{"id":"https://openalex.org/W3207833773","doi":"https://doi.org/10.1186/s12859-021-04433-9","title":"CL-ACP: a parallel combination of CNN and LSTM anticancer peptide recognition model","display_name":"CL-ACP: a parallel combination of CNN and LSTM anticancer peptide recognition model","publication_year":2021,"publication_date":"2021-10-20","ids":{"openalex":"https://openalex.org/W3207833773","doi":"https://doi.org/10.1186/s12859-021-04433-9","mag":"3207833773","pmid":"https://pubmed.ncbi.nlm.nih.gov/34670488"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04433-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04433-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04433-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04433-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101815036","display_name":"Huiqing Wang","orcid":"https://orcid.org/0000-0001-8611-6546"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiqing Wang","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102865897","display_name":"Zhao Jian","orcid":"https://orcid.org/0000-0003-1757-3609"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhao","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China. zhaojian0384@link.tyut.edu.cn","College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China. zhaojian0384@link.tyut.edu.cn","institution_ids":[]},{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001663093","display_name":"Hong Sheng Zhao","orcid":"https://orcid.org/0000-0002-1092-6443"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Zhao","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631655","display_name":"Haolin Li","orcid":"https://orcid.org/0009-0003-7200-1432"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haolin Li","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100347490","display_name":"Juan Wang","orcid":"https://orcid.org/0000-0003-3934-0435"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Wang","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, 030024, China","institution_ids":["https://openalex.org/I9086337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101815036"],"corresponding_institution_ids":["https://openalex.org/I9086337"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.3626,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89175153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"512","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8360000252723694,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8360000252723694,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.7644708156585693},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"Antimicrobial peptides","score":0.6244248151779175},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5830598473548889},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5706453919410706},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5019938945770264},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49947071075439453},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4169023633003235},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2942601144313812},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28782549500465393},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20067575573921204}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7644708156585693},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.6244248151779175},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5830598473548889},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5706453919410706},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5019938945770264},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49947071075439453},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4169023633003235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2942601144313812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28782549500465393},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20067575573921204},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-021-04433-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04433-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04433-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34670488","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34670488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:ffcc8d8cb3bd4ef28de7d52a6f125dfb","is_oa":true,"landing_page_url":"https://doaj.org/article/ffcc8d8cb3bd4ef28de7d52a6f125dfb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-22 (2021)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:7431159","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8527680","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8527680","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8527680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04433-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04433-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04433-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1875800433","display_name":null,"funder_award_id":"61976150","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3627249483","display_name":null,"funder_award_id":"201903D121151","funder_id":"https://openalex.org/F4320336035","funder_display_name":"Shanxi Provincial Key Research and Development Project"},{"id":"https://openalex.org/G4648151815","display_name":null,"funder_award_id":"61976150","funder_id":"https://openalex.org/F4320336035","funder_display_name":"Shanxi Provincial Key Research and Development Project"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336035","display_name":"Shanxi Provincial Key Research and Development Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207833773.pdf","grobid_xml":"https://content.openalex.org/works/W3207833773.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1502957213","https://openalex.org/W1570643690","https://openalex.org/W1583514903","https://openalex.org/W1832693441","https://openalex.org/W1854791334","https://openalex.org/W1969191557","https://openalex.org/W1987335002","https://openalex.org/W1995757481","https://openalex.org/W2025609725","https://openalex.org/W2061784494","https://openalex.org/W2074196504","https://openalex.org/W2077563243","https://openalex.org/W2083416546","https://openalex.org/W2095705004","https://openalex.org/W2097834518","https://openalex.org/W2113021574","https://openalex.org/W2118911320","https://openalex.org/W2118978333","https://openalex.org/W2126224226","https://openalex.org/W2129699232","https://openalex.org/W2133056039","https://openalex.org/W2146097585","https://openalex.org/W2156125289","https://openalex.org/W2165319492","https://openalex.org/W2166095803","https://openalex.org/W2193490462","https://openalex.org/W2340970647","https://openalex.org/W2403862021","https://openalex.org/W2425527025","https://openalex.org/W2508429489","https://openalex.org/W2555538399","https://openalex.org/W2567713795","https://openalex.org/W2597655663","https://openalex.org/W2600536947","https://openalex.org/W2603655232","https://openalex.org/W2606001457","https://openalex.org/W2607268717","https://openalex.org/W2608969085","https://openalex.org/W2625609557","https://openalex.org/W2626778328","https://openalex.org/W2776278222","https://openalex.org/W2778179010","https://openalex.org/W2785281832","https://openalex.org/W2788314593","https://openalex.org/W2791090830","https://openalex.org/W2794956775","https://openalex.org/W2806146459","https://openalex.org/W2810675213","https://openalex.org/W2889607424","https://openalex.org/W2898683498","https://openalex.org/W2899854625","https://openalex.org/W2901879913","https://openalex.org/W2903682118","https://openalex.org/W2906946803","https://openalex.org/W2937145808","https://openalex.org/W2943935116","https://openalex.org/W2946794439","https://openalex.org/W2951092885","https://openalex.org/W2969322050","https://openalex.org/W2971874382","https://openalex.org/W2979343355","https://openalex.org/W3000523282","https://openalex.org/W3047148695","https://openalex.org/W3048086963","https://openalex.org/W3128972055","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4293226380","https://openalex.org/W2883687614","https://openalex.org/W4385723643","https://openalex.org/W2314450753","https://openalex.org/W2396126703","https://openalex.org/W2390495284","https://openalex.org/W3136610278","https://openalex.org/W2999569426","https://openalex.org/W1614895742","https://openalex.org/W2158714878"],"abstract_inverted_index":{"BACKGROUND:":[0],"Anticancer":[1],"peptides":[2,75],"are":[3,89,122],"defence":[4],"substances":[5],"with":[6],"innate":[7],"immune":[8],"functions":[9],"that":[10,51],"can":[11,172],"selectively":[12],"act":[13],"on":[14,141,161],"cancer":[15],"cells":[16,20],"without":[17],"harming":[18],"normal":[19],"and":[21,44,56,70,85,96,137,159,165,180,195],"many":[22],"studies":[23],"have":[24],"been":[25],"conducted":[26],"to":[27,59,76,91,110,148],"identify":[28],"anticancer":[29,37,61,74,113,134,163,178],"peptides.":[30,62],"In":[31],"this":[32],"paper,":[33],"we":[34],"introduce":[35],"the":[36,78,93,100,112,153,162,181],"peptide":[38,114,135,139,164,167,210],"secondary":[39,68],"structures":[40,69],"as":[41,204],"additional":[42],"features":[43],"propose":[45],"an":[46],"effective":[47],"computational":[48],"model,":[49],"CL-ACP,":[50],"uses":[52,67],"a":[53,104,205],"combined":[54,183],"network":[55,88,185],"attention":[57],"mechanism":[58,107],"predict":[60],"RESULTS:":[63],"The":[64,81],"CL-ACP":[65,126,151,171,188],"model":[66],"original":[71],"sequences":[72],"of":[73,99,119,132,157,187],"construct":[77],"feature":[79,101,120,193],"space.":[80,102],"long":[82],"short-term":[83],"memory":[84],"convolutional":[86],"neural":[87,184],"used":[90,109],"extract":[92],"contextual":[94],"dependence":[95],"local":[97],"correlations":[98],"Furthermore,":[103],"multi-head":[105],"self-attention":[106],"is":[108,200],"strengthen":[111],"sequences.":[115],"Finally,":[116],"three":[117],"categories":[118],"information":[121],"classified":[123],"by":[124],"cascading.":[125],"was":[127],"validated":[128],"using":[129],"two":[130],"types":[131],"datasets,":[133,140,168],"datasets":[136],"antimicrobial":[138,166,175,209],"which":[142],"it":[143],"achieved":[144,152],"good":[145],"results":[146],"compared":[147],"previous":[149],"methods.":[150],"highest":[154],"AUC":[155],"values":[156],"0.935":[158],"0.972":[160],"respectively.":[169],"CONCLUSIONS:":[170],"effectively":[173],"recognize":[174],"peptides,":[176,179],"especially":[177],"parallel":[182],"structure":[186],"does":[189],"not":[190],"require":[191],"complex":[192],"design":[194],"high":[196],"time":[197],"cost.":[198],"It":[199],"suitable":[201],"for":[202],"application":[203],"useful":[206],"tool":[207],"in":[208],"design.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}