{"id":"https://openalex.org/W4287959313","doi":"https://doi.org/10.1186/s12859-022-04840-6","title":"Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types","display_name":"Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types","publication_year":2022,"publication_date":"2022-07-25","ids":{"openalex":"https://openalex.org/W4287959313","doi":"https://doi.org/10.1186/s12859-022-04840-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/35879674"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-04840-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04840-6","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12859-022-04840-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072190061","display_name":"Amin Ghareyazi","orcid":"https://orcid.org/0000-0003-1688-283X"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amin Ghareyazi","raw_affiliation_strings":["Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076298294","display_name":"Amirreza Kazemi","orcid":null},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA","IR"],"is_corresponding":false,"raw_author_name":"Amirreza Kazemi","raw_affiliation_strings":["Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran","Department of Computer Engineering, Simon Fraser University, Burnaby, BC, 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran","institution_ids":["https://openalex.org/I133529467"]},{"raw_affiliation_string":"Department of Computer Engineering, Simon Fraser University, Burnaby, BC, 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009409152","display_name":"Kimia Hamidieh","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kimia Hamidieh","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, ON, M5S 3H2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, ON, M5S 3H2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062640830","display_name":"Hamed Dashti","orcid":"https://orcid.org/0000-0003-0399-0524"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamed Dashti","raw_affiliation_strings":["Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029311152","display_name":"Maedeh Sadat Tahaei","orcid":null},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maedeh Sadat Tahaei","raw_affiliation_strings":["Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063512925","display_name":"Hamid R. Rabiee","orcid":"https://orcid.org/0000-0002-9835-4493"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamid R. Rabiee","raw_affiliation_strings":["Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran. rabiee@sharif.edu","Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran. rabiee@sharif.edu","institution_ids":["https://openalex.org/I133529467"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, 11365, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019852514","display_name":"Hamid Alinejad\u2010Rokny","orcid":"https://orcid.org/0000-0002-2189-9153"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hamid Alinejad-Rokny","raw_affiliation_strings":["AI-Enabled Processes (AIP) Research Centre, Macquarie University, Sydney, 2109, Australia","BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia","UNSW Data Science Hub, The University of New South Wales (UNSW Sydney), Sydney, NSW, 2052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI-Enabled Processes (AIP) Research Centre, Macquarie University, Sydney, 2109, Australia","institution_ids":["https://openalex.org/I99043593"]},{"raw_affiliation_string":"BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"UNSW Data Science Hub, The University of New South Wales (UNSW Sydney), Sydney, NSW, 2052, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068034214","display_name":"Abdollah Dehzangi","orcid":"https://orcid.org/0000-0001-8577-0271"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL","US"],"is_corresponding":true,"raw_author_name":"Iman Dehzangi","raw_affiliation_strings":["Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, 08102, USA. i.dehzangi@rutgers.edu","Department of Computer Science, Rutgers University, Camden, NJ, 08102, USA. i.dehzangi@rutgers.edu","Department of Computer Science, Rutgers University, Camden, NJ, 08102, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, 08102, USA. i.dehzangi@rutgers.edu","institution_ids":["https://openalex.org/I4210096112","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Computer Science, Rutgers University, Camden, NJ, 08102, USA. i.dehzangi@rutgers.edu","institution_ids":["https://openalex.org/I4210096112","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Computer Science, Rutgers University, Camden, NJ, 08102, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5068034214"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4210096112"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.2889,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50715391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"23","issue":"1","first_page":"298","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4341000020503998,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4341000020503998,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6125776767730713},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.600608229637146},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5722676515579224},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5670375227928162},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.5636521577835083},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5469711422920227},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.520904004573822},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5145070552825928},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.43055182695388794},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.308204710483551},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09494385123252869}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6125776767730713},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.600608229637146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5722676515579224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5670375227928162},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5636521577835083},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5469711422920227},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.520904004573822},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5145070552825928},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43055182695388794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.308204710483551},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09494385123252869}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-022-04840-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04840-6","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35879674","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35879674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:c71f036df464483bafb873ebb63bed3d","is_oa":true,"landing_page_url":"https://doaj.org/article/c71f036df464483bafb873ebb63bed3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss 1, Pp 1-21 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9316662","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9316662","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-04840-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04840-6","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W575556124","https://openalex.org/W1503899947","https://openalex.org/W1967220865","https://openalex.org/W1967925876","https://openalex.org/W1988478139","https://openalex.org/W2047555270","https://openalex.org/W2065332623","https://openalex.org/W2075661710","https://openalex.org/W2088891952","https://openalex.org/W2100070345","https://openalex.org/W2103017472","https://openalex.org/W2105528101","https://openalex.org/W2115708739","https://openalex.org/W2118151336","https://openalex.org/W2123696077","https://openalex.org/W2125117729","https://openalex.org/W2136787567","https://openalex.org/W2161289668","https://openalex.org/W2296948836","https://openalex.org/W2345356016","https://openalex.org/W2464717012","https://openalex.org/W2470355111","https://openalex.org/W2537679995","https://openalex.org/W2593488635","https://openalex.org/W2610948411","https://openalex.org/W2615333661","https://openalex.org/W2782558706","https://openalex.org/W2796153844","https://openalex.org/W2803934991","https://openalex.org/W2805428254","https://openalex.org/W2914746407","https://openalex.org/W2968925044","https://openalex.org/W2987059474","https://openalex.org/W3000719174","https://openalex.org/W3003665978","https://openalex.org/W3031460986","https://openalex.org/W3080816559","https://openalex.org/W3139023757","https://openalex.org/W3196331722","https://openalex.org/W3199752775","https://openalex.org/W4230962320","https://openalex.org/W4399521654"],"related_works":["https://openalex.org/W2134041901","https://openalex.org/W2607268051","https://openalex.org/W2016712296","https://openalex.org/W1992632337","https://openalex.org/W2550943714","https://openalex.org/W3212350425","https://openalex.org/W2388007221","https://openalex.org/W2511508046","https://openalex.org/W2363458739","https://openalex.org/W2028961943"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,262],"advent":[2],"of":[3,57,74,85,176,199,232,247,252],"high":[4],"throughput":[5],"sequencing":[6],"has":[7],"enabled":[8],"researchers":[9],"to":[10,61,106,114,122],"systematically":[11],"evaluate":[12],"the":[13,25,32,55,127,173,181,200,208,212,245,250,253],"genetic":[14],"variations":[15],"in":[16,24,31,111,186,204,219,234,258],"cancer,":[17],"identifying":[18,259],"many":[19,37,112],"cancer-associated":[20,63,260],"genes.":[21,261],"Although":[22],"cancers":[23],"same":[26,33],"tissue":[27],"are":[28,216,272],"widely":[29],"categorized":[30],"group,":[34],"they":[35],"demonstrate":[36],"differences":[38],"concerning":[39],"their":[40,194],"mutational":[41,71,79,174,182,256],"profiles.":[42,72],"Hence,":[43],"there":[44],"is":[45],"no":[46],"definitive":[47],"treatment":[48,93],"for":[49,167,184,265],"most":[50,205],"cancer":[51,75,86,116,129,134,143,168,220,236],"types.":[52,94,135],"This":[53,159],"reveals":[54],"importance":[56,246],"developing":[58],"new":[59,102,160],"pipelines":[60],"identify":[62,107,115,140],"genes":[64,109,228],"accurately":[65],"and":[66,147,211,229,255,270],"re-classify":[67],"patients":[68,76,87],"with":[69,77],"similar":[70,78],"Classification":[73],"profiles":[80],"may":[81],"help":[82],"discover":[83],"subtypes":[84],"who":[88],"might":[89],"benefit":[90],"from":[91,126],"specific":[92],"RESULTS:":[95],"In":[96,238],"this":[97],"study,":[98],"we":[99,139,179,202,223],"propose":[100],"a":[101,137,164],"machine":[103],"learning":[104],"pipeline":[105,121,269],"protein-coding":[108],"mutated":[110,227],"samples":[113,124,185],"subtypes.":[117,144,237],"We":[118],"apply":[119],"our":[120,240,266],"12,270":[123],"collected":[125],"international":[128],"genome":[130],"consortium,":[131],"covering":[132],"19":[133],"As":[136],"result,":[138],"17":[141],"different":[142,230],"Comprehensive":[145],"phenotypic":[146],"genotypic":[148],"analysis":[149,271],"indicates":[150],"distinguishable":[151],"properties,":[152],"including":[153,207],"unique":[154],"cancer-related":[155],"signaling":[156],"pathways.":[157],"CONCLUSIONS:":[158],"subtyping":[161],"approach":[162],"offers":[163],"novel":[165],"opportunity":[166],"drug":[169],"development":[170],"based":[171],"on":[172,242],"profile":[175],"patients.":[177],"Additionally,":[178],"analyze":[180],"signatures":[183],"each":[187],"subtype,":[188],"which":[189],"provides":[190],"important":[191],"insight":[192],"into":[193],"active":[195],"molecular":[196],"mechanisms.":[197],"Some":[198],"pathways":[201],"identified":[203,225],"subtypes,":[206],"cell":[209],"cycle":[210],"Axon":[213],"guidance":[214],"pathways,":[215],"frequently":[217],"observed":[218],"disease.":[221],"Interestingly,":[222],"also":[224],"several":[226],"rates":[231],"mutation":[233],"multiple":[235],"addition,":[239],"study":[241],"\"gene-motif\"":[243],"suggests":[244],"considering":[248],"both":[249],"context":[251],"mutations":[254],"processes":[257],"source":[263],"codes":[264],"proposed":[267],"clustering":[268],"publicly":[273],"available":[274],"at:":[275],"https://github.com/bcb-sut/Pan-Cancer":[276],".":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}