[245,278],"interactions.":[246],"For":[247],"NSABP":[248],"B-31,":[249],"12":[250],"gene-treatment":[251,279,290],"were":[253],"identified":[254],"more":[255],"than":[256],"20%":[257],"by":[258],"different":[260],"methods.":[261],"Among":[262],"them,":[263],"approach":[268],"offered":[269],"trade-off":[272],"high":[275,283],"number":[276],"proportion":[284],"both":[288],"effect.":[295],"CONCLUSIONS:":[296],"Adaptive":[297],"Single":[300],"outperformed":[313],"their":[314],"competitors":[315],"favoring":[317],"interaction.":[324],"methods":[330],"tends":[331],"decrease":[333],"presence":[336],"prognostic":[338],"biomarkers.":[339]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}