{"id":"https://openalex.org/W3149462980","doi":"https://doi.org/10.1186/s12859-021-04017-7","title":"Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development","display_name":"Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development","publication_year":2021,"publication_date":"2021-04-08","ids":{"openalex":"https://openalex.org/W3149462980","doi":"https://doi.org/10.1186/s12859-021-04017-7","mag":"3149462980","pmid":"https://pubmed.ncbi.nlm.nih.gov/33832440"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04017-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04017-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04017-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04017-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026068211","display_name":"Aleksandra Gruca","orcid":"https://orcid.org/0000-0003-2337-1894","observed_orcids":["https://orcid.org/0000-0003-2337-1894"]},"institutions":[{"id":"https://openalex.org/I119004910","display_name":"Silesian University of Technology","ror":"https://ror.org/02dyjk442","country_code":"PL","type":"education","lineage":["https://openalex.org/I119004910"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Gruca","raw_affiliation_strings":["Department of Computer Network and Systems, Silesian University of Technology, Gliwice, Poland","Department of Computer Networks and Systems, Silesian University of Technology, Gliwice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Network and Systems, Silesian University of Technology, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]},{"raw_affiliation_string":"Department of Computer Networks and Systems, Silesian University of Technology, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056172762","display_name":"Joanna Ziemska-Legi\u0119cka","orcid":"https://orcid.org/0000-0003-1267-3467","observed_orcids":["https://orcid.org/0000-0003-1267-3467"]},"institutions":[{"id":"https://openalex.org/I4210128244","display_name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences","ror":"https://ror.org/034tvp782","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Ziemska-Legiecka","raw_affiliation_strings":["Institute of Biochemistry and Biophysics PAS, Warsaw, Poland","Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biophysics PAS, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244"]},{"raw_affiliation_string":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011890249","display_name":"Patryk Jarnot","orcid":"https://orcid.org/0000-0002-8318-2270","observed_orcids":["https://orcid.org/0000-0002-8318-2270"]},"institutions":[{"id":"https://openalex.org/I119004910","display_name":"Silesian University of Technology","ror":"https://ror.org/02dyjk442","country_code":"PL","type":"education","lineage":["https://openalex.org/I119004910"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Patryk Jarnot","raw_affiliation_strings":["Department of Computer Network and Systems, Silesian University of Technology, Gliwice, Poland","Department of Computer Networks and Systems, Silesian University of Technology, Gliwice, Poland"],"raw_orcid":"https://orcid.org/0000-0002-8318-2270","affiliations":[{"raw_affiliation_string":"Department of Computer Network and Systems, Silesian University of Technology, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]},{"raw_affiliation_string":"Department of Computer Networks and Systems, Silesian University of Technology, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028084929","display_name":"Elzbieta A. Sarnowska","orcid":"https://orcid.org/0000-0001-7723-1198","observed_orcids":["https://orcid.org/0000-0001-7723-1198"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Elzbieta Sarnowska","raw_affiliation_strings":["Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079506820","display_name":"Tomasz Jacek Sarnowski","orcid":"https://orcid.org/0000-0002-3805-2039","observed_orcids":["https://orcid.org/0000-0002-3805-2039"]},"institutions":[{"id":"https://openalex.org/I4210128244","display_name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences","ror":"https://ror.org/034tvp782","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz J. Sarnowski","raw_affiliation_strings":["Institute of Biochemistry and Biophysics PAS, Warsaw, Poland","Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-3805-2039","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biophysics PAS, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244"]},{"raw_affiliation_string":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003289842","display_name":"Marcin Grynberg","orcid":"https://orcid.org/0000-0003-1887-7209","observed_orcids":["https://orcid.org/0000-0003-1887-7209"]},"institutions":[{"id":"https://openalex.org/I4210128244","display_name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences","ror":"https://ror.org/034tvp782","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Marcin Grynberg","raw_affiliation_strings":["Institute of Biochemistry and Biophysics PAS, Warsaw, Poland","Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-1887-7209","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biophysics PAS, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244"]},{"raw_affiliation_string":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003289842"],"corresponding_institution_ids":["https://openalex.org/I4210128244","https://openalex.org/I99542240"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.6735,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.62785871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"182","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/low-complexity-regions","display_name":"low complexity regions","score":0.9900000095367432},{"id":"https://openalex.org/keywords/epitope-prediction","display_name":"epitope prediction","score":0.6790000200271606},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.949999988079071},{"id":"https://openalex.org/keywords/b-cell-epitopes","display_name":"B-cell epitopes","score":1.0},{"id":"https://openalex.org/keywords/vaccine-target-selection","display_name":"vaccine target selection","score":0.7480000257492065},{"id":"https://openalex.org/keywords/nsp3","display_name":"NSP3","score":0.8149999976158142},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autoimmune-disease-susceptibility","display_name":"autoimmune disease susceptibility","score":0.675000011920929},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8240792751312256},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7259958982467651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6871613264083862},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.634881854057312},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.6067276000976562},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5363197922706604},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.45788872241973877},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3702981472015381},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35973507165908813},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2397032082080841},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.07650011777877808}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086462","descriptor_name":"Coronavirus Nucleocapsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086462","descriptor_name":"Coronavirus Nucleocapsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086462","descriptor_name":"Coronavirus Nucleocapsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086462","descriptor_name":"Coronavirus Nucleocapsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-021-04017-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04017-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04017-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"doi:10.1101/2020.08.11.245993","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.08.11.245993","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/08/11/2020.08.11.245993.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:33832440","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33832440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8027979","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8027979","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1d0f06eaff8d4ce19cc2f0afce183536","is_oa":true,"landing_page_url":"https://doaj.org/article/1d0f06eaff8d4ce19cc2f0afce183536","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04017-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04017-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04017-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3149462980.pdf","grobid_xml":"https://content.openalex.org/works/W3149462980.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W1237762235","https://openalex.org/W1492738623","https://openalex.org/W1528032072","https://openalex.org/W1559960346","https://openalex.org/W1662940398","https://openalex.org/W1821853514","https://openalex.org/W1876888557","https://openalex.org/W1966238900","https://openalex.org/W1967546787","https://openalex.org/W1971894038","https://openalex.org/W1972591948","https://openalex.org/W1974479059","https://openalex.org/W2004789352","https://openalex.org/W2009299532","https://openalex.org/W2016995212","https://openalex.org/W2024927615","https://openalex.org/W2025200316","https://openalex.org/W2039663472","https://openalex.org/W2045949302","https://openalex.org/W2046231927","https://openalex.org/W2048102092","https://openalex.org/W2049741584","https://openalex.org/W2051916497","https://openalex.org/W2055043387","https://openalex.org/W2063693562","https://openalex.org/W2066536058","https://openalex.org/W2067669402","https://openalex.org/W2072485950","https://openalex.org/W2072654650","https://openalex.org/W2079635715","https://openalex.org/W2087420232","https://openalex.org/W2093356049","https://openalex.org/W2094875270","https://openalex.org/W2103017472","https://openalex.org/W2104732024","https://openalex.org/W2106107191","https://openalex.org/W2106675204","https://openalex.org/W2107158607","https://openalex.org/W2125079066","https://openalex.org/W2129328366","https://openalex.org/W2137529106","https://openalex.org/W2137738918","https://openalex.org/W2143906670","https://openalex.org/W2144441003","https://openalex.org/W2150529110","https://openalex.org/W2150608129","https://openalex.org/W2151847720","https://openalex.org/W2154139219","https://openalex.org/W2154511791","https://openalex.org/W2165246093","https://openalex.org/W2165514480","https://openalex.org/W2235975933","https://openalex.org/W2292472819","https://openalex.org/W2326896496","https://openalex.org/W2398753954","https://openalex.org/W2513713807","https://openalex.org/W2532189500","https://openalex.org/W2604658068","https://openalex.org/W2605369788","https://openalex.org/W2605631608","https://openalex.org/W2610356532","https://openalex.org/W2623016513","https://openalex.org/W2738943575","https://openalex.org/W2767841706","https://openalex.org/W2768064447","https://openalex.org/W2781977790","https://openalex.org/W2803748520","https://openalex.org/W2898389621","https://openalex.org/W2900359059","https://openalex.org/W2912250830","https://openalex.org/W2946250110","https://openalex.org/W2973684955","https://openalex.org/W2975816879","https://openalex.org/W2977428858","https://openalex.org/W2991012415","https://openalex.org/W3007121066","https://openalex.org/W3007886991","https://openalex.org/W3009335299","https://openalex.org/W3009437769","https://openalex.org/W3010350910","https://openalex.org/W3011032288","https://openalex.org/W3011102168","https://openalex.org/W3011127849","https://openalex.org/W3011488280","https://openalex.org/W3011680753","https://openalex.org/W3012944241","https://openalex.org/W3013216225","https://openalex.org/W3013348202","https://openalex.org/W3014001472","https://openalex.org/W3014478762","https://openalex.org/W3015228903","https://openalex.org/W3015371627","https://openalex.org/W3016299116","https://openalex.org/W3016630335","https://openalex.org/W3017559857","https://openalex.org/W3020076836","https://openalex.org/W3020968939","https://openalex.org/W3023190340","https://openalex.org/W3023810580","https://openalex.org/W3024057275","https://openalex.org/W3026143991","https://openalex.org/W3026951563","https://openalex.org/W3027042213","https://openalex.org/W3028098130","https://openalex.org/W3030602524","https://openalex.org/W3031365196","https://openalex.org/W3033450058","https://openalex.org/W3035920796","https://openalex.org/W3036328479","https://openalex.org/W3036703196","https://openalex.org/W3046425184","https://openalex.org/W3047160870","https://openalex.org/W3080689315","https://openalex.org/W3081626042","https://openalex.org/W3084457882","https://openalex.org/W3092209456","https://openalex.org/W3096975836","https://openalex.org/W3101317276","https://openalex.org/W3107854744","https://openalex.org/W3109398830","https://openalex.org/W3110571029","https://openalex.org/W3119807775","https://openalex.org/W3125800928","https://openalex.org/W3126232912","https://openalex.org/W3135626597","https://openalex.org/W3207605229","https://openalex.org/W4233120011","https://openalex.org/W4236236547","https://openalex.org/W4247890068","https://openalex.org/W4249531936","https://openalex.org/W6628129683","https://openalex.org/W6675471023"],"related_works":["https://openalex.org/W3092794487","https://openalex.org/W2094752534","https://openalex.org/W1982829397","https://openalex.org/W2885268310","https://openalex.org/W2347437365","https://openalex.org/W2106414650","https://openalex.org/W2025055488","https://openalex.org/W1999412725","https://openalex.org/W2575115220","https://openalex.org/W4390205769"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,158],"rapid":[3],"spread":[4],"of":[5,22,45,130,135,139,151,180,182],"the":[6,12,35,46,61,89,114,127,149,152,178],"COVID-19":[7],"demands":[8],"immediate":[9],"response":[10],"from":[11,97],"scientific":[13],"communities.":[14],"Appropriate":[15],"countermeasures":[16],"mean":[17],"thoughtful":[18],"and":[19,43,85,107],"educated":[20],"choice":[21],"viral":[23,52,131],"targets":[24],"(epitopes).":[25],"There":[26],"are":[27,65,92,133,175],"several":[28],"articles":[29],"that":[30,64,74],"discuss":[31],"such":[32,69,192],"choices":[33],"in":[34,80,126],"SARS-CoV-2":[36,90,116,140],"proteome,":[37],"other":[38],"focus":[39],"on":[40,148],"phylogenetic":[41],"traits":[42],"history":[44],"Coronaviridae":[47],"genome/proteome.":[48],"However":[49],"none":[50],"consider":[51],"protein":[53],"low":[54,76],"complexity":[55,77],"regions":[56,78,96],"(LCRs).":[57],"Recently":[58],"we":[59],"created":[60],"first":[62],"methods":[63],"able":[66],"to":[67,95,119,142,154,169,177],"compare":[68],"fragments.":[70],"Results":[71],"We":[72],"show":[73],"five":[75,115],"(LCRs)":[79],"three":[81],"proteins":[82,124,144],"(nsp3,":[83],"S":[84],"N)":[86],"encoded":[87,125],"by":[88],"genome":[91],"highly":[93],"similar":[94,118],"human":[98,120,143],"proteome.":[99],"As":[100],"many":[101],"as":[102],"21":[103],"predicted":[104,109],"T-cell":[105],"epitopes":[106,111,184],"27":[108],"B-cell":[110],"overlap":[112],"with":[113],"LCRs":[117,141,161],"proteins.":[121],"Interestingly,":[122],"replication":[123],"central":[128],"part":[129],"RNA":[132],"devoid":[134],"LCRs.":[136],"Conclusions":[137],"Similarity":[138],"may":[145,162],"have":[146],"implications":[147],"ability":[150],"virus":[153],"counteract":[155],"immune":[156],"defenses.":[157],"vaccine":[159],"targeted":[160],"potentially":[163],"be":[164],"ineffective":[165],"or":[166,187],"alternatively":[167],"lead":[168],"autoimmune":[170],"diseases":[171],"development.":[172],"These":[173],"findings":[174],"crucial":[176],"process":[179],"selection":[181],"new":[183],"for":[185],"drugs":[186],"vaccines":[188],"which":[189],"should":[190],"omit":[191],"regions.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
