{"id":"https://openalex.org/W4283009707","doi":"https://doi.org/10.1186/s12859-022-04778-9","title":"Benchmarking imputation methods for network inference using a novel method of synthetic scRNA-seq data generation","display_name":"Benchmarking imputation methods for network inference using a novel method of synthetic scRNA-seq data generation","publication_year":2022,"publication_date":"2022-06-17","ids":{"openalex":"https://openalex.org/W4283009707","doi":"https://doi.org/10.1186/s12859-022-04778-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/35715748"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-04778-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04778-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04778-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04778-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085756499","display_name":"Ayoub Lasri","orcid":"https://orcid.org/0000-0003-0806-9072"},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ayoub Lasri","raw_affiliation_strings":["Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052845258","display_name":"Vahid Shahrezaei","orcid":"https://orcid.org/0000-0002-4013-5458"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vahid Shahrezaei","raw_affiliation_strings":["Department of Mathematics, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030884353","display_name":"Marc Sturrock","orcid":"https://orcid.org/0000-0002-7435-5256"},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Marc Sturrock","raw_affiliation_strings":["Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. marcsturrock@rcsi.ie","Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. marcsturrock@rcsi.ie","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030884353"],"corresponding_institution_ids":["https://openalex.org/I142762351"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.3915,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.53763103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"1","first_page":"236","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.892396092414856},{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.8132364153862},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7453100681304932},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5662846565246582},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46755659580230713},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3848561644554138},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.33909374475479126},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.28492915630340576}],"concepts":[{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.892396092414856},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.8132364153862},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7453100681304932},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5662846565246582},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46755659580230713},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3848561644554138},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.33909374475479126},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.28492915630340576},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-022-04778-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04778-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04778-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35715748","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35715748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9204969","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9204969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ba75e4b3f5f1475f912b93374399f45c","is_oa":false,"landing_page_url":"https://doaj.org/article/ba75e4b3f5f1475f912b93374399f45c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss 1, Pp 1-26 (2022)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/98038","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/98038","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-04778-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04778-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-022-04778-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2112830090","display_name":"Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics","funder_award_id":"766069","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8619702546","display_name":null,"funder_award_id":"766069","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283009707.pdf","grobid_xml":"https://content.openalex.org/works/W4283009707.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1504401263","https://openalex.org/W1851422093","https://openalex.org/W1862404147","https://openalex.org/W1986688807","https://openalex.org/W1998362531","https://openalex.org/W2008620264","https://openalex.org/W2012139697","https://openalex.org/W2022507599","https://openalex.org/W2045462035","https://openalex.org/W2046451925","https://openalex.org/W2055234679","https://openalex.org/W2069295116","https://openalex.org/W2076513103","https://openalex.org/W2084018951","https://openalex.org/W2084924279","https://openalex.org/W2090841507","https://openalex.org/W2092247630","https://openalex.org/W2096741761","https://openalex.org/W2098924153","https://openalex.org/W2106927126","https://openalex.org/W2109384743","https://openalex.org/W2110287212","https://openalex.org/W2120575449","https://openalex.org/W2128551987","https://openalex.org/W2135937351","https://openalex.org/W2137474062","https://openalex.org/W2139997707","https://openalex.org/W2141734233","https://openalex.org/W2141956986","https://openalex.org/W2143558987","https://openalex.org/W2151019321","https://openalex.org/W2155418451","https://openalex.org/W2157593856","https://openalex.org/W2157825442","https://openalex.org/W2158443938","https://openalex.org/W2612502013","https://openalex.org/W2616922646","https://openalex.org/W2674402523","https://openalex.org/W2751468300","https://openalex.org/W2753908609","https://openalex.org/W2757234574","https://openalex.org/W2766437506","https://openalex.org/W2784007581","https://openalex.org/W2792693509","https://openalex.org/W2793372306","https://openalex.org/W2795843099","https://openalex.org/W2800502420","https://openalex.org/W2804715272","https://openalex.org/W2805619986","https://openalex.org/W2808743742","https://openalex.org/W2865352686","https://openalex.org/W2886347923","https://openalex.org/W2900510132","https://openalex.org/W2901677030","https://openalex.org/W2904703945","https://openalex.org/W2913199358","https://openalex.org/W2913620844","https://openalex.org/W2949067670","https://openalex.org/W2950104637","https://openalex.org/W2951217100","https://openalex.org/W2951381561","https://openalex.org/W2952382191","https://openalex.org/W2963132013","https://openalex.org/W2977512847","https://openalex.org/W2980147288","https://openalex.org/W2998840182","https://openalex.org/W3000350302","https://openalex.org/W3003223963","https://openalex.org/W3005737795","https://openalex.org/W3017016043","https://openalex.org/W3040819442","https://openalex.org/W3080162757","https://openalex.org/W3083729062","https://openalex.org/W3089871235","https://openalex.org/W3093153369","https://openalex.org/W3102865994","https://openalex.org/W3103967557","https://openalex.org/W3124015948","https://openalex.org/W3141673961","https://openalex.org/W3154494298","https://openalex.org/W3157094484","https://openalex.org/W3158356304","https://openalex.org/W3172945473","https://openalex.org/W4206643206","https://openalex.org/W4225649080","https://openalex.org/W7061737731"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W2024529227","https://openalex.org/W2055961818","https://openalex.org/W2903115227","https://openalex.org/W1574575415","https://openalex.org/W3144172081","https://openalex.org/W3179858851","https://openalex.org/W3028371478","https://openalex.org/W2081476516"],"abstract_inverted_index":{"BACKGROUND:":[0],"Single":[1],"cell":[2,101],"RNA-sequencing":[3],"(scRNA-seq)":[4],"has":[5],"very":[6],"rapidly":[7],"become":[8],"the":[9,27,36,160,167],"new":[10],"workhorse":[11],"of":[12,29,43,61,78,96,111,118,162,169,187],"modern":[13],"biology":[14],"providing":[15],"an":[16],"unprecedented":[17],"global":[18],"view":[19],"on":[20,35,166],"cellular":[21],"diversity":[22],"and":[23,53,125,179,185],"heterogeneity.":[24],"In":[25],"particular,":[26],"structure":[28],"gene-gene":[30],"expression":[31],"correlation":[32],"contains":[33],"information":[34],"underlying":[37],"gene":[38,120,151],"regulatory":[39,121,152],"networks.":[40],"However,":[41,85],"interpretation":[42],"scRNA-seq":[44,81,113,192],"data":[45,62,114,134],"is":[46,87],"challenging":[47],"due":[48],"to":[49,58,146],"specific":[50],"experimental":[51],"error":[52],"biases":[54],"that":[55,142],"are":[56],"unique":[57],"this":[59,72,156],"kind":[60],"including":[63],"drop-out":[64],"(or":[65],"technical":[66],"zeros).":[67],"METHODS:":[68],"To":[69],"deal":[70],"with":[71,135],"problem":[73],"several":[74,170],"methods":[75,165],"for":[76,80,109,150,182],"imputation":[77,164],"zeros":[79],"have":[82],"been":[83],"developed.":[84],"it":[86],"not":[88],"clear":[89],"how":[90],"these":[91],"processing":[92],"steps":[93],"affect":[94],"inference":[95,172,189],"genetic":[97],"networks":[98,122],"from":[99],"single":[100],"data.":[102,193],"Here,":[103],"we":[104,158],"introduce":[105],"Biomodelling.jl,":[106],"a":[107,136,177],"tool":[108,130,157,181],"generation":[110],"synthetic":[112],"using":[115,191],"multiscale":[116],"modelling":[117],"stochastic":[119],"in":[123],"growing":[124],"dividing":[126],"cells.":[127],"RESULTS:":[128],"Our":[129],"produces":[131],"realistic":[132],"transcription":[133],"known":[137],"ground":[138],"truth":[139],"network":[140,153,171,188],"topology":[141],"can":[143],"be":[144],"used":[145],"benchmark":[147],"different":[148,163],"approaches":[149,190],"inference.":[154],"Using":[155],"investigate":[159],"impact":[161],"performance":[168],"algorithms.":[173],"CONCLUSIONS:":[174],"Biomodelling.jl":[175],"provides":[176],"versatile":[178],"useful":[180],"future":[183],"development":[184],"benchmarking":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
