{"id":"https://openalex.org/W4297493462","doi":"https://doi.org/10.1186/s12859-022-04947-w","title":"Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data","display_name":"Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data","publication_year":2022,"publication_date":"2022-09-28","ids":{"openalex":"https://openalex.org/W4297493462","doi":"https://doi.org/10.1186/s12859-022-04947-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/36171548"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-04947-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04947-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04947-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04947-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014863750","display_name":"Hung Mai","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung Mai","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA","School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046842618","display_name":"Jingxuan Bao","orcid":"https://orcid.org/0000-0001-7127-3258"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingxuan Bao","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA","School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078473635","display_name":"Dokyoon Kim","orcid":"https://orcid.org/0000-0002-4592-9564"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dokyoon Kim","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA. li.shen@pennmedicine.upenn.edu","Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5443-0503","affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA. li.shen@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania, B306 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5593,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.72098637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"23","issue":"S3","first_page":"398","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6779999732971191,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6779999732971191,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7850840091705322},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6653780937194824},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6224066615104675},{"id":"https://openalex.org/keywords/brain-size","display_name":"Brain size","score":0.5829098224639893},{"id":"https://openalex.org/keywords/imaging-genetics","display_name":"Imaging genetics","score":0.5647582411766052},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5448281168937683},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5445793271064758},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.5234985947608948},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5008218288421631},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4952792227268219},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4648299217224121},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4538184702396393},{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.4468987286090851},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.4190168082714081},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.4161761999130249},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.31801795959472656},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.27751392126083374},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15447133779525757},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.12547603249549866}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7850840091705322},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6653780937194824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6224066615104675},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5829098224639893},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.5647582411766052},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5448281168937683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5445793271064758},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5234985947608948},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5008218288421631},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4952792227268219},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4648299217224121},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4538184702396393},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.4468987286090851},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4190168082714081},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.4161761999130249},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31801795959472656},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27751392126083374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15447133779525757},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12547603249549866},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-022-04947-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04947-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04947-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36171548","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36171548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:053695b5b074403e9f63beacf13dfe24","is_oa":true,"landing_page_url":"https://doaj.org/article/053695b5b074403e9f63beacf13dfe24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss S3, Pp 1-13 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9520794","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9520794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-04947-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04947-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04947-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1041081925","display_name":null,"funder_award_id":"R01 LM013463","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G133065045","display_name":null,"funder_award_id":"R01 AG058854","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2084909827","display_name":null,"funder_award_id":"R01 LM013463","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2376235505","display_name":null,"funder_award_id":"U01 AG068057","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5459904085","display_name":null,"funder_award_id":"R01 AG058854","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5850737185","display_name":null,"funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G661028523","display_name":null,"funder_award_id":"U01 AG068057","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297493462.pdf","grobid_xml":"https://content.openalex.org/works/W4297493462.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1967917209","https://openalex.org/W1971613077","https://openalex.org/W1974435914","https://openalex.org/W1974897177","https://openalex.org/W2001961510","https://openalex.org/W2018838463","https://openalex.org/W2066470779","https://openalex.org/W2070683563","https://openalex.org/W2110065044","https://openalex.org/W2116668074","https://openalex.org/W2126824241","https://openalex.org/W2136145485","https://openalex.org/W2140054173","https://openalex.org/W2159417227","https://openalex.org/W2176735277","https://openalex.org/W2209106767","https://openalex.org/W2272246971","https://openalex.org/W2509927311","https://openalex.org/W2530834332","https://openalex.org/W2574432813","https://openalex.org/W2606416664","https://openalex.org/W2759086237","https://openalex.org/W2895486342","https://openalex.org/W2895693082","https://openalex.org/W2900569176","https://openalex.org/W2952810115","https://openalex.org/W2982638646","https://openalex.org/W2982818586","https://openalex.org/W2986919234","https://openalex.org/W3012009865"],"related_works":["https://openalex.org/W3120350366","https://openalex.org/W2071852132","https://openalex.org/W4384126845","https://openalex.org/W2100045083","https://openalex.org/W1968017914","https://openalex.org/W3215310816","https://openalex.org/W1827224149","https://openalex.org/W3176395874","https://openalex.org/W4389955870","https://openalex.org/W2534338666"],"abstract_inverted_index":{"BACKGROUND:":[0],"Brain":[1],"volume":[2,127,131,135],"has":[3],"been":[4],"widely":[5],"studied":[6],"in":[7,169],"the":[8,107,142,199,256,260],"neuroimaging":[9],"field,":[10],"since":[11],"it":[12,54],"is":[13,55,74],"an":[14,94],"important":[15,253],"and":[16,24,27,47,110,133,155,193,205,216],"heritable":[17],"trait":[18],"associated":[19,151,166,202],"with":[20,152,167,190,218,229],"brain":[21,51,126,130,248],"development,":[22],"aging":[23],"various":[25],"neurological":[26],"psychiatric":[28],"disorders.":[29],"Genome-wide":[30],"association":[31,176],"studies":[32],"(GWAS)":[33],"have":[34],"successfully":[35],"identified":[36,145],"numerous":[37],"associations":[38],"between":[39],"genetic":[40,59,257],"variants":[41],"such":[42],"as":[43],"single":[44],"nucleotide":[45],"polymorphisms":[46],"complex":[48,234],"traits":[49],"like":[50],"volume.":[52],"However,":[53],"unclear":[56],"how":[57,212],"these":[58,213],"variations":[60],"influence":[61],"regional":[62],"gene":[63],"expression":[64,243],"levels,":[65],"which":[66],"may":[67],"subsequently":[68],"lead":[69],"to":[70,85,117,164,187,247],"phenotypic":[71],"changes.":[72],"S-PrediXcan":[73,95,225],"a":[75,139,173],"tissue-specific":[76,119,230],"transcriptomic":[77,120,231],"data":[78,100],"analysis":[79,96,237],"method":[80],"that":[81,148,208,224],"can":[82,226],"be":[83,165,188],"applied":[84],"bridge":[86],"this":[87,90],"gap.":[88],"In":[89],"work,":[91],"we":[92,144],"perform":[93],"on":[97,122,233],"GWAS":[98],"summary":[99],"from":[101],"two":[102,123],"large":[103],"imaging":[104],"genetics":[105],"initiatives,":[106],"UK":[108],"Biobank":[109],"Enhancing":[111],"Neuroimaging":[112],"Genetics":[113],"through":[114],"Meta":[115],"Analysis,":[116],"identify":[118,227],"effects":[121,232],"closely":[124],"related":[125,246],"measures:":[128],"total":[129],"(TBV)":[132],"intracranial":[134],"(ICV).":[136],"RESULTS:":[137],"As":[138],"result":[140],"of":[141,159,180,259],"analysis,":[143],"10":[146,160],"genes":[147,161,183,214,228,241],"are":[149,245],"highly":[150],"both":[153],"TBV":[154,168],"ICV.":[156],"Nine":[157],"out":[158],"were":[162,184],"found":[163,186],"another":[170],"study":[171],"using":[172],"different":[174],"gene-based":[175],"analysis.":[177],"Moreover,":[178],"most":[179],"our":[181],"discovered":[182],"also":[185,238],"correlated":[189],"multiple":[191],"cognitive":[192],"behavioral":[194],"traits.":[195,235,250],"Further":[196],"analyses":[197],"revealed":[198],"protein-protein":[200],"interactions,":[201],"molecular":[203],"pathways":[204],"biological":[206],"functions":[207],"offer":[209],"insight":[210],"into":[211,255],"function":[215],"interact":[217],"others.":[219],"CONCLUSIONS:":[220],"These":[221],"results":[222],"confirm":[223],"The":[236],"suggested":[239],"novel":[240],"whose":[242],"levels":[244],"volumetric":[249],"This":[251],"provides":[252],"insights":[254],"mechanisms":[258],"human":[261],"brain.":[262]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}