{"id":"https://openalex.org/W3157357664","doi":"https://doi.org/10.1186/s12859-022-04693-z","title":"Evaluation of statistical approaches for association testing in noisy drug screening data","display_name":"Evaluation of statistical approaches for association testing in noisy drug screening data","publication_year":2022,"publication_date":"2022-05-18","ids":{"openalex":"https://openalex.org/W3157357664","doi":"https://doi.org/10.1186/s12859-022-04693-z","mag":"3157357664","pmid":"https://pubmed.ncbi.nlm.nih.gov/35585485"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-04693-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04693-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04693-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04693-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066881174","display_name":"Petr Smirnov","orcid":"https://orcid.org/0000-0001-9395-8450"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Petr Smirnov","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Canada","Princess Margaret Cancer Center, University Health Network, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073900195","display_name":"Ian C. P. Smith","orcid":"https://orcid.org/0000-0003-3957-4397"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ian Smith","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Canada","Princess Margaret Cancer Center, University Health Network, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088177470","display_name":"Zhaleh Safikhani","orcid":"https://orcid.org/0000-0002-1429-1692"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zhaleh Safikhani","raw_affiliation_strings":["Princess Margaret Cancer Center, University Health Network, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044757260","display_name":"Wail Ba-Alawi","orcid":"https://orcid.org/0000-0002-2747-4703"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wail Ba-alawi","raw_affiliation_strings":["Princess Margaret Cancer Center, University Health Network, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037976911","display_name":"Farnoosh Khodakarami","orcid":"https://orcid.org/0009-0005-0550-339X"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Farnoosh Khodakarami","raw_affiliation_strings":["Princess Margaret Cancer Center, University Health Network, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032366086","display_name":"Eva Lin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Lin","raw_affiliation_strings":["Department of Discovery Oncology, Genentech Inc., South San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"Department of Discovery Oncology, Genentech Inc., South San Francisco, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036753038","display_name":"Yihong Yu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yihong Yu","raw_affiliation_strings":["Department of Discovery Oncology, Genentech Inc., South San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"Department of Discovery Oncology, Genentech Inc., South San Francisco, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063029120","display_name":"Scott E. Martin","orcid":"https://orcid.org/0000-0001-5685-9787"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Martin","raw_affiliation_strings":["Department of Discovery Oncology, Genentech Inc., South San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"Department of Discovery Oncology, Genentech Inc., South San Francisco, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066064145","display_name":"Janosch Ortmann","orcid":"https://orcid.org/0000-0002-3811-6047"},"institutions":[{"id":"https://openalex.org/I159129438","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","ror":"https://ror.org/002rjbv21","country_code":"CA","type":"education","lineage":["https://openalex.org/I159129438","https://openalex.org/I49663120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Janosch Ortmann","raw_affiliation_strings":["D\u00e9partement d'analytique, op\u00e9rations et technologies de l'information, \u00c9cole des sciences de la gestion, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Canada"],"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'analytique, op\u00e9rations et technologies de l'information, \u00c9cole des sciences de la gestion, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Canada","institution_ids":["https://openalex.org/I159129438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["FI","NO"],"is_corresponding":false,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":["Institute for Cancer Research, Oslo University Hospital, Oslo, Norway","Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland","Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway","iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]},{"raw_affiliation_string":"Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018837401","display_name":"Marc Hafner","orcid":"https://orcid.org/0000-0003-1337-7598"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Hafner","raw_affiliation_strings":["Department of Oncology Bioinformatics, Genentech Inc., South San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology Bioinformatics, Genentech Inc., South San Francisco, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010487226","display_name":"Benjamin Haibe\u2010Kains","orcid":"https://orcid.org/0000-0002-7684-0079"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benjamin Haibe-Kains","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Canada. bhaibeka@uhnresearch.ca","Princess Margaret Cancer Center, University Health Network, Toronto, Canada. bhaibeka@uhnresearch.ca","Vector Institute, Toronto, Canada. bhaibeka@uhnresearch.ca","Princess Margaret Cancer Center, University Health Network, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Canada. bhaibeka@uhnresearch.ca","institution_ids":[]},{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada. bhaibeka@uhnresearch.ca","institution_ids":[]},{"raw_affiliation_string":"Vector Institute, Toronto, Canada. bhaibeka@uhnresearch.ca","institution_ids":[]},{"raw_affiliation_string":"Princess Margaret Cancer Center, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5066881174"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2802654988"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.4518,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.93382314,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"23","issue":"1","first_page":"188","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.6629232168197632},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.5655975341796875},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.553541362285614},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.5534647703170776},{"id":"https://openalex.org/keywords/pearson-product-moment-correlation-coefficient","display_name":"Pearson product-moment correlation coefficient","score":0.5481319427490234},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.514553964138031},{"id":"https://openalex.org/keywords/spearmans-rank-correlation-coefficient","display_name":"Spearman's rank correlation coefficient","score":0.46911197900772095},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.468715101480484},{"id":"https://openalex.org/keywords/rank-correlation","display_name":"Rank correlation","score":0.46061989665031433},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.4568517804145813},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.43514376878738403},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4307124614715576},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3107948899269104},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28475233912467957},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25432753562927246},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22097811102867126},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09618771076202393}],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6629232168197632},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5655975341796875},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.553541362285614},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.5534647703170776},{"id":"https://openalex.org/C55078378","wikidata":"https://www.wikidata.org/wiki/Q1136628","display_name":"Pearson product-moment correlation coefficient","level":2,"score":0.5481319427490234},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.514553964138031},{"id":"https://openalex.org/C159744936","wikidata":"https://www.wikidata.org/wiki/Q1126730","display_name":"Spearman's rank correlation coefficient","level":2,"score":0.46911197900772095},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.468715101480484},{"id":"https://openalex.org/C101601086","wikidata":"https://www.wikidata.org/wiki/Q3753228","display_name":"Rank correlation","level":2,"score":0.46061989665031433},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4568517804145813},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.43514376878738403},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4307124614715576},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3107948899269104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28475233912467957},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25432753562927246},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22097811102867126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09618771076202393},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-022-04693-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04693-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04693-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35585485","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35585485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:e870269f0d154878a9f79007d3823635","is_oa":true,"landing_page_url":"https://doaj.org/article/e870269f0d154878a9f79007d3823635","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss 1, Pp 1-24 (2022)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/344307","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/344307","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9118710","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118710","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:www.duo.uio.no:10852/94198","is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-96748","pdf_url":null,"source":{"id":"https://openalex.org/S4306401717","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-04693-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04693-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04693-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G329941513","display_name":null,"funder_award_id":"340141","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3609107129","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3732400637","display_name":null,"funder_award_id":"326238","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G5066627347","display_name":null,"funder_award_id":"344698","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7701213674","display_name":"Tailoring the targeted treatment of chronic lymphocytic leukemia","funder_award_id":"344698","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G8051717526","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8194661698","display_name":"Machine Learning for Systems Pharmacology","funder_award_id":"340141","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G8318064016","display_name":null,"funder_award_id":"Horizon","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320323824","display_name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","ror":"https://ror.org/05pgg4z49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3157357664.pdf","grobid_xml":"https://content.openalex.org/works/W3157357664.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1531160357","https://openalex.org/W1688204489","https://openalex.org/W1978394996","https://openalex.org/W1987833288","https://openalex.org/W1990750581","https://openalex.org/W2002917158","https://openalex.org/W2004546853","https://openalex.org/W2010181950","https://openalex.org/W2011474181","https://openalex.org/W2025440555","https://openalex.org/W2028747292","https://openalex.org/W2034838115","https://openalex.org/W2039696903","https://openalex.org/W2105381419","https://openalex.org/W2106101128","https://openalex.org/W2108068107","https://openalex.org/W2108933868","https://openalex.org/W2111489524","https://openalex.org/W2111495793","https://openalex.org/W2125789330","https://openalex.org/W2133254377","https://openalex.org/W2149407433","https://openalex.org/W2152883907","https://openalex.org/W2169843745","https://openalex.org/W2175970000","https://openalex.org/W2220553089","https://openalex.org/W2261944919","https://openalex.org/W2407075689","https://openalex.org/W2461427403","https://openalex.org/W2496056904","https://openalex.org/W2530047883","https://openalex.org/W2557547609","https://openalex.org/W2560084579","https://openalex.org/W2767216042","https://openalex.org/W2951934944","https://openalex.org/W2953253500","https://openalex.org/W2963427644","https://openalex.org/W2983719595","https://openalex.org/W2999565413","https://openalex.org/W3087283263","https://openalex.org/W3169622827","https://openalex.org/W3202488690","https://openalex.org/W4234509242","https://openalex.org/W4240249213","https://openalex.org/W4243509150","https://openalex.org/W4248694980","https://openalex.org/W6728365446"],"related_works":["https://openalex.org/W3152154711","https://openalex.org/W2999441357","https://openalex.org/W1911095394","https://openalex.org/W2773390159","https://openalex.org/W2749680699","https://openalex.org/W2357941858","https://openalex.org/W2358850878","https://openalex.org/W2555516226","https://openalex.org/W2963320501","https://openalex.org/W2389190814"],"abstract_inverted_index":{"We":[0],"observe":[1,25],"that":[2,26],"the":[3,11,27,31,38],"rCI":[4],"and":[5,16],"kCI":[6],"are":[7],"better":[8],"powered":[9],"than":[10],"concordance":[12],"index":[13],"in":[14],"simulation":[15],"show":[17],"some":[18],"improvement":[19],"on":[20],"real":[21],"data.":[22],"Surprisingly,":[23],"we":[24],"Pearson":[28],"correlation":[29],"was":[30],"most":[32],"robust":[33],"to":[34],"measurement":[35],"noise":[36],"among":[37],"different":[39],"metrics.":[40]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}
