{"id":"https://openalex.org/W3021007339","doi":"https://doi.org/10.1186/s12859-020-3515-9","title":"Comparative analysis of similarity measurements in miRNAs with applications to miRNA-disease association predictions","display_name":"Comparative analysis of similarity measurements in miRNAs with applications to miRNA-disease association predictions","publication_year":2020,"publication_date":"2020-05-04","ids":{"openalex":"https://openalex.org/W3021007339","doi":"https://doi.org/10.1186/s12859-020-3515-9","mag":"3021007339","pmid":"https://pubmed.ncbi.nlm.nih.gov/32366225"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-3515-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3515-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3515-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3515-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100741607","display_name":"Hailin Chen","orcid":"https://orcid.org/0000-0002-5119-4517"},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hailin Chen","raw_affiliation_strings":["School of Software, East China Jiaotong University, Nanchang, 330013, China. chl_mail@csu.edu.cn","School of Software, East China Jiaotong University, Nanchang, 330013, China"],"raw_orcid":"https://orcid.org/0000-0002-5119-4517","affiliations":[{"raw_affiliation_string":"School of Software, East China Jiaotong University, Nanchang, 330013, China. chl_mail@csu.edu.cn","institution_ids":["https://openalex.org/I13985625"]},{"raw_affiliation_string":"School of Software, East China Jiaotong University, Nanchang, 330013, China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052907331","display_name":"Ruiyu Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiyu Guo","raw_affiliation_strings":["School of Software, East China Jiaotong University, Nanchang, 330013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, East China Jiaotong University, Nanchang, 330013, China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028229932","display_name":"Guanghui Li","orcid":"https://orcid.org/0000-0002-6884-5670"},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanghui Li","raw_affiliation_strings":["School of Information Engineering, East China Jiaotong University, Nanchang, 330013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Engineering, East China Jiaotong University, Nanchang, 330013, China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441786","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-3304-9161"},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["School of Science, East China Jiaotong University, Nanchang, 330013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, East China Jiaotong University, Nanchang, 330013, China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101841980","display_name":"Zuping Zhang","orcid":"https://orcid.org/0000-0001-6169-9191"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuping Zhang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, 410083, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100741607"],"corresponding_institution_ids":["https://openalex.org/I13985625"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.3428,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.7932983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"176","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9593999981880188,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9593999981880188,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6362171173095703},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.615780770778656},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.593205451965332},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5251531004905701},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5237569808959961},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4577331840991974},{"id":"https://openalex.org/keywords/semantic-similarity","display_name":"Semantic similarity","score":0.4516732096672058},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.43371981382369995},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4269689917564392},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38517454266548157},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38089749217033386},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34268754720687866},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.254014790058136},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2482404112815857},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1928013265132904}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6362171173095703},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.615780770778656},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.593205451965332},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5251531004905701},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5237569808959961},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4577331840991974},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.4516732096672058},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.43371981382369995},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4269689917564392},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38517454266548157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38089749217033386},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34268754720687866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.254014790058136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2482404112815857},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1928013265132904},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-3515-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3515-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3515-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32366225","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32366225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:8d232bc46da04c92865eb822a6ff5797","is_oa":true,"landing_page_url":"https://doaj.org/article/8d232bc46da04c92865eb822a6ff5797","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-14 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7199309","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7199309","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-3515-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3515-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3515-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2224960039","display_name":"\u57fa\u4e8e\u9776\u6807miRNA\u7684\u836f\u7269\u91cd\u5b9a\u4f4d\u9884\u6d4b\u7b97\u6cd5\u7814\u7a76","funder_award_id":"61862026","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320327522","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3021007339.pdf","grobid_xml":"https://content.openalex.org/works/W3021007339.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1560512206","https://openalex.org/W1577392641","https://openalex.org/W2009626621","https://openalex.org/W2014069457","https://openalex.org/W2014946489","https://openalex.org/W2022732522","https://openalex.org/W2047967134","https://openalex.org/W2094884005","https://openalex.org/W2095691234","https://openalex.org/W2110234420","https://openalex.org/W2119687825","https://openalex.org/W2120287619","https://openalex.org/W2124756133","https://openalex.org/W2128768066","https://openalex.org/W2129158737","https://openalex.org/W2141222510","https://openalex.org/W2158135353","https://openalex.org/W2163169932","https://openalex.org/W2219667518","https://openalex.org/W2313125707","https://openalex.org/W2463737032","https://openalex.org/W2502698579","https://openalex.org/W2516934006","https://openalex.org/W2557394189","https://openalex.org/W2575293459","https://openalex.org/W2750900465","https://openalex.org/W2752943586","https://openalex.org/W2753269195","https://openalex.org/W2756511952","https://openalex.org/W2768924715","https://openalex.org/W2780584018","https://openalex.org/W2780777007","https://openalex.org/W2799341160","https://openalex.org/W2802314916","https://openalex.org/W2803463181","https://openalex.org/W2809363952","https://openalex.org/W2820941669","https://openalex.org/W2888358121","https://openalex.org/W2890610025","https://openalex.org/W2898440040","https://openalex.org/W2926842391","https://openalex.org/W2944230847","https://openalex.org/W2962928958","https://openalex.org/W2963032163","https://openalex.org/W2966349991","https://openalex.org/W3146565636","https://openalex.org/W4200351727","https://openalex.org/W4246271082"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W2114797768","https://openalex.org/W2380654781","https://openalex.org/W2176214140","https://openalex.org/W2516873349"],"abstract_inverted_index":{"BACKGROUND:":[0],"As":[1],"regulators":[2],"of":[3,14,21,38,72,91,101],"gene":[4,87],"expression,":[5],"microRNAs":[6],"(miRNAs)":[7],"are":[8,42,58,104,111,205,223,228],"increasingly":[9],"recognized":[10],"as":[11],"critical":[12],"biomarkers":[13],"human":[15],"diseases.":[16],"Till":[17],"now,":[18],"a":[19,131,156],"series":[20],"computational":[22],"methods":[23,46],"have":[24],"been":[25],"proposed":[26],"to":[27,60,135,250],"predict":[28],"new":[29,197],"miRNA-disease":[30,140,198,234],"associations":[31],"based":[32,113,151],"on":[33,53,114,139,152],"similarity":[34,49,56,107,145,164,192,247],"measurements.":[35,146,174],"Different":[36],"categories":[37,71],"features":[39],"in":[40,44,80,85,243],"miRNAs":[41,110],"applied":[43],"these":[45,54,115],"for":[47,196,207,231],"miRNA-miRNA":[48],"calculation.":[50],"Benchmarking":[51],"tests":[52],"miRNA":[55,75,77,82,92],"measures":[57],"warranted":[59],"assess":[61],"their":[62,137],"effectiveness":[63],"and":[64,95,106,155,201,245,278],"robustness.":[65],"RESULTS:":[66],"In":[67],"this":[68],"study,":[69],"5":[70,123,173,218,275],"features,":[73,219],"i.e.":[74],"sequences,":[76],"expression":[78,83],"profiles":[79,84],"cell-lines,":[81],"tissues,":[86],"ontology":[88],"(GO)":[89],"annotations":[90],"target":[93],"genes":[94],"Medical":[96],"Subject":[97],"Heading":[98],"(MeSH)":[99],"terms":[100,168],"miRNA-associated":[102],"diseases,":[103],"collected":[105],"values":[108],"between":[109],"quantified":[112],"feature":[116,252,276],"spaces,":[117],"respectively.":[118],"We":[119,263],"systematically":[120],"compare":[121],"the":[122,144,163,172,180,202,217,274],"similarities":[124],"from":[125],"multi-statistical":[126],"views.":[127],"Furthermore,":[128],"we":[129],"adopt":[130],"rule-based":[132],"inference":[133],"method":[134],"test":[136],"performance":[138],"association":[141,199],"predictions":[142,200],"with":[143],"Comprehensive":[147],"comparison":[148],"is":[149,194],"made":[150],"leave-one-out":[153],"cross-validations":[154],"case":[157],"study.":[158],"Experimental":[159],"results":[160,204,239],"demonstrate":[161],"that":[162,179,215,265],"measurement":[165,193],"using":[166],"MeSH":[167],"performs":[169],"best":[170],"among":[171],"It":[175],"should":[176],"be":[177,241],"noted":[178],"other":[181],"4":[182],"measurements":[183,248],"can":[184],"also":[185],"achieve":[186],"reliable":[187,260],"prediction":[188,238,261],"performance.":[189],"The":[190],"best-performed":[191],"used":[195],"inferred":[203],"released":[206],"further":[208],"biomedical":[209],"screening.":[210],"CONCLUSIONS:":[211],"Our":[212],"study":[213],"suggests":[214],"all":[216],"even":[220],"though":[221],"some":[222],"restricted":[224],"by":[225],"data":[226],"availability,":[227],"useful":[229],"information":[230,272],"inferring":[232],"novel":[233],"associations.":[235],"However,":[236],"biased":[237],"might":[240],"produced":[242],"GO-":[244],"MeSH-based":[246],"due":[249],"incomplete":[251],"spaces.":[253],"Similarity":[254],"fusion":[255],"may":[256],"help":[257],"produce":[258],"more":[259,270],"results.":[262],"expect":[264],"future":[266],"studies":[267],"will":[268],"provide":[269],"detailed":[271],"into":[273],"spaces":[277],"widen":[279],"our":[280],"understanding":[281],"about":[282],"disease":[283],"pathogenesis.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}