{"id":"https://openalex.org/W4317437103","doi":"https://doi.org/10.1186/s12859-023-05147-w","title":"Accommodating multiple potential normalizations in microbiome associations studies","display_name":"Accommodating multiple potential normalizations in microbiome associations studies","publication_year":2023,"publication_date":"2023-01-19","ids":{"openalex":"https://openalex.org/W4317437103","doi":"https://doi.org/10.1186/s12859-023-05147-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/36658484"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-023-05147-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05147-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05147-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05147-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114859696","display_name":"Hoseung Song","orcid":"https://orcid.org/0000-0003-2689-3735"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoseung Song","raw_affiliation_strings":["Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031964723","display_name":"Wodan Ling","orcid":"https://orcid.org/0000-0001-7196-8543"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wodan Ling","raw_affiliation_strings":["Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022433604","display_name":"Ni Zhao","orcid":"https://orcid.org/0000-0002-7762-3949"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ni Zhao","raw_affiliation_strings":["Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017913887","display_name":"Anna Plantinga","orcid":"https://orcid.org/0000-0001-6281-7727"},"institutions":[{"id":"https://openalex.org/I22675022","display_name":"Williams College","ror":"https://ror.org/04avkmd49","country_code":"US","type":"education","lineage":["https://openalex.org/I22675022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna M. Plantinga","raw_affiliation_strings":["Department of Mathematics and Statistics, Williams College, Williamstown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Williams College, Williamstown, MA, USA","institution_ids":["https://openalex.org/I22675022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038249697","display_name":"Courtney A. Broedlow","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney A. Broedlow","raw_affiliation_strings":["Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073843981","display_name":"Nichole R. Klatt","orcid":"https://orcid.org/0000-0003-2968-5480"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nichole R. Klatt","raw_affiliation_strings":["Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005618107","display_name":"Tiffany Hensley\u2010McBain","orcid":"https://orcid.org/0000-0001-6753-5622"},"institutions":[{"id":"https://openalex.org/I4210160556","display_name":"McLaughlin Research Institute","ror":"https://ror.org/05j752d14","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Hensley-McBain","raw_affiliation_strings":["McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT, USA","institution_ids":["https://openalex.org/I4210160556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000129649","display_name":"Michael C. Wu","orcid":"https://orcid.org/0000-0002-3357-6570"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael C. Wu","raw_affiliation_strings":["Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. mcwu@fredhutch.org","Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. mcwu@fredhutch.org","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000129649"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.1274,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77330948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11819","display_name":"Data-Driven Disease Surveillance","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.8691495656967163},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5898986458778381},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.4484022259712219},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43958359956741333},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35320615768432617},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34787455201148987},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.333159476518631},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2475256621837616}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.8691495656967163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5898986458778381},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.4484022259712219},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43958359956741333},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35320615768432617},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34787455201148987},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.333159476518631},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2475256621837616},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-023-05147-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05147-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05147-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36658484","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36658484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9850542","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9850542","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9850542/pdf/12859_2023_Article_5147.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7478464c58bc477f98f48d5f4a4f1bfd","is_oa":true,"landing_page_url":"https://doaj.org/article/7478464c58bc477f98f48d5f4a4f1bfd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 24, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-023-05147-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-023-05147-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-023-05147-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6399999856948853,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[{"id":"https://openalex.org/G2079622261","display_name":null,"funder_award_id":"R01 GM129512, R01 HL155417","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3821584580","display_name":null,"funder_award_id":"R01 HL155417","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4195767192","display_name":null,"funder_award_id":"R01 GM129512","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5611841272","display_name":null,"funder_award_id":"R01 HL155417","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6697275907","display_name":null,"funder_award_id":"R01 GM129512","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317437103.pdf"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1516274582","https://openalex.org/W1975271432","https://openalex.org/W1984883254","https://openalex.org/W2004014148","https://openalex.org/W2026006003","https://openalex.org/W2027946048","https://openalex.org/W2034354646","https://openalex.org/W2037878492","https://openalex.org/W2078112764","https://openalex.org/W2105937617","https://openalex.org/W2133856765","https://openalex.org/W2165799971","https://openalex.org/W2165909549","https://openalex.org/W2167062509","https://openalex.org/W2170055238","https://openalex.org/W2179438025","https://openalex.org/W2413207665","https://openalex.org/W2561012278","https://openalex.org/W2566219535","https://openalex.org/W2592244930","https://openalex.org/W2593051452","https://openalex.org/W2593860444","https://openalex.org/W2646189686","https://openalex.org/W2749493208","https://openalex.org/W2751993817","https://openalex.org/W2761225166","https://openalex.org/W2766375361","https://openalex.org/W2767888154","https://openalex.org/W2769209214","https://openalex.org/W2784198355","https://openalex.org/W2808937895","https://openalex.org/W2889418962","https://openalex.org/W2892058508","https://openalex.org/W2896038997","https://openalex.org/W2923028972","https://openalex.org/W2938785635","https://openalex.org/W2942110779","https://openalex.org/W2946594675","https://openalex.org/W2960429843","https://openalex.org/W2971815815","https://openalex.org/W2996861814","https://openalex.org/W3097282786","https://openalex.org/W3109541743","https://openalex.org/W3141470266","https://openalex.org/W3171259862","https://openalex.org/W3198822282","https://openalex.org/W3206798488","https://openalex.org/W3211779138","https://openalex.org/W4239901565","https://openalex.org/W4281710733","https://openalex.org/W4366595090","https://openalex.org/W6600991396","https://openalex.org/W6715967266"],"related_works":["https://openalex.org/W3007549562","https://openalex.org/W4389663543","https://openalex.org/W164715714","https://openalex.org/W2302405038","https://openalex.org/W2115118361","https://openalex.org/W1988395127","https://openalex.org/W2113656714","https://openalex.org/W2077607936","https://openalex.org/W1485027987","https://openalex.org/W2031691750"],"abstract_inverted_index":{"BACKGROUND:":[0],"Microbial":[1],"communities":[2],"are":[3],"known":[4],"to":[5,9,22,71,133,185,221],"be":[6],"closely":[7],"related":[8],"many":[10],"diseases,":[11],"such":[12],"as":[13,146,148],"obesity":[14],"and":[15,17,45,81,94,119,157,210,230],"HIV,":[16],"it":[18,68,211,241],"is":[19,52,69,109,117,183,212,242],"of":[20,38,75,89,98,161,174,251],"interest":[21],"identify":[23],"differentially":[24],"abundant":[25],"microbial":[26,39],"species":[27,40],"between":[28,79],"two":[29],"or":[30,36,49],"more":[31],"environments.":[32],"Since":[33],"the":[34,73,76,87,96,159,162,177,186,192,218,222,233,238],"abundances":[35],"counts":[37],"usually":[41],"have":[42,64],"different":[43],"scales":[44],"suffer":[46],"from":[47,204],"zero-inflation":[48],"over-dispersion,":[50],"normalization":[51,62,93,100,167,188,208],"a":[53,112,129,141,248],"critical":[54],"step":[55],"before":[56],"conducting":[57],"differential":[58],"abundance":[59],"analysis.":[60],"Several":[61],"approaches":[63],"been":[65],"proposed,":[66],"but":[67],"difficult":[70],"optimize":[72],"characterization":[74],"true":[77],"relationship":[78],"taxa":[80],"interesting":[82],"outcomes.":[83],"RESULTS:":[84],"To":[85],"avoid":[86],"challenge":[88],"picking":[90],"an":[91,104,213],"optimal":[92,224],"accommodate":[95],"advantages":[97],"several":[99],"strategies,":[101],"we":[102],"propose":[103],"omnibus":[105,163,200],"approach.":[106],"Our":[107],"approach":[108,164,179],"based":[110],"on":[111],"Cauchy":[113],"combination":[114],"test,":[115],"which":[116,226],"flexible":[118],"powerful":[120,151,219],"by":[121],"aggregating":[122],"individual":[123,166],"p":[124],"values.":[125],"We":[126,138],"also":[127],"consider":[128],"truncated":[130],"test":[131,201],"statistic":[132],"prevent":[134],"substantial":[135],"power":[136,181,234],"loss.":[137],"experiment":[139],"with":[140,165],"basic":[142],"linear":[143],"regression":[144],"model":[145],"well":[147],"recently":[149],"proposed":[150,199],"association":[152],"tests":[153],"for":[154],"microbiome":[155],"data":[156],"compare":[158],"performance":[160],"approaches.":[168],"Experimental":[169],"results":[170],"show":[171],"that,":[172],"regardless":[173],"simulation":[175],"settings,":[176],"new":[178],"exhibits":[180],"that":[182,216],"close":[184],"best":[187,239],"strategy,":[189],"while":[190],"controling":[191],"type":[193],"I":[194],"error":[195],"well.":[196],"CONCLUSIONS:":[197],"The":[198],"releases":[202],"researchers":[203],"choosing":[205],"among":[206],"various":[207],"methods":[209],"aggregated":[214],"method":[215],"provides":[217],"result":[220],"underlying":[223],"normalization,":[225,240],"requires":[227],"tedious":[228],"trial":[229],"error.":[231],"While":[232],"may":[235],"not":[236],"exceed":[237],"always":[243],"much":[244],"better":[245],"than":[246],"using":[247],"poor":[249],"choice":[250],"normalization.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}