{"id":"https://openalex.org/W4311843963","doi":"https://doi.org/10.1186/s12859-022-05086-y","title":"Establishment and validation of a predictive model of preeclampsia based on transcriptional signatures of 43 genes in decidua basalis and peripheral blood","display_name":"Establishment and validation of a predictive model of preeclampsia based on transcriptional signatures of 43 genes in decidua basalis and peripheral blood","publication_year":2022,"publication_date":"2022-12-07","ids":{"openalex":"https://openalex.org/W4311843963","doi":"https://doi.org/10.1186/s12859-022-05086-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/36476092"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-05086-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-05086-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-05086-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-05086-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104119949","display_name":"Hongya Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongya Zhang","raw_affiliation_strings":["Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China","Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China","Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China","institution_ids":["https://openalex.org/I2800570007","https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I2800570007","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035710123","display_name":"Xuexiang Li","orcid":"https://orcid.org/0000-0002-9309-8259"},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuexiang Li","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000657358","display_name":"Tianying Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianying Zhang","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054902068","display_name":"Qianhui Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianhui Zhou","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China","institution_ids":["https://openalex.org/I28006308"]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100438400","display_name":"Cong Zhang","orcid":"https://orcid.org/0000-0002-9650-4398"},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cong Zhang","raw_affiliation_strings":["Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China. zhangxinyunlife@163.com","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China. zhangxinyunlife@163.com","Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China. zhangxinyunlife@163.com","Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China","Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China","Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China. zhangxinyunlife@163.com","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, 88 East Wenhua Road, Jinan, 250014, Shandong, China. zhangxinyunlife@163.com","institution_ids":[]},{"raw_affiliation_string":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China. zhangxinyunlife@163.com","institution_ids":[]},{"raw_affiliation_string":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I2800570007","https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100438400"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I28006308"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1789,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56421776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"23","issue":"1","first_page":"527","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5501840114593506},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5475963950157166},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5233563780784607},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5069342255592346},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5022566318511963},{"id":"https://openalex.org/keywords/predictive-marker","display_name":"Predictive marker","score":0.42335045337677},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3649614453315735},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2966073155403137},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2751350402832031},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25727859139442444},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22302156686782837},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.10380899906158447}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5501840114593506},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5475963950157166},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5233563780784607},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5069342255592346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5022566318511963},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.42335045337677},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3649614453315735},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2966073155403137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2751350402832031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25727859139442444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22302156686782837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10380899906158447}],"mesh":[{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-022-05086-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-05086-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-05086-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36476092","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36476092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f542c20f2de24b7d879b1bd88c335755","is_oa":true,"landing_page_url":"https://doaj.org/article/f542c20f2de24b7d879b1bd88c335755","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss 1, Pp 1-17 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9730617","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9730617","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-05086-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-05086-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-05086-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1572164912","display_name":null,"funder_award_id":"SDKL2017018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3259716468","display_name":null,"funder_award_id":"31871512","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4363397561","display_name":null,"funder_award_id":"32170863","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4572439582","display_name":null,"funder_award_id":"20DZ2270900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8643175780","display_name":null,"funder_award_id":"2019YFA0802600","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311843963.pdf","grobid_xml":"https://content.openalex.org/works/W4311843963.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1479945039","https://openalex.org/W1506177854","https://openalex.org/W1569789076","https://openalex.org/W1966327575","https://openalex.org/W1978940943","https://openalex.org/W2006089703","https://openalex.org/W2019667426","https://openalex.org/W2024440558","https://openalex.org/W2028572689","https://openalex.org/W2035434033","https://openalex.org/W2059849577","https://openalex.org/W2061325358","https://openalex.org/W2064533570","https://openalex.org/W2072253523","https://openalex.org/W2093775195","https://openalex.org/W2097360283","https://openalex.org/W2102312968","https://openalex.org/W2108818258","https://openalex.org/W2114130914","https://openalex.org/W2131180333","https://openalex.org/W2133650808","https://openalex.org/W2138255346","https://openalex.org/W2139230481","https://openalex.org/W2141586026","https://openalex.org/W2143180984","https://openalex.org/W2153425075","https://openalex.org/W2153454827","https://openalex.org/W2159482845","https://openalex.org/W2164730973","https://openalex.org/W2200191592","https://openalex.org/W2285317998","https://openalex.org/W2328311982","https://openalex.org/W2341276202","https://openalex.org/W2409014598","https://openalex.org/W2504846901","https://openalex.org/W2529672335","https://openalex.org/W2529798299","https://openalex.org/W2626427494","https://openalex.org/W2742971656","https://openalex.org/W2754876366","https://openalex.org/W2774435616","https://openalex.org/W2781215760","https://openalex.org/W2791900271","https://openalex.org/W2806748015","https://openalex.org/W2808436993","https://openalex.org/W2885591256","https://openalex.org/W2890010993","https://openalex.org/W2900144939","https://openalex.org/W2909091351","https://openalex.org/W2916697167","https://openalex.org/W2960659672","https://openalex.org/W2969718750","https://openalex.org/W2980696159","https://openalex.org/W3003512840","https://openalex.org/W3015426139","https://openalex.org/W3037871252","https://openalex.org/W3038735634","https://openalex.org/W3040750692","https://openalex.org/W3082278489","https://openalex.org/W3090821702","https://openalex.org/W3096828292","https://openalex.org/W3135677515","https://openalex.org/W3160415285","https://openalex.org/W3208083157","https://openalex.org/W4205590923","https://openalex.org/W4211051919","https://openalex.org/W4211203631","https://openalex.org/W4294216483","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2037892364","https://openalex.org/W2319154570","https://openalex.org/W3152114242","https://openalex.org/W3028764459"],"abstract_inverted_index":{"Preeclampsia":[0],"(PE)":[1],"has":[2,17],"an":[3,197],"increasing":[4],"incidence":[5],"worldwide,":[6],"and":[7,22,42,75,90,111,129,138,142,149,158,173,176,183,209,239,252],"there":[8],"is":[9,33],"no":[10],"gold":[11],"standard":[12],"for":[13,204,211,249],"prediction.":[14],"Recent":[15],"progress":[16],"shown":[18],"that":[19,189],"abnormal":[20],"decidualization":[21],"impaired":[23],"vascular":[24],"remodeling":[25],"are":[26,92,151,226],"essential":[27],"to":[28,37,47,82,120],"PE":[29,46,74,137,172,182,250],"pathogenesis.":[30],"Therefore,":[31,241],"it":[32],"of":[34,45,65,73,125,136,171,181,202],"great":[35],"significance":[36],"analyze":[38],"the":[39,93,106,123,126,159,200,205,212,218,224,230],"decidua":[40,66],"basalis":[41,67],"blood":[43],"changes":[44],"explore":[48],"new":[49],"methods.":[50],"Here,":[51],"we":[52,104,216],"performed":[53],"weighted":[54],"gene":[55],"co-expression":[56],"network":[57],"analysis":[58],"based":[59],"on":[60],"9553":[61],"differentially":[62],"expressed":[63],"genes":[64,117,128,222],"data":[68],"(GSE60438":[69],"includes":[70,133,168,178],"25":[71],"cases":[72,135,170,180],"23":[76],"non-cases)":[77,140],"from":[78,122],"Gene":[79],"Expression":[80],"Omnibus":[81],"screen":[83],"relevant":[84,119],"module-eigengenes":[85],"(MEs).":[86],"Among":[87],"them,":[88],"MEblue":[89],"MEgrey":[91],"most":[94,118],"correlated":[95],"with":[96,196,229],"PE,":[97],"which":[98],"contains":[99],"371":[100,127],"core":[101],"genes.":[102],"Subsequently,":[103],"applied":[105],"logistic":[107],"least":[108],"absolute":[109],"shrinkage":[110],"selection":[112],"operator":[113],"regression,":[114],"screened":[115],"43":[116,219],"prediction":[121],"intersections":[124],"training":[130,206],"set":[131],"(GSE48424":[132],"18":[134,139],"genes,":[141],"built":[143],"a":[144,246],"predictive":[145,191,233,243],"model.":[146],"The":[147,186],"specificity":[148],"sensitivity":[150],"illustrated":[152],"by":[153,163],"receiver":[154],"operating":[155],"characteristic":[156],"curves,":[157],"stability":[160],"was":[161],"verified":[162],"two":[164],"validation":[165,213],"sets":[166],"(GSE86200":[167],"12":[169],"48":[174],"non-cases,":[175],"GSE85307":[177],"47":[179],"110":[184],"non-cases).":[185],"results":[187],"demonstrated":[188],"our":[190],"model":[192,225,244],"shows":[193],"good":[194],"predictions,":[195],"area":[198],"under":[199],"curve":[201],"0.991":[203],"set,":[207],"0.874":[208],"0.986":[210],"sets.":[214],"Finally,":[215],"found":[217],"key":[220],"marker":[221],"in":[223],"closely":[227],"associated":[228],"clinically":[231],"accepted":[232],"molecules,":[234],"including":[235],"FLT1,":[236],"PIGF,":[237],"ENG":[238],"VEGF.":[240],"this":[242],"provides":[245],"potential":[247],"approach":[248],"diagnosis":[251],"treatment.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
