{"id":"https://openalex.org/W3133259203","doi":"https://doi.org/10.1186/s12859-021-04030-w","title":"A base measure of precision for protein stability predictors: structural sensitivity","display_name":"A base measure of precision for protein stability predictors: structural sensitivity","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3133259203","doi":"https://doi.org/10.1186/s12859-021-04030-w","mag":"3133259203","pmid":"https://pubmed.ncbi.nlm.nih.gov/33632133"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04030-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04030-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04030-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04030-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002860465","display_name":"Octav Caldararu","orcid":"https://orcid.org/0000-0002-5900-6568"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Octav Caldararu","raw_affiliation_strings":["DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5900-6568","affiliations":[{"raw_affiliation_string":"DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001029093","display_name":"Tom L. Blundell","orcid":"https://orcid.org/0000-0002-2708-8992"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tom L. Blundell","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK"],"raw_orcid":"https://orcid.org/0000-0002-2708-8992","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084810235","display_name":"Kasper P. Kepp","orcid":"https://orcid.org/0000-0002-6754-7348"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kasper P. Kepp","raw_affiliation_strings":["DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark. kpj@kemi.dtu.dk","DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-6754-7348","affiliations":[{"raw_affiliation_string":"DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark. kpj@kemi.dtu.dk","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.7682,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91534082,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"88","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9319000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9319000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.7175344228744507},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6701488494873047},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.514595627784729},{"id":"https://openalex.org/keywords/base","display_name":"Base (topology)","score":0.4828120172023773},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.45833900570869446},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42939549684524536},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4163256883621216},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35851603746414185},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32090920209884644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30099013447761536},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28645747900009155},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2727721333503723},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.1546851098537445},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14562112092971802},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12540364265441895},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.0758402943611145}],"concepts":[{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.7175344228744507},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6701488494873047},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.514595627784729},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.4828120172023773},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.45833900570869446},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42939549684524536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4163256883621216},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35851603746414185},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32090920209884644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30099013447761536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28645747900009155},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2727721333503723},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1546851098537445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14562112092971802},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12540364265441895},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0758402943611145},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12859-021-04030-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04030-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04030-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33632133","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33632133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:1f9e892e31e840a187afe844259b3511","is_oa":true,"landing_page_url":"https://doaj.org/article/1f9e892e31e840a187afe844259b3511","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7908712","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7908712","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/991a8d71-b422-4028-9799-26e55e43417a","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/991a8d71-b422-4028-9799-26e55e43417a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Caldararu , O , Blundell , T L &amp; Kepp , K P 2021 , ' A base measure of precision for protein stability predictors: structural sensitivity ' , BMC Bioinformatics , vol. 22 , no. 1 , 88 . https://doi.org/10.1186/s12859-021-04030-w","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/318123","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/318123","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/318683","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/318683","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.65238","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.65238","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17863/cam.65800","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.65800","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04030-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04030-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04030-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1563700229","display_name":null,"funder_award_id":"8022-00041B","funder_id":"https://openalex.org/F4320327387","funder_display_name":"Danmarks Frie Forskningsfond"},{"id":"https://openalex.org/G4329770299","display_name":null,"funder_award_id":"8022-00041B","funder_id":"https://openalex.org/F4320322928","funder_display_name":"Danmarks Frie Forskningsfond"}],"funders":[{"id":"https://openalex.org/F4320322928","display_name":"Danmarks Frie Forskningsfond","ror":"https://ror.org/02sptwz63"},{"id":"https://openalex.org/F4320327387","display_name":"Danmarks Frie Forskningsfond","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133259203.pdf","grobid_xml":"https://content.openalex.org/works/W3133259203.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W579166296","https://openalex.org/W1966979475","https://openalex.org/W1974599488","https://openalex.org/W1990823383","https://openalex.org/W1996576490","https://openalex.org/W2002052142","https://openalex.org/W2004360551","https://openalex.org/W2005756796","https://openalex.org/W2008662159","https://openalex.org/W2008708467","https://openalex.org/W2023490488","https://openalex.org/W2025670719","https://openalex.org/W2031239680","https://openalex.org/W2031553026","https://openalex.org/W2041476324","https://openalex.org/W2050717189","https://openalex.org/W2083147938","https://openalex.org/W2085560162","https://openalex.org/W2087588307","https://openalex.org/W2092387745","https://openalex.org/W2093847279","https://openalex.org/W2103459989","https://openalex.org/W2109083660","https://openalex.org/W2111878373","https://openalex.org/W2130479394","https://openalex.org/W2134488721","https://openalex.org/W2136513422","https://openalex.org/W2145644903","https://openalex.org/W2147082825","https://openalex.org/W2149580316","https://openalex.org/W2151529283","https://openalex.org/W2153457180","https://openalex.org/W2155137057","https://openalex.org/W2159591337","https://openalex.org/W2160354385","https://openalex.org/W2168749685","https://openalex.org/W2171741848","https://openalex.org/W2172034373","https://openalex.org/W2310980987","https://openalex.org/W2326486590","https://openalex.org/W2346045962","https://openalex.org/W2519539312","https://openalex.org/W2604342372","https://openalex.org/W2794503008","https://openalex.org/W2902559445","https://openalex.org/W2916078022","https://openalex.org/W3048947632"],"related_works":["https://openalex.org/W4255837520","https://openalex.org/W2387011115","https://openalex.org/W4234808182","https://openalex.org/W2382043075","https://openalex.org/W2809151339","https://openalex.org/W2360673138","https://openalex.org/W2809370583","https://openalex.org/W2333722679","https://openalex.org/W4255628145","https://openalex.org/W2093320919"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prediction":[1],"of":[2,9,15,23,40,56,66,91,102,109,117,120,145,152,187,193,203,259,303],"the":[3,38,54,88,99,146,172,176,188,191,214,219,244,253,257,260,281,301,304],"change":[4],"in":[5,64,196,262],"fold":[6],"stability":[7,93,204,294],"(\u0394\u0394G)":[8],"a":[10,47,84,114,150,225,263],"protein":[11,19,92,221,239,293],"upon":[12],"mutation":[13],"is":[14,83,210],"major":[16],"importance":[17,192],"to":[18,34,53,86,155,249],"engineering":[20],"and":[21,75,131,209,216,243,284,296],"screening":[22],"disease-causing":[24],"variants.":[25],"Many":[26],"prediction":[27,94,105,205],"methods":[28,42,63,106,140,160,206,270,299],"can":[29],"use":[30,108],"3D":[31],"structural":[32,89,100,127,201,222],"information":[33],"predict":[35],"\u0394\u0394G.":[36],"While":[37],"performance":[39],"these":[41,62],"has":[43,50],"been":[44],"extensively":[45],"studied,":[46],"new":[48,226],"problem":[49],"arisen":[51],"due":[52],"abundance":[55],"crystal":[57],"structures:":[58],"How":[59],"precise":[60],"are":[61,235],"terms":[65],"structure":[67,71,272],"input":[68],"used,":[69,74],"which":[70],"should":[72],"be":[73],"how":[76],"much":[77,162],"does":[78],"it":[79],"matter?":[80],"Thus,":[81],"there":[82],"need":[85],"quantify":[87],"sensitivity":[90,101,128,151,164,202],"methods.":[95],"RESULTS:":[96],"We":[97,168],"computed":[98],"six":[103],"widely-used":[104],"by":[107,213,218],"saturated":[110],"computational":[111],"mutagenesis":[112],"on":[113,237],"diverse":[115],"set":[116],"87":[118],"structures":[119,240,278],"25":[121],"proteins.":[122],"Our":[123,266],"results":[124],"show":[125],"that":[126,141,171,232,268,275,297],"varies":[129,207],"massively":[130],"surprisingly":[132],"falls":[133],"into":[134],"two":[135],"very":[136],"distinct":[137],"groups,":[138],"with":[139,175],"take":[142],"detailed":[143],"account":[144],"local":[147],"environment":[148],"showing":[149],"~":[153],"0.6":[154],"0.8":[156],"kcal/mol,":[157],"whereas":[158],"machine-learning":[159,269],"display":[161],"lower":[163],"(~":[165],"0.1":[166],"kcal/mol).":[167],"also":[169,256],"observe":[170],"precision":[173,258],"correlates":[174],"accuracy":[177,186,254],"for":[178,291],"mutation-type-balanced":[179],"data":[180],"sets":[181],"but":[182,255],"not":[183,251],"generally":[184],"reported":[185],"methods,":[189],"indicating":[190],"mutation-type":[194],"balance":[195],"both":[197],"contexts.":[198],"CONCLUSIONS:":[199],"The":[200],"greatly":[208],"caused":[211],"mainly":[212],"models":[215],"less":[217],"actual":[220],"differences.":[223],"As":[224],"recommended":[227],"standard,":[228],"we":[229],"therefore":[230],"suggest":[231],"\u0394\u0394G":[233],"values":[234],"evaluated":[236],"three":[238],"when":[241],"available":[242],"associated":[245],"standard":[246],"deviation":[247],"reported,":[248],"emphasize":[250],"just":[252],"method":[261],"specific":[264],"study.":[265],"observation":[267],"deemphasize":[271],"may":[273],"indicate":[274],"folded":[276,282,305],"wild-type":[277,306],"alone,":[279],"without":[280],"mutant":[283],"unfolded":[285],"structures,":[286],"only":[287],"add":[288],"modest":[289],"value":[290],"assessing":[292],"effects,":[295],"side-chain-sensitive":[298],"overstate":[300],"significance":[302],"structure.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":7}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
