{"id":"https://openalex.org/W3032564623","doi":"https://doi.org/10.1186/s12859-020-3531-9","title":"CRISPRpred(SEQ): a sequence-based method for sgRNA on target activity prediction using traditional machine learning","display_name":"CRISPRpred(SEQ): a sequence-based method for sgRNA on target activity prediction using traditional machine learning","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3032564623","doi":"https://doi.org/10.1186/s12859-020-3531-9","mag":"3032564623","pmid":"https://pubmed.ncbi.nlm.nih.gov/32487025"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-3531-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3531-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3531-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3531-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052737765","display_name":"Ali Haisam Muhammad Rafid","orcid":"https://orcid.org/0000-0003-4368-3633"},"institutions":[{"id":"https://openalex.org/I183697816","display_name":"Bangladesh University of Engineering and Technology","ror":"https://ror.org/05a1qpv97","country_code":"BD","type":"education","lineage":["https://openalex.org/I183697816"]},{"id":"https://openalex.org/I63169043","display_name":"United International University","ror":"https://ror.org/01tqv1p28","country_code":"BD","type":"education","lineage":["https://openalex.org/I63169043"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Ali Haisam Muhammad Rafid","raw_affiliation_strings":["Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","Department of Computer Science and Engineering, United International University, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I183697816"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, United International University, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I63169043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037232111","display_name":"Md. Toufikuzzaman","orcid":"https://orcid.org/0000-0003-4267-5156"},"institutions":[{"id":"https://openalex.org/I183697816","display_name":"Bangladesh University of Engineering and Technology","ror":"https://ror.org/05a1qpv97","country_code":"BD","type":"education","lineage":["https://openalex.org/I183697816"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Toufikuzzaman","raw_affiliation_strings":["Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I183697816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733249","display_name":"Mohammad Saifur Rahman","orcid":"https://orcid.org/0000-0002-9887-4456"},"institutions":[{"id":"https://openalex.org/I183697816","display_name":"Bangladesh University of Engineering and Technology","ror":"https://ror.org/05a1qpv97","country_code":"BD","type":"education","lineage":["https://openalex.org/I183697816"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mohammad Saifur Rahman","raw_affiliation_strings":["Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh. msrahman@cse.buet.ac.bd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I183697816"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh. msrahman@cse.buet.ac.bd","institution_ids":["https://openalex.org/I183697816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029174615","display_name":"M. Sohel Rahman","orcid":"https://orcid.org/0000-0001-9419-6478"},"institutions":[{"id":"https://openalex.org/I183697816","display_name":"Bangladesh University of Engineering and Technology","ror":"https://ror.org/05a1qpv97","country_code":"BD","type":"education","lineage":["https://openalex.org/I183697816"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"M. Sohel Rahman","raw_affiliation_strings":["Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh. msrahman@cse.buet.ac.bd"],"raw_orcid":"https://orcid.org/0000-0001-9419-6478","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I183697816"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh. msrahman@cse.buet.ac.bd","institution_ids":["https://openalex.org/I183697816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052737765"],"corresponding_institution_ids":["https://openalex.org/I183697816","https://openalex.org/I63169043"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.9173,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.91968523,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"223","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9775999784469604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9775999784469604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7832159399986267},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7667853236198425},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.7026808857917786},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6908756494522095},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.5783579349517822},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.5290077328681946},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.07143527269363403}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7832159399986267},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7667853236198425},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.7026808857917786},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6908756494522095},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.5783579349517822},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5290077328681946},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.07143527269363403},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017394","descriptor_name":"RNA, Guide, Kinetoplastida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-3531-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3531-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3531-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32487025","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32487025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:1179e5fca13a44afae98e5775618ff5b","is_oa":false,"landing_page_url":"https://doaj.org/article/1179e5fca13a44afae98e5775618ff5b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7268231","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7268231","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-3531-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3531-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3531-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316680","display_name":"University of Engineering and Technology, Lahore","ror":"https://ror.org/0051w2v06"},{"id":"https://openalex.org/F4320325821","display_name":"Bangladesh University of Engineering and Technology","ror":"https://ror.org/05a1qpv97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3032564623.pdf","grobid_xml":"https://content.openalex.org/works/W3032564623.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1869792624","https://openalex.org/W1879165674","https://openalex.org/W1930624869","https://openalex.org/W1973260880","https://openalex.org/W1982846895","https://openalex.org/W2003082286","https://openalex.org/W2006373538","https://openalex.org/W2045435533","https://openalex.org/W2056132907","https://openalex.org/W2076063813","https://openalex.org/W2101234009","https://openalex.org/W2113242816","https://openalex.org/W2114245320","https://openalex.org/W2119821739","https://openalex.org/W2122410182","https://openalex.org/W2134298288","https://openalex.org/W2174058075","https://openalex.org/W2220694776","https://openalex.org/W2252568502","https://openalex.org/W2402498701","https://openalex.org/W2461013690","https://openalex.org/W2740658361","https://openalex.org/W2769318086","https://openalex.org/W2782213427","https://openalex.org/W2786944838","https://openalex.org/W2790756470","https://openalex.org/W2797525703","https://openalex.org/W2804549231","https://openalex.org/W2810756255","https://openalex.org/W2888855349","https://openalex.org/W2906828558","https://openalex.org/W2912664120","https://openalex.org/W2913791355","https://openalex.org/W2957191877","https://openalex.org/W2973312556","https://openalex.org/W3105114834","https://openalex.org/W3105982350"],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W2961085424","https://openalex.org/W3215138031","https://openalex.org/W4306674287","https://openalex.org/W3009238340","https://openalex.org/W4360585206","https://openalex.org/W4321369474","https://openalex.org/W4285208911","https://openalex.org/W4387369504","https://openalex.org/W3046775127"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"latest":[2],"works":[3],"on":[4],"CRISPR":[5],"genome":[6,33],"editing":[7,34],"tools":[8],"mainly":[9],"employs":[10],"deep":[11,15,47,94,185],"learning":[12,16,42,48,69,95,102,178,186],"techniques.":[13],"However,":[14],"models":[17],"lack":[18],"explainability":[19],"and":[20,39,71,126,166],"they":[21],"are":[22],"harder":[23],"to":[24,29,108,139],"reproduce.":[25],"We":[26,78,150],"were":[27],"motivated":[28],"build":[30],"an":[31],"accurate":[32],"tool":[35],"using":[36,98,162],"sequence-based":[37],"features":[38,73,160],"traditional":[40,67,100,176],"machine":[41,68,101,177],"that":[43,64,85,152,180],"can":[44,157,167,181],"compete":[45],"with":[46,84,170],"models.":[49,187],"RESULTS:":[50],"In":[51],"this":[52],"paper,":[53],"we":[54,104],"present":[55],"CRISPRpred(SEQ),":[56],"a":[57,93,171],"method":[58,173],"for":[59,111,129],"sgRNA":[60,76,164],"on-target":[61],"activity":[62],"prediction":[63],"leverages":[65],"only":[66,99,161,175],"techniques":[70],"hand-crafted":[72],"extracted":[74],"from":[75],"sequences.":[77],"compare":[79],"the":[80,88,112,120,130,163,184],"results":[81],"of":[82,86,115,146],"CRISPRpred(SEQ)":[83,135],"DeepCRISPR,":[87],"current":[89],"state-of-the-art,":[90],"which":[91],"uses":[92],"pipeline.":[96],"Despite":[97],"methods,":[103],"have":[105],"been":[106,137],"able":[107,138],"beat":[109,141,183],"DeepCRISPR":[110,142],"three":[113,131],"out":[114,145],"four":[116],"cell":[117,132,148],"lines":[118],"in":[119,143],"benchmark":[121],"dataset":[122],"convincingly":[123,140],"(2.174%,":[124],"6.905%":[125],"8.119%":[127],"improvement":[128],"lines).":[133],"CONCLUSION:":[134],"has":[136],"3":[144],"4":[147],"lines.":[149],"believe":[151],"by":[153],"exploring":[154],"further,":[155],"one":[156],"design":[158],"better":[159,172],"sequences":[165],"come":[168],"up":[169],"leveraging":[174],"algorithms":[179],"fully":[182]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2020-06-05T00:00:00"}