{"id":"https://openalex.org/W3196986006","doi":"https://doi.org/10.1186/s12859-021-04345-8","title":"The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma","display_name":"The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma","publication_year":2021,"publication_date":"2021-09-05","ids":{"openalex":"https://openalex.org/W3196986006","doi":"https://doi.org/10.1186/s12859-021-04345-8","mag":"3196986006","pmid":"https://pubmed.ncbi.nlm.nih.gov/34482818"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04345-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04345-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04345-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04345-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024542372","display_name":"Xiaoxiao Zhao","orcid":"https://orcid.org/0000-0002-8006-6418"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoxiao Zhao","raw_affiliation_strings":["Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China","School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China","School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China","Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023844372","display_name":"Jianghuai Ji","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianghuai Ji","raw_affiliation_strings":["Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou, 310022, People's Republic of China","Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, 310022, People's Republic of China","Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, People\u2019s Republic of China","Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou, 310022, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, 310022, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, People\u2019s Republic of China","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050205891","display_name":"Shijia Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijia Wang","raw_affiliation_strings":["Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China","School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China","School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China","Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103040531","display_name":"Rendong Wang","orcid":"https://orcid.org/0000-0002-6384-1654"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rendong Wang","raw_affiliation_strings":["Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China","School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China","Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China","School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022159919","display_name":"Qiuhong Yu","orcid":"https://orcid.org/0000-0002-7598-2526"},"institutions":[{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuhong Yu","raw_affiliation_strings":["Department of Hyperbaric Oxygen, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan Xi Lu, Fengtai District, Beijing, 100070, People's Republic of China. yuqiuhong@bjtth.org","Department of Hyperbaric Oxygen, Beijing Tiantan Hospital, Capital Medical University, Beijing, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Department of Hyperbaric Oxygen, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan Xi Lu, Fengtai District, Beijing, 100070, People's Republic of China. yuqiuhong@bjtth.org","institution_ids":[]},{"raw_affiliation_string":"Department of Hyperbaric Oxygen, Beijing Tiantan Hospital, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210087691","https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103067399","display_name":"Dongguo Li","orcid":"https://orcid.org/0000-0001-6327-8315"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongguo Li","raw_affiliation_strings":["Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China. ldg213@ccmu.edu.cn","School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China. ldg213@ccmu.edu.cn","Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China","School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, 100069, People's Republic of China. ldg213@ccmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, 10 You An Men Wai, Xi Tou Tiao, Beijing, 100069, People's Republic of China. ldg213@ccmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"School of Biomedical Engineering, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024542372"],"corresponding_institution_ids":["https://openalex.org/I183519381"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.4057,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59484651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"420","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.9083974957466125},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7909373044967651},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7460903525352478},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7078174352645874},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.7032418251037598},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.6955604553222656},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5370088815689087},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4693891406059265},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4645284116268158},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35724031925201416},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.35448259115219116}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9083974957466125},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7909373044967651},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7460903525352478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7078174352645874},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7032418251037598},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6955604553222656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5370088815689087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4693891406059265},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4645284116268158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35724031925201416},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35448259115219116}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-021-04345-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04345-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04345-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34482818","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34482818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:eca7e5b89cd1400f9027840881dfb090","is_oa":true,"landing_page_url":"https://doaj.org/article/eca7e5b89cd1400f9027840881dfb090","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-20 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8420065","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8420065","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04345-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04345-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04345-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46000000834465027}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321496","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196986006.pdf","grobid_xml":"https://content.openalex.org/works/W3196986006.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W651409287","https://openalex.org/W1552528612","https://openalex.org/W1560814177","https://openalex.org/W1573845599","https://openalex.org/W1598815929","https://openalex.org/W1893588436","https://openalex.org/W1965755380","https://openalex.org/W1983347147","https://openalex.org/W1992213480","https://openalex.org/W2004078197","https://openalex.org/W2004966039","https://openalex.org/W2006617902","https://openalex.org/W2006905341","https://openalex.org/W2016015848","https://openalex.org/W2017502278","https://openalex.org/W2035618305","https://openalex.org/W2036512590","https://openalex.org/W2049695002","https://openalex.org/W2060818768","https://openalex.org/W2070668576","https://openalex.org/W2073121745","https://openalex.org/W2096465161","https://openalex.org/W2106030955","https://openalex.org/W2116631246","https://openalex.org/W2117977572","https://openalex.org/W2129360146","https://openalex.org/W2131050852","https://openalex.org/W2137439281","https://openalex.org/W2140234083","https://openalex.org/W2145144631","https://openalex.org/W2146512944","https://openalex.org/W2154175915","https://openalex.org/W2158681922","https://openalex.org/W2159675211","https://openalex.org/W2160333540","https://openalex.org/W2160382843","https://openalex.org/W2161040458","https://openalex.org/W2161324363","https://openalex.org/W2167996825","https://openalex.org/W2168528745","https://openalex.org/W2211132464","https://openalex.org/W2223740898","https://openalex.org/W2257174722","https://openalex.org/W2295455218","https://openalex.org/W2306400575","https://openalex.org/W2319773917","https://openalex.org/W2366536035","https://openalex.org/W2411644900","https://openalex.org/W2418186536","https://openalex.org/W2465336312","https://openalex.org/W2487261336","https://openalex.org/W2530446311","https://openalex.org/W2562572692","https://openalex.org/W2594600378","https://openalex.org/W2605887020","https://openalex.org/W2612830447","https://openalex.org/W2625826824","https://openalex.org/W2730614208","https://openalex.org/W2752211734","https://openalex.org/W2767546566","https://openalex.org/W2787726011","https://openalex.org/W2789326851","https://openalex.org/W2791754076","https://openalex.org/W2792944991","https://openalex.org/W2800289222","https://openalex.org/W2884785743","https://openalex.org/W2891484912","https://openalex.org/W2905285542","https://openalex.org/W2908692769","https://openalex.org/W2921313893","https://openalex.org/W2936992526","https://openalex.org/W2967078353","https://openalex.org/W2968607401","https://openalex.org/W2976130815","https://openalex.org/W2976640061","https://openalex.org/W2980417691","https://openalex.org/W2980603427","https://openalex.org/W2982144506","https://openalex.org/W2982638111","https://openalex.org/W2989938222","https://openalex.org/W2996301489","https://openalex.org/W2996674223","https://openalex.org/W2998474530","https://openalex.org/W2998960573","https://openalex.org/W3000568989","https://openalex.org/W3000678056","https://openalex.org/W3001263282","https://openalex.org/W3004157702","https://openalex.org/W3005921293","https://openalex.org/W3007487640","https://openalex.org/W3009074495","https://openalex.org/W3017345619","https://openalex.org/W3036384505","https://openalex.org/W3047660745","https://openalex.org/W3088559224","https://openalex.org/W3090879446","https://openalex.org/W3111742505","https://openalex.org/W3123684955"],"related_works":["https://openalex.org/W4205403772","https://openalex.org/W2769193000","https://openalex.org/W2029110662","https://openalex.org/W2033874367","https://openalex.org/W2980158117","https://openalex.org/W2124167740","https://openalex.org/W2094569740","https://openalex.org/W779414787","https://openalex.org/W2129873144","https://openalex.org/W2343562240"],"abstract_inverted_index":{"Our":[0],"study":[1],"provides":[2],"novel":[3],"insights":[4],"for":[5,18],"understanding":[6],"the":[7,19],"regulation":[8],"of":[9,23],"aberrant":[10],"enhancer":[11],"region":[12],"methylation":[13],"and":[14,21],"developing":[15],"methylation-based":[16],"biomarkers":[17],"diagnosis":[20],"treatment":[22],"GBM.":[24]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-03-29T08:15:47.926485","created_date":"2025-10-10T00:00:00"}