{"id":"https://openalex.org/W3157120757","doi":"https://doi.org/10.1186/s12859-021-04002-0","title":"Accelerated global sensitivity analysis of genome-wide constraint-based metabolic models","display_name":"Accelerated global sensitivity analysis of genome-wide constraint-based metabolic models","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W3157120757","doi":"https://doi.org/10.1186/s12859-021-04002-0","mag":"3157120757","pmid":"https://pubmed.ncbi.nlm.nih.gov/33902438"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-021-04002-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04002-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04002-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04002-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043650939","display_name":"Marco S. Nobile","orcid":"https://orcid.org/0000-0002-7692-7203"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Marco S. Nobile","raw_affiliation_strings":["Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands","Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy","SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]},{"raw_affiliation_string":"Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040479427","display_name":"Vasco Coelho","orcid":"https://orcid.org/0000-0003-1689-0434"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vasco Coelho","raw_affiliation_strings":["Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065568541","display_name":"Dario Pescini","orcid":"https://orcid.org/0000-0002-3090-4823"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Pescini","raw_affiliation_strings":["Department of Statistics and Quantiative Methods, University of Milano-Bicocca, Milan, Italy","SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Quantiative Methods, University of Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049497722","display_name":"Chiara Damiani","orcid":"https://orcid.org/0000-0002-5742-8302"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chiara Damiani","raw_affiliation_strings":["Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy. chiara.damiani@unimib.it","SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy. chiara.damiani@unimib.it","Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy","SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5742-8302","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy. chiara.damiani@unimib.it","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy. chiara.damiani@unimib.it","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO/ISBE.IT Centre for Systems Biology, Milan, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049497722"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I66752286"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":1721,"currency":"EUR","value_usd":1856},"fwci":0.5924,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63071929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":"S2","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.7681042551994324},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6844737529754639},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5090691447257996},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.4997704029083252},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4645547568798065},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3651743233203888},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25942695140838623},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1353350579738617},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1343000829219818},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0926370918750763}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.7681042551994324},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6844737529754639},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5090691447257996},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.4997704029083252},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4645547568798065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3651743233203888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25942695140838623},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1353350579738617},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1343000829219818},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0926370918750763},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12859-021-04002-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04002-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04002-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33902438","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33902438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pure.tue.nl:openaire/4f80231f-7c44-48d5-8ad4-d0cc9412d5b2","is_oa":true,"landing_page_url":"https://research.tue.nl/en/publications/4f80231f-7c44-48d5-8ad4-d0cc9412d5b2","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nobile, M S, Coelho, V, Pescini, D & Damiani, C 2021, 'Accelerated global sensitivity analysis of genome-wide constraint-based metabolic models', BMC Bioinformatics, vol. 22, no. Suppl 2, 78. https://doi.org/10.1186/s12859-021-04002-0","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:boa.unimib.it:10281/316482","is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/316482","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:b956b190330a4b708260c39c8aaab11c","is_oa":true,"landing_page_url":"https://doaj.org/article/b956b190330a4b708260c39c8aaab11c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss S2, Pp 1-17 (2021)","raw_type":"article"},{"id":"pmh:oai:iris.unive.it:10278/3755268","is_oa":false,"landing_page_url":"http://hdl.handle.net/10278/3755268","pdf_url":null,"source":{"id":"https://openalex.org/S4306402336","display_name":"ARCA (Universit\u00e0 Ca' Foscari Venezia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149461666","host_organization_name":"Ca' Foscari University of Venice","host_organization_lineage":["https://openalex.org/I149461666"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8074438","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8074438","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.tue.nl:publications/4f80231f-7c44-48d5-8ad4-d0cc9412d5b2","is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85104894180&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nobile, M S, Coelho, V, Pescini, D & Damiani, C 2021, 'Accelerated global sensitivity analysis of genome-wide constraint-based metabolic models', BMC Bioinformatics, vol. 22, no. Suppl 2, 78. https://doi.org/10.1186/s12859-021-04002-0","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:tue:oai:pure.tue.nl:publications/4f80231f-7c44-48d5-8ad4-d0cc9412d5b2","is_oa":true,"landing_page_url":"https://research.tue.nl/nl/publications/4f80231f-7c44-48d5-8ad4-d0cc9412d5b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 22(Suppl 2):78. BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-021-04002-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-021-04002-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-021-04002-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[{"id":"https://openalex.org/G4161689722","display_name":null,"funder_award_id":"Dipartimenti di Eccellenza- 2017","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320317295","display_name":"Dipartimenti di Eccellenza","ror":null},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3157120757.pdf","grobid_xml":"https://content.openalex.org/works/W3157120757.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W100464641","https://openalex.org/W999207820","https://openalex.org/W1995343013","https://openalex.org/W2016493615","https://openalex.org/W2029767409","https://openalex.org/W2035363534","https://openalex.org/W2038012176","https://openalex.org/W2038778951","https://openalex.org/W2044001670","https://openalex.org/W2044935306","https://openalex.org/W2078355959","https://openalex.org/W2088765131","https://openalex.org/W2101589741","https://openalex.org/W2111046434","https://openalex.org/W2115949387","https://openalex.org/W2132302738","https://openalex.org/W2141755357","https://openalex.org/W2143400799","https://openalex.org/W2161304688","https://openalex.org/W2181049364","https://openalex.org/W2418056440","https://openalex.org/W2533957110","https://openalex.org/W2613587040","https://openalex.org/W2760505998","https://openalex.org/W2789128799","https://openalex.org/W2941717576","https://openalex.org/W2942457503","https://openalex.org/W2951692764","https://openalex.org/W2952015518","https://openalex.org/W3000767803","https://openalex.org/W3015204006","https://openalex.org/W3018608736"],"related_works":["https://openalex.org/W2146126338","https://openalex.org/W2109563298","https://openalex.org/W4283377562","https://openalex.org/W1999460937","https://openalex.org/W832244386","https://openalex.org/W2086525401","https://openalex.org/W2155541527","https://openalex.org/W2097664794","https://openalex.org/W2378757965","https://openalex.org/W2171305205"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genome-wide":[1],"reconstructions":[2,232],"of":[3,11,36,45,62,90,100,120,135,173,194,201,211,226,233,251,279,305,307,313,317],"metabolism":[4,13,235],"opened":[5],"the":[6,21,34,43,51,71,75,87,91,109,121,132,156,164,170,174,191,209,249,303,311],"way":[7],"to":[8,42,69,107,126,131,141,186,215],"thorough":[9],"investigations":[10],"cell":[12],"for":[14,86,111],"health":[15],"care":[16],"and":[17,207,237],"industrial":[18],"purposes.":[19],"However,":[20],"predictions":[22],"offered":[23],"by":[24,33,58,98,199],"Flux":[25],"Balance":[26],"Analysis":[27],"(FBA)":[28],"can":[29],"be":[30,297],"strongly":[31],"affected":[32],"choice":[35],"flux":[37,44],"boundaries,":[38,64],"with":[39,248,265],"particular":[40],"regard":[41],"reactions":[46],"that":[47,138,154,241,270,287],"sink":[48],"nutrients":[49],"into":[50,299],"system.":[52],"To":[53],"mitigate":[54],"possible":[55],"errors":[56],"introduced":[57],"a":[59,65,84,113,117,151,217,224,276,314],"poor":[60],"selection":[61],"such":[63],"rational":[66],"approach":[67,228],"suggests":[68],"focus":[70],"modeling":[72],"efforts":[73],"on":[74,145,158,229],"pivotal":[76],"ones.":[77],"METHODS:":[78],"In":[79],"this":[80],"work,":[81],"we":[82,168,183,204],"present":[83],"methodology":[85,153],"automatic":[88],"identification":[89],"key":[92],"fluxes":[93],"in":[94,255,258,271],"genome-wide":[95,146,175,231,308],"constraint-based":[96,177],"models,":[97,147,309],"means":[99,200],"variance-based":[101],"sensitivity":[102,143,219,318],"analysis.":[103,220,319],"The":[104],"goal":[105],"is":[106,275],"identify":[108],"parameters":[110,244,293],"which":[112,295],"small":[114],"perturbation":[115],"entails":[116],"large":[118],"variation":[119],"model":[122,292],"outcomes,":[123],"also":[124,268],"referred":[125],"as":[127],"sensitive":[128,243],"parameters.":[129],"Due":[130],"high":[133],"number":[134],"FBA":[136,185,213],"simulations":[137],"are":[139,245,262],"necessary":[140],"assess":[142,216],"coefficients":[144],"our":[148,227],"method":[149],"exploits":[150],"master-slave":[152],"distributes":[155],"computation":[157],"massively":[159],"multi-core":[160],"architectures.":[161],"We":[162,222,239,267],"performed":[163],"following":[165],"steps:":[166],"(1)":[167],"determined":[169],"putative":[171],"parameterizations":[172],"metabolic":[176],"model,":[178,189],"using":[179],"Saltelli's":[180],"method;":[181],"(2)":[182],"applied":[184],"each":[187],"parameterized":[188],"distributing":[190],"massive":[192],"amount":[193],"calculations":[195],"over":[196],"multiple":[197],"nodes":[198],"MPI;":[202],"(3)":[203],"then":[205],"recollected":[206],"exploited":[208],"results":[210,285],"all":[212],"runs":[214],"global":[218,315],"RESULTS:":[221],"show":[223],"proof-of-concept":[225],"latest":[230],"human":[234],"Recon2.2":[236],"Recon3D.":[238],"report":[240],"most":[242,272],"mainly":[246],"associated":[247,263],"intake":[250],"essential":[252],"amino":[253],"acids":[254],"Recon2.2,":[256],"whereas":[257],"Recon":[259],"3D":[260],"they":[261],"largely":[264],"phospholipids.":[266],"illustrate":[269],"cases":[273],"there":[274],"significant":[277],"contribution":[278],"higher":[280],"order":[281],"effects.":[282],"CONCLUSION:":[283],"Our":[284],"indicate":[286],"interaction":[288],"effects":[289],"between":[290],"different":[291],"exist,":[294],"should":[296],"taken":[298],"account":[300],"especially":[301],"at":[302],"stage":[304],"calibration":[306],"supporting":[310],"importance":[312],"strategy":[316]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
