{"id":"https://openalex.org/W3201367988","doi":"https://doi.org/10.1186/s12859-021-04377-0","title":"Identification of driver genes based on gene mutational effects and network centrality","display_name":"Identification of driver genes based on gene mutational effects and network centrality","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3201367988","doi":"https://doi.org/10.1186/s12859-021-04377-0","mag":"3201367988","pmid":"https://pubmed.ncbi.nlm.nih.gov/34560840"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04377-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04377-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04377-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04377-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101155039","display_name":"Yunyun Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-Yun Tang","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085214222","display_name":"Pi-Jing Wei","orcid":"https://orcid.org/0000-0003-2770-8781"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pi-Jing Wei","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078955823","display_name":"Jianping Zhao","orcid":"https://orcid.org/0000-0002-8486-744X"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-ping Zhao","raw_affiliation_strings":["College of Mathematics and System Sciences, Xinjiang University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065943710","display_name":"Junfeng Xia","orcid":"https://orcid.org/0000-0003-3024-1705"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Xia","raw_affiliation_strings":["Institute of Physical Science and Information Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Science and Information Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101959312","display_name":"Ruifen Cao","orcid":"https://orcid.org/0000-0002-4223-3422"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-Fen Cao","raw_affiliation_strings":["Engineering Research Center of Big Data Application in Private Health Medicine, Fujian Province University, Putian, Fujian, China","Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Big Data Application in Private Health Medicine, Fujian Province University, Putian, Fujian, China","institution_ids":[]},{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun-Hou Zheng","raw_affiliation_strings":["College of Mathematics and System Sciences, Xinjiang University, Urumqi, China. zhengch99@126.com","Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China. zhengch99@126.com","College of Mathematics and System Sciences, Xinjiang University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences, Xinjiang University, Urumqi, China. zhengch99@126.com","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China. zhengch99@126.com","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"College of Mathematics and System Sciences, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064185915"],"corresponding_institution_ids":["https://openalex.org/I143868143","https://openalex.org/I96908189"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.2961,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.52604869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"S3","first_page":"457","last_page":"457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8495000004768372,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8495000004768372,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7549017667770386},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6374492049217224},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6185531616210938},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.607403039932251},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.576721727848053},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5468223094940186},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.5350379347801208},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4913293421268463},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.43949854373931885},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4340100586414337},{"id":"https://openalex.org/keywords/gene-mutation","display_name":"Gene mutation","score":0.4271126985549927},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.41889840364456177},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2766292691230774}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7549017667770386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6374492049217224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6185531616210938},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.607403039932251},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.576721727848053},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5468223094940186},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.5350379347801208},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4913293421268463},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.43949854373931885},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4340100586414337},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4271126985549927},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41889840364456177},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2766292691230774},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-021-04377-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04377-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04377-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34560840","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34560840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:3c8bbb5747a4471bb5081cefd51baa78","is_oa":true,"landing_page_url":"https://doaj.org/article/3c8bbb5747a4471bb5081cefd51baa78","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss S3, Pp 1-16 (2021)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:7352614","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8461858","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8461858","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8461858","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04377-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04377-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04377-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G247010507","display_name":null,"funder_award_id":"61873001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5006237592","display_name":null,"funder_award_id":"U19A2064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5160078536","display_name":null,"funder_award_id":"U19A2064, 61873001, 61872220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5609717784","display_name":"\u57fa\u4e8e\u4f4e\u79e9\u548c\u56fe\u6b63\u5219\u7ea6\u675f\u7684\u77e9\u9635\u5206\u89e3\u65b9\u6cd5\u7814\u7a76\u53ca\u5728\u764c\u75c7\u591a\u7ec4\u5b66\u6570\u636e\u4e2d\u7684\u5e94\u7528","funder_award_id":"61872220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6322265744","display_name":null,"funder_award_id":"U19A2064, 61873001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8031058355","display_name":null,"funder_award_id":"61861146002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3201367988.pdf","grobid_xml":"https://content.openalex.org/works/W3201367988.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W633291512","https://openalex.org/W1144409159","https://openalex.org/W1836956425","https://openalex.org/W1855299742","https://openalex.org/W1923105751","https://openalex.org/W1968024981","https://openalex.org/W1976815080","https://openalex.org/W1992250165","https://openalex.org/W2012254260","https://openalex.org/W2014881369","https://openalex.org/W2015631955","https://openalex.org/W2023568503","https://openalex.org/W2024161072","https://openalex.org/W2044433401","https://openalex.org/W2059300459","https://openalex.org/W2060833569","https://openalex.org/W2065806906","https://openalex.org/W2072572998","https://openalex.org/W2076865561","https://openalex.org/W2082887122","https://openalex.org/W2088891952","https://openalex.org/W2092180333","https://openalex.org/W2096328220","https://openalex.org/W2096791516","https://openalex.org/W2100867326","https://openalex.org/W2102140136","https://openalex.org/W2105136962","https://openalex.org/W2114029728","https://openalex.org/W2114031931","https://openalex.org/W2117098110","https://openalex.org/W2121906867","https://openalex.org/W2122863289","https://openalex.org/W2127611185","https://openalex.org/W2138155367","https://openalex.org/W2139227366","https://openalex.org/W2141014201","https://openalex.org/W2141432783","https://openalex.org/W2141783822","https://openalex.org/W2142892229","https://openalex.org/W2144940507","https://openalex.org/W2149082178","https://openalex.org/W2152176732","https://openalex.org/W2158485828","https://openalex.org/W2159522138","https://openalex.org/W2159987716","https://openalex.org/W2163798887","https://openalex.org/W2165759834","https://openalex.org/W2345065869","https://openalex.org/W2442835468","https://openalex.org/W2493614923","https://openalex.org/W2508622936","https://openalex.org/W2518398099","https://openalex.org/W2527478131","https://openalex.org/W2562827486","https://openalex.org/W2613500826","https://openalex.org/W2626236443","https://openalex.org/W2737623232","https://openalex.org/W2744557261","https://openalex.org/W2784142616","https://openalex.org/W2884736612","https://openalex.org/W2915168078","https://openalex.org/W2983296017","https://openalex.org/W2989906520","https://openalex.org/W4238448376","https://openalex.org/W4248974836"],"related_works":["https://openalex.org/W4229078645","https://openalex.org/W1977345676","https://openalex.org/W4282032776","https://openalex.org/W2047552823","https://openalex.org/W4321606905","https://openalex.org/W2769306272","https://openalex.org/W376580281","https://openalex.org/W3203526752","https://openalex.org/W4312467679","https://openalex.org/W1967925377"],"abstract_inverted_index":{"BACKGROUND:":[0],"As":[1],"one":[2,59],"of":[3,23,36,46,60,64,89,122,154,186],"the":[4,8,20,42,50,61,87,101,115,119,145,152,160,174,206],"deadliest":[5],"diseases":[6],"in":[7,94,114,189],"world,":[9],"cancer":[10,66,187],"is":[11,58],"driven":[12],"by":[13,117],"a":[14,76,131],"few":[15],"somatic":[16,37],"mutations":[17,38,51,91,178],"that":[18,200],"disrupt":[19],"normal":[21,126],"growth":[22],"cells,":[24],"and":[25,30,44,56,80,125,128,140,180,216,221],"leads":[26],"to":[27,85,144,159,205,214],"abnormal":[28],"proliferation":[29],"tumor":[31,54,123],"development.":[32],"The":[33,163,190,196],"vast":[34],"majority":[35],"did":[39],"not":[40],"affect":[41],"occurrence":[43,55],"development":[45,57],"cancer;":[47],"thus,":[48],"identifying":[49],"responsible":[52],"for":[53,104,134],"main":[62],"targets":[63],"current":[65],"treatments.":[67],"RESULTS:":[68],"To":[69],"effectively":[70],"identify":[71,218],"driver":[72,170,219,223],"genes,":[73],"we":[74,99,108,150],"adopted":[75],"semi-local":[77],"centrality":[78],"measure":[79],"gene":[81,90,95,137,157],"mutation":[82,102,136],"effect":[83,88,179],"function":[84],"assess":[86],"on":[92],"changes":[93],"expression":[96,120],"patterns.":[97],"Firstly,":[98],"calculated":[100,151],"score":[103,153],"each":[105,135,155],"gene.":[106],"Secondly,":[107],"identified":[109],"differentially":[110],"expressed":[111],"genes":[112,142,166,220],"(DEGs)":[113],"cohort":[116],"comparing":[118],"profiles":[121],"samples":[124],"samples,":[127],"then":[129],"constructed":[130],"local":[132],"network":[133,181],"using":[138],"DEGs":[139],"mutant":[141,156,165],"according":[143,158],"protein-protein":[146],"interaction":[147],"network.":[148],"Finally,":[149],"objective":[161],"function.":[162],"top-ranking":[164],"were":[167,194],"selected":[168],"as":[169,177,210],"genes.":[171],"We":[172],"name":[173],"proposed":[175],"method":[176,202],"centrality.":[182],"CONCLUSIONS:":[183],"Four":[184],"types":[185],"data":[188,198],"Cancer":[191],"Genome":[192],"Atlas":[193],"tested.":[195],"experimental":[197],"proved":[199],"our":[201],"was":[203,212],"superior":[204],"existing":[207],"network-centric":[208],"method,":[209],"it":[211],"able":[213],"quickly":[215],"easily":[217],"rare":[222],"factors.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}