{"id":"https://openalex.org/W3167160116","doi":"https://doi.org/10.1186/s12859-021-04231-3","title":"Double matrix completion for circRNA-disease association prediction","display_name":"Double matrix completion for circRNA-disease association prediction","publication_year":2021,"publication_date":"2021-06-08","ids":{"openalex":"https://openalex.org/W3167160116","doi":"https://doi.org/10.1186/s12859-021-04231-3","mag":"3167160116","pmid":"https://pubmed.ncbi.nlm.nih.gov/34103016"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04231-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04231-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04231-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04231-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031496985","display_name":"Zonglan Zuo","orcid":null},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong-Lan Zuo","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101959312","display_name":"Ruifen Cao","orcid":"https://orcid.org/0000-0002-4223-3422"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-Fen Cao","raw_affiliation_strings":["Engineering Research Center of Big Data Application in Private Health Medicine, Fujian Province University, Putian, Fujian, China","Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Big Data Application in Private Health Medicine, Fujian Province University, Putian, Fujian, China","institution_ids":[]},{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085214222","display_name":"Pi-Jing Wei","orcid":"https://orcid.org/0000-0003-2770-8781"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pi-Jing Wei","raw_affiliation_strings":["Institute of Physical Science and Information Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Science and Information Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065943710","display_name":"Junfeng Xia","orcid":"https://orcid.org/0000-0003-3024-1705"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Feng Xia","raw_affiliation_strings":["Institute of Physical Science and Information Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Science and Information Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun-Hou Zheng","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China. zhengch99@126.com","Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China. zhengch99@126.com","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064185915"],"corresponding_institution_ids":["https://openalex.org/I143868143"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.4803,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82224232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"307","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.7736999988555908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.7736999988555908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.559291660785675},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5285906791687012},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49960947036743164},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.43849822878837585},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3824256658554077},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34624767303466797},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3214077949523926},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20130655169487},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.06976628303527832}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.559291660785675},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5285906791687012},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49960947036743164},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.43849822878837585},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3824256658554077},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34624767303466797},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3214077949523926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20130655169487},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06976628303527832},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-021-04231-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04231-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04231-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34103016","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34103016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:702cf44c844a4f588db16ef9fe819001","is_oa":true,"landing_page_url":"https://doaj.org/article/702cf44c844a4f588db16ef9fe819001","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-15 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8185931","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8185931","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04231-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04231-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-021-04231-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G247010507","display_name":null,"funder_award_id":"61873001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5006237592","display_name":null,"funder_award_id":"U19A2064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3167160116.pdf","grobid_xml":"https://content.openalex.org/works/W3167160116.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1846631206","https://openalex.org/W1977878983","https://openalex.org/W2115662330","https://openalex.org/W2128049108","https://openalex.org/W2426535589","https://openalex.org/W2587410747","https://openalex.org/W2744528004","https://openalex.org/W2782571367","https://openalex.org/W2799307902","https://openalex.org/W2800766678","https://openalex.org/W2807602500","https://openalex.org/W2884943532","https://openalex.org/W2898991725","https://openalex.org/W2899436082","https://openalex.org/W2899915536","https://openalex.org/W2906953716","https://openalex.org/W2909637325","https://openalex.org/W2922405516","https://openalex.org/W2939522662","https://openalex.org/W2942820662","https://openalex.org/W2951739649","https://openalex.org/W2960557205","https://openalex.org/W2966844369","https://openalex.org/W2976877817","https://openalex.org/W2980767508","https://openalex.org/W2981316968","https://openalex.org/W2991094260","https://openalex.org/W2991743543","https://openalex.org/W2991794871","https://openalex.org/W2996505894","https://openalex.org/W3000082418","https://openalex.org/W3004538479","https://openalex.org/W3004779847","https://openalex.org/W3005712826","https://openalex.org/W3010585088","https://openalex.org/W3014858999","https://openalex.org/W3026308742","https://openalex.org/W3036319301","https://openalex.org/W3093286659","https://openalex.org/W3133431009"],"related_works":["https://openalex.org/W2375480909","https://openalex.org/W2353314428","https://openalex.org/W2012019886","https://openalex.org/W2166090428","https://openalex.org/W2381021552","https://openalex.org/W2354749003","https://openalex.org/W2377121353","https://openalex.org/W2350529538","https://openalex.org/W2076713575","https://openalex.org/W2014996787"],"abstract_inverted_index":{"BACKGROUND:":[0],"Circular":[1],"RNAs":[2],"(circRNAs)":[3],"are":[4,24,39,135],"a":[5,12,50,75,89,108,198,237],"class":[6],"of":[7,18,30,43,92,133,145,157,195,211,218],"single-stranded":[8],"RNA":[9],"molecules":[10],"with":[11,183,190],"closed-loop":[13],"structure.":[14],"A":[15],"growing":[16],"body":[17],"research":[19],"has":[20,197],"shown":[21],"that":[22,226],"circRNAs":[23,235],"closely":[25],"related":[26],"to":[27,35,48,54,64,97,137,165],"the":[28,56,125,139,143,155,167,175,180,184,193,209,212,216,219,233],"development":[29],"diseases.":[31],"Because":[32],"biological":[33,62,240],"experiments":[34,63],"verify":[36],"circRNA-disease":[37,59,84,122],"associations":[38,60],"time-consuming":[40],"and":[41,94,101,116,130,147,159,205],"wasteful":[42],"resources,":[44],"it":[45],"is":[46,163,171],"necessary":[47],"propose":[49,74],"reliable":[51],"computational":[52],"method":[53,79,228],"predict":[55],"potential":[57,83,234],"candidate":[58],"for":[61,81,114,231,236,239],"make":[65],"them":[66],"more":[67],"efficient.":[68],"RESULTS:":[69],"In":[70],"this":[71],"paper,":[72],"we":[73,87],"double":[76],"matrix":[77,91,113,141,151,161,168,177],"completion":[78,162],"(DMCCDA)":[80],"predicting":[82],"associations.":[85,123],"First,":[86],"constructed":[88],"similarity":[90,112,129,132,187],"circRNA":[93,98,115,127,146,158],"disease":[95,103,117,134,238],"according":[96],"sequence":[99,128],"information":[100],"semantic":[102,131],"information.":[104],"We":[105],"also":[106],"built":[107],"Gauss":[109],"interaction":[110],"profile":[111],"based":[118],"on":[119],"experimentally":[120],"verified":[121],"Then,":[124],"corresponding":[126,185],"used":[136,164],"update":[138,166],"association":[140,176],"from":[142,154],"perspective":[144,156],"disease,":[148,160],"respectively,":[149],"by":[150,173],"multiplication.":[152],"Finally,":[153],"block,":[169],"which":[170],"formed":[172],"splicing":[174],"obtained":[178],"in":[179,202],"previous":[181],"step":[182],"Gaussian":[186],"matrix.":[188],"Compared":[189],"other":[191],"approaches,":[192],"model":[194],"DMCCDA":[196,220],"relatively":[199],"good":[200],"result":[201],"leave-one-out":[203],"cross-validation":[204],"five-fold":[206],"cross-validation.":[207],"Additionally,":[208],"results":[210,224],"case":[213],"studies":[214],"illustrate":[215],"effectiveness":[217],"model.":[221],"CONCLUSION:":[222],"The":[223],"show":[225],"our":[227],"works":[229],"well":[230],"recommending":[232],"experiments.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}