{"id":"https://openalex.org/W4221106438","doi":"https://doi.org/10.1186/s12859-022-04608-y","title":"Task-driven knowledge graph filtering improves prioritizing drugs for repurposing","display_name":"Task-driven knowledge graph filtering improves prioritizing drugs for repurposing","publication_year":2022,"publication_date":"2022-03-04","ids":{"openalex":"https://openalex.org/W4221106438","doi":"https://doi.org/10.1186/s12859-022-04608-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/35246025"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-022-04608-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04608-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04608-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04608-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088353225","display_name":"Florin Ratajczak","orcid":"https://orcid.org/0000-0003-3246-5032"},"institutions":[{"id":"https://openalex.org/I1325886976","display_name":"Siemens (Germany)","ror":"https://ror.org/059mq0909","country_code":"DE","type":"company","lineage":["https://openalex.org/I1325886976"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210153902","display_name":"Siemens Healthineers (Germany)","ror":"https://ror.org/0449c4c15","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210153902"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florin Ratajczak","raw_affiliation_strings":["Digital Technology and Innovation, Siemens Healthineers, Erlangen, Germany. florin.ratajczak@helmholtz-muenchen.de","Helmholtz Zentrum M\u00fcnchen Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH), Munich, Germany. florin.ratajczak@helmholtz-muenchen.de","Helmholtz Zentrum M\u00fcnchen Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH), Munich, Germany","Digital Technology and Innovation, Siemens Healthineers, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Technology and Innovation, Siemens Healthineers, Erlangen, Germany. florin.ratajczak@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I1325886976"]},{"raw_affiliation_string":"Helmholtz Zentrum M\u00fcnchen Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH), Munich, Germany. florin.ratajczak@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Helmholtz Zentrum M\u00fcnchen Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH), Munich, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Digital Technology and Innovation, Siemens Healthineers, Erlangen, Germany","institution_ids":["https://openalex.org/I4210153902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065653342","display_name":"Mitchell Joblin","orcid":"https://orcid.org/0000-0001-8812-3379"},"institutions":[{"id":"https://openalex.org/I1325886976","display_name":"Siemens (Germany)","ror":"https://ror.org/059mq0909","country_code":"DE","type":"company","lineage":["https://openalex.org/I1325886976"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mitchell Joblin","raw_affiliation_strings":["Corporate Technology, Siemens AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporate Technology, Siemens AG, Munich, Germany","institution_ids":["https://openalex.org/I1325886976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012024770","display_name":"Martin Ringsquandl","orcid":"https://orcid.org/0000-0001-5004-312X"},"institutions":[{"id":"https://openalex.org/I1325886976","display_name":"Siemens (Germany)","ror":"https://ror.org/059mq0909","country_code":"DE","type":"company","lineage":["https://openalex.org/I1325886976"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Ringsquandl","raw_affiliation_strings":["Corporate Technology, Siemens AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporate Technology, Siemens AG, Munich, Germany","institution_ids":["https://openalex.org/I1325886976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006443017","display_name":"Marcel Hildebrandt","orcid":null},"institutions":[{"id":"https://openalex.org/I1325886976","display_name":"Siemens (Germany)","ror":"https://ror.org/059mq0909","country_code":"DE","type":"company","lineage":["https://openalex.org/I1325886976"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcel Hildebrandt","raw_affiliation_strings":["Corporate Technology, Siemens AG, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporate Technology, Siemens AG, Munich, Germany","institution_ids":["https://openalex.org/I1325886976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088353225"],"corresponding_institution_ids":["https://openalex.org/I1325886976","https://openalex.org/I3018134672","https://openalex.org/I4210153902"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.5592,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.82549591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.31529998779296875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.31529998779296875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.305400013923645,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.27410000562667847,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.8713915348052979},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.6806831359863281},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6365399956703186},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.53675377368927},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5216498970985413},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4910621643066406},{"id":"https://openalex.org/keywords/knowledge-graph","display_name":"Knowledge graph","score":0.444876104593277},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4150583744049072},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.26662498712539673},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.23509228229522705},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22057011723518372},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.19196856021881104},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14747145771980286},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.12531614303588867},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09235620498657227},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08815246820449829},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08478131890296936}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.8713915348052979},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6806831359863281},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6365399956703186},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.53675377368927},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5216498970985413},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4910621643066406},{"id":"https://openalex.org/C2987255567","wikidata":"https://www.wikidata.org/wiki/Q33002955","display_name":"Knowledge graph","level":2,"score":0.444876104593277},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4150583744049072},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.26662498712539673},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.23509228229522705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22057011723518372},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19196856021881104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14747145771980286},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.12531614303588867},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09235620498657227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08815246820449829},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08478131890296936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-022-04608-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04608-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04608-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35246025","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35246025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:push-zb.helmholtz-munich.de:64516","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=64516","pdf_url":"https://push-zb.helmholtz-munich.de/deliver.php?id=33054","source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics 23:84 (2022)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:bc47291f086341fd8c36f1644c2cdecd","is_oa":true,"landing_page_url":"https://doaj.org/article/bc47291f086341fd8c36f1644c2cdecd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 23, Iss 1, Pp 1-19 (2022)","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:64516","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64516","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics 23:84 (2022)","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8894843","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8894843","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-022-04608-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-022-04608-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-022-04608-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322923","display_name":"Siemens","ror":"https://ror.org/059mq0909"},{"id":"https://openalex.org/F4320327217","display_name":"Siemens Healthineers","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4221106438.pdf","grobid_xml":"https://content.openalex.org/works/W4221106438.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W2019707847","https://openalex.org/W2022166150","https://openalex.org/W2062941476","https://openalex.org/W2080133951","https://openalex.org/W2120699290","https://openalex.org/W2187413858","https://openalex.org/W2263739890","https://openalex.org/W2300469216","https://openalex.org/W2444690946","https://openalex.org/W2560674852","https://openalex.org/W2605190880","https://openalex.org/W2728059831","https://openalex.org/W2780779540","https://openalex.org/W2786016794","https://openalex.org/W2809867059","https://openalex.org/W2896002881","https://openalex.org/W2949311246","https://openalex.org/W2966864197","https://openalex.org/W2998922495","https://openalex.org/W3004919484","https://openalex.org/W3020759564","https://openalex.org/W3029004538","https://openalex.org/W3030536242","https://openalex.org/W3033425553","https://openalex.org/W3043498388","https://openalex.org/W3044927477","https://openalex.org/W3088218313","https://openalex.org/W3090929175","https://openalex.org/W3091737929","https://openalex.org/W3093150592","https://openalex.org/W3106378800","https://openalex.org/W3106972347","https://openalex.org/W3110533165","https://openalex.org/W3141379714","https://openalex.org/W3158528877","https://openalex.org/W3165737823"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4320009247","https://openalex.org/W4206422705","https://openalex.org/W3186872001","https://openalex.org/W3174741986","https://openalex.org/W4389861022"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"repurposing":[2,95,221],"aims":[3],"at":[4],"finding":[5],"new":[6,21,27,74],"targets":[7,29],"for":[8,30,132,209,281,299],"already":[9],"developed":[10],"drugs.":[11],"It":[12],"becomes":[13],"more":[14,326],"relevant":[15,131],"as":[16,93],"the":[17,53,81,117,122,126,133,154,159,170,193,210,216,234],"cost":[18],"of":[19,35,156,166,195,212,219,236,254,268,278],"discovering":[20],"drugs":[22],"steadily":[23],"increases.":[24],"To":[25],"find":[26,229],"potential":[28],"a":[31,186,325],"drug,":[32],"an":[33,249,265,318],"abundance":[34],"methods":[36],"and":[37,63,78,150,182,197,207,242,260,272,324],"existing":[38],"biomedical":[39,54,83,203],"knowledge":[40,48,106,191,204],"from":[41],"different":[42],"domains":[43],"can":[44,69,120,313],"be":[45,70,314],"leveraged.":[46],"Recently,":[47],"graphs":[49,68,205,292],"have":[50],"emerged":[51],"in":[52,99,116,158,192,251,302,317,321],"domain":[55,190],"that":[56,128,188,230,295,310,322],"integrate":[57],"information":[58],"about":[59],"genes,":[60],"drugs,":[61],"diseases":[62,151],"other":[64,164],"biological":[65],"domains.":[66],"Knowledge":[67,291],"used":[71,105],"to":[72,124,142,145,163,177,200,248,256],"predict":[73,146,178],"connections":[75],"between":[76,148,180],"compounds":[77,149,181,280],"diseases,":[79],"leveraging":[80],"interconnected":[82],"data":[84,127],"around":[85],"them.":[86],"While":[87],"real":[88],"world":[89],"use":[90,198],"cases":[91],"such":[92],"drug":[94,220,305],"are":[96,173,296],"only":[97],"interested":[98],"one":[100],"specific":[101,300],"relation":[102,114,135],"type,":[103],"widely":[104],"graph":[107,160],"embedding":[108],"models":[109,123],"simultaneously":[110,223],"optimize":[111],"over":[112],"all":[113],"types":[115],"graph.":[118],"This":[119],"lead":[121],"underfit":[125],"is":[129,161,288],"most":[130],"desired":[134],"type.":[136],"For":[137],"example,":[138],"if":[139],"we":[140],"want":[141],"learn":[143],"embeddings":[144,172],"links":[147,179],"but":[152],"almost":[153],"entirety":[155],"relations":[157],"incident":[162],"pairs":[165],"entity":[167],"types,":[168],"then":[169],"resulting":[171,316],"likely":[174],"not":[175],"optimised":[176],"diseases.":[183],"We":[184,228,307],"propose":[185],"method":[187,232],"leverages":[189],"form":[194],"metapaths":[196],"them":[199],"filter":[201],"two":[202],"(Hetionet":[206],"DRKG)":[208],"purpose":[211],"improving":[213],"performance":[214,253,320],"on":[215,240,244,258,262,270,274],"prediction":[217,252],"task":[218,323],"while":[222,246],"increasing":[224],"computational":[225],"efficiency.":[226],"RESULTS:":[227],"our":[231,303],"reduces":[233],"number":[235],"entities":[237],"by":[238],"60%":[239],"Hetionet":[241,259,271],"26%":[243],"DRKG,":[245,263],"leading":[247],"improvement":[250,267],"up":[255],"40.8%":[257],"14.2%":[261],"with":[264],"average":[266],"20.6%":[269],"8.9%":[273],"DRKG.":[275],"Additionally,":[276],"prioritization":[277],"antiviral":[279],"SARS":[282],"CoV-2":[283],"improves":[284],"after":[285],"task-driven":[286],"filtering":[287],"applied.":[289],"CONCLUSION:":[290],"contain":[293],"facts":[294,312],"counter":[297],"productive":[298],"tasks,":[301],"case":[304],"repurposing.":[306],"also":[308],"demonstrate":[309],"these":[311],"removed,":[315],"improved":[319],"efficient":[327],"learning":[328],"process.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}