{"id":"https://openalex.org/W3166566839","doi":"https://doi.org/10.1186/s12859-021-04235-z","title":"Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics","display_name":"Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics","publication_year":2021,"publication_date":"2021-06-05","ids":{"openalex":"https://openalex.org/W3166566839","doi":"https://doi.org/10.1186/s12859-021-04235-z","mag":"3166566839","pmid":"https://pubmed.ncbi.nlm.nih.gov/34090341"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04235-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04235-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04235-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04235-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061572430","display_name":"Jia\u2010You Lin","orcid":"https://orcid.org/0000-0003-0699-2461"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jia-You Lin","raw_affiliation_strings":["Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041854407","display_name":"Bao-Rong Juo","orcid":null},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bao-Rong Juo","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112647192","display_name":"Yu-Hsuan Yeh","orcid":"https://orcid.org/0009-0008-9122-9551"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Hsuan Yeh","raw_affiliation_strings":["Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057464375","display_name":"Shu-Hsuan Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Hsuan Fu","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348260","display_name":"Yi\u2010Ting Chen","orcid":"https://orcid.org/0000-0002-0063-4965"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ting Chen","raw_affiliation_strings":["Department of Biomedical Sciences, Chang Gung University, Taoyuan, 33302, Taiwan","Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Chang Gung University, Taoyuan, 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112262960","display_name":"Chien-Lun Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I141243467","display_name":"Chang Gung University of Science and Technology","ror":"https://ror.org/009knm296","country_code":"TW","type":"education","lineage":["https://openalex.org/I141243467"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093734","display_name":"Taoyuan Chang Gung Memorial Hospital","ror":"https://ror.org/00fk9d670","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093734"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chien-Lun Chen","raw_affiliation_strings":["College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan. clc2679@cgmh.org.tw","Department of Urology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan. clc2679@cgmh.org.tw","Department of Urology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan. clc2679@cgmh.org.tw","institution_ids":["https://openalex.org/I141243467","https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Urology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan. clc2679@cgmh.org.tw","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093734"]},{"raw_affiliation_string":"Department of Urology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan","institution_ids":["https://openalex.org/I3020100970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103209475","display_name":"Kun\u2010Pin Wu","orcid":"https://orcid.org/0000-0002-3108-0221"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kun-Pin Wu","raw_affiliation_strings":["Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan. kpwu@nycu.edu.tw","Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan. kpwu@nycu.edu.tw","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103209475","https://openalex.org/A5112262960"],"corresponding_institution_ids":["https://openalex.org/I141243467","https://openalex.org/I148366613","https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210093734"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":2.0698,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.87988957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"22","issue":"1","first_page":"305","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9420999884605408,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9420999884605408,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"Bladder cancer","score":0.8430341482162476},{"id":"https://openalex.org/keywords/cystoscopy","display_name":"Cystoscopy","score":0.6353065967559814},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6123033165931702},{"id":"https://openalex.org/keywords/urine","display_name":"Urine","score":0.5002405643463135},{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.4902847111225128},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4659408628940582},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.45410406589508057},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.43786177039146423},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.4361559748649597},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.41721606254577637},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3075779676437378},{"id":"https://openalex.org/keywords/urinary-system","display_name":"Urinary system","score":0.3039478361606598},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.27170097827911377}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8430341482162476},{"id":"https://openalex.org/C2778769751","wikidata":"https://www.wikidata.org/wiki/Q246090","display_name":"Cystoscopy","level":3,"score":0.6353065967559814},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6123033165931702},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5002405643463135},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4902847111225128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4659408628940582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45410406589508057},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.43786177039146423},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4361559748649597},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41721606254577637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3075779676437378},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.3039478361606598},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27170097827911377},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-021-04235-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04235-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04235-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34090341","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34090341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8180080","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8180080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:be85445aa3a24ec1a0c52c872fd93100","is_oa":true,"landing_page_url":"https://doaj.org/article/be85445aa3a24ec1a0c52c872fd93100","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-16 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04235-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04235-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04235-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3166566839.pdf","grobid_xml":"https://content.openalex.org/works/W3166566839.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W95147771","https://openalex.org/W1139124521","https://openalex.org/W1498250171","https://openalex.org/W1778413072","https://openalex.org/W1964561132","https://openalex.org/W1970286046","https://openalex.org/W1974304599","https://openalex.org/W1975624790","https://openalex.org/W1978211809","https://openalex.org/W1980098245","https://openalex.org/W1987633528","https://openalex.org/W1988310576","https://openalex.org/W2001899785","https://openalex.org/W2004867370","https://openalex.org/W2012167887","https://openalex.org/W2015292648","https://openalex.org/W2034420332","https://openalex.org/W2039220817","https://openalex.org/W2060168804","https://openalex.org/W2061292354","https://openalex.org/W2063177645","https://openalex.org/W2069470844","https://openalex.org/W2080943203","https://openalex.org/W2083340629","https://openalex.org/W2083975795","https://openalex.org/W2084063317","https://openalex.org/W2084362806","https://openalex.org/W2084788991","https://openalex.org/W2095387199","https://openalex.org/W2117994982","https://openalex.org/W2132066552","https://openalex.org/W2134657894","https://openalex.org/W2162446904","https://openalex.org/W2168745915","https://openalex.org/W2169777179","https://openalex.org/W2327028950","https://openalex.org/W2411337970","https://openalex.org/W2473162054","https://openalex.org/W2568346436","https://openalex.org/W2743370588","https://openalex.org/W2746811993","https://openalex.org/W2769216223","https://openalex.org/W2801490189","https://openalex.org/W2912123626","https://openalex.org/W3119247560","https://openalex.org/W4229977739","https://openalex.org/W4244249122","https://openalex.org/W4252684946"],"related_works":["https://openalex.org/W4366750509","https://openalex.org/W2037888279","https://openalex.org/W1976078694","https://openalex.org/W2029203446","https://openalex.org/W2531822697","https://openalex.org/W2892025615","https://openalex.org/W3170858564","https://openalex.org/W1975705637","https://openalex.org/W3213079831","https://openalex.org/W2082430484"],"abstract_inverted_index":{"BACKGROUND:":[0],"Early":[1],"detection":[2,206,229],"of":[3,45,104,107,119,147,160,180,207,230],"bladder":[4,12,47,67,149,166,209,216,231],"cancer":[5,13,48,68,72,150,167,217],"remains":[6],"challenging":[7],"because":[8],"patients":[9,63,73],"with":[10,65,132,187],"early-stage":[11,46,66,208,215],"usually":[14],"have":[15],"no":[16],"incentive":[17],"to":[18,31],"take":[19],"cytology":[20],"or":[21,69],"cystoscopy":[22],"tests":[23],"if":[24],"they":[25],"are":[26],"asymptomatic.":[27],"Our":[28],"goal":[29],"is":[30],"find":[32],"non-invasive":[33],"marker":[34,85,121,126],"candidates":[35,127],"that":[36],"may":[37,223],"help":[38],"us":[39],"gain":[40],"insight":[41],"into":[42],"the":[43,89,108,116,120,148,162,178,194,205,228],"metabolism":[44,222],"and":[49,74,88,135,189,218,220],"be":[50,184],"examined":[51],"in":[52,83,95,143,165,174,185],"routine":[53],"health":[54],"checks.":[55],"RESULTS:":[56],"We":[57,100,152],"acquired":[58],"urine":[59,198],"samples":[60,80,92,109,168],"from":[61],"124":[62],"diagnosed":[64],"hernia":[70,175],"(63":[71],"61":[75],"controls).":[76],"In":[77,193],"which":[78],"100":[79],"were":[81,93],"included":[82,94],"our":[84,96],"discovery":[86,122],"cohort,":[87,123],"remaining":[90],"24":[91],"independent":[97],"test":[98,131],"cohort.":[99],"obtained":[101],"metabolic":[102,117],"profiles":[103,118],"922":[105],"compounds":[106,141],"by":[110],"gas":[111],"chromatography-mass":[112],"spectrometry.":[113],"Based":[114],"on":[115],"we":[124,138],"selected":[125,154,200],"using":[128],"Wilcoxon":[129],"rank-sum":[130],"Bonferroni":[133],"correction":[134],"leave-one-out":[136],"cross-validation;":[137],"further":[139],"excluded":[140],"detected":[142],"less":[144],"than":[145],"60%":[146],"samples.":[151,176],"finally":[153],"eight":[155,163],"putative":[156,201],"markers.":[157],"The":[158,211],"abundance":[159],"all":[161],"markers":[164,182,203],"was":[169],"high":[170],"but":[171],"extremely":[172],"low":[173],"Moreover,":[177],"up-regulation":[179],"these":[181],"might":[183],"association":[186],"sugars":[188,219],"polyols":[190,221],"metabolism.":[191],"CONCLUSIONS:":[192],"present":[195],"study,":[196],"comparative":[197],"metabolomics":[199],"metabolite":[202],"for":[204,226],"cancer.":[210,232],"suggested":[212],"relations":[213],"between":[214],"create":[224],"opportunities":[225],"improving":[227]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}