{"id":"https://openalex.org/W3175544068","doi":"https://doi.org/10.1186/s12859-021-04273-7","title":"BiGAN: LncRNA-disease association prediction based on bidirectional generative adversarial network","display_name":"BiGAN: LncRNA-disease association prediction based on bidirectional generative adversarial network","publication_year":2021,"publication_date":"2021-06-30","ids":{"openalex":"https://openalex.org/W3175544068","doi":"https://doi.org/10.1186/s12859-021-04273-7","mag":"3175544068","pmid":"https://pubmed.ncbi.nlm.nih.gov/34193046"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04273-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04273-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04273-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04273-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101648196","display_name":"Qiang Yang","orcid":"https://orcid.org/0000-0002-6524-9443"},"institutions":[{"id":"https://openalex.org/I55022517","display_name":"Heilongjiang University","ror":"https://ror.org/04zyhq975","country_code":"CN","type":"education","lineage":["https://openalex.org/I55022517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Yang","raw_affiliation_strings":["School of Electronic Engineering, Heilongjiang University, Harbin, 150080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic Engineering, Heilongjiang University, Harbin, 150080, China","institution_ids":["https://openalex.org/I55022517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100628723","display_name":"Xiaokun Li","orcid":"https://orcid.org/0000-0002-6645-6890"},"institutions":[{"id":"https://openalex.org/I4210140537","display_name":"Education Department of Heilongjiang Province","ror":"https://ror.org/04rn1rm44","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210140537"]},{"id":"https://openalex.org/I55022517","display_name":"Heilongjiang University","ror":"https://ror.org/04zyhq975","country_code":"CN","type":"education","lineage":["https://openalex.org/I55022517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaokun Li","raw_affiliation_strings":["Postdoctoral Program of Heilongjiang Hengxun Technology Co., Ltd., Harbin, 150090, China. li.xiaokun@163.com","School of Electronic Engineering, Heilongjiang University, Harbin, 150080, China. li.xiaokun@163.com","School of Electronic Engineering, Heilongjiang University, Harbin, 150080, China"],"raw_orcid":"https://orcid.org/0000-0002-6645-6890","affiliations":[{"raw_affiliation_string":"Postdoctoral Program of Heilongjiang Hengxun Technology Co., Ltd., Harbin, 150090, China. li.xiaokun@163.com","institution_ids":["https://openalex.org/I4210140537"]},{"raw_affiliation_string":"School of Electronic Engineering, Heilongjiang University, Harbin, 150080, China. li.xiaokun@163.com","institution_ids":["https://openalex.org/I55022517"]},{"raw_affiliation_string":"School of Electronic Engineering, Heilongjiang University, Harbin, 150080, China","institution_ids":["https://openalex.org/I55022517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100628723"],"corresponding_institution_ids":["https://openalex.org/I4210140537","https://openalex.org/I55022517"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":2.9146,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92979399,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"22","issue":"1","first_page":"357","last_page":"357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.6484941840171814},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6354791522026062},{"id":"https://openalex.org/keywords/semantic-similarity","display_name":"Semantic similarity","score":0.580142080783844},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5273119807243347},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5036341547966003},{"id":"https://openalex.org/keywords/discriminator","display_name":"Discriminator","score":0.5008530616760254},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4473942816257477},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3982830047607422},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3297092616558075},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21995079517364502},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1429855227470398}],"concepts":[{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.6484941840171814},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6354791522026062},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.580142080783844},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5273119807243347},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5036341547966003},{"id":"https://openalex.org/C2779803651","wikidata":"https://www.wikidata.org/wiki/Q5282088","display_name":"Discriminator","level":3,"score":0.5008530616760254},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4473942816257477},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3982830047607422},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3297092616558075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21995079517364502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1429855227470398},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-021-04273-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04273-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04273-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34193046","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34193046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:7f3299e0478144ed857f58d1133d7ec6","is_oa":false,"landing_page_url":"https://doaj.org/article/7f3299e0478144ed857f58d1133d7ec6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-17 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8247109","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8247109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04273-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04273-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04273-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7099999785423279}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3175544068.pdf","grobid_xml":"https://content.openalex.org/works/W3175544068.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1966397536","https://openalex.org/W1966716734","https://openalex.org/W1974874858","https://openalex.org/W1975847255","https://openalex.org/W1976364879","https://openalex.org/W1976988381","https://openalex.org/W1978967539","https://openalex.org/W1986705163","https://openalex.org/W1999008082","https://openalex.org/W1999746344","https://openalex.org/W2002185065","https://openalex.org/W2055027431","https://openalex.org/W2071271349","https://openalex.org/W2071462293","https://openalex.org/W2100982253","https://openalex.org/W2106554405","https://openalex.org/W2107952955","https://openalex.org/W2112001233","https://openalex.org/W2124826140","https://openalex.org/W2128983843","https://openalex.org/W2130388134","https://openalex.org/W2141211932","https://openalex.org/W2141222510","https://openalex.org/W2144137532","https://openalex.org/W2146573461","https://openalex.org/W2152970345","https://openalex.org/W2157825442","https://openalex.org/W2169179075","https://openalex.org/W2408796111","https://openalex.org/W2433743436","https://openalex.org/W2518772378","https://openalex.org/W2531500048","https://openalex.org/W2571471366","https://openalex.org/W2801501532","https://openalex.org/W2802616725","https://openalex.org/W2880850155","https://openalex.org/W2886762160","https://openalex.org/W2895679848","https://openalex.org/W2899830787","https://openalex.org/W2910817051","https://openalex.org/W2912672202","https://openalex.org/W2942942195","https://openalex.org/W2954835093","https://openalex.org/W3047927730","https://openalex.org/W3080501980"],"related_works":["https://openalex.org/W4293202849","https://openalex.org/W1980965563","https://openalex.org/W1489300767","https://openalex.org/W4380714744","https://openalex.org/W2387995142","https://openalex.org/W2380654781","https://openalex.org/W2114797768","https://openalex.org/W2176214140","https://openalex.org/W2516873349","https://openalex.org/W1990601549"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"increasing":[2],"number":[3],"of":[4,15,20,52,79,115,125,178,209],"studies":[5,173],"have":[6,139],"shown":[7],"that":[8,141,175,197],"lncRNAs":[9,116,133,161,179],"are":[10,33,170,186],"crucial":[11],"for":[12,46,57,162,206],"the":[13,18,25,102,122,142,155,181,207],"control":[14],"hormones":[16],"and":[17,28,50,54,84,97,109,117,134,165],"regulation":[19],"various":[21],"physiological":[22],"processes":[23],"in":[24,31,151,180],"human":[26,37],"body,":[27],"deletion":[29],"mutations":[30],"RNA":[32],"related":[34],"to":[35,87,128,158],"many":[36],"diseases.":[38,118,135],"LncRNA-":[39],"disease":[40,98,103],"association":[41,131,208],"prediction":[42,184],"is":[43,55],"very":[44],"useful":[45],"understanding":[47],"pathogenesis,":[48],"diagnosis,":[49],"prevention":[51],"diseases,":[53],"helpful":[56],"labelling":[58],"relevant":[59],"biological":[60,190],"information.":[61],"RESULTS:":[62],"In":[63],"this":[64],"manuscript,":[65],"we":[66],"propose":[67],"a":[68,82,85],"computational":[69,137],"model":[70,157,200],"named":[71],"bidirectional":[72],"generative":[73],"adversarial":[74],"network":[75],"(BiGAN),":[76],"which":[77],"consists":[78],"an":[80,202],"encoder,":[81],"generator,":[83],"discriminator":[86],"predict":[88,129,159],"new":[89],"lncRNA-disease":[90,210],"associations.":[91],"We":[92,153],"construct":[93],"features":[94,124,127],"between":[95,132],"lncRNA":[96,106],"pairs":[99],"by":[100,188],"utilizing":[101],"semantic":[104],"similarity,":[105,108],"sequence":[107],"Gaussian":[110],"interaction":[111],"profile":[112],"kernel":[113],"similarities":[114],"The":[119,136,168,193],"BiGAN":[120,143],"maps":[121],"latent":[123],"similarity":[126],"unverified":[130],"results":[138,169,195],"proved":[140],"performs":[144],"significantly":[145],"better":[146],"than":[147],"other":[148],"state-of-the-art":[149],"approaches":[150],"cross-validation.":[152],"employed":[154],"proposed":[156,199],"candidate":[160],"renal":[163],"cancer":[164],"colon":[166],"cancer.":[167],"promising.":[171],"Case":[172],"show":[174],"almost":[176],"70%":[177],"top":[182],"10":[183],"lists":[185],"verified":[187],"recent":[189],"research.":[191],"CONCLUSION:":[192],"experimental":[194],"indicated":[196],"our":[198],"had":[201],"accurate":[203],"predictive":[204],"ability":[205],"pairs.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":12}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
