{"id":"https://openalex.org/W3137094678","doi":"https://doi.org/10.1186/s12859-021-04052-4","title":"Bayesian approach for predicting responses to therapy from high-dimensional time-course gene expression profiles","display_name":"Bayesian approach for predicting responses to therapy from high-dimensional time-course gene expression profiles","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3137094678","doi":"https://doi.org/10.1186/s12859-021-04052-4","mag":"3137094678","pmid":"https://pubmed.ncbi.nlm.nih.gov/33736614"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04052-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04052-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04052-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04052-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039201962","display_name":"Arika Fukushima","orcid":null},"institutions":[{"id":"https://openalex.org/I133984924","display_name":"Doshisha University","ror":"https://ror.org/01fxdkm29","country_code":"JP","type":"education","lineage":["https://openalex.org/I133984924"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Arika Fukushima","raw_affiliation_strings":["Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan","institution_ids":["https://openalex.org/I133984924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071767668","display_name":"Masahiro Sugimoto","orcid":"https://orcid.org/0000-0003-3316-2543"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Sugimoto","raw_affiliation_strings":["Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, 997-0052, Japan","Research and Development Center for Minimally Invasive Therapies, Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo, 160-8402, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Research and Development Center for Minimally Invasive Therapies, Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo, 160-8402, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006539938","display_name":"Satoru Hiwa","orcid":"https://orcid.org/0000-0001-6547-626X"},"institutions":[{"id":"https://openalex.org/I133984924","display_name":"Doshisha University","ror":"https://ror.org/01fxdkm29","country_code":"JP","type":"education","lineage":["https://openalex.org/I133984924"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Hiwa","raw_affiliation_strings":["Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan","institution_ids":["https://openalex.org/I133984924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036543534","display_name":"Tomoyuki Hiroyasu","orcid":"https://orcid.org/0000-0003-0730-7905"},"institutions":[{"id":"https://openalex.org/I133984924","display_name":"Doshisha University","ror":"https://ror.org/01fxdkm29","country_code":"JP","type":"education","lineage":["https://openalex.org/I133984924"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Hiroyasu","raw_affiliation_strings":["Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan. tomo@is.doshisha.ac.jp","Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0730-7905","affiliations":[{"raw_affiliation_string":"Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan. tomo@is.doshisha.ac.jp","institution_ids":["https://openalex.org/I133984924"]},{"raw_affiliation_string":"Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe-shi, Kyoto, 610-0321, Japan","institution_ids":["https://openalex.org/I133984924"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039201962"],"corresponding_institution_ids":["https://openalex.org/I133984924"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0814,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42200118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"22","issue":"1","first_page":"132","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/time-point","display_name":"Time point","score":0.6302945613861084},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5637049674987793},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.466940313577652},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4657158851623535},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.45617198944091797},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4423673748970032},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40944725275039673},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3788216710090637},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3776119351387024},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3694308400154114},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36422044038772583},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32803040742874146},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2588675618171692},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10869976878166199}],"concepts":[{"id":"https://openalex.org/C2779466056","wikidata":"https://www.wikidata.org/wiki/Q107630651","display_name":"Time point","level":2,"score":0.6302945613861084},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5637049674987793},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.466940313577652},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4657158851623535},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.45617198944091797},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4423673748970032},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40944725275039673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3788216710090637},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3776119351387024},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3694308400154114},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36422044038772583},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32803040742874146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2588675618171692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10869976878166199},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-021-04052-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04052-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04052-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33736614","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33736614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:1afe3df35228403da608820be3b17ba9","is_oa":true,"landing_page_url":"https://doaj.org/article/1afe3df35228403da608820be3b17ba9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-20 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7977599","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7977599","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04052-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04052-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04052-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G14060251","display_name":"Dynamic brain-to-brain network analysis during social interaction","funder_award_id":"20K11963","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5611108758","display_name":null,"funder_award_id":"20B205","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137094678.pdf","grobid_xml":"https://content.openalex.org/works/W3137094678.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1480888202","https://openalex.org/W1493357981","https://openalex.org/W1556637198","https://openalex.org/W1570643690","https://openalex.org/W1970047903","https://openalex.org/W1978606949","https://openalex.org/W1982964625","https://openalex.org/W1986022901","https://openalex.org/W1986304925","https://openalex.org/W1993273815","https://openalex.org/W1993528080","https://openalex.org/W1994672146","https://openalex.org/W2027545702","https://openalex.org/W2031511512","https://openalex.org/W2032919054","https://openalex.org/W2036736994","https://openalex.org/W2038240472","https://openalex.org/W2039018899","https://openalex.org/W2040007196","https://openalex.org/W2047044113","https://openalex.org/W2056024268","https://openalex.org/W2063717803","https://openalex.org/W2068743483","https://openalex.org/W2069115890","https://openalex.org/W2075796873","https://openalex.org/W2076021613","https://openalex.org/W2093431298","https://openalex.org/W2103445423","https://openalex.org/W2104193042","https://openalex.org/W2105559737","https://openalex.org/W2124234055","https://openalex.org/W2144563439","https://openalex.org/W2144738674","https://openalex.org/W2150677775","https://openalex.org/W2158418996","https://openalex.org/W2172273303","https://openalex.org/W2263348188","https://openalex.org/W2297853534","https://openalex.org/W2511712066","https://openalex.org/W2555574677","https://openalex.org/W2562162676","https://openalex.org/W2566250991","https://openalex.org/W2741235538","https://openalex.org/W2766708656","https://openalex.org/W2784987599","https://openalex.org/W2803981438","https://openalex.org/W2884337809","https://openalex.org/W2895435383","https://openalex.org/W2909240409","https://openalex.org/W2919801824","https://openalex.org/W2937720651","https://openalex.org/W2939923974","https://openalex.org/W2947159602","https://openalex.org/W2951775082","https://openalex.org/W3103900655","https://openalex.org/W3152196550"],"related_works":["https://openalex.org/W2392243736","https://openalex.org/W86652014","https://openalex.org/W3129895999","https://openalex.org/W2328518092","https://openalex.org/W3101249758","https://openalex.org/W2382079200","https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W2374091470","https://openalex.org/W4388218547"],"abstract_inverted_index":{"BACKGROUND:":[0],"Historical":[1],"and":[2,82,125,138,150,166],"updated":[3],"information":[4,21],"provided":[5,22],"by":[6,23],"time-course":[7,30,64,86],"data":[8,31,65,114,178],"collected":[9,101,116],"during":[10],"an":[11],"entire":[12],"treatment":[13,52],"period":[14],"proves":[15],"to":[16,40,44,108,136,175,192],"be":[17,78],"more":[18,145],"useful":[19],"than":[20,147],"single-point":[24],"data.":[25],"Accurate":[26],"predictions":[27],"made":[28],"using":[29,97,177],"on":[32,66],"multiple":[33,67,94,126,180],"biomarkers":[34],"that":[35,76,133,203],"indicate":[36],"a":[37,103],"patient's":[38],"response":[39,135,174],"therapy":[41,110,137,176],"contribute":[42],"positively":[43],"the":[45,58,154,161],"decision-making":[46],"process":[47],"associated":[48,159,206],"with":[49,119,160,207],"designing":[50],"effective":[51],"programs":[53],"for":[54,80],"various":[55],"diseases.":[56,208],"Therefore,":[57],"development":[59],"of":[60,105,156,163,194],"prediction":[61,81,91],"methods":[62,75,143,149],"incorporating":[63],"markers":[68],"is":[69],"necessary.":[70],"RESULTS:":[71],"We":[72],"proposed":[73,170],"new":[74],"may":[77],"used":[79],"gene":[83,87,98],"selection":[84],"via":[85],"expression":[88,99],"profiles.":[89],"Our":[90,142],"method":[92,171,199],"consolidated":[93],"probabilities":[95],"calculated":[96],"profiles":[100],"over":[102],"series":[104],"time":[106,181,189],"points":[107,190],"predict":[109],"response.":[111],"Using":[112],"two":[113],"sets":[115],"from":[117],"patients":[118],"hepatitis":[120],"C":[121],"virus":[122],"(HCV)":[123],"infection":[124,165],"sclerosis":[127],"(MS),":[128],"we":[129],"performed":[130],"numerical":[131],"experiments":[132],"predicted":[134,173],"evaluated":[139],"their":[140],"accuracies.":[141],"were":[144,158,204],"accurate":[146],"conventional":[148,195],"successfully":[151,200],"selected":[152,201],"genes,":[153],"functions":[155],"which":[157],"pathology":[162],"HCV":[164],"MS.":[167],"CONCLUSIONS:":[168],"The":[169],"accurately":[172],"at":[179,187],"points.":[182],"It":[183],"showed":[184],"higher":[185],"accuracies":[186],"early":[188],"compared":[191],"those":[193],"methods.":[196],"Furthermore,":[197],"this":[198],"genes":[202],"directly":[205]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}