{"id":"https://openalex.org/W4295755448","doi":"https://doi.org/10.1186/s12859-022-04895-5","title":"Transforming L1000 profiles to RNA-seq-like profiles with deep learning","display_name":"Transforming L1000 profiles to RNA-seq-like profiles with deep learning","publication_year":2022,"publication_date":"2022-09-13","ids":{"openalex":"https://openalex.org/W4295755448","doi":"https://doi.org/10.1186/s12859-022-04895-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/36100892"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-04895-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04895-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04895-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04895-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003685784","display_name":"Minji Jeon","orcid":"https://orcid.org/0000-0001-5731-6186"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Minji Jeon","raw_affiliation_strings":["Department of Medicine, Korea University College of Medicine, Seoul, Republic of Korea","Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Korea University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060461473","display_name":"Zhuorui Xie","orcid":"https://orcid.org/0000-0002-8256-5878"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuorui Xie","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007301355","display_name":"John Erol Evangelista","orcid":"https://orcid.org/0000-0003-4836-0518"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Evangelista","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053232618","display_name":"Megan L. Wojciechowicz","orcid":"https://orcid.org/0000-0001-7558-5646"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan L. Wojciechowicz","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066447491","display_name":"Daniel Clarke","orcid":"https://orcid.org/0000-0003-3471-7416"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. B. Clarke","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032951414","display_name":"Avi Ma\u2019ayan","orcid":"https://orcid.org/0000-0002-6904-1017"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Ma\u2019ayan","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003685784"],"corresponding_institution_ids":["https://openalex.org/I197347611","https://openalex.org/I98704320"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.9964,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87135192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"374","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.7206349968910217},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6409673094749451},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6337591409683228},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5501176714897156},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.539214015007019},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5324296355247498},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5026452541351318},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.45450669527053833},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.45327556133270264},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4399428367614746},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.41573068499565125},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.41141289472579956},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3417097330093384}],"concepts":[{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.7206349968910217},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6409673094749451},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6337591409683228},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5501176714897156},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.539214015007019},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5324296355247498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5026452541351318},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.45450669527053833},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.45327556133270264},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4399428367614746},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41573068499565125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41141289472579956},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3417097330093384}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-022-04895-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04895-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04895-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36100892","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36100892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9472394","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9472394","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f89bbb4138654da9a599cd18de174665","is_oa":true,"landing_page_url":"https://doaj.org/article/f89bbb4138654da9a599cd18de174665","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss 1, Pp 1-18 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-04895-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04895-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04895-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1142117526","display_name":null,"funder_award_id":"U24CA224260","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2777337649","display_name":null,"funder_award_id":"U54HL127624","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3391060122","display_name":null,"funder_award_id":"U54HL127624","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5571811426","display_name":null,"funder_award_id":"OT2OD030160","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G6537611215","display_name":null,"funder_award_id":"U24CA224260","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7335327132","display_name":null,"funder_award_id":"HL127624","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7694433223","display_name":null,"funder_award_id":"R01DK131525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8032380657","display_name":null,"funder_award_id":"OT2OD030160","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8085970047","display_name":null,"funder_award_id":"R01DK131525","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295755448.pdf","grobid_xml":"https://content.openalex.org/works/W4295755448.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1546952499","https://openalex.org/W1968667574","https://openalex.org/W1993635951","https://openalex.org/W2012298500","https://openalex.org/W2018838463","https://openalex.org/W2020541351","https://openalex.org/W2021433392","https://openalex.org/W2029650881","https://openalex.org/W2059005938","https://openalex.org/W2066177130","https://openalex.org/W2098023402","https://openalex.org/W2107859602","https://openalex.org/W2115852450","https://openalex.org/W2121604817","https://openalex.org/W2141549282","https://openalex.org/W2163303508","https://openalex.org/W2219434425","https://openalex.org/W2247766769","https://openalex.org/W2264017649","https://openalex.org/W2314266733","https://openalex.org/W2345356016","https://openalex.org/W2520597008","https://openalex.org/W2612467560","https://openalex.org/W2770804047","https://openalex.org/W2787486407","https://openalex.org/W2791291745","https://openalex.org/W2892055372","https://openalex.org/W2921157237","https://openalex.org/W2921600589","https://openalex.org/W2947483631","https://openalex.org/W2953067954","https://openalex.org/W2955977336","https://openalex.org/W2962793481","https://openalex.org/W2964395860","https://openalex.org/W2970971581","https://openalex.org/W3093888535","https://openalex.org/W3100015175","https://openalex.org/W3129146415","https://openalex.org/W3135513616","https://openalex.org/W4212774754","https://openalex.org/W4225865462"],"related_works":["https://openalex.org/W4362511652","https://openalex.org/W4362511917","https://openalex.org/W4362511922","https://openalex.org/W4362485688","https://openalex.org/W4362530184","https://openalex.org/W4362530193","https://openalex.org/W2904597490","https://openalex.org/W4362592482","https://openalex.org/W4362511560","https://openalex.org/W4377231761"],"abstract_inverted_index":{"The":[0,64,84,126,149,170,191,220],"L1000":[1,40,65,121],"technology,":[2,7],"a":[3,13,43,114,141,162,185,208],"cost-effective":[4],"high-throughput":[5],"transcriptomics":[6,108],"has":[8],"been":[9],"applied":[10,166],"to":[11,24,123,128,167],"profile":[12],"collection":[14],"of":[15,50,59,72,86,95,143],"human":[16,97],"cell":[17],"lines":[18],"for":[19,47,56,61,93,104,227],"their":[20],"gene":[21,146,159,232],"expression":[22,71,147],"response":[23],">":[25],"30,000":[26],"chemical":[27],"and":[28,52,55,101,199,217,231],"genetic":[29],"perturbations.":[30],"In":[31],"total,":[32],"there":[33],"are":[34,80,131,176,224],"currently":[35],"over":[36],"3":[37],"million":[38],"available":[39,226],"profiles.":[41,125,148],"Such":[42],"dataset":[44,212],"is":[45,140],"invaluable":[46],"the":[48,69,96,102,129,132,138,153,180,215],"discovery":[49,92],"drug":[51],"target":[53],"candidates":[54],"inferring":[57],"mechanisms":[58],"action":[60],"small":[62],"molecules.":[63],"assay":[66],"only":[67],"measures":[68],"mRNA":[70],"978":[73,134,158,172],"landmark":[74,135,154,174],"genes":[75,79,136,155,175],"while":[76,137],"11,350":[77],"additional":[78],"computationally":[81],"reliably":[82],"inferred.":[83],"lack":[85],"full":[87,181],"genome":[88,182],"coverage":[89],"limits":[90],"knowledge":[91],"half":[94],"protein":[98],"coding":[99],"genes,":[100],"potential":[103],"integration":[105],"with":[106,184,236],"other":[107],"profiling":[109],"data.":[110,169],"Here":[111],"we":[112],"present":[113],"Deep":[115],"Learning":[116],"two-step":[117,192],"model":[118,130,150,165,193],"that":[119],"transforms":[120,152],"profiles":[122,160,223],"RNA-seq-like":[124,145,157,173,222],"input":[127],"measured":[133],"output":[139],"vector":[142],"23,614":[144],"first":[151],"into":[156,179],"using":[161],"modified":[163],"CycleGAN":[164],"unpaired":[168],"transformed":[171],"then":[177],"extrapolated":[178],"space":[183],"fully":[186],"connected":[187],"neural":[188],"network":[189],"model.":[190],"achieves":[194],"0.914":[195],"Pearson's":[196],"correlation":[197],"coefficients":[198],"1.167":[200],"root":[201],"mean":[202],"square":[203],"errors":[204],"when":[205],"tested":[206],"on":[207],"published":[209],"paired":[210],"L1000/RNA-seq":[211],"produced":[213],"by":[214],"LINCS":[216],"GTEx":[218],"programs.":[219],"processed":[221],"made":[225],"download,":[228],"signature":[229],"search,":[230],"centric":[233],"reverse":[234],"search":[235],"unique":[237],"case":[238],"studies.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
